Einar Martin Aandahl

  • Consultant, Group leader MD, PhD
  • +47 2284 0543

  Norway

 

Publications 2019

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Richter L, Phung D, Greiff V, Risnes LF, Yao Y, Neumann RS, Yaqub S, Øyen O, Horneland R, Aandahl EM, Paulsen V, Sollid LM, Qiao SW, Baekkevold ES, Jahnsen FL (2019)
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med (in press)
DOI 10.1084/jem.20190414, PubMed 31337737

Chellappa S, Kushekhar K, Munthe LA, Tjønnfjord GE, Aandahl EM, Okkenhaug K, Taskén K (2019)
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J Immunol, 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703, PubMed 30692213

Thorsen T, Solheim JM, Labori KJ, Line PD, Aandahl EM (2019)
Liver transplantation as a lifesaving procedure for posthepatectomy liver failure and iatrogenic liver injuries
Langenbecks Arch Surg, 404 (3), 301-308
DOI 10.1007/s00423-019-01780-3, PubMed 30929063

Publications 2018

Nordheim E, Horneland R, Aandahl EM, Grzyb K, Aabakken L, Paulsen V, Midtvedt K, Hartmann A, Jenssen T (2018)
Pancreas transplant rejection episodes are not revealed by biopsies of the donor duodenum in a prospective study with paired biopsies
Am J Transplant, 18 (5), 1256-1261
DOI 10.1111/ajt.14658, PubMed 29316221

Richter L, Landsverk OJB, Atlasy N, Bujko A, Yaqub S, Horneland R, Øyen O, Aandahl EM, Lundin KEA, Stunnenberg HG, Bækkevold ES, Jahnsen FL (2018)
Transcriptional profiling reveals monocyte-related macrophages phenotypically resembling DC in human intestine
Mucosal Immunol, 11 (5), 1512-1523
DOI 10.1038/s41385-018-0060-1, PubMed 30038215

Publications 2017

Bujko A, Atlasy N, Landsverk OJB, Richter L, Yaqub S, Horneland R, Øyen O, Aandahl EM, Aabakken L, Stunnenberg HG, Bækkevold ES, Jahnsen FL (2017)
Transcriptional and functional profiling defines human small intestinal macrophage subsets
J Exp Med, 215 (2), 441-458
DOI 10.1084/jem.20170057, PubMed 29273642

Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2017)
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
J Immunol, 198 (4), 1729-1739
DOI 10.4049/jimmunol.1600061, PubMed 28053236

Landsverk OJ, Snir O, Casado RB, Richter L, Mold JE, Réu P, Horneland R, Paulsen V, Yaqub S, Aandahl EM, Øyen OM, Thorarensen HS, Salehpour M, Possnert G, Frisén J, Sollid LM, Baekkevold ES, Jahnsen FL (2017)
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812

Lindahl JP, Horneland R, Nordheim E, Hartmann A, Aandahl EM, Grzyb K, Haugaa H, Kjøsen G, Åsberg A, Jenssen T (2017)
Outcomes in Pancreas Transplantation With Exocrine Drainage Through a Duodenoduodenostomy Versus Duodenojejunostomy
Am J Transplant, 18 (1), 154-162
DOI 10.1111/ajt.14420, PubMed 28696022

Publications 2015

Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2015)
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Oncoimmunology, 5 (4), e1102828
DOI 10.1080/2162402X.2015.1102828, PubMed 27141387

Chellappa S, Lieske NV, Hagness M, Line PD, Taskén K, Aandahl EM (2015)
Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells
J Leukoc Biol, 100 (1), 5-16
DOI 10.1189/jlb.2HI0815-334R, PubMed 26715685

Thorsen T, Dahlgren US, Aandahl EM, Grzyb K, Karlsen TH, Boberg KM, Rydberg L, Naper C, Foss A, Bennet W (2015)
Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications
Transpl Int, 28 (7), 800-12
DOI 10.1111/tri.12552, PubMed 25736519

Thorsen T, Aandahl EM, Bennet W, Olausson M, Ericzon BG, Nowak G, Duraj F, Isoniemi H, Rasmussen A, Karlsen TH, Foss A (2015)
Transplantation With Livers From Deceased Donors Older Than 75 Years
Transplantation, 99 (12), 2534-42
DOI 10.1097/TP.0000000000000728, PubMed 25909464

Publications 2014

Eskesen AN, Bjøro K, Aandahl EM, Line PD, Melum E (2014)
Low use of surveillance and early diagnosis of hepatocellular carcinoma in Norway--a population-based cohort study
Cancer Epidemiol, 38 (6), 741-7
DOI 10.1016/j.canep.2014.10.005, PubMed 25454262

Horneland R, Paulsen V, Lindahl JP, Grzyb K, Eide TJ, Lundin K, Aabakken L, Jenssen T, Aandahl EM, Foss A, Øyen O (2014)
Pancreas transplantation with enteroanastomosis to native duodenum poses technical challenges--but offers improved endoscopic access for scheduled biopsies and therapeutic interventions
Am J Transplant, 15 (1), 242-50
DOI 10.1111/ajt.12953, PubMed 25394773

Landskron J, Helland Ø, Torgersen KM, Aandahl EM, Gjertsen BT, Bjørge L, Taskén K (2014)
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients
Cancer Immunol Immunother, 64 (3), 337-47
DOI 10.1007/s00262-014-1636-6, PubMed 25416072

Skånland SS, Moltu K, Berge T, Aandahl EM, Taskén K (2014)
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
Biochem J, 460 (3), 399-410
DOI 10.1042/BJ20140040, PubMed 24665965

Publications 2013

Brudvik KW, Bains SJ, Seeberg LT, Labori KJ, Waage A, Taskén K, Aandahl EM, Bjørnbeth BA (2013)
Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience
HPB Surg, 2013, 727095
DOI 10.1155/2013/727095, PubMed 23840074

Publications 2012

Hagness M, Henjum K, Landskron J, Brudvik KW, Bjørnbeth BA, Foss A, Taskén K, Aandahl EM (2012)
Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells
J Immunol, 188 (11), 5459-66
DOI 10.4049/jimmunol.1101367, PubMed 22539784

Publications 2011

Brudvik KW, Henjum K, Aandahl EM, Bjørnbeth BA, Taskén K (2011)
Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
Cancer Immunol Immunother, 61 (7), 1045-53
DOI 10.1007/s00262-011-1174-4, PubMed 22159472

Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011)
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice
Mol Cancer, 10, 149
DOI 10.1186/1476-4598-10-149, PubMed 22168384

Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D (2011)
An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses
J Virol, 85 (13), 6557-66
DOI 10.1128/JVI.00073-11, PubMed 21490090

Solstad T, Bains SJ, Landskron J, Aandahl EM, Thiede B, Taskén K, Torgersen KM (2011)
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
Blood, 118 (19), 5141-51
DOI 10.1182/blood-2011-02-339242, PubMed 21937704

Publications 2010

Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Taskén K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF (2010)
A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
Eur J Immunol, 40 (1), 134-41
DOI 10.1002/eji.200939258, PubMed 19877008

Publications 2009

Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM (2009)
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
Eur J Immunol, 39 (5), 1280-7
DOI 10.1002/eji.200839002, PubMed 19384871

Yaqub S, Aandahl EM (2009)
Inflammation versus adaptive immunity in cancer pathogenesis
Crit Rev Oncog, 15 (1-2), 43-63
PubMed 20136627

Publications 2008

Bryn T, Mahic M, Aandahl EM, Frøland SS, Aukrust P, Taskén K (2008)
Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients
AIDS Res Hum Retroviruses, 24 (7), 1013-5
DOI 10.1089/aid.2008.0071, PubMed 18593346

Mahic M, Henjum K, Yaqub S, Bjørnbeth BA, Torgersen KM, Taskén K, Aandahl EM (2008)
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation
Eur J Immunol, 38 (3), 640-6
DOI 10.1002/eji.200737529, PubMed 18266270

Mahic M, Kalland ME, Aandahl EM, Torgersen KM, Taskén K (2008)
Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation
Scand J Immunol, 68 (4), 391-6
DOI 10.1111/j.1365-3083.2008.02148.x, PubMed 18782268

Mahic M, Yaqub S, Bryn T, Henjum K, Eide DM, Torgersen KM, Aandahl EM, Taskén K (2008)
Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation
J Leukoc Biol, 83 (5), 1111-7
DOI 10.1189/jlb.0507329, PubMed 18270250

Torgersen KM, Aandahl EM, Taskén K (2008)
Molecular architecture of signal complexes regulating immune cell function
Handb Exp Pharmacol (186), 327-63
DOI 10.1007/978-3-540-72843-6_14, PubMed 18491059

Aandahl EM, Torgersen KM, Taskén K (2008)
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Hum Immunol, 69 (11), 696-9
DOI 10.1016/j.humimm.2008.08.291, PubMed 18817824

Publications 2007

Bryn T, Yaqub S, Mahic M, Henjum K, Aandahl EM, Taskén K (2007)
LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
Int Immunol, 20 (2), 235-45
DOI 10.1093/intimm/dxm134, PubMed 18156149

Ruppelt A, Mosenden R, Grönholm M, Aandahl EM, Tobin D, Carlson CR, Abrahamsen H, Herberg FW, Carpén O, Taskén K (2007)
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
J Immunol, 179 (8), 5159-68
DOI 10.4049/jimmunol.179.8.5159, PubMed 17911601

Yaqub S, Henjum K, Mahic M, Jahnsen FL, Aandahl EM, Bjørnbeth BA, Taskén K (2007)
Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
Cancer Immunol Immunother, 57 (6), 813-21
DOI 10.1007/s00262-007-0417-x, PubMed 17962941

Publications 2006

Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K (2006)
The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
J Immunol, 176 (12), 7361-70
DOI 10.4049/jimmunol.176.12.7361, PubMed 16751380

Hesstvedt L, Hasseltvedt V, Aandahl E, Caugant D, Høiby EA (2006)
Septicaemia due to Actinobaculum schalii
Scand J Infect Dis, 38 (8), 735-7
DOI 10.1080/00365540500540467, PubMed 16857631

Kvale D, Ormaasen V, Kran AM, Johansson CC, Aukrust P, Aandahl EM, Frøland SS, Taskén K (2006)
Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
AIDS, 20 (6), 813-20
DOI 10.1097/01.aids.0000218544.54586.f1, PubMed 16549964

Mahic M, Yaqub S, Johansson CC, Taskén K, Aandahl EM (2006)
FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism
J Immunol, 177 (1), 246-54
DOI 10.4049/jimmunol.177.1.246, PubMed 16785520

Publications 2005

Hagen IJ, Aandahl E, Hasseltvedt V (2005)
Five case histories of tularaemia infection in Oppland and Hedmark Counties, Norway
Euro Surveill, 10 (3), E050317.4
DOI 10.2807/esw.10.11.02666-en, PubMed 16702642

Nixon DF, Aandahl EM, Michaëlsson J (2005)
CD4+CD25+ regulatory T cells in HIV infection
Microbes Infect, 7 (7-8), 1063-5
DOI 10.1016/j.micinf.2005.03.026, PubMed 15893493

Publications 2004

Johansson CC, Bryn T, Aandahl EM, Areklett MA, Aukrust P, Taskén K, Frøland SS (2004)
Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy
AIDS, 18 (6), 951-2
DOI 10.1097/00002030-200404090-00015, PubMed 15060445

Rahmouni S, Aandahl EM, Nayjib B, Zeddou M, Giannini S, Verlaet M, Greimers R, Boniver J, Tasken K, Moutschen M (2004)
Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Biochem J, 384 (Pt 3), 469-76
DOI 10.1042/BJ20031859, PubMed 15344910

Taskén K, Aandahl EM (2004)
Localized effects of cAMP mediated by distinct routes of protein kinase A
Physiol Rev, 84 (1), 137-67
DOI 10.1152/physrev.00021.2003, PubMed 14715913

Aandahl EM, Michaëlsson J, Moretto WJ, Hecht FM, Nixon DF (2004)
Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
J Virol, 78 (5), 2454-9
DOI 10.1128/jvi.78.5.2454-2459.2004, PubMed 14963140

Aandahl EM, Quigley MF, Moretto WJ, Moll M, Gonzalez VD, Sönnerborg A, Lindbäck S, Hecht FM, Deeks SG, Rosenberg MG, Nixon DF, Sandberg JK (2004)
Expansion of CD7(low) and CD7(negative) CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment
Blood, 104 (12), 3672-8
DOI 10.1182/blood-2004-07-2540, PubMed 15308569

Publications 2003

Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS (2003)
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
J Immunol, 170 (11), 5772-7
DOI 10.4049/jimmunol.170.11.5772, PubMed 12759461

Johansson CC, Dahle MK, Blomqvist SR, Grønning LM, Aandahl EM, Enerbäck S, Taskén K (2003)
A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha
J Biol Chem, 278 (19), 17573-9
DOI 10.1074/jbc.M300311200, PubMed 12621056

Nixon DF, Aandahl EM, Sandberg JK (2003)
New observations on CD8 cell responses
AIDS, 17 Suppl 4, S61-5
DOI 10.1097/00002030-200317004-00007, PubMed 15080181

Aandahl EM, Sandberg JK, Beckerman KP, Taskén K, Moretto WJ, Nixon DF (2003)
CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets
J Immunol, 170 (5), 2349-55
DOI 10.4049/jimmunol.170.5.2349, PubMed 12594257

Publications 2002

Aandahl EM, Moretto WJ, Haslett PA, Vang T, Bryn T, Tasken K, Nixon DF (2002)
Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I
J Immunol, 169 (2), 802-8
DOI 10.4049/jimmunol.169.2.802, PubMed 12097383

Publications 2001

Rahmouni S, Aandahl EM, Trebak M, Boniver J, Taskén K, Moutschen M (2001)
Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing
FASEB J, 15 (8), 1466-8
DOI 10.1096/fj.00-0813fje, PubMed 11387259

Publications 2000

Taskén K, Hansson V, Aukrust P, Frøland S, Skålhegg BS, Müller F, Tobin D, Vang T, Torgersen KM, Aandahl EM (2000)
PKAI as a potential target for therapeutic intervention
Drug News Perspect, 13 (1), 12-8
PubMed 12937648

Publications 1999

Aukrust P, Aandahl EM, Skålhegg BS, Nordøy I, Hansson V, Taskén K, Frøland SS, Müller F (1999)
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
J Immunol, 162 (2), 1178-85
PubMed 9916750

Aandahl EM (1999)
[Image of physicians as professionals]
Tidsskr Nor Laegeforen, 119 (29), 4371
PubMed 10667143

Aandahl EM, Aukrust P, Müller F, Hansson V, Taskén K, Frøland SS (1999)
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART
AIDS, 13 (17), F109-14
DOI 10.1097/00002030-199912030-00001, PubMed 10597771

Publications 1998

Skålhegg BS, Johansen AK, Levy FO, Andersson KB, Aandahl EM, Blomhoff HK, Hansson V, Taskén K (1998)
Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
J Cell Physiol, 177 (1), 85-93
DOI 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A, PubMed 9731748

Aandahl EM, Aukrust P, Skålhegg BS, Müller F, Frøland SS, Hansson V, Taskén K (1998)
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
FASEB J, 12 (10), 855-62
DOI 10.1096/fasebj.12.10.855, PubMed 9657525

Publications 1987

Gran JT, Eng J, Refvem OK, Denstad T, Aandahl E (1987)
Monoarthritis due to Mycobacterium chelonei
J Rheumatol, 14 (4), 852-3
PubMed 3668994

Publications 1981

Sander J, Aandahl E, Fellner H, Kalstad S (1981)
The treatment of urinary tract infections in out-patients A double-blind comparison between trimethoprim and nitrofurantoin
J Int Med Res, 9 (3), 181-5
DOI 10.1177/030006058100900305, PubMed 7016626

Publications 1965

Iversen OH, Aandahl E, Elgjo K (1965)
The effect of an epidermis-specific mitotic inhibitor (chalone) extracted from epidermal cells
Acta Pathol Microbiol Scand, 64 (4), 506-10
DOI 10.1111/apm.1965.64.4.506, PubMed 5829962

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