Patrik Wernhoff

  • Postdoc; PhD


1996-2002: PhD in Medical Science (Lund University, Sweden)

1987-1995: Bachelor in Microbiology and Genetics (Uppsala University , Sweden)

Research interests/projects:

  • Humoral immunology: B-cells, antibody production and characterization.
  • Cellular immunology: T-cell responses, Chimeric antigen Receptor (CAR).
  • Cancer: Mutagenesis, Melanoma, Herediary tumors.
  • Bioinformatics: Next Generation Sequencing, data analyze, RNA/DNA sequences.

Work experience:

2020- present: Postdoctoral research, Dept. of Cellular Therapy, OUS-Radiumhospitalet, Oslo, Norway.

2017- 2019: Postdoctoral research, Dept. Of Tumor Biology, Institute of Cancer Research (OUS-Radiumhospitalet), Oslo, Norway.

2016-2016: Postdoctoral research, Akershus Universitetssjukhus, Oslo, Norway.

2011-2013: Postdoctoral research/ Researcher, Transgenic Core Facility & LTCF/Reproduction Immunology, Lund University, Sweden.

 2006-2008: Postdoctoral research, National Veterinary Institute, Dept. Of Veterinary Diagnostics and Research, Danmark.

2003-2005: Postdoctoral research, Dept. Of Immunology, Rostock University, Germany.


Marie Curie Grant: Postdoctoral position, Rostock University, Germany.


Publications 2022

Maggadóttir SM, Kvalheim G, Wernhoff P, Sæbøe-Larssen S, Revheim ME, Josefsen D, Wälchli S, Helland Å, Inderberg EM (2022)
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
Front Oncol, 12, 1031232
DOI 10.3389/fonc.2022.1031232, PubMed 36439452

Zavaleta E, Solis N, Palacios MI, Zevallos-Escobar LE, Corales EV, Bazo-Alvarez JC, Dominguez-Barrera C, Campos A, Wernhoff P, Ekstrøm PO, Møller P, Visnovska T, Hovig E, Balazar-Palacios J, Alvarez-Valenzuela K, Nakken S, Dominguez-Valentin M (2022)
Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru
Cancers (Basel), 14 (22)
DOI 10.3390/cancers14225603, PubMed 36428697

Publications 2021

Solis N, Zavaleta E, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M (2021)
Challenges to Bringing Personalized Medicine to a Low-Resource Setting in Peru
Int J Environ Res Public Health, 18 (4)
DOI 10.3390/ijerph18041470, PubMed 33557277

Publications 2020

Flem-Karlsen K, Nyakas M, Farstad IN, McFadden E, Wernhoff P, Jacobsen KD, Flørenes VA, Mælandsmo GM (2020)
Soluble AXL as a marker of disease progression and survival in melanoma
PLoS One, 15 (1), e0227187
DOI 10.1371/journal.pone.0227187, PubMed 31917795

Lavelle TJ, Alver TN, Heintz KM, Wernhoff P, Nygaard V, Nakken S, Øy GF, Bøe SL, Urbanucci A, Hovig E (2020)
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071719, PubMed 32605315

Publications 2019

Della Valle A, Rossi BM, Palmero EI, Antelo M, Vaccaro CA, López-Kostner F, Alvarez K, Cruz-Correa M, Bruno LI, Forones NM, Mindiola JAR, Buleje J, Spirandelli F, Bohorquez M, Cock-Rada AM, Sullcahuaman Y, Nascimento I, Abe-Sandes K, Lino-Silva LS, Petracchi F, Mampel A, Rodriguez Y, Rossi NT, Yañez CB, Rubio C et al. (2019)
A snapshot of current genetic testing practice in Lynch syndrome: The results of a representative survey of 33 Latin American existing centres/registries
Eur J Cancer, 119, 112-121
DOI 10.1016/j.ejca.2019.07.017, PubMed 31442815

Flørenes VA, Flem-Karlsen K, McFadden E, Bergheim IR, Nygaard V, Nygård V, Farstad IN, Øy GF, Emilsen E, Giller-Fleten K, Ree AH, Flatmark K, Gullestad HP, Hermann R, Ryder T, Wernhoff P, Mælandsmo GM (2019)
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111

Juraleviciute M, Pozniak J, Nsengimana J, Harland M, Randerson-Moor J, Wernhoff P, Bassarova A, Øy GF, Trøen G, Flørenes VA, Bishop DT, Herlyn M, Newton-Bishop J, Slipicevic A (2019)
MX 2 is a novel regulator of cell cycle in melanoma cells
Pigment Cell Melanoma Res, 33 (3), 446-457
DOI 10.1111/pcmr.12837, PubMed 31660681

Publications 2018

Vaccaro CA, López-Kostner F, Adriana DV, Palmero EI, Rossi BM, Antelo M, Solano A, Carraro DM, Forones NM, Bohorquez M, Lino-Silva LS, Buleje J, Spirandelli F, Abe-Sandes K, Nascimento I, Sullcahuaman Y, Sarroca C, Gonzalez ML, Herrando AI, Alvarez K, Neffa F, Galvão HC, Esperon P, Golubicki M, Cisterna D et al. (2018)
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
Int J Cancer, 145 (2), 318-326
DOI 10.1002/ijc.31920, PubMed 30303536

Publications 2017

Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C et al. (2017)
A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America
BMC Cancer, 17 (1), 623
DOI 10.1186/s12885-017-3599-4, PubMed 28874130

Publications 2016

DA Silva FC, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M (2016)
Update on Hereditary Colorectal Cancer
Anticancer Res, 36 (9), 4399-405
DOI 10.21873/anticanres.10983, PubMed 27630275

Dominguez-Valentin M, Wernhoff P, Cajal AR, Kalfayan PG, Piñero TA, Gonzalez ML, Ferro A, Sammartino I, Causada Calo NS, Vaccaro CA (2016)
MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome
Front Oncol, 6, 189
DOI 10.3389/fonc.2016.00189, PubMed 27606285

Publications 2014

de Oliveira BM, Matsumura CY, Fontes-Oliveira CC, Gawlik KI, Acosta H, Wernhoff P, Durbeej M (2014)
Quantitative proteomic analysis reveals metabolic alterations, calcium dysregulation, and increased expression of extracellular matrix proteins in laminin α2 chain-deficient muscle
Mol Cell Proteomics, 13 (11), 3001-13
DOI 10.1074/mcp.M113.032276, PubMed 24994560

Ñique Carbajal C, Sánchez Renteria F, Lettiero B, Wernhoff P, Domínguez-Valentin M (2014)
[Molecular characterization of hereditary colorectal cancer in Peru]
Rev Gastroenterol Peru, 34 (4), 299-303
PubMed 25594752

Publications 2013

Dominguez-Valentin M, Nilbert M, Wernhoff P, López-Köstner F, Vaccaro C, Sarroca C, Palmero EI, Giraldo A, Ashton-Prolla P, Alvarez K, Ferro A, Neffa F, Caris J, Carraro DM, Rossi BM (2013)
Mutation spectrum in South American Lynch syndrome families
Hered Cancer Clin Pract, 11 (1), 18
DOI 10.1186/1897-4287-11-18, PubMed 24344984

Publications 2007

Yu X, Bauer K, Wernhoff P, Ibrahim SM (2007)
Using an advanced intercross line to identify quantitative trait loci controlling immune response during collagen-induced arthritis
Genes Immun, 8 (4), 296-301
DOI 10.1038/sj.gene.6364385, PubMed 17361202

Publications 2006

Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson A, Holmdahl R, Mattsson R (2006)
Identification of genetic regions of importance for reproductive performance in female mice
Genetics, 173 (2), 901-9
DOI 10.1534/genetics.105.054049, PubMed 16547111

Yu X, Bauer K, Wernhoff P, Koczan D, Möller S, Thiesen HJ, Ibrahim SM (2006)
Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross line
J Immunol, 177 (10), 7042-9
DOI 10.4049/jimmunol.177.10.7042, PubMed 17082620

Publications 2005

Johannesson M, Karlsson J, Wernhoff P, Nandakumar KS, Lindqvist AK, Olsson L, Cook AD, Andersson A, Holmdahl R (2005)
Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice
Genes Immun, 6 (3), 175-85
DOI 10.1038/sj.gene.6364155, PubMed 15716976

Karlsson J, Johannesson M, Lindvall T, Wernhoff P, Holmdahl R, Andersson A (2005)
Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio
J Immunol, 174 (1), 533-41
DOI 10.4049/jimmunol.174.1.533, PubMed 15611280

Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM (2005)
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease
Hum Mol Genet, 14 (14), 1977-89
DOI 10.1093/hmg/ddi203, PubMed 15917267

Publications 2004

Bauer K, Yu X, Wernhoff P, Koczan D, Thiesen HJ, Ibrahim SM (2004)
Identification of new quantitative trait loci in mice with collagen-induced arthritis
Arthritis Rheum, 50 (11), 3721-8
DOI 10.1002/art.20624, PubMed 15529344

Publications 2003

Olofsson P, Lu S, Holmberg J, Song T, Wernhoff P, Pettersson U, Holmdahl R (2003)
A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis
Arthritis Rheum, 48 (8), 2332-42
DOI 10.1002/art.11100, PubMed 12905489

Olofsson P, Wernhoff P, Holmberg J, Holmdahl R (2003)
Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6
Genomics, 82 (6), 652-9
DOI 10.1016/s0888-7543(03)00208-8, PubMed 14611807

Wernhoff P, Olofsson P, Holmdahl R (2003)
The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis
Arthritis Rheum, 48 (12), 3584-96
DOI 10.1002/art.11342, PubMed 14674011

Publications 2001

Kraetsch HG, Unger C, Wernhoff P, Schneider C, Kalden JR, Holmdahl R, Burkhardt H (2001)
Cartilage-specific autoimmunity in rheumatoid arthritis: characterization of a triple helical B cell epitope in the integrin-binding-domain of collagen type II
Eur J Immunol, 31 (6), 1666-73
DOI 10.1002/1521-4141(200106)31:6<1666::aid-immu1666>;2-t, PubMed 11385610

Wernhoff P, Unger C, Bajtner E, Burkhardt H, Holmdahl R (2001)
Identification of conformation-dependent epitopes and V gene selection in the B cell response to type II collagen in the DA rat
Int Immunol, 13 (7), 909-19
DOI 10.1093/intimm/13.7.909, PubMed 11431421

Yang HT, Bergsteinsdottir K, Wernhoff P, Linington C, Pettersson U, Holmdahl R (2001)
Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate
J Neuroimmunol, 117 (1-2), 21-9
DOI 10.1016/s0165-5728(01)00320-4, PubMed 11431001

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