Luisa Luna

  • Research scientist Ph.D.
  • 23074065
 

Publications 2017

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564

Publications 2016

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939

Publications 2015

Skarpengland T, Laugsand LE, Janszky I, Luna L, Halvorsen B, Platou CG, Wang W, Vatten LJ, Damås JK, Aukrust P, Bjørås M, Åsvold BO (2015)
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study
DNA Repair (Amst), 28, 21-7
DOI 10.1016/j.dnarep.2015.01.013, PubMed 25703835

Publications 2014

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Publications 2013

Krokeide SZ, Laerdahl JK, Salah M, Luna L, Cederkvist FH, Fleming AM, Burrows CJ, Dalhus B, Bjørås M (2013)
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
DNA Repair (Amst), 12 (12), 1159-64
DOI 10.1016/j.dnarep.2013.04.026, PubMed 23755964

Rolseth V, Krokeide SZ, Kunke D, Neurauter CG, Suganthan R, Sejersted Y, Hildrestrand GA, Bjørås M, Luna L (2013)
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress
Biochim Biophys Acta, 1833 (5), 1157-64
DOI 10.1016/j.bbamcr.2012.12.024, PubMed 23305905

Publications 2012

Neurauter CG, Luna L, Bjørås M (2012)
Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway
DNA Repair (Amst), 11 (4), 401-9
DOI 10.1016/j.dnarep.2012.01.007, PubMed 22365498

Ranneberg-Nilsen T, Rollag H, Slettebakk R, Backe PH, Olsen Ø, Luna L, Bjørås M (2012)
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
PLoS One, 7 (3), e34119
DOI 10.1371/journal.pone.0034119, PubMed 22479537

Regnell CE, Hildrestrand GA, Sejersted Y, Medin T, Moldestad O, Rolseth V, Krokeide SZ, Suganthan R, Luna L, Bjørås M, Bergersen LH (2012)
Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells
Cell Rep, 2 (3), 503-10
DOI 10.1016/j.celrep.2012.08.008, PubMed 22959434

Vik ES, Alseth I, Forsbring M, Helle IH, Morland I, Luna L, Bjørås M, Dalhus B (2012)
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
DOI 10.1016/j.dnarep.2012.07.002, PubMed 22858590

Publications 2011

Sejersted Y, Hildrestrand GA, Kunke D, Rolseth V, Krokeide SZ, Neurauter CG, Suganthan R, Atneosen-Åsegg M, Fleming AM, Saugstad OD, Burrows CJ, Luna L, Bjørås M (2011)
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
Proc Natl Acad Sci U S A, 108 (46), 18802-7
DOI 10.1073/pnas.1106880108, PubMed 22065741

Publications 2009

Hildrestrand GA, Duggal S, Bjørås M, Luna L, Brinchmann JE (2009)
Modulation of DNA glycosylase activities in mesenchymal stem cells
Exp Cell Res, 315 (15), 2558-67
DOI 10.1016/j.yexcr.2009.05.017, PubMed 19477173

Hildrestrand GA, Neurauter CG, Diep DB, Castellanos CG, Krauss S, Bjørås M, Luna L (2009)
Expression patterns of Neil3 during embryonic brain development and neoplasia
BMC Neurosci, 10, 45
DOI 10.1186/1471-2202-10-45, PubMed 19426544

Yndestad A, Neurauter CG, Oie E, Forstrøm RJ, Vinge LE, Eide L, Luna L, Aukrust P, Bjørås M (2009)
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure
Mutat Res, 666 (1-2), 32-8
DOI 10.1016/j.mrfmmm.2009.03.008, PubMed 19481677

Publications 2008

Krokeide SZ, Bolstad N, Laerdahl JK, Bjørås M, Luna L (2008)
Expression and purification of NEIL3, a human DNA glycosylase homolog
Protein Expr Purif, 65 (2), 160-4
DOI 10.1016/j.pep.2008.11.014, PubMed 19121397

Lorenzo Y, Azqueta A, Luna L, Bonilla F, Domínguez G, Collins AR (2008)
The carotenoid beta-cryptoxanthin stimulates the repair of DNA oxidation damage in addition to acting as an antioxidant in human cells
Carcinogenesis, 30 (2), 308-14
DOI 10.1093/carcin/bgn270, PubMed 19056931

Ranneberg-Nilsen T, Dale HA, Luna L, Slettebakk R, Sundheim O, Rollag H, Bjørås M (2008)
Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44)
J Mol Biol, 381 (2), 276-88
DOI 10.1016/j.jmb.2008.05.028, PubMed 18599070

Rolseth V, Rundén-Pran E, Luna L, McMurray C, Bjørås M, Ottersen OP (2008)
Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains
DNA Repair (Amst), 7 (9), 1578-88
DOI 10.1016/j.dnarep.2008.06.007, PubMed 18603019

Rolseth V, Rundén-Pran E, Neurauter CG, Yndestad A, Luna L, Aukrust P, Ottersen OP, Bjørås M (2008)
Base excision repair activities in organotypic hippocampal slice cultures exposed to oxygen and glucose deprivation
DNA Repair (Amst), 7 (6), 869-78
DOI 10.1016/j.dnarep.2008.02.009, PubMed 18406215

Publications 2007

Hildrestrand GA, Diep DB, Kunke D, Bolstad N, Bjørås M, Krauss S, Luna L (2007)
The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation
DNA Repair (Amst), 6 (6), 723-32
DOI 10.1016/j.dnarep.2006.12.008, PubMed 17236821

Hildrestrand GA, Rolseth V, Bjørås M, Luna L (2007)
Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis
DNA Repair (Amst), 6 (10), 1425-33
DOI 10.1016/j.dnarep.2007.04.008, PubMed 17556049

Publications 2006

Ranneberg-Nilsen T, Bjørås M, Luna L, Slettebakk R, Dale HA, Seeberg E, Rollag H (2006)
Human cytomegalovirus infection modulates DNA base excision repair in fibroblast cells
Virology, 348 (2), 389-97
DOI 10.1016/j.virol.2006.01.001, PubMed 16476462

Publications 2005

Aukrust P, Luna L, Ueland T, Johansen RF, Müller F, Frøland SS, Seeberg EC, Bjørås M (2005)
Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients
Blood, 105 (12), 4730-5
DOI 10.1182/blood-2004-11-4272, PubMed 15705786

Luna L, Rolseth V, Hildrestrand GA, Otterlei M, Dantzer F, Bjørås M, Seeberg E (2005)
Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant
Nucleic Acids Res, 33 (6), 1813-24
DOI 10.1093/nar/gki325, PubMed 15800211

Morland I, Luna L, Gustad E, Seeberg E, Bjørås M (2005)
Product inhibition and magnesium modulate the dual reaction mode of hOgg1
DNA Repair (Amst), 4 (3), 381-7
DOI 10.1016/j.dnarep.2004.11.002, PubMed 15661661

Olsen PA, Randøl M, Luna L, Brown T, Krauss S (2005)
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
J Gene Med, 7 (12), 1534-44
DOI 10.1002/jgm.804, PubMed 16025558

Publications 2003

Dantzer F, Bjørås M, Luna L, Klungland A, Seeberg E (2003)
Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
DNA Repair (Amst), 2 (6), 707-18
DOI 10.1016/S1568-7864(03)00041-7, PubMed 12767349

Liu Y, Reichelt WH, Luna L, Elgjo K, Reichelt KL (2003)
The effects of a growth-inhibiting tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), on gene expression and cell cycle progression of two lymphoma cell lines
Anticancer Res, 23 (4), 3159-65
PubMed 12926049

Publications 2002

Bjørås M, Seeberg E, Luna L, Pearl LH, Barrett TE (2002)
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
J Mol Biol, 317 (2), 171-7
DOI 10.1006/jmbi.2002.5400, PubMed 11902834

Dantzer F, Luna L, Bjørås M, Seeberg E (2002)
Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo
Nucleic Acids Res, 30 (11), 2349-57
DOI 10.1093/nar/30.11.2349, PubMed 12034821

Morland I, Rolseth V, Luna L, Rognes T, Bjørås M, Seeberg E (2002)
Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA
Nucleic Acids Res, 30 (22), 4926-36
DOI 10.1093/nar/gkf618, PubMed 12433996

Reichelt WH, Liu Y, Luna L, Eigjo K, Reichelt KL (2002)
Early oncogene mRNA expression in HT-29 cells treated with the endogenous colon mitosis inhibitor pyroglutamyl-histidyl-glycine
Anticancer Res, 22 (2A), 991-6
PubMed 12014683

Publications 2001

Eide L, Luna L, Gustad EC, Henderson PT, Essigmann JM, Demple B, Seeberg E (2001)
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA
Biochemistry, 40 (22), 6653-9
DOI 10.1021/bi0028901, PubMed 11380260

Publications 2000

Luna L, Bjørås M, Hoff E, Rognes T, Seeberg E (2000)
Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA
Mutat Res, 460 (2), 95-104
DOI 10.1016/S0921-8777(00)00015-X, PubMed 10882850

Seeberg E, Luna L, Morland I, Eide L, Johnsen B, Larsen E, Alseth I, Dantzer F, Baynton K, Aamodt R, Kristiansen KI, Rognes T, Klungland A, Bjørås M (2000)
Base removers and strand scissors: different strategies employed in base excision and strand incision at modified base residues in DNA
Cold Spring Harb Symp Quant Biol, 65, 135-42
DOI 10.1101/sqb.2000.65.135, PubMed 12760028

Publications 1999

Luna L, Bjoras M, Berdal KG, Alseth I, Eide L, Rognes T, Seeberg E (1999)
Genes and enzymes for the removal of oxidative DNA base damage
ALFRED BENZON SYMP S, 44, 272-283

Publications 1997

Bjorâs M, Luna L, Johnsen B, Hoff E, Haug T, Rognes T, Seeberg E (1997)
Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites
EMBO J, 16 (20), 6314-22
DOI 10.1093/emboj/16.20.6314, PubMed 9321410

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