Mahmood Reza Amiry-Moghaddam

  • Professor of Molecular Neuroscience; MD, PhD
  • +47 22 85 12 73

Publications 2019

Amiry-Moghaddam M (2019)
AQP4 and the Fate of Gliomas
Cancer Res, 79 (11), 2810-2811
DOI 10.1158/0008-5472.CAN-19-1185, PubMed 31160309

Rao SB, Katoozi S, Skauli N, Froehner SC, Ottersen OP, Adams ME, Amiry-Moghaddam M (2019)
Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina
Glia, 67 (6), 1138-1149
DOI 10.1002/glia.23600, PubMed 30803043

Vatnehol SAS, Hol PK, Bjørnerud A, Amiry-Moghaddam M, Haglerød C, Storås TH (2019)
Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters
MAGMA, 32 (3), 359-368
DOI 10.1007/s10334-018-00731-1, PubMed 30604145

Vatnehol SAS, Hol PK, Bjørnerud A, Amiry-Moghaddam M, Haglerød C, Storås TH (2019)
Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen
DOI 10.1007/s10334-019-00783-x, PubMed 31606810

Publications 2018

Formaggio F, Saracino E, Mola MG, Rao SB, Amiry-Moghaddam M, Muccini M, Zamboni R, Nicchia GP, Caprini M, Benfenati V (2018)
LRRC8A is essential for swelling-activated chloride current and for regulatory volume decrease in astrocytes
FASEB J, 33 (1), 101-113
DOI 10.1096/fj.201701397RR, PubMed 29957062

Moen I, Ugland H, Strömberg N, Sjöström E, Karlson A, Ringstad L, Bysell H, Amiry-Moghaddam M, Haglerød C (2018)
Development of a novel in situ gelling skin dressing: Delivering high levels of dissolved oxygen at pH 5.5
Health Sci Rep, 1 (7), e57
DOI 10.1002/hsr2.57, PubMed 30623087

Stahl K, Rahmani S, Prydz A, Skauli N, MacAulay N, Mylonakou MN, Torp R, Skare Ø, Berg T, Leergaard TB, Paulsen RE, Ottersen OP, Amiry-Moghaddam M (2018)
Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease
PLoS One, 13 (3), e0194896
DOI 10.1371/journal.pone.0194896, PubMed 29566083

Publications 2017

Katoozi S, Skauli N, Rahmani S, Camassa LMA, Boldt HB, Ottersen OP, Amiry-Moghaddam M (2017)
Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions
Brain Struct Funct, 222 (9), 3959-3972
DOI 10.1007/s00429-017-1448-5, PubMed 28551776

Prydz A, Stahl K, Puchades M, Davarpaneh N, Nadeem M, Ottersen OP, Gundersen V, Amiry-Moghaddam M (2017)
Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice
Neuroscience, 359, 258-266
DOI 10.1016/j.neuroscience.2017.07.029, PubMed 28735099

Publications 2016

Bjertness E, Htay TT, Maung NS, Soe ZW, Aye SS, Ottersen OP, Liabsuetrakul T, Grøttum P, Hovland M, Amiry-Moghaddam M (2016)
E-learning resources in Myanmar
Lancet, 388 (10063), 2990-2991
DOI 10.1016/S0140-6736(16)32520-X, PubMed 27998528

Hoddevik EH, Khan FH, Rahmani S, Ottersen OP, Boldt HB, Amiry-Moghaddam M (2016)
Factors determining the density of AQP4 water channel molecules at the brain-blood interface
Brain Struct Funct, 222 (4), 1753-1766
DOI 10.1007/s00429-016-1305-y, PubMed 27629271

Huang W, Li Q, Amiry-Moghaddam M, Hokama M, Sardi SH, Nagao M, Warman ML, Olsen BR (2016)
Critical Endothelial Regulation by LRP5 during Retinal Vascular Development
PLoS One, 11 (3), e0152833
DOI 10.1371/journal.pone.0152833, PubMed 27031698

Nakayama S, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A (2016)
Conivaptan, a Selective Arginine Vasopressin V1a and V2 Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4
Neurocrit Care, 24 (2), 273-82
DOI 10.1007/s12028-015-0236-4, PubMed 26732270

Nakayama S, Migliati E, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A (2016)
Osmotherapy With Hypertonic Saline Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4
Crit Care Med, 44 (8), e702-10
DOI 10.1097/CCM.0000000000001671, PubMed 27035238

Publications 2015

Camassa LMA, Lunde LK, Hoddevik EH, Stensland M, Boldt HB, De Souza GA, Ottersen OP, Amiry-Moghaddam M (2015)
Mechanisms underlying AQP4 accumulation in astrocyte endfeet
Glia, 63 (11), 2073-2091
DOI 10.1002/glia.22878, PubMed 26119521

Ricanek P, Lunde LK, Frye SA, Støen M, Nygård S, Morth JP, Rydning A, Vatn MH, Amiry-Moghaddam M, Tønjum T (2015)
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
DOI 10.2147/CEG.S70119, PubMed 25624769

Publications 2014

Lunde LK, Camassa LM, Hoddevik EH, Khan FH, Ottersen OP, Boldt HB, Amiry-Moghaddam M (2014)
Postnatal development of the molecular complex underlying astrocyte polarization
Brain Struct Funct, 220 (4), 2087-101
DOI 10.1007/s00429-014-0775-z, PubMed 24777283

Publications 2013

Alvestad S, Hammer J, Hoddevik EH, Skare Ø, Sonnewald U, Amiry-Moghaddam M, Ottersen OP (2013)
Mislocalization of AQP4 precedes chronic seizures in the kainate model of temporal lobe epilepsy
Epilepsy Res, 105 (1-2), 30-41
DOI 10.1016/j.eplepsyres.2013.01.006, PubMed 23357720

Amiry-Moghaddam M, Ottersen OP (2013)
Immunogold cytochemistry in neuroscience
Nat Neurosci, 16 (7), 798-804
DOI 10.1038/nn.3418, PubMed 23799472

Magdolenova Z, Drlickova M, Henjum K, Rundén-Pran E, Tulinska J, Bilanicova D, Pojana G, Kazimirova A, Barancokova M, Kuricova M, Liskova A, Staruchova M, Ciampor F, Vavra I, Lorenzo Y, Collins A, Rinna A, Fjellsbø L, Volkovova K, Marcomini A, Amiry-Moghaddam M, Dusinska M (2013)
Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles
Nanotoxicology, 9 Suppl 1, 44-56
DOI 10.3109/17435390.2013.847505, PubMed 24228750

Nagelhus EA, Amiry-Moghaddam M, Bergersen LH, Bjaalie JG, Eriksson J, Gundersen V, Leergaard TB, Morth JP, Storm-Mathisen J, Torp R, Walhovd KB, Tønjum T (2013)
The glia doctrine: addressing the role of glial cells in healthy brain ageing
Mech Ageing Dev, 134 (10), 449-59
DOI 10.1016/j.mad.2013.10.001, PubMed 24141107

Publications 2012

Nuruddin S, Wojniusz S, Ropstad E, Krogenæs A, Evans NP, Robinson JE, Solbakk AK, Amiry-Moghaddam M, Haraldsen IR, Sex On Brain European Research Group – SOBER (2012)
Peri-pubertal gonadotropin-releasing hormone analog treatment affects hippocampus gene expression without changing spatial orientation in young sheep
Behav Brain Res, 242, 9-16
DOI 10.1016/j.bbr.2012.12.027, PubMed 23266521

Promeneur D, Lunde LK, Amiry-Moghaddam M, Agre P (2012)
Protective role of brain water channel AQP4 in murine cerebral malaria
Proc Natl Acad Sci U S A, 110 (3), 1035-40
DOI 10.1073/pnas.1220566110, PubMed 23277579

Rutkovskiy A, Bliksøen M, Hillestad V, Amin M, Czibik G, Valen G, Vaage J, Amiry-Moghaddam M, Stensløkken KO (2012)
Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia
J Mol Cell Cardiol, 56, 22-33
DOI 10.1016/j.yjmcc.2012.12.002, PubMed 23238222

Rutkovskiy A, Stensløkken KO, Mariero LH, Skrbic B, Amiry-Moghaddam M, Hillestad V, Valen G, Perreault MC, Ottersen OP, Gullestad L, Dahl CP, Vaage J (2012)
Aquaporin-4 in the heart: expression, regulation and functional role in ischemia
Basic Res Cardiol, 107 (5), 280
DOI 10.1007/s00395-012-0280-6, PubMed 22777185

Publications 2011

Benfenati V, Caprini M, Dovizio M, Mylonakou MN, Ferroni S, Ottersen OP, Amiry-Moghaddam M (2011)
An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes
Proc Natl Acad Sci U S A, 108 (6), 2563-8
DOI 10.1073/pnas.1012867108, PubMed 21262839

Jacobsen Ø, Maekawa H, Ge NH, Görbitz CH, Rongved P, Ottersen OP, Amiry-Moghaddam M, Klaveness J (2011)
Stapling of a 3(10)-helix with click chemistry
J Org Chem, 76 (5), 1228-38
DOI 10.1021/jo101670a, PubMed 21275402

Kielland A, Camassa LM, Døhlen G, Munthe LA, Blomhoff R, Amiry-Moghaddam M, Carlsen H (2011)
NF-κB activity in perinatal brain during infectious and hypoxic-ischemic insults revealed by a reporter mouse
Brain Pathol, 22 (4), 499-510
DOI 10.1111/j.1750-3639.2011.00548.x, PubMed 22059637

Stahl K, Mylonakou MN, Skare Ø, Amiry-Moghaddam M, Torp R (2011)
Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease
Brain Res, 1378, 105-18
DOI 10.1016/j.brainres.2010.12.090, PubMed 21236244

Yang J, Lunde LK, Nuntagij P, Oguchi T, Camassa LM, Nilsson LN, Lannfelt L, Xu Y, Amiry-Moghaddam M, Ottersen OP, Torp R (2011)
Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease
J Alzheimers Dis, 27 (4), 711-22
DOI 10.3233/JAD-2011-110725, PubMed 21891870

Publications 2010

Amiry-Moghaddam M, Hoddevik EH, Ottersen OP (2010)
Aquaporins: multifarious roles in brain
Neuroscience, 168 (4), 859-61
DOI 10.1016/j.neuroscience.2010.04.071, PubMed 20450960

Berle M, Wester KG, Ulvik RJ, Kroksveen AC, Haaland OA, Amiry-Moghaddam M, Berven FS, Helland CA (2010)
Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults
Cerebrospinal Fluid Res, 7, 8
DOI 10.1186/1743-8454-7-8, PubMed 20537169

Helland CA, Aarhus M, Knappskog P, Olsson LK, Lund-Johansen M, Amiry-Moghaddam M, Wester K (2010)
Increased NKCC1 expression in arachnoid cysts supports secretory basis for cyst formation
Exp Neurol, 224 (2), 424-8
DOI 10.1016/j.expneurol.2010.05.002, PubMed 20471979

Liu X, Nakayama S, Amiry-Moghaddam M, Ottersen OP, Bhardwaj A (2010)
Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content, and aquaporin-4 expression following experimental stroke
Neurocrit Care, 12 (1), 124-31
DOI 10.1007/s12028-009-9277-x, PubMed 19806476

Migliati ER, Amiry-Moghaddam M, Froehner SC, Adams ME, Ottersen OP, Bhardwaj A (2010)
Na(+)-K (+)-2Cl (-) cotransport inhibitor attenuates cerebral edema following experimental stroke via the perivascular pool of aquaporin-4
Neurocrit Care, 13 (1), 123-31
DOI 10.1007/s12028-010-9376-8, PubMed 20458553

Publications 2009

Jacobsen Ø, Klaveness J, Petter Ottersen O, Amiry-Moghaddam MR, Rongved P (2009)
Synthesis of cyclic peptide analogues of the 3(10) helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesis
Org Biomol Chem, 7 (8), 1599-611
DOI 10.1039/b823559g, PubMed 19343246

Mylonakou MN, Petersen PH, Rinvik E, Rojek A, Valdimarsdottir E, Zelenin S, Zeuthen T, Nielsen S, Ottersen OP, Amiry-Moghaddam M (2009)
Analysis of mice with targeted deletion of AQP9 gene provides conclusive evidence for expression of AQP9 in neurons
J Neurosci Res, 87 (6), 1310-22
DOI 10.1002/jnr.21952, PubMed 19115411

Publications 2008

Liu X, Zhang W, Alkayed NJ, Froehner SC, Adams ME, Amiry-Moghaddam M, Ottersen OP, Hurn PD, Bhardwaj A (2008)
Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke
J Cereb Blood Flow Metab, 28 (12), 1898-906
DOI 10.1038/jcbfm.2008.83, PubMed 18648381

Zeynalov E, Chen CH, Froehner SC, Adams ME, Ottersen OP, Amiry-Moghaddam M, Bhardwaj A (2008)
The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema
Crit Care Med, 36 (9), 2634-40
DOI 10.1097/CCM.0b013e3181847853, PubMed 18679106

Publications 2007

Benfenati V, Amiry-Moghaddam M, Caprini M, Mylonakou MN, Rapisarda C, Ottersen OP, Ferroni S (2007)
Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes
Neuroscience, 148 (4), 876-92
DOI 10.1016/j.neuroscience.2007.06.039, PubMed 17719182

Publications 2006

Bragg AD, Amiry-Moghaddam M, Ottersen OP, Adams ME, Froehner SC (2006)
Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on alpha-syntrophin
Glia, 53 (8), 879-90
DOI 10.1002/glia.20347, PubMed 16609960

Frydenlund DS, Bhardwaj A, Otsuka T, Mylonakou MN, Yasumura T, Davidson KG, Zeynalov E, Skare O, Laake P, Haug FM, Rash JE, Agre P, Ottersen OP, Amiry-Moghaddam M (2006)
Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice
Proc Natl Acad Sci U S A, 103 (36), 13532-6
DOI 10.1073/pnas.0605796103, PubMed 16938871

Warskulat U, Borsch E, Reinehr R, Heller-Stilb B, Mönnighoff I, Buchczyk D, Donner M, Flögel U, Kappert G, Soboll S, Beer S, Pfeffer K, Marschall HU, Gabrielsen M, Amiry-Moghaddam M, Ottersen OP, Dienes HP, Häussinger D (2006)
Chronic liver disease is triggered by taurine transporter knockout in the mouse
FASEB J, 20 (3), 574-6
DOI 10.1096/fj.05-5016fje, PubMed 16421246

Publications 2005

Amiry-Moghaddam M, Lindland H, Zelenin S, Roberg BA, Gundersen BB, Petersen P, Rinvik E, Torgner IA, Ottersen OP (2005)
Brain mitochondria contain aquaporin water channels: evidence for the expression of a short AQP9 isoform in the inner mitochondrial membrane
FASEB J, 19 (11), 1459-67
DOI 10.1096/fj.04-3515com, PubMed 16126913

Eid T, Lee TS, Thomas MJ, Amiry-Moghaddam M, Bjørnsen LP, Spencer DD, Agre P, Ottersen OP, de Lanerolle NC (2005)
Loss of perivascular aquaporin 4 may underlie deficient water and K+ homeostasis in the human epileptogenic hippocampus
Proc Natl Acad Sci U S A, 102 (4), 1193-8
DOI 10.1073/pnas.0409308102, PubMed 15657133

Puwarawuttipanit W, Bragg AD, Frydenlund DS, Mylonakou MN, Nagelhus EA, Peters MF, Kotchabhakdi N, Adams ME, Froehner SC, Haug FM, Ottersen OP, Amiry-Moghaddam M (2005)
Differential effect of alpha-syntrophin knockout on aquaporin-4 and Kir4.1 expression in retinal macroglial cells in mice
Neuroscience, 137 (1), 165-75
DOI 10.1016/j.neuroscience.2005.08.051, PubMed 16257493

Solbu TT, Boulland JL, Zahid W, Lyamouri Bredahl MK, Amiry-Moghaddam M, Storm-Mathisen J, Roberg BA, Chaudhry FA (2005)
Induction and targeting of the glutamine transporter SN1 to the basolateral membranes of cortical kidney tubule cells during chronic metabolic acidosis suggest a role in pH regulation
J Am Soc Nephrol, 16 (4), 869-77
DOI 10.1681/ASN.2004060433, PubMed 15716335

Publications 2004

Amiry-Moghaddam M, Frydenlund DS, Ottersen OP (2004)
Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport
Neuroscience, 129 (4), 999-1010
DOI 10.1016/j.neuroscience.2004.08.049, PubMed 15561415

Amiry-Moghaddam M, Xue R, Haug FM, Neely JD, Bhardwaj A, Agre P, Adams ME, Froehner SC, Mori S, Ottersen OP (2004)
Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia
FASEB J, 18 (3), 542-4
DOI 10.1096/fj.03-0869fje, PubMed 14734638

Publications 2003

Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A (2003)
An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain
Proc Natl Acad Sci U S A, 100 (4), 2106-11
DOI 10.1073/pnas.0437946100, PubMed 12578959

Amiry-Moghaddam M, Ottersen OP (2003)
The molecular basis of water transport in the brain
Nat Rev Neurosci, 4 (12), 991-1001
DOI 10.1038/nrn1252, PubMed 14682361

Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP (2003)
Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
Proc Natl Acad Sci U S A, 100 (23), 13615-20
DOI 10.1073/pnas.2336064100, PubMed 14597704

Publications 2001

Neely JD, Amiry-Moghaddam M, Ottersen OP, Froehner SC, Agre P, Adams ME (2001)
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
Proc Natl Acad Sci U S A, 98 (24), 14108-13
DOI 10.1073/pnas.241508198, PubMed 11717465

Niermann H, Amiry-Moghaddam M, Holthoff K, Witte OW, Ottersen OP (2001)
A novel role of vasopressin in the brain: modulation of activity-dependent water flux in the neocortex
J Neurosci, 21 (9), 3045-51
DOI 10.1523/JNEUROSCI.21-09-03045.2001, PubMed 11312289

Publications 2000

Elkjaer M, Vajda Z, Nejsum LN, Kwon T, Jensen UB, Amiry-Moghaddam M, Frøkiaer J, Nielsen S (2000)
Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain
Biochem Biophys Res Commun, 276 (3), 1118-28
DOI 10.1006/bbrc.2000.3505, PubMed 11027599

Publications 1999

Wen H, Nagelhus EA, Amiry-Moghaddam M, Agre P, Ottersen OP, Nielsen S (1999)
Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel
Eur J Neurosci, 11 (3), 935-45
DOI 10.1046/j.1460-9568.1999.00502.x, PubMed 10103087

Publications 1997

Landsend AS, Amiry-Moghaddam M, Matsubara A, Bergersen L, Usami S, Wenthold RJ, Ottersen OP (1997)
Differential localization of delta glutamate receptors in the rat cerebellum: coexpression with AMPA receptors in parallel fiber-spine synapses and absence from climbing fiber-spine synapses
J Neurosci, 17 (2), 834-42
PubMed 8987804

Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997)
Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
J Neurosci, 17 (1), 171-80
PubMed 8987746

Publications 1996

Amiry-Moghaddam M, Nagelhus EA, Agre P, Nielsen S, Ottersen OP (1996)
Taurine and water channels are co-localized in renal tubule cells and other tissues. Immunocytochemical studies in rats
Adv Exp Med Biol, 403, 165-71
DOI 10.1007/978-1-4899-0182-8_19, PubMed 8915354

Publications 1994

Amiry-Moghaddam M, Nagelhus E, Ottersen OP (1994)
Light- and electronmicroscopic distribution of taurine, an organic osmolyte, in rat renal tubule cells
Kidney Int, 45 (1), 10-22
DOI 10.1038/ki.1994.2, PubMed 8126997

Nagelhus EA, Amiry-Moghaddam M, Lehmann A, Ottersen OP (1994)
Taurine as an organic osmolyte in the intact brain: immunocytochemical and biochemical studies
Adv Exp Med Biol, 359, 325-34
DOI 10.1007/978-1-4899-1471-2_33, PubMed 7887272

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