Ida Skrinde Leren

  • MD, PhD

 

Ida Skrinde Leren, MD, PhD, Associate researcher

Leren successfully defended her thesis "Ventricular arrhythmias in cardiac ion channel diseases; occurrence, treatment and risk stratification" in June 2016. Her supervisors were Associate Professor Kristina Hermann Haugaa, MD, PhD and Professor Thor Edvardsen, MD, PhD.

Dr. Leren was awarded with His Majesty the King’s Gold Medal for Best Doctoral Thesis within Medicin anno 2016.

The findings in the thesis gained wide international attention and helped change clinical practice and guidelines for the treatment of CPVT (catecholaminergic polymorphic ventricular tachycardia). The recommendations now state that asymptomatic family members receive pre-treatment with beta-blockers as preventative care. The follow-up study examined differences in the treatment effect of different beta-blockers at CPVT and indicated that the beta-blocker nadolol was better in protecting against severe rhythm disturbances than the traditional beta- blockers.

This finding has been important for the selection of drugs for these young patients and is the largest study of its kind. The third article illustrated the connection between the electrical and mechanical function of the heart utilizing sensitive image surveys developed at Oslo University Hospital.  

 

 

Original articles

van der Werf C, Lieve KV, Bos JM, Lane CM, Denjoy I, Roses-Noguer F, Aiba T, Wada Y, Ingles J, Leren IS, Rudic B, Schwartz PJ, Maltret A, Sacher F, Skinner JR, Krahn AD, Roston TM, Tfelt-Hansen J, Swan H, Robyns T, Ohno S, Roberts JD, van den Berg MP, Kammeraad JA, Probst V et al. (2019)
Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest
Eur Heart J, 40 (35), 2953-2961
DOI 10.1093/eurheartj/ehz309, PubMed 31145795

Haugaa KH, Leren IS (2019)
Prevalence, Clinical Presentation, and Management of Channelopathies and Cardiomyopathies, Long QT Syndrome, Brugada Syndrome, Arrhythmogenic Cardiomyopathy, and Hypertrophic Cardiomyopathy
Curr. Cardiovascu. Risk Rep., 13 (7), 16

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

Rootwelt-Norberg C, Lie ØH, Dejgaard LA, Chivulescu M, Leren IS, Edvardsen T, Haugaa KH (2018)
Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center
Int J Cardiol, 279, 79-83
DOI 10.1016/j.ijcard.2018.12.066, PubMed 30638987

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK (2018)
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100, PubMed 30399185

Lie ØH, Rootwelt-Norberg C, Dejgaard LA, Leren IS, Stokke MK, Edvardsen T, Haugaa KH (2018)
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017, PubMed 30031702

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2018)
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int J Cardiol, 250, 157-163
DOI 10.1016/j.ijcard.2017.07.015, PubMed 29169752

Klaeboe LG, Haland TF, Leren IS, Ter Bekke RMA, Brekke PH, Røsjø H, Omland T, Gullestad L, Aakhus S, Haugaa KH, Edvardsen T (2017)
Prognostic Value of Left Ventricular Deformation Parameters in Patients with Severe Aortic Stenosis: A Pilot Study of the Usefulness of Strain Echocardiography
J Am Soc Echocardiogr, 30 (8), 727-735.e1
DOI 10.1016/j.echo.2017.04.009, PubMed 28599826

Haland TF, Hasselberg NE, Almaas VM, Dejgaard LA, Saberniak J, Leren IS, Berge KE, Haugaa KH, Edvardsen T (2017)
The systolic paradox in hypertrophic cardiomyopathy
Open Heart, 4 (1), e000571
DOI 10.1136/openhrt-2016-000571, PubMed 28674623

Leren IS, Saberniak J, Haland TF, Edvardsen T, Haugaa KH (2017)
Combination of ECG and Echocardiography for Identification of Arrhythmic Events in Early ARVC
JACC-Cardiovasc. Imag., 10 (5), 504-513

Broch K, Leren IS, Saberniak J, Ueland T, Edvardsen T, Gullestad L, Haugaa KH (2017)
Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy
Biomarkers, 22 (3-4), 367-371
DOI 10.1080/1354750X.2016.1278266, PubMed 28067540

Haland TF, Saberniak J, Leren IS, Edvardsen T, Haugaa KH (2016)
Echocardiographic comparison between left ventricular non-compaction and hypertrophic cardiomyopathy
Int J Cardiol, 228, 900-905
DOI 10.1016/j.ijcard.2016.11.162, PubMed 27894062

Leren IS, Saberniak J, Haland TF, Edvardsen T, Haugaa KH (2016)
Combination of ECG and Echocardiography for Identification of Arrhythmic Events in Early ARVC
JACC Cardiovasc Imaging, 10 (5), 503-513
DOI 10.1016/j.jcmg.2016.06.011, PubMed 27771401

McLeod K, Wall S, Leren IS, Saberniak J, Haugaa KH (2016)
Ventricular structure in ARVC: going beyond volumes as a measure of risk
J Cardiovasc Magn Reson, 18 (1), 73
DOI 10.1186/s12968-016-0291-9, PubMed 27756409

Saberniak J, Leren IS, Haland TF, Beitnes JO, Hopp E, Borgquist R, Edvardsen T, Haugaa KH (2016)
Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia
Eur Heart J Cardiovasc Imaging, 18 (1), 62-69
DOI 10.1093/ehjci/jew014, PubMed 26903598

Haland TF, Almaas VM, Hasselberg NE, Saberniak J, Leren IS, Hopp E, Edvardsen T, Haugaa KH (2016)
Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 17 (6), 613-21
DOI 10.1093/ehjci/jew005, PubMed 26873460

Barros MV, Leren IS, Edvardsen T, Haugaa KH, Carmo AA, Lage TA, Nunes MC, Rocha MO, Ribeiro AL (2016)
Mechanical Dispersion Assessed by Strain Echocardiography Is Associated with Malignant Arrhythmias in Chagas Cardiomyopathy
J Am Soc Echocardiogr, 29 (4), 368-74
DOI 10.1016/j.echo.2015.12.008, PubMed 26833338

Leren IS, Saberniak J, Majid E, Haland TF, Edvardsen T, Haugaa KH (2015)
Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise stress testing compared with β1-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia
Heart Rhythm, 13 (2), 433-40
DOI 10.1016/j.hrthm.2015.09.029, PubMed 26432584

Sarvari SI, Haugaa KH, Stokke TM, Ansari HZ, Leren IS, Hegbom F, Smiseth OA, Edvardsen T (2015)
Strain echocardiographic assessment of left atrial function predicts recurrence of atrial fibrillation
Eur Heart J Cardiovasc Imaging, 17 (6), 660-7
DOI 10.1093/ehjci/jev185, PubMed 26219297

Leren IS, Hasselberg NE, Saberniak J, Håland TF, Kongsgård E, Smiseth OA, Edvardsen T, Haugaa KH (2015)
Cardiac Mechanical Alterations and Genotype Specific Differences in Subjects With Long QT Syndrome
JACC Cardiovasc Imaging, 8 (5), 501-510
DOI 10.1016/j.jcmg.2014.12.023, PubMed 25890583

Haugaa KH, Leren IS, Berge KE, Bathen J, Loennechen JP, Anfinsen OG, Früh A, Edvardsen T, Kongsgård E, Leren TP, Amlie JP (2010)
High prevalence of exercise-induced arrhythmias in catecholaminergic polymorphic ventricular tachycardia mutation-positive family members diagnosed by cascade genetic screening
Europace, 12 (3), 417-23
DOI 10.1093/europace/eup448, PubMed 20106799

Review articles

Haugaa KH, Haland TF, Leren IS, Saberniak J, Edvardsen T (2015)
Arrhythmogenic right ventricular cardiomyopathy, clinical manifestations, and diagnosis
Europace, 18 (7), 965-72
DOI 10.1093/europace/euv340, PubMed 26498164

Leren IS, Haugaa KH, Edvardsen T, Anfinsen OG, Kongsgård E, Berge KE, Leren TP, Amlie JP (2010)
[Catecholaminergic polymorphic ventricular tachycardia]
Tidsskr Nor Laegeforen, 130 (2), 139-42
DOI 10.4045/tidsskr.09.0529, PubMed 20125202

Other articles

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2017)
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
DOI 10.1016/j.dib.2017.08.018, PubMed 28971120

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