Caroline E. Nunes-Xavier
Position: PostDoc, PhD
Phone: +47 22 78 18 75

Area of research
B7-H3/CD276 is a glycosylated type 1 transmembrane protein that is overexpressed in various types of cancer, facilitating tumor metastasis formation and resistance to therapy. We are interested in the molecular basis of the B7-H3 biological properties and its relation to tumorigenesis.

Academic qualifications
PhD in Molecular Biology of Cancer, Marie Curie predoctoral fellow, University of Valencia, Spain. 2011
Master in Molecular Biology, Cellular Biology and Genetics, University of Valencia, Spain. 2008
Master in Molecular Biology, Biochemistry and Physiology, University of Oslo, Norway. 2007
Bachelor in Natural Sciences, University of Oslo, Norway. 2005


Author network for Caroline Elisabeth Nunes-Xavier by COREMINE medical

Publications 2017

Flem-Karlsen K, Tekle C, Andersson Y, Flatmark K, Fodstad Ø, Nunes-Xavier CE (2017)
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells
Pigment Cell Melanoma Res, 30 (5), 467-476
PubMed 28513992

Publications 2016

Alonso A, Nunes-Xavier CE, Bayón Y, Pulido R (2016)
The Extended Family of Protein Tyrosine Phosphatases
Methods Mol Biol, 1447, 1-23
PubMed 27514797

Errarte P, Guarch R, Pulido R, Blanco L, Nunes-Xavier CE, Beitia M, Gil J, Angulo JC, López JI, Larrinaga G (2016)
The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases
PLoS One, 11 (12), e0169105
PubMed 28033421

Nunes-Xavier CE, Karlsen KF, Tekle C, Pedersen C, Øyjord T, Hongisto V, Nesland JM, Tan M, Sahlberg KK, Fodstad Ø (2016)
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors
Oncotarget, 7 (6), 6891-901
PubMed 26771843

Nunes-Xavier CE, Pulido R (2016)
Global RT-PCR and RT-qPCR Analysis of the mRNA Expression of the Human PTPome
Methods Mol Biol, 1447, 25-37
PubMed 27514798

Publications 2014

Nygren MK, Tekle C, Ingebrigtsen VA, Mäkelä R, Krohn M, Aure MR, Nunes-Xavier CE, Perälä M, Tramm T, Alsner J, Overgaard J, Nesland JM, Borgen E, Børresen-Dale AL, Fodstad Ø, Sahlberg KK, Leivonen SK (2014)
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c
Br J Cancer, 110 (8), 2072-80
PubMed 24577056

Ríos P, Nunes-Xavier CE, Tabernero L, Köhn M, Pulido R (2014)
Dual-specificity phosphatases as molecular targets for inhibition in human disease
Antioxid Redox Signal, 20 (14), 2251-73
PubMed 24206177

Publications 2013

Nunes-Xavier CE, Martín-Pérez J, Elson A, Pulido R (2013)
Protein tyrosine phosphatases as novel targets in breast cancer therapy
Biochim Biophys Acta, 1836 (2), 211-26
PubMed 23756181

Publications 2012

Cejudo-Marín R, Tárrega C, Nunes-Xavier CE, Pulido R (2012)
Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function
J Mol Biol, 420 (1-2), 128-38
PubMed 22504224

Publications 2011

Nunes-Xavier C, Romá-Mateo C, Ríos P, Tárrega C, Cejudo-Marín R, Tabernero L, Pulido R (2011)
Dual-specificity MAP kinase phosphatases as targets of cancer treatment
Anticancer Agents Med Chem, 11 (1), 109-32
PubMed 21288197

Nunes-Xavier CE, Elson A, Pulido R (2011)
Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells
J Biol Chem, 287 (5), 3433-44
PubMed 22117074

Publications 2010

Nunes-Xavier CE, Tárrega C, Cejudo-Marín R, Frijhoff J, Sandin A, Ostman A, Pulido R (2010)
Differential up-regulation of MAP kinase phosphatases MKP3/DUSP6 and DUSP5 by Ets2 and c-Jun converge in the control of the growth arrest versus proliferation response of MCF-7 breast cancer cells to phorbol ester
J Biol Chem, 285 (34), 26417-30
PubMed 20554528

Tárrega C, Nunes-Xavier C, Cejudo-Marín R, Martín-Pérez J, Pulido R (2010)
Studying the regulation of MAP Kinase by MAP Kinase phosphatases in vitro and in cell systems
Methods Mol Biol, 661, 305-21
PubMed 20811991