Selected publications

Schläfli AMTokarchuk IParejo SJutzi SBerezowska SEngedal NTschan MP (2021)
ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells
Sci Rep11 (1)9011
DOI 10.1038/s41598-021-87966-6PubMed 33907223

Humbert M, Morán M, de la Cruz-Ojeda P, Muntané J, Wiedmer T, Apostolova N, McKenna SL, Velasco G, Balduini W, Eckhart L, Janji B, Sampaio-Marques B, Ludovico P, Žerovnik E, Langer R, Perren A, Engedal N, Tschan MP (2020)
Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot
Biology (Basel), 9 (3)
DOI 10.3390/biology9030059, PubMed 32245178

Lindner P, Christensen SB, Nissen P, Møller JV, Engedal N (2020)
Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components
Cell Commun Signal, 18 (1), 12
DOI 10.1186/s12964-019-0499-z, PubMed 31987044

Zhen Y, Spangenberg H, Munson MJ, Brech A, Schink KO, Tan KW, Sørensen V, Wenzel EM, Radulovic M, Engedal N, Simonsen A, Raiborg C, Stenmark H (2019)
ESCRT-mediated phagophore sealing during mitophagy
Autophagy, 16 (5), 826-841
DOI 10.1080/15548627.2019.1639301, PubMed 31366282

Luhr M, Torgersen ML, Szalai P, Hashim A, Brech A, Staerk J, Engedal N (2019)
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
J Biol Chem, 294 (20), 8197-8217
DOI 10.1074/jbc.RA118.002829, PubMed 30926605

Szalai P, Parys JB, Bultynck G, Christensen SB, Nissen P, Møller JV, Engedal N (2018)
Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death
Cell Calcium, 76, 48-61
DOI 10.1016/j.ceca.2018.09.005, PubMed 30261424

Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F (2018)
Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 14 (8), 1435-1455
DOI 10.1080/15548627.2018.1474314, PubMed 29940786

Luhr M, Szalai P, Engedal N (2018)
The Lactate Dehydrogenase Sequestration Assay - A Simple and Reliable Method to Determine Bulk Autophagic Sequestration Activity in Mammalian Cells
J Vis Exp (137)
DOI 10.3791/57971, PubMed 30102280

Szalai P, Engedal N (2018)
An Image-based Assay for High-throughput Analysis of Cell Proliferation and Cell Death of Adherent Cells
Bio-protocol, 8 (9), e2835

Luhr M, Saetre F, Engedal N (2018)
The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines
Bio-protocol, 8 (9), e2836

Kjos I, Borg Distefano M, Sætre F, Repnik U, Holland P, Jones AT, Engedal N, Simonsen A, Bakke O, Progida C (2017)
Rab7b modulates autophagic flux by interacting with Atg4B
EMBO Rep, 18 (10), 1727-1739
DOI 10.15252/embr.201744069, PubMed 28835545

Engedal N, Seglen PO (2015)
Autophagy of cytoplasmic bulk cargo does not require LC3
Autophagy, 12 (2), 439-41
DOI 10.1080/15548627.2015.1076606, PubMed 26237084

Szalai P, Hagen LK, Sætre F, Luhr M, Sponheim M, Øverbye A, Mills IG, Seglen PO, Engedal N (2015)
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Exp Cell Res, 333 (1), 21-38
DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710

Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
Macroautophagic cargo sequestration assays
Methods, 75, 25-36
DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638

Torgersen ML, Engedal N, Bøe SO, Hokland P, Simonsen A (2013)
Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells
Blood, 122 (14), 2467-76
DOI 10.1182/blood-2013-05-500629, PubMed 23970379

Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164

Publications

Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T et al. (2021)
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Nat Commun, 12 (1), 5307
DOI 10.1038/s41467-021-25624-1, PubMed 34489465

Luhr M, Sætre F, Engedal N (2018)
The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines
Bio Protoc, 8 (9), e2836
DOI 10.21769/BioProtoc.2836, PubMed 34286043

Szalai P, Engedal N (2018)
An Image-based Assay for High-throughput Analysis of Cell Proliferation and Cell Death of Adherent Cells
Bio Protoc, 8 (9), e2835
DOI 10.21769/BioProtoc.2835, PubMed 34286042