Lasse Pihlstrøm

  • Postdoc; MD, PhD
 

Publications 2019

Bandres-Ciga S, Saez-Atienzar S, Bonet-Ponce L, Billingsley K, Vitale D, Blauwendraat C, Gibbs JR, Pihlstrøm L, Gan-Or Z, International Parkinson's Disease Genomics Consortium (IPDGC), Cookson MR, Nalls MA, Singleton AB (2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
Mov Disord, 34 (4), 460-468
DOI 10.1002/mds.27614, PubMed 30675927

Blauwendraat C, Heilbron K, Vallerga CL, Bandres-Ciga S, von Coelln R, Pihlstrøm L, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Siitonen A, Iwaki H, Leonard H, Noyce AJ, Tan M, Gibbs JR, Hernandez DG, Scholz SW, Jankovic J, Shulman LM, Lesage S, Corvol JC, Brice A, van Hilten JJ, Marinus J et al. (2019)
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms
Mov Disord, 34 (6), 866-875
DOI 10.1002/mds.27659, PubMed 30957308

Fernandez-Santiago R, Martin-Flores N, Antonelli F, Cerquera C, Moreno V, Bandres-Ciga S, Manduchi E, Tolosa E, Singleton AB, Moore JH, Noyce AJ, Kaiyrzhanov R, Middlehurst B, Kia DA, Tan M, Houlden H, Morris HR, Plun-Favreau H, Holmans P, Hardy J, Trabzuni D, Bras J, Quinn J, Mok KY, Kinghorn KJ et al. (2019)
SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease
Mov. Disord., 34 (9), 1333-1344

Iqbal Z, Koht J, Pihlstrøm L, Henriksen SP, Cappelletti C, Russel MB, Norberto de Souza O, Skogseid IM, Toft M (2019)
Missense mutations in DYT-TOR1A dystonia
Neurol Genet, 5 (4), e343
DOI 10.1212/NXG.0000000000000343, PubMed 31321303

Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs JR, International Parkinson's Disease Genomics Consortium, Chitrala KN, Day-Williams AG, Brice A, Alves G et al. (2019)
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts
Mov Disord
DOI 10.1002/mds.27845, PubMed 31505070

Iwaki H, Blauwendraat C, Leonard HL, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP et al. (2019)
Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts
Neurol Genet, 5 (4), e348
DOI 10.1212/NXG.0000000000000348, PubMed 31404238

Ligaard J, Sannæs J, Pihlstrøm L (2019)
Deep brain stimulation and genetic variability in Parkinson's disease: a review of the literature
NPJ Parkinsons Dis, 5, 18
DOI 10.1038/s41531-019-0091-7, PubMed 31508488

Makarious MB, Diez-Fairen M, Krohn L, Blauwendraat C, Bandres-Ciga S, Ding J, Pihlstrøm L, Houlden H, Scholz SW, Gan-Or Z (2019)
ARSA variants in α-synucleinopathies
Brain (in press)
DOI 10.1093/brain/awz340, PubMed 31670782

Nalls MA, Blauwendraat C, Vallerga CL, Heilbron K, Bandres-Ciga S, Chang D, Tan M, Kia DA, Noyce AJ, Xue A, Bras J, Young E, von Coelln R, Simón-Sánchez J, Schulte C, Sharma M, Krohn L, Pihlstrøm L, Siitonen A, Iwaki H, Leonard H, Faghri F, Gibbs JR, Hernandez DG, Scholz SW et al. (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Lancet Neurol, 18 (12), 1091-1102
DOI 10.1016/S1474-4422(19)30320-5, PubMed 31701892

Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I et al. (2019)
GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
Sci Rep, 9 (1), 7013
DOI 10.1038/s41598-019-43458-2, PubMed 31065058

Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I et al. (2019)
Author Correction: GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
Sci Rep, 9 (1), 15168
DOI 10.1038/s41598-019-51827-0, PubMed 31619746

Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, Dawson TM, Rosenthal LS, Houlden H, Pletnikova O, Troncoso J, Scholz SW (2019)
Assessment of APOE in atypical parkinsonism syndromes
Neurobiol Dis, 127, 142-146
DOI 10.1016/j.nbd.2019.02.016, PubMed 30798004

Publications 2018

Berge-Seidl V, Pihlstrøm L, Wszolek ZK, Ross OA, Toft M (2018)
No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease
Neurobiol Aging, 74, 236.e1-236.e5
DOI 10.1016/j.neurobiolaging.2018.09.022, PubMed 30340792

Bjørnarå KA, Pihlstrøm L, Dietrichs E, Toft M (2018)
Risk variants of the α-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study
BMC Neurol, 18 (1), 20
DOI 10.1186/s12883-018-1023-6, PubMed 29466944

Blauwendraat C, Reed X, Kia DA, Gan-Or Z, Lesage S, Pihlstrøm L, Guerreiro R, Gibbs JR, Sabir M, Ahmed S, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Hernandez DG, Chung SJ, Goldwurm S, Toft M, Schulte C, Bras J, Wood NW, Brice A, Morris HR et al. (2018)
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
JAMA Neurol, 75 (11), 1416-1422
DOI 10.1001/jamaneurol.2018.1885, PubMed 30039155

Kishore A, Ashok Kumar Sreelatha A, Sturm M, von-Zweydorf F, Pihlstrøm L, Raimondi F, Russell R, Lichtner P, Banerjee M, Krishnan S, Rajan R, Puthenveedu DK, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD), Bauer P, Riess O, Gloeckner CJ, Kruger R, Gasser T, Sharma M (2018)
Understanding the role of genetic variability in LRRK2 in Indian population
Mov Disord, 34 (4), 496-505
DOI 10.1002/mds.27558, PubMed 30485545

Kristiansen M, Maple-Grødem J, Alves G, Arepalli S, Hernandez DG, Iwaki H, Nalls MA, Singleton A, Tysnes OB, Toft M, Pihlstrøm L (2018)
A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease
Mov Disord, 34 (2), 298-299
DOI 10.1002/mds.27555, PubMed 30484896

Pihlstrøm L, Blauwendraat C, Cappelletti C, Berge-Seidl V, Langmyhr M, Henriksen SP, van de Berg WDJ, Gibbs JR, Cookson MR, International Parkinson Disease Genomics Consortium, North American Brain Expression Consortium, Singleton AB, Nalls MA, Toft M (2018)
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease
Ann Neurol, 84 (1), 117-129
DOI 10.1002/ana.25274, PubMed 30146727

Pihlstrøm L, Schottlaender L, Chelban V, Houlden H, MSA Exome Consortium (2018)
LRP10 in α-synucleinopathies
Lancet Neurol, 17 (12), 1033-1034
DOI 10.1016/S1474-4422(18)30407-1, PubMed 30507385

Pihlstrøm L, Schottlaender L, Chelban V, MSA Exome Consortium, Meissner WG, Federoff M, Singleton A, Houlden H (2018)
Lysosomal storage disorder gene variants in multiple system atrophy
Brain, 141 (7), e53
DOI 10.1093/brain/awy124, PubMed 29741613

Publications 2017

Berge-Seidl V, Pihlstrøm L, Maple-Grødem J, Forsgren L, Linder J, Larsen JP, Tysnes OB, Toft M (2017)
The GBA variant E326K is associated with Parkinson's disease and explains a genome-wide association signal
Neurosci Lett, 658, 48-52
DOI 10.1016/j.neulet.2017.08.040, PubMed 28830825

Blauwendraat C, Faghri F, Pihlstrom L, Geiger JT, Elbaz A, Lesage S, Corvol JC, May P, Nicolas A, Abramzon Y, Murphy NA, Gibbs JR, Ryten M, Ferrari R, Bras J, Guerreiro R, Williams J, Sims R, Lubbe S, Hernandez DG, Mok KY, Robak L, Campbell RH, Rogaeva E, Traynor BJ et al. (2017)
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
Neurobiol Aging, 57, 247.e9-247.e13
DOI 10.1016/j.neurobiolaging.2017.05.009, PubMed 28602509

Blauwendraat C, Kia DA, Pihlstrøm L, Gan-Or Z, Lesage S, Gibbs JR, Ding J, Alcalay RN, Hassin-Baer S, Pittman AM, Brooks J, Edsall C, Chung SJ, Goldwurm S, Toft M, Schulte C, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hernandez D, Singleton AB, Nalls MA, Brice A, Scholz SW, Wood NW (2017)
Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease
Neurobiol Aging, 64, 159.e5-159.e8
DOI 10.1016/j.neurobiolaging.2017.12.012, PubMed 29398121

Ezat B, Pihlstrøm L, Aasly J, Tysnes OB, Egge A, Dietrichs E (2017)
Use of advanced therapies for Parkinson's disease in Norway
Tidsskr Nor Laegeforen, 137 (9), 619-623
DOI 10.4045/tidsskr.16.0711, PubMed 28468476

Fagan ES, Pihlstrøm L (2017)
Genetic risk factors for cognitive decline in Parkinson's disease: a review of the literature
Eur J Neurol, 24 (4), 561-e20
DOI 10.1111/ene.13258, PubMed 28220571

Faiz KW, Pihlstrøm L (2017)
[Parkinson's disease and parkinsonism]
Tidsskr Nor Laegeforen, 137 (4), 298
DOI 10.4045/tidsskr.16.0915, PubMed 28225240

Iqbal Z, Rydning SL, Wedding IM, Koht J, Pihlstrøm L, Rengmark AH, Henriksen SP, Tallaksen CM, Toft M (2017)
Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia
PLoS One, 12 (3), e0174667
DOI 10.1371/journal.pone.0174667, PubMed 28362824

Iqbal Z, Rydning SL, Wedding IM, Koht J, Pihlstrøm L, Rengmark AH, Henriksen SP, Tallaksen CME, Toft M (2017)
Correction: Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia
PLoS One, 12 (10), e0186571
DOI 10.1371/journal.pone.0186571, PubMed 29023604

Pihlstrøm L (2017)
Dr. Watson og vi
Tidsskr Nor Laegeforen, 137 (5), 388
DOI 10.4045/tidsskr.17.0070, PubMed 28272576

Pihlstrøm L, Wiethoff S, Houlden H (2017)
Genetics of neurodegenerative diseases: an overview
Handb Clin Neurol, 145, 309-323
DOI 10.1016/B978-0-12-802395-2.00022-5, PubMed 28987179

Publications 2016

Chelban V, Manole A, Pihlstrøm L, Schottlaender L, Efthymiou S, OConnor E, Meissner WG, Holton JL, Houlden H (2016)
Analysis of the prion protein gene in multiple system atrophy
Neurobiol Aging, 49, 216.e15-216.e18
DOI 10.1016/j.neurobiolaging.2016.09.021, PubMed 27793473

Iqbal Z, Pihlstrøm L, Rengmark A, Henriksen SP, Linder J, Forsgren L, Toft M (2016)
Rare variants in dementia genes and Parkinson's disease
Eur J Hum Genet, 24 (12), 1661-1662
DOI 10.1038/ejhg.2016.79, PubMed 27329738

Pihlstrøm L (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (10), 944
DOI 10.4045/tidsskr.16.0422, PubMed 27272377

Pihlstrøm L (2016)
Når leger vet for mye
Tidsskr Nor Laegeforen, 136 (18), 1570
DOI 10.4045/tidsskr.16.0796, PubMed 27731607

Pihlstrøm L, Morset KR, Grimstad E, Vitelli V, Toft M (2016)
A cumulative genetic risk score predicts progression in Parkinson's disease
Mov Disord, 31 (4), 487-90
DOI 10.1002/mds.26505, PubMed 26853697

Rengmark A, Pihlstrøm L, Linder J, Forsgren L, Toft M (2016)
Low frequency of GCH1 and TH mutations in Parkinson's disease
Parkinsonism Relat Disord, 29, 109-11
DOI 10.1016/j.parkreldis.2016.05.010, PubMed 27185167

Publications 2015

Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J et al. (2015)
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
Alzheimers Dement, 11 (12), 1407-1416
DOI 10.1016/j.jalz.2014.12.009, PubMed 25936935

Pihlstrom L (2015)
The old man and his coat
Tidsskr. Nor. Laegeforen., 135 (2), 162

Pihlstrom L (2015)
With beard in your inbox
Tidsskr. Nor. Laegeforen., 135 (7), 676

Pihlstrøm L (2015)
[The wonders of practical teaching]
Tidsskr Nor Laegeforen, 135 (20), 1878
DOI 10.4045/tidsskr.15.1014, PubMed 26534820

Pihlstrøm L, Rengmark A, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Dietrichs E, Toft M (2015)
Fine mapping and resequencing of the PARK16 locus in Parkinson's disease
J Hum Genet, 60 (7), 357-62
DOI 10.1038/jhg.2015.34, PubMed 25855069

Pihlstrøm L, Toft M (2015)
Cumulative genetic risk and age at onset in Parkinson's disease
Mov Disord, 30 (12), 1712-3
DOI 10.1002/mds.26366, PubMed 26234887

Wang L, Aasly JO, Annesi G, Bardien S, Bozi M, Brice A, Carr J, Chung SJ, Clarke C, Crosiers D, Deutschländer A, Eckstein G, Farrer MJ, Goldwurm S, Garraux G, Hadjigeorgiou GM, Hicks AA, Hattori N, Klein C, Jeon B, Kim YJ, Lesage S, Lin JJ, Lynch T, Lichtner P et al. (2015)
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease
Neurology, 85 (15), 1283-92
DOI 10.1212/WNL.0000000000002016, PubMed 26354989

Publications 2014

Pihlstrøm L (2014)
[Re: Affection for affection]
Tidsskr Nor Laegeforen, 134 (20), 1920
DOI 10.4045/tidsskr.14.1211, PubMed 25350431

Pihlstrøm L, Berge V, Rengmark A, Toft M (2014)
Parkinson's disease correlates with promoter methylation in the α-synuclein gene
Mov Disord, 30 (4), 577-80
DOI 10.1002/mds.26073, PubMed 25545759

Pihlstrøm L, Nedregaard B, Krossnes B, Aamodt AH (2014)
[Septic embolus]
Tidsskr Nor Laegeforen, 134 (9), 945
DOI 10.4045/tidsskr.13.1656, PubMed 24828721

Pihlstrøm L, Rengmark A, Bjørnarå KA, Toft M (2014)
Effective variant detection by targeted deep sequencing of DNA pools: an example from Parkinson's disease
Ann Hum Genet, 78 (3), 243-52
DOI 10.1111/ahg.12060, PubMed 24660942

Publications 2012

Pihlstrøm L, Axelsson G, Bjørnarå KA, Dizdar N, Fardell C, Forsgren L, Holmberg B, Larsen JP, Linder J, Nissbrandt H, Tysnes OB, Ohman E, Dietrichs E, Toft M (2012)
Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease
Neurobiol Aging, 34 (6), 1708.e7-13
DOI 10.1016/j.neurobiolaging.2012.10.019, PubMed 23153929

Publications 2011

Kvåle G, Fadnes LT, Tryland M, Pihlstrøm L (2011)
Climate change--the biggest health threat of our time
Tidsskr Nor Laegeforen, 131 (17), 1670-2
DOI 10.4045/tidsskr.11.0607, PubMed 21901045

Pihlstrøm L (2011)
[The sardonic smile]
Tidsskr Nor Laegeforen, 131 (24), 2500-3
DOI 10.4045/tidsskr.11.0256, PubMed 22170142

Pihlstrøm L, Alfstad KÅ, Solyga V, Ringstad GA, Kerty E (2011)
[A 55-year old man with recurrent brain infarction]
Tidsskr Nor Laegeforen, 131 (11), 1089-91
DOI 10.4045/tidsskr.10.0162, PubMed 21681238

Pihlstrøm L, Toft M (2011)
Genetic variability in SNCA and Parkinson's disease
Neurogenetics, 12 (4), 283-93
DOI 10.1007/s10048-011-0292-7, PubMed 21800132

Pihlstrøm L, Toft M (2011)
Parkinson's disease: What remains of the "missing heritability"?
Mov Disord, 26 (11), 1971-3
DOI 10.1002/mds.23898, PubMed 21812035

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