
Leiv Otto Watne
- Researcher
- +47-23016137
Publications 2023
Matrix metalloproteinases are associated with brain atrophy in cognitively unimpaired individuals
Neurobiol Aging, 131, 11-23 (in press)
DOI 10.1016/j.neurobiolaging.2023.05.012, PubMed 37549446
Sex-specific associations of matrix metalloproteinases in Alzheimer's disease
Biol Sex Differ, 14 (1), 35
DOI 10.1186/s13293-023-00514-x, PubMed 37221606
Associations of neuroinflammatory IL-6 and IL-8 with brain atrophy, memory decline, and core AD biomarkers - in cognitively unimpaired older adults
Brain Behav Immun, 113, 56-65
DOI 10.1016/j.bbi.2023.06.027, PubMed 37400002
Longitudinal trajectories of functional recovery after hip fracture
PLoS One, 18 (3), e0283551
DOI 10.1371/journal.pone.0283551, PubMed 36989248
Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers
J Neurosci, 43 (28), 5241-5250
DOI 10.1523/JNEUROSCI.2330-22.2023, PubMed 37365003
[We need to pay attention to delirium]
Tidsskr Nor Laegeforen, 143 (5)
DOI 10.4045/tidsskr.23.0037, PubMed 36987895
Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
Alzheimers Dement (in press)
DOI 10.1002/alz.13162, PubMed 37264981
Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort
Lancet Healthy Longev, 4 (8), e399-e408
DOI 10.1016/S2666-7568(23)00098-3, PubMed 37459878
What we know about the possible link between delirium and dementia with Lewy bodies, and why we need to learn more
Acta Psychiatr Scand, 147 (5), 401-402
DOI 10.1111/acps.13526, PubMed 37102380
Impaired glucose utilization in the brain of patients with delirium following hip fracture
Brain (in press)
DOI 10.1093/brain/awad296, PubMed 37658825
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients
J Clin Invest, 133 (2)
DOI 10.1172/JCI163472, PubMed 36409557
Publications 2022
Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease
Transl Psychiatry, 12 (1), 151
DOI 10.1038/s41398-022-01901-5, PubMed 35397615
Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients
EBioMedicine, 80, 104043
DOI 10.1016/j.ebiom.2022.104043, PubMed 35533500
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Oxid Med Cell Longev, 2022, 5019752
DOI 10.1155/2022/5019752, PubMed 36312896
Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults
Neurobiol Aging, 116, 80-91
DOI 10.1016/j.neurobiolaging.2022.04.010, PubMed 35584575
Publications 2021
Orthogeriatrics prevents functional decline in hip fracture patients: report from two randomized controlled trials
BMC Geriatr, 21 (1), 208
DOI 10.1186/s12877-021-02152-7, PubMed 33765935
Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation
Front Cardiovasc Med, 8, 640970
DOI 10.3389/fcvm.2021.640970, PubMed 33829048
Poor Self-Reported Sleep is Related to Regional Cortical Thinning in Aging but not Memory Decline-Results From the Lifebrain Consortium
Cereb Cortex, 31 (4), 1953-1969
DOI 10.1093/cercor/bhaa332, PubMed 33236064
Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium
J Alzheimers Dis, 81 (2), 667-677
DOI 10.3233/JAD-201341, PubMed 33814433
Cerebrospinal fluid catecholamines in delirium and dementia
Brain Commun, 3 (3), fcab121
DOI 10.1093/braincomms/fcab121, PubMed 34423298
Orthogeriatric co-management reduces incidence of delirium in hip fracture patients
Osteoporos Int, 32 (11), 2225-2233
DOI 10.1007/s00198-021-05974-8, PubMed 33963884
Association between psychotropic drug use and handgrip strength in older hospitalized patients
Eur Geriatr Med, 12 (6), 1213-1220
DOI 10.1007/s41999-021-00511-6, PubMed 34033072
Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan
Brain Behav Immun, 100, 243-253
DOI 10.1016/j.bbi.2021.12.008, PubMed 34920091
Delirium is common in patients hospitalized with COVID-19
Intern Emerg Med, 16 (7), 1997-2000
DOI 10.1007/s11739-021-02715-x, PubMed 33830418
Publications 2020
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Int Rev Neurobiol, 155, 169-202
DOI 10.1016/bs.irn.2020.02.008, PubMed 32854854
A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease
Alzheimers Dement (Amst), 12 (1), e12128
DOI 10.1002/dad2.12128, PubMed 33313376
Delirium in patients with hip fracture is associated with increased heart rate variability
Aging Clin Exp Res, 32 (11), 2311-2318
DOI 10.1007/s40520-019-01447-5, PubMed 31916197
Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression
Cereb Cortex, 30 (4), 2144-2156
DOI 10.1093/cercor/bhz228, PubMed 32142100
Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium
Sleep, 43 (5)
DOI 10.1093/sleep/zsz280, PubMed 31738420
Longitudinal association between hippocampus atrophy and episodic-memory decline in non-demented APOE ε4 carriers
Alzheimers Dement (Amst), 12 (1), e12110
DOI 10.1002/dad2.12110, PubMed 33015312
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex, 30 (4), 2295-2306
DOI 10.1093/cercor/bhz240, PubMed 31812991
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Neurobiol Aging, 93, 1-15
DOI 10.1016/j.neurobiolaging.2020.04.002, PubMed 32438258
Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
J Neurosci, 40 (29), 5681-5696
DOI 10.1523/JNEUROSCI.2876-19.2020, PubMed 32513828
Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification
Sci Rep, 10 (1), 15886
DOI 10.1038/s41598-020-72878-8, PubMed 32985583
Fatty Acid-Binding Protein 3 in Cerebrospinal Fluid of Hip Fracture Patients with Delirium
J Alzheimers Dis, 77 (1), 183-190
DOI 10.3233/JAD-200364, PubMed 32804136
[Not Available]
Tidsskr Nor Laegeforen, 140
DOI 10.4045/tidsskr.20.0264, PubMed 32323958
Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis
Cells, 9 (7)
DOI 10.3390/cells9071686, PubMed 32668809
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
J Alzheimers Dis, 73 (4), 1363-1372
DOI 10.3233/JAD-190941, PubMed 31929159
Results after introduction of a hip fracture care pathway: comparison with usual care
Acta Orthop, 91 (2), 139-145
DOI 10.1080/17453674.2019.1710804, PubMed 31928088
Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan
Neurol Genet, 6 (5), e506
DOI 10.1212/NXG.0000000000000506, PubMed 33134508
Publications 2019
Delirium screening in an acute geriatric ward by nurses using 4AT: results from a quality improvement project
Eur Geriatr Med, 10 (4), 667-671
DOI 10.1007/s41999-019-00215-y, PubMed 34652742
Publications 2018
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
Cereb Cortex, 28 (8), 2775-2785
DOI 10.1093/cercor/bhx157, PubMed 28655157
Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
Dement Geriatr Cogn Disord, 46 (5-6), 346-357
DOI 10.1159/000494754, PubMed 30522125
CSF sodium at toxic levels precedes delirium in hip fracture patients
Neurotoxicology, 69, 11-16
DOI 10.1016/j.neuro.2018.08.010, PubMed 30149051
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
J Neuroinflammation, 15 (1), 304
DOI 10.1186/s12974-018-1331-1, PubMed 30390679
Effects of nutritional intervention upon bone turnover in elderly hip fracture patients. Randomized controlled trial
Clin Nutr ESPEN, 29, 52-58
DOI 10.1016/j.clnesp.2017.11.012, PubMed 30661701
[Delirium – still underdiagnosed]
Tidsskr Nor Laegeforen, 138 (5)
DOI 10.4045/tidsskr.18.0118, PubMed 29513435
Delirium- still under diagnosed
Tidsskr. Nor. Laegeforen., 138 (5), 418
Publications 2017
Decreases in heart rate variability are associated with postoperative complications in hip fracture patients
PLoS One, 12 (7), e0180423
DOI 10.1371/journal.pone.0180423, PubMed 28742855
Prosthetic joint infection-a devastating complication of hemiarthroplasty for hip fracture
Acta Orthop, 88 (4), 383-389
DOI 10.1080/17453674.2017.1301009, PubMed 28271919
CSF biomarkers in delirium: a systematic review
Int J Geriatr Psychiatry, 33 (11), 1479-1500
DOI 10.1002/gps.4720, PubMed 28585290
Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
DOI 10.1159/000481853, PubMed 29282410
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783
Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium
J Alzheimers Dis, 55 (1), 371-379
DOI 10.3233/JAD-160461, PubMed 27662296
[Assessment of mental status in acutely ill elderly]
Tidsskr Nor Laegeforen, 137 (12-13), 859
DOI 10.4045/tidsskr.17.0480, PubMed 28655228
Perioperative hemodynamics and risk for delirium and new onset dementia in hip fracture patients; A prospective follow-up study
PLoS One, 12 (7), e0180641
DOI 10.1371/journal.pone.0180641, PubMed 28700610
Inflammation, Amyloid, and Atrophy in The Aging Brain: Relationships with Longitudinal Changes in Cognition
J Alzheimers Dis, 58 (3), 829-840
DOI 10.3233/JAD-161146, PubMed 28505968
Publications 2016
Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture
J Neuroinflammation, 13 (1), 170
DOI 10.1186/s12974-016-0636-1, PubMed 27357281
Blood-Cerebrospinal Fluid Barrier Integrity in Delirium Determined by Q-Albumin
Dement Geriatr Cogn Disord, 41 (3-4), 192-8
DOI 10.1159/000443789, PubMed 27058253
CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults
Neurobiol Aging, 49, 138-144
DOI 10.1016/j.neurobiolaging.2016.09.012, PubMed 27794264
Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture
J Am Geriatr Soc, 64 (7), 1456-63
DOI 10.1111/jgs.14238, PubMed 27341529
Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
BMC Geriatr, 16, 149
DOI 10.1186/s12877-016-0324-0, PubMed 27484129
[Not Available]
Tidsskr Nor Laegeforen, 136 (16), 1325-6
DOI 10.4045/tidsskr.16.0686, PubMed 27637035
Publications 2015
[Why orthogeriatrics?]
Tidsskr Nor Laegeforen, 135 (6), 523-4
DOI 10.4045/tidsskr.15.0188, PubMed 25806757
Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients
Arch Gerontol Geriatr, 64, 38-44
DOI 10.1016/j.archger.2015.12.004, PubMed 26952375
Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients
BMC Res Notes, 8, 186
DOI 10.1186/s13104-015-1129-5, PubMed 25943983
Vitamin deficiency as a risk factor for delirium
Eur. Geriatr. Med., 6 (4), 314-318
DOI 10.1016/j.eurger.2014.09.002
Micronutrients and the risk of hip fracture: Case-control study
Clin Nutr, 36 (2), 438-443
DOI 10.1016/j.clnu.2015.12.014, PubMed 26795217
Publications 2014
New consciousness scale for delirium
Tidsskr Nor Laegeforen, 134 (2), 150
DOI 10.4045/tidsskr.13.1603, PubMed 24477145
A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium
Palliat Support Care, 13 (4), 937-44
DOI 10.1017/S1478951514000613, PubMed 24991706
Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: a case control study
Clin Nutr, 34 (1), 101-6
DOI 10.1016/j.clnu.2014.01.016, PubMed 24559841
Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium
J Am Geriatr Soc, 62 (1), 94-102
DOI 10.1111/jgs.12612, PubMed 24383557
The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: randomized controlled trial (Oslo Orthogeriatric Trial)
BMC Med, 12, 63
DOI 10.1186/1741-7015-12-63, PubMed 24735588
Response to Paul Regal
J Am Geriatr Soc, 62 (7), 1415
DOI 10.1111/jgs.12875, PubMed 25039530
Publications 2013
[Delirium in elderly patients]
Tidsskr Nor Laegeforen, 133 (15), 1596-600
DOI 10.4045/tidsskr.12.1327, PubMed 23970274
Publications 2012
The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial
BMC Geriatr, 12, 36
DOI 10.1186/1471-2318-12-36, PubMed 22817102