Alexander Nilsskog Fraser

  • Consultant orthopaedic surgeon, Diakonhjemmet hospital; PhD
  • +47 22 11 80 80

Project:
The DELPHI trail:
Clinical investigation for displaced proximal humeral fractures in the elderly: a randomized study of two surgical treatments: reverse total prosthetic replacement versus angular stable plate Philos (The DELPHI trial)

The DELPHI trial is a semi-blinded, multicenter RCT, involving 7 hospitals. The aim is to establish best treatment for proximal humeral fractures in the elderly. We plan to publish two and five year clinical results, with the main outcome being the Constant score. We will include a self reported quality og life score(15D), radiographic score and an economic evaluation.

RSA phantom study:
- Precision and accuracy of the reversed total shoulder arthroplasty
We have implanted a Delta Xtend reversed shoulder prosthesis in to sawbone scapula and humerus. We aim to:
1. Test for best marker placement
2. Establish EGS or KAD based feasibility
3. Test for precision and accuracy in radiostereometric measurements of the metaglen in the Delta Xtend prosthesis

RSA clinical trail:
The phantom study will be the basis for a clinical RSA trial, where we aim to establish in vivo 3D migration (stability) of the metaglen in reversed shoulder arthroplasty up to 2 years.

Supervisers:
Tore Fjalestad, consultant orthopaedic surgeon, PhD
Jan Erik Madsen, consultant orthopaedic surgeon, Prof.
Stephan Röhrl, consultant orthopaedic surgeon, PhD

DELPHI homepage: http://www.oslo-universitetssykehus.no/aktuelt_/prosjekter_/Sider/brudd-i-overarmsbenet.aspx

DELPHI protocol: http://www.biomedcentral.com/1471-2474/15/323

 

Publications 2026

Eilertsen L, Brekke IF, Haavardsholm E, Storrønning I, Sand SM, Husby IE, Sexton J, Martinsen MI, Valland H, Lillegraven S, Fraser AN (2026)
Cohort of 101 consecutive Nexel total elbow arthroplasties
J Shoulder Elbow Surg, 35 (8), 1979-1988
DOI 10.1016/j.jse.2026.01.021, PubMed 41722847

Publications 2024

Fjalestad T, Wagle T, Midtgaard KS, Fraser AN (2024)
[Proximal humerus fractures]
Tidsskr Nor Laegeforen, 144 (14)
DOI 10.4045/tidsskr.24.0143, PubMed 39605143

Fraser AN, Wagle TM, Karlberg AC, Madsen JE, Mellberg M, Lian T, Mader S, Eilertsen L, Apold H, Larsen LB, Pripp AH, Fjalestad T (2024)
Reverse Shoulder Arthroplasty Is Superior to Plate Fixation for Displaced Proximal Humeral Fractures in the Elderly: Five-Year Follow-up of the DelPhi Randomized Controlled Trial
J Bone Joint Surg Am, 106 (21), 1945-1956
DOI 10.2106/JBJS.23.01431, PubMed 39303024

Publications 2022

Bjørdal J, Fraser AN, Wagle TM, Kleven L, Lien OA, Eilertsen L, Mader K, Apold H, Larsen LB, Madsen JE, Fjalestad T (2022)
A cost-effectiveness analysis of reverse total shoulder arthroplasty compared with locking plates in the management of displaced proximal humerus fractures in the elderly: the DelPhi trial
J Shoulder Elbow Surg, 31 (10), 2187-2195
DOI 10.1016/j.jse.2022.05.022, PubMed 35781083

Bønes I, Karlberg AC, Liljeholm M, Fraser AN, Madsen JE, Fjalestad T (2022)
Pegs not superior to screws for fixation of fractures of the proximal humerus
J Orthop Surg Res, 17 (1), 66
DOI 10.1186/s13018-022-02947-3, PubMed 35109905

Publications 2021

Fraser AN, Bøe B, Fjalestad T, Madsen JE, Röhrl SM (2021)
Stable glenoid component of reverse total shoulder arthroplasty at 2 years as measured with model-based radiostereometric analysis (RSA)
Acta Orthop, 92 (6), 644-650
DOI 10.1080/17453674.2021.1943932, PubMed 34196600

Tallay E, Lindberg SK, Lee-Ødegård S, Bjordal J, Fraser AN, Madsen JE, Fjalestad T (2021)
External validity in a multicenter randomized clinical trial of proximal humeral fractures: the DelPhi trial
Eur J Orthop Surg Traumatol, 32 (2), 317-323
DOI 10.1007/s00590-021-02982-6, PubMed 33880653

Publications 2020

Fraser AN, Bjørdal J, Wagle TM, Karlberg AC, Lien OA, Eilertsen L, Mader K, Apold H, Larsen LB, Madsen JE, Fjalestad T (2020)
Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial
J Bone Joint Surg Am, 102 (6), 477-485
DOI 10.2106/JBJS.19.01071, PubMed 31977825

Publications 2018

Fraser AN, Tsukanaka M, Fjalestad T, Madsen JE, Röhrl SM (2018)
Model-based RSA is suitable for clinical trials on the glenoid component of reverse total shoulder arthroplasty
J Orthop Res, 36 (12), 3299-3307
DOI 10.1002/jor.24111, PubMed 30035319

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