Publications 2023

Christensen EE, Prebensen CH, Martinsen AB, Stiff ET, Hoff R, Kvale D, Holten AR (2023)
Mortality and Sequential Organ Failure Assessment Score in Patients With Suspected Sepsis: The Impact of Acute and Preexisting Organ Failures and Infection Likelihood
Crit Care Explor, 5 (2), e0865
DOI 10.1097/CCE.0000000000000865, PubMed 36844375

Publications 2022

Christensen EE, Binde C, Leegaard M, Tonby K, Dyrhol-Riise AM, Kvale D, Amundsen EK, Holten AR (2022)
DIAGNOSTIC ACCURACY AND ADDED VALUE OF INFECTION BIOMARKERS IN PATIENTS WITH POSSIBLE SEPSIS IN THE EMERGENCY DEPARTMENT
Shock, 58 (4), 251-259
DOI 10.1097/SHK.0000000000001981, PubMed 36130401

Meyer-Myklestad MH, Medhus AW, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Stiksrud B, Trøseid M, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Reikvam DH (2022)
Human Immunodeficiency Virus-Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction
J Infect Dis, 225 (4), 661-674
DOI 10.1093/infdis/jiaa714, PubMed 33216130

Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH (2022)
Probiotics to HIV-Infected Immunological Nonresponders: Altered Mucosal Immunity and Microbial Diversity Restricted to Ileum
J Acquir Immune Defic Syndr, 89 (1), 77-86
DOI 10.1097/QAI.0000000000002817, PubMed 34878437

Wæhre T, Tunheim G, Bodin JE, Laake I, Kvale D, Kran AB, Brekke H, Løken R, Oftung F, Mjaaland S, Dyrhol-Riise AM (2022)
Clinical characteristics and outcomes in hospitalized adult influenza patients: an observational study from Norway 2014-2018
Infect Dis (Lond), 54 (5), 367-377
DOI 10.1080/23744235.2021.2022196, PubMed 34983302

Publications 2021

Amundsen EK, Binde C, Christensen EE, Klingenberg O, Kvale D, Holten AR (2021)
Prognostic Value of Nucleated RBCs for Patients With Suspected Sepsis in the Emergency Department: A Single-Center Prospective Cohort Study
Crit Care Explor, 3 (7), e0490
DOI 10.1097/CCE.0000000000000490, PubMed 34291222

Jenum S, Tonby K, Rueegg CS, Rühwald M, Kristiansen MP, Bang P, Olsen IC, Sellæg K, Røstad K, Mustafa T, Taskén K, Kvale D, Mortensen R, Dyrhol-Riise AM (2021)
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat Commun, 12 (1), 6774
DOI 10.1038/s41467-021-27029-6, PubMed 34811370

Jøntvedt Jørgensen M, Nore KG, Aass HCD, Layre E, Nigou J, Mortensen R, Tasken K, Kvale D, Jenum S, Tonby K, Dyrhol-Riise AM (2021)
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front Cell Infect Microbiol, 11, 669623
DOI 10.3389/fcimb.2021.669623, PubMed 34307194

Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH (2021)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4⁺ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047

Lundin KEA, Røsjø H, Myhren H, Kvale D, Rosvold EO (2021)
[Medical education and training during a pandemic]
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.21.0581, PubMed 34505488

Publications 2020

Lyngbakken MN, Berdal JE, Eskesen A, Kvale D, Olsen IC, Rangberg A, Jonassen CM, Omland T, Røsjø H, Dalgard O (2020)
Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trial
Trials, 21 (1), 485
DOI 10.1186/s13063-020-04420-0, PubMed 32503662

Lyngbakken MN, Berdal JE, Eskesen A, Kvale D, Olsen IC, Rueegg CS, Rangberg A, Jonassen CM, Omland T, Røsjø H, Dalgard O (2020)
A pragmatic randomized controlled trial reports lack of efficacy of hydroxychloroquine on coronavirus disease 2019 viral kinetics
Nat Commun, 11 (1), 5284
DOI 10.1038/s41467-020-19056-6, PubMed 33082342

Publications 2017

Brekke K, Sommerfelt M, Ökvist M, Dyrhol-Riise AM, Kvale D (2017)
The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
BMC Infect Dis, 17 (1), 228
DOI 10.1186/s12879-017-2316-x, PubMed 28340570

Feruglio SL, Kvale D, Dyrhol-Riise AM (2017)
T Cell Responses and Regulation and the Impact of In Vitro IL-10 and TGF-β Modulation During Treatment of Active Tuberculosis
Scand J Immunol, 85 (2), 138-146
DOI 10.1111/sji.12511, PubMed 27862137

Prebensen C, Trøseid M, Ueland T, Dahm A, Sandset PM, Aaberge I, Waalen K, Dyrhol-Riise AM, Taskén K, Kvale D (2017)
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
PLoS One, 12 (5), e0176527
DOI 10.1371/journal.pone.0176527, PubMed 28464042

Publications 2016

Prebensen C, Lind A, Dyrhol-Riise AM, Kvale D (2016)
Regulation of Gag- and Env-Specific CD8+ T Cell Responses in ART-Naïve HIV-Infected Patients: Potential Implications for Individualized Immunotherapy
PLoS One, 11 (4), e0153849
DOI 10.1371/journal.pone.0153849, PubMed 27128502

Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trøseid M, Taskén K, Dyrhol-Riise AM (2016)
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144

Tonby K, Wergeland I, Lieske NV, Kvale D, Tasken K, Dyrhol-Riise AM (2016)
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
BMC Infect Dis, 16 (1), 599
DOI 10.1186/s12879-016-1938-8, PubMed 27776487

Publications 2015

Feruglio SL, Tonby K, Kvale D, Dyrhol-Riise AM (2015)
Early dynamics of T helper cell cytokines and T regulatory cells in response to treatment of active Mycobacterium tuberculosis infection
Clin Exp Immunol, 179 (3), 454-65
DOI 10.1111/cei.12468, PubMed 25313008

Lieske NV, Tonby K, Kvale D, Dyrhol-Riise AM, Tasken K (2015)
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors
PLoS One, 10 (11), e0141903
DOI 10.1371/journal.pone.0141903, PubMed 26544592

Prebensen C, Ueland T, Michelsen AE, Lind A, Pettersen FO, Mollnes TE, Aukrust P, Dyrhol-Riise AM, Kvale D (2015)
High MIP-1β Levels in Plasma Predict Long-Term Immunological Nonresponse to Suppressive Antiretroviral Therapy in HIV Infection
J Acquir Immune Defic Syndr, 69 (4), 395-402
DOI 10.1097/QAI.0000000000000617, PubMed 26115437

Stiksrud B, Nowak P, Nwosu FC, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AE, Sandset PM, Rudi K, Hov JR, Dyrhol-Riise AM, Trøseid M (2015)
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART
J Acquir Immune Defic Syndr, 70 (4), 329-37
DOI 10.1097/QAI.0000000000000784, PubMed 26258571

Tonby K, Ruhwald M, Kvale D, Dyrhol-Riise AM (2015)
IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection
Sci Rep, 5, 9223
DOI 10.1038/srep09223, PubMed 25783975

Wergeland I, Pullar N, Assmus J, Ueland T, Tonby K, Feruglio S, Kvale D, Damås JK, Aukrust P, Mollnes TE, Dyrhol-Riise AM (2015)
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
J Infect, 70 (4), 381-91
DOI 10.1016/j.jinf.2014.12.019, PubMed 25597826

Publications 2014

Brekke K, Lind A, Holm-Hansen C, Haugen IL, Sørensen B, Sommerfelt M, Kvale D (2014)
Intranasal administration of a therapeutic HIV vaccine (Vacc-4x) induces dose-dependent systemic and mucosal immune responses in a randomized controlled trial
PLoS One, 9 (11), e112556
DOI 10.1371/journal.pone.0112556, PubMed 25398137

Kran AMB, Lind A, Sommerfelt MM, Baksaas I, Sørensen B, Kvale D (2014)
Comparable Cellular Immune Responses in Patients with and without Antiretroviral Treatment after Immunization with HIV-1 P24, P17 and Tat Consensus Peptides (Vacc-5q)
J AIDS Clin Res, 5 (4), 1000294
DOI 10.4172/2155-6113.1000296, PublikaID 217

Lind A, Brekke K, Pettersen FO, Mollnes TE, Trøseid M, Kvale D (2014)
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers
PLoS One, 9 (1), e85604
DOI 10.1371/journal.pone.0085604, PubMed 24416431

Manner IW, Baekken M, Oektedalen O, Kvale D, Nowak P, Nielsen SD, Os I, Trøseid M (2014)
Plasma lipopolysaccharide and triglycerides are independently associated and both markers correlate with the development of metabolic syndrome in HIV infection
J Acquir Immune Defic Syndr, 65 (4), e158-61
DOI 10.1097/QAI.0000000000000055, PubMed 24577189

Pedersen KK, Manner IW, Seljeflot I, Kvale D, Os I, Gerstoft J, Nielsen SD, Trøseid M (2014)
Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART
J Acquir Immune Defic Syndr, 67 (4), 370-4
DOI 10.1097/QAI.0000000000000339, PubMed 25226210

Trøseid M, Manner IW, Pedersen KK, Haissman JM, Kvale D, Nielsen SD (2014)
Microbial translocation and cardiometabolic risk factors in HIV infection
AIDS Res Hum Retroviruses, 30 (6), 514-22
DOI 10.1089/aid.2013.0280, PubMed 24521167

Publications 2013

Drozd F, Skeie LG, Kraft P, Kvale D (2013)
A web-based intervention trial for depressive symptoms and subjective well-being in patients with chronic HIV infection
AIDS Care, 26 (9), 1080-9
DOI 10.1080/09540121.2013.869541, PubMed 24359563

Feruglio SL, Trøseid M, Damås JK, Kvale D, Dyrhol-Riise AM (2013)
Soluble markers of the Toll-like receptor 4 pathway differentiate between active and latent tuberculosis and are associated with treatment responses
PLoS One, 8 (7), e69896
DOI 10.1371/journal.pone.0069896, PubMed 23875007

Lind A, Brekke K, Sommerfelt M, Holmberg JO, Aass HC, Baksaas I, Sørensen B, Dyrhol-Riise AM, Kvale D (2013)
Boosters of a therapeutic HIV-1 vaccine induce divergent T cell responses related to regulatory mechanisms
Vaccine, 31 (41), 4611-8
DOI 10.1016/j.vaccine.2013.07.037, PubMed 23906886

Manner IW, Baekken M, Kvale D, Oektedalen O, Pedersen M, Nielsen SD, Nowak P, Os I, Trøseid M (2013)
Markers of microbial translocation predict hypertension in HIV-infected individuals
HIV Med, 14 (6), 354-61
DOI 10.1111/hiv.12015, PubMed 23332095

Pedersen KK, Pedersen M, Trøseid M, Gaardbo JC, Lund TT, Thomsen C, Gerstoft J, Kvale D, Nielsen SD (2013)
Microbial translocation in HIV infection is associated with dyslipidemia, insulin resistance, and risk of myocardial infarction
J Acquir Immune Defic Syndr, 64 (5), 425-33
DOI 10.1097/QAI.0b013e31829f919d, PubMed 23797689

Ushakova A, Pettersen FO, Mæland A, Lindqvist BH, Kvale D (2013)
Bayesian estimation of HIV-1 dynamics in vivo
Math Med Biol, 32 (1), 38-55
DOI 10.1093/imammb/dqt018, PubMed 24078026

Publications 2012

Brantsæter AB, Johannessen A, Holberg-Petersen M, Sandvik L, Naman E, Kivuyo SL, Rollag H, Bruun JN, Kvale D (2012)
Cytomegalovirus viremia in dried blood spots is associated with an increased risk of death in HIV-infected patients: a cohort study from rural Tanzania
Int J Infect Dis, 16 (12), e879-85
DOI 10.1016/j.ijid.2012.08.003, PubMed 23031419

Lind A, Sommerfelt M, Holmberg JO, Baksaas I, Sørensen B, Kvale D (2012)
Intradermal vaccination of HIV-infected patients with short HIV Gag p24-like peptides induces CD4 + and CD8 + T cell responses lasting more than seven years
Scand J Infect Dis, 44 (8), 566-72
DOI 10.3109/00365548.2011.653581, PubMed 22339485

Trøseid M, Lind A, Nowak P, Barqasho B, Heger B, Lygren I, Pedersen KK, Kanda T, Funaoka H, Damås JK, Kvale D (2012)
Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: possible implication for TLR4-signalling and chronic immune activation
Innate Immun, 19 (3), 290-7
DOI 10.1177/1753425912461042, PubMed 23070967

Publications 2011

Kran AM, Sommerfelt MA, Baksaas I, Sørensen B, Kvale D (2011)
Delayed-type hypersensitivity responses to HIV Gag p24 relate to clinical outcome after peptide-based therapeutic immunization for chronic HIV infection
APMIS, 120 (3), 204-9
DOI 10.1111/j.1600-0463.2011.02843.x, PubMed 22339677

Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D (2011)
An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses
J Virol, 85 (13), 6557-66
DOI 10.1128/JVI.00073-11, PubMed 21490090

Publications 2010

Kran AM, Jonassen TO, Sommerfelt MA, Løvgården G, Sørensen B, Kvale D (2010)
Low frequency of amino acid alterations following therapeutic immunization with HIV-1 Gag p24-like peptides
AIDS, 24 (17), 2609-18
DOI 10.1097/QAD.0b013e32833e502b, PubMed 20935558

Pettersen FO, Taskén K, Kvale D (2010)
Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection
Clin Exp Immunol, 161 (2), 315-23
DOI 10.1111/j.1365-2249.2010.04179.x, PubMed 20491784

Publications 2009

Maagaard A, Kvale D (2009)
Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?
J Antimicrob Chemother, 64 (5), 901-9
DOI 10.1093/jac/dkp316, PubMed 19740910

Maagaard A, Kvale D (2009)
Long term adverse effects related to nucleoside reverse transcriptase inhibitors: clinical impact of mitochondrial toxicity
Scand J Infect Dis, 41 (11-12), 808-17
DOI 10.3109/00365540903186181, PubMed 19922062

Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM (2009)
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
Eur J Immunol, 39 (5), 1280-7
DOI 10.1002/eji.200839002, PubMed 19384871

Publications 2008

Holm M, Pettersen FO, Kvale D (2008)
PD-1 predicts CD4 loss rate in chronic HIV-1 infection better than HIV RNA and CD38 but not in cryopreserved samples
Curr HIV Res, 6 (1), 49-58
DOI 10.2174/157016208783571955, PubMed 18288975

Maagaard A, Holberg-Petersen M, Løvgården G, Holm M, Pettersen FO, Kvale D (2008)
Distinct mechanisms for mitochondrial DNA loss in T and B lymphocytes from HIV-infected patients exposed to nucleoside reverse-transcriptase inhibitors and those naive to antiretroviral treatment
J Infect Dis, 198 (10), 1474-81
DOI 10.1086/592713, PubMed 18851688

Publications 2007

Maagaard A, Holberg-Petersen M, Torjesen PA, Bruun JN, Kvale D (2007)
Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients
HIV Clin Trials, 8 (5), 345-53
DOI 10.1310/hct0805-345, PubMed 17956836

Publications 2006

Kran AM, Kvale D (2006)
[Immunopathogenesis and therapeutic immunization in HIV-infection]
Tidsskr Nor Laegeforen, 126 (23), 3112-6
PubMed 17160117

Kran AM, Sørensen B, Sommerfelt MA, Nyhus J, Baksaas I, Kvale D (2006)
Long-term HIV-specific responses and delayed resumption of antiretroviral therapy after peptide immunization targeting dendritic cells
AIDS, 20 (4), 627-30
DOI 10.1097/01.aids.0000210620.75707.ac, PubMed 16470131

Kvale D, Ormaasen V, Kran AM, Johansson CC, Aukrust P, Aandahl EM, Frøland SS, Taskén K (2006)
Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
AIDS, 20 (6), 813-20
DOI 10.1097/01.aids.0000218544.54586.f1, PubMed 16549964

Publications 2005

Abrahamsen IW, Sømme S, Heldal D, Egeland T, Kvale D, Tjønnfjord GE (2005)
Immune reconstitution after allogeneic stem cell transplantation: the impact of stem cell source and graft-versus-host disease
Haematologica, 90 (1), 86-93
PubMed 15642674

Kran AM, Sommerfelt MA, Sørensen B, Nyhus J, Baksaas I, Bruun JN, Kvale D (2005)
Reduced viral burden amongst high responder patients following HIV-1 p24 peptide-based therapeutic immunization
Vaccine, 23 (31), 4011-5
DOI 10.1016/j.vaccine.2005.03.010, PubMed 15963359

Kvale D, Kran AM, Sommerfelt MA, Nyhus J, Baksaas I, Bruun JN, Sørensen B (2005)
Divergent in vitro and in vivo correlates of HIV-specific T-cell responses during onset of HIV viraemia
AIDS, 19 (6), 563-7
DOI 10.1097/01.aids.0000163932.76531.c6, PubMed 15802974

Nyhus J, Kran AM, Sommerfelt MA, Baksaas I, Sørensen B, Kvale D (2005)
Multiple antigen concentrations in delayed-type hypersensitivity (DTH) and response diversity during and after immunization with a peptide-based HIV-1 immunotherapy candidate (Vacc-4x)
Vaccine, 24 (10), 1543-50
DOI 10.1016/j.vaccine.2005.10.012, PubMed 16289707

Publications 2004

Kran AM, Sørensen B, Nyhus J, Sommerfelt MA, Baksaas I, Bruun JN, Kvale D (2004)
HLA- and dose-dependent immunogenicity of a peptide-based HIV-1 immunotherapy candidate (Vacc-4x)
AIDS, 18 (14), 1875-83
DOI 10.1097/00002030-200409240-00003, PubMed 15353973

Publications 2002

Kvale D, Aaberge IS, Frøland SS (2002)
Predictive value of immunologic parameters and HIV RNA in relation to humoral pneumococcal polysaccharide vaccine responses in patients with HIV infection
Eur J Clin Microbiol Infect Dis, 21 (9), 688-90
DOI 10.1007/s10096-002-0803-4, PubMed 12373505

Müller F, Tjønnfjord GE, Nordøy I, Kvale D, Mellbye OJ, Aukrust P, Frøland SS (2002)
Immunophenotypic analyses of CD34(+) cell subsets in bone marrow from HIV-infected patients during highly- active antiretroviral therapy
Eur J Clin Invest, 32 (7), 535-40
DOI 10.1046/j.1365-2362.2002.00995.x, PubMed 12153555

Rollag H, Sagedal S, Kristiansen KI, Kvale D, Holter E, Degré M, Nordal KP (2002)
Cytomegalovirus DNA concentration in plasma predicts development of cytomegalovirus disease in kidney transplant recipients
Clin Microbiol Infect, 8 (7), 431-4
DOI 10.1046/j.1469-0691.2002.00449.x, PubMed 12199854

Publications 2000

Sindre H, Haraldsen G, Beck S, Hestdal K, Kvale D, Brandtzaeg P, Degré M, Rollag H (2000)
Human intestinal endothelium shows high susceptibility to cytomegalovirus and altered expression of adhesion molecules after infection
Scand J Immunol, 51 (4), 354-60
DOI 10.1046/j.1365-3083.2000.00676.x, PubMed 10736107

Publications 1999

Aukrust P, Müller F, Lien E, Nordoy I, Liabakk NB, Kvale D, Espevik T, Froland SS (1999)
Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy: persistent TNF activation is associated with virologic and immunologic treatment failure
J Infect Dis, 179 (1), 74-82
DOI 10.1086/314572, PubMed 9841825

Kvale D, Aukrust P, Osnes K, Müller F, Frøland SS (1999)
CD4+ and CD8+ lymphocytes and HIV RNA in HIV infection: high baseline counts and in particular rapid decrease of CD8+ lymphocytes predict AIDS
AIDS, 13 (2), 195-201
DOI 10.1097/00002030-199902040-00007, PubMed 10202825

Nilsen EM, Johansen FE, Kvale D, Krajci P, Brandtzaeg P (1999)
Different regulatory pathways employed in cytokine-enhanced expression of secretory component and epithelial HLA class I genes
Eur J Immunol, 29 (1), 168-79
DOI 10.1002/(SICI)1521-4141(199901)29:01<168::AID-IMMU168>3.0.CO;2-8, PubMed 9933098

Stylianou E, Aukrust P, Kvale D, Müller F, Frøland SS (1999)
IL-10 in HIV infection: increasing serum IL-10 levels with disease progression--down-regulatory effect of potent anti-retroviral therapy
Clin Exp Immunol, 116 (1), 115-20
DOI 10.1046/j.1365-2249.1999.00865.x, PubMed 10209514

Publications 1998

Haraldsen G, Sollid LM, Bakke O, Farstad IN, Kvale D, Molberg, Norstein J, Stang E, Brandtzaeg P (1998)
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells
Gastroenterology, 114 (4), 649-56
DOI 10.1016/s0016-5085(98)70578-5, PubMed 9516385

Publications 1997

Farstad IN, Halstensen TS, Kvale D, Fausa O, Brandtzaeg P (1997)
Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin alpha 4 beta 7 to naive and memory phenotypes
Am J Pathol, 150 (1), 187-99
PubMed 9006335

Jensenius M, Maeland A, Kvale D, Farstad IN, Vene S, Bruu AL (1997)
[Q-fever imported into Norway]
Tidsskr Nor Laegeforen, 117 (27), 3937-40
PubMed 9441420

Publications 1996

Haraldsen G, Kvale D, Lien B, Farstad IN, Brandtzaeg P (1996)
Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
J Immunol, 156 (7), 2558-65
PubMed 8786319

Kvale D, Holme R (1996)
Intercellular adhesion molecule-1 (ICAM-1; CD54) expression in human hepatocytic cells depends on protein kinase C
J Hepatol, 25 (5), 670-6
DOI 10.1016/s0168-8278(96)80237-6, PubMed 8938544

Publications 1995

Haraldsen G, Rugtveit J, Kvale D, Scholz T, Muller WA, Hovig T, Brandtzaeg P (1995)
Isolation and longterm culture of human intestinal microvascular endothelial cells
Gut, 37 (2), 225-34
DOI 10.1136/gut.37.2.225, PubMed 7557573

Krajci P, Kvale D, Brandtzaeg P (1995)
Cloning, chromosomal localization, and linkage analysis of the gene encoding human transmembrane secretory component (the poly-Ig receptor)
Adv Exp Med Biol, 371A, 617-23
DOI 10.1007/978-1-4615-1941-6_130, PubMed 8526003

Kvale D, Brandtzaeg P (1995)
Constitutive and cytokine induced expression of HLA molecules, secretory component, and intercellular adhesion molecule-1 is modulated by butyrate in the colonic epithelial cell line HT-29
Gut, 36 (5), 737-42
DOI 10.1136/gut.36.5.737, PubMed 7797124

Kvale D, Brandtzaeg P (1995)
Butyrate differentially affects constitutive and cytokine-induced expression of HLA molecules, secretory component (SC), and ICAM-1 in a colonic epithelial cell line (HT-29, clone m3)
Adv Exp Med Biol, 371A, 183-8
DOI 10.1007/978-1-4615-1941-6_37, PubMed 8525902

Publications 1994

Buø L, Bjørnland K, Karlsrud TS, Kvale D, Kjønniksen I, Fodstad O, Brandtzaeg P, Johansen HT, Aasen AO (1994)
Expression and release of plasminogen activators, their inhibitors and receptor by human tumor cell lines
Anticancer Res, 14 (6B), 2445-51
PubMed 7872665

Rognes T, Seeberg E, Kvale D (1994)
SpeedGenie: demo guide : Windows version 1.1 : sequence database searching software
MedProbe, Oslo, 73 s.
BIBSYS 950678996

Rognes T, Seeberg E, Kvale D (1994)
SpeedGenie User's Guide
MedProbe, Oslo, 89 s.
PublikaID 45

Publications 1993

Krajci P, Taskén K, Kvale D, Brandtzaeg P (1993)
Interferon-gamma stimulation of messenger RNA for human secretory component (poly-Ig receptor) depends on continuous intermediate protein synthesis
Scand J Immunol, 37 (2), 251-6
DOI 10.1111/j.1365-3083.1993.tb01763.x, PubMed 8434236

Kvale D, Brandtzaeg P (1993)
Immune modulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human hepatocytic cell lines
J Hepatol, 17 (3), 347-52
DOI 10.1016/s0168-8278(05)80216-8, PubMed 7686194

Publications 1992

Brandtzaeg P, Halstensen TS, Huitfeldt HS, Krajci P, Kvale D, Scott H, Thrane PS (1992)
Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract
Ann N Y Acad Sci, 664, 157-79
DOI 10.1111/j.1749-6632.1992.tb39758.x, PubMed 1456647

BRANDTZAEG P, HALSTENSEN TS, HUITFELDT HS, KRAJCI P, KVALE D, SCOTT H, THRANE PS (1992)
EPITHELIAL EXPRESSION OF HLA, SECRETORY COMPONENT (POLY-IG RECEPTOR), AND ADHESION MOLECULES IN THE HUMAN ALIMENTARY-TRACT
Ann.NY Acad.Sci., 664, 157-179
DOI 10.1111/j.1749-6632.1992.tb39758.x

Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992)
Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)
Eur J Immunol, 22 (9), 2309-15
DOI 10.1002/eji.1830220920, PubMed 1355431

Kvale D, Krajci P, Brandtzaeg P (1992)
Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines
Scand J Immunol, 35 (6), 669-76
DOI 10.1111/j.1365-3083.1992.tb02973.x, PubMed 1376489

Kvale D, Norstein J, Meling GI, Børmer OP, Brandtzaeg P, Langmark F, Rognum TO (1992)
Circulating secretory component in relation to early diagnosis and treatment of liver metastasis from colorectal carcinomas
J Clin Pathol, 45 (7), 568-71
DOI 10.1136/jcp.45.7.568, PubMed 1517455

Publications 1991

Aukrust P, Frøland SS, Kvale D, Egge K, Farstad IN, Holter E, Moum B (1991)
[Symptomatic cytomegalovirus infection in patients with acquired immunodeficiency syndrome]
Tidsskr Nor Laegeforen, 111 (28), 3379-84
PubMed 1665253

Publications 1990

Schrumpf E, Elgjo K, Fausa O, Haukenes G, Kvale D, Rollag H (1990)
The significance of anti-hepatitis C virus antibodies measured in chronic liver disease
Scand J Gastroenterol, 25 (11), 1169-74
DOI 10.3109/00365529008998550, PubMed 2177219

Taskén K, Kvale D, Hansson V, Jahnsen T (1990)
Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells
Biochem Biophys Res Commun, 172 (2), 409-14
DOI 10.1016/0006-291x(90)90688-j, PubMed 2241943

Publications 1989

Brandtzaeg P, Halstensen TS, Kett K, Krajci P, Kvale D, Rognum TO, Scott H, Sollid LM (1989)
Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes
Gastroenterology, 97 (6), 1562-84
DOI 10.1016/0016-5085(89)90406-x, PubMed 2684725

BRANDTZAEG P, HALSTENSEN TS, KETT K, KVALE D, ROGNUM TO, SCOTT H, SOLLID LM (1989)
PHYSIOLOGY AND IMMUNOPATHOLOGY OF THE INTESTINAL SECRETORY IMMUNE-SYSTEM
Ital. J. Gastroenterol., 21 (1), 21-34

Kvale D (1989)
Human secretory component: cellular studies and clinical applications for patients with cancer and liver disease
Dag Kvale, Oslo, 1 b. (flere pag.)
BIBSYS 890177198, ISBN 82-90187-47-5

Kvale D, Jahnsen T (1989)
[New biotechnologic products in treatment and prevention]
Tidsskr Nor Laegeforen, 109 (33), 3427-30
PubMed 2609304

Publications 1988

Brandtzaeg P, Kvale D, Sollid LM, Thrane PS (1988)
The poly-Ig receptor--functional aspects of secretory component expression
Adv Exp Med Biol, 237, 9-20
DOI 10.1007/978-1-4684-5535-9_2, PubMed 3151046

Brandtzaeg P, Sollid LM, Bjerke K, Kett K, Kvale D, Rognum TO, Scott H, Thrane PS (1988)
Interactions of lymphoid cells with the epithelial environment
Monogr Allergy, 24, 51-9
PubMed 3163099

Brandtzaeg P, Sollid LM, Thrane PS, Kvale D, Bjerke K, Scott H, Kett K, Rognum TO (1988)
Lymphoepithelial interactions in the mucosal immune system
Gut, 29 (8), 1116-30
DOI 10.1136/gut.29.8.1116, PubMed 3044933

Kvale D, Bartek J, Sollid LM, Brandtzaeg P (1988)
Rapid selection of cultured cells with increased expression of a membrane marker (secretory component)
Int J Cancer, 42 (4), 638-41
DOI 10.1002/ijc.2910420428, PubMed 2459074

Kvale D, Brandtzaeg P (1988)
Does secretory component (SC) exist as free SC in human serum?
J Immunol Methods, 113 (2), 279-81, 87-88
DOI 10.1016/0022-1759(88)90342-0, PubMed 3171192

KVALE D, BRANDTZAEG P (1988)
FREE SECRETORY COMPONENT IN HUMAN-SERUM - REPLY
J. Immunol. Methods, 113 (2), 287-288
DOI 10.1016/0022-1759(88)90344-4

Kvale D, Brandtzaeg P, Løvhaug D (1988)
Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by tumour necrosis factor-alpha and gamma interferon
Scand J Immunol, 28 (3), 351-7
DOI 10.1111/j.1365-3083.1988.tb01460.x, PubMed 3143150

Kvale D, Løvhaug D, Sollid LM, Brandtzaeg P (1988)
Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig
J Immunol, 140 (9), 3086-9
PubMed 3361127

Sollid LM, Brandtzaeg P, Kvale D, Gaudernack G, Scott H, Thorsby E (1988)
T cell-epithelium interactions in relation to gut immunity
Monogr Allergy, 24, 60-5
PubMed 3129651

Publications 1987

Brandtzaeg P, Bjerke K, Kett K, Kvale D, Rognum TO, Scott H, Sollid LM, Valnes K (1987)
Production and secretion of immunoglobulins in the gastrointestinal tract
Ann Allergy, 59 (5 Pt 2), 21-39
PubMed 3318585

Kvale D, Brandtzaeg P (1987)
Reaction to the article: ELISA for measurement of secretory IgA distinct from monomeric IgA
J Immunol Methods, 103 (1), 147-50
DOI 10.1016/0022-1759(87)90254-7, PubMed 3655382

Kvale D, Rognum TO, Brandtzaeg P (1987)
Relation between circulating secretory component (SC) and liver metastasis of colonic or mammary carcinoma
Adv Exp Med Biol, 216B, 1101-7
PubMed 3425420

Kvale D, Rognum TO, Brandtzaeg P (1987)
Early detection of liver metastasis in patients with colorectal carcinoma by increased levels of circulating IgA- and IgM-associated secretory component
Br J Cancer, 56 (5), 629-32
DOI 10.1038/bjc.1987.256, PubMed 3426927

Kvale D, Rognum TO, Brandtzaeg P (1987)
Elevated levels of secretory immunoglobulins A and M in serum of patients with large bowel carcinoma indicate liver metastasis
Cancer, 59 (2), 203-7
DOI 10.1002/1097-0142(19870115)59:2<203::aid-cncr2820590204>3.0.co;2-p, PubMed 3802011

Kvale D, Rognum TO, Thorud E, Fosså SD, Rø JS, Brandtzaeg P (1987)
Circulating secretory component in breast neoplasms
J Clin Pathol, 40 (6), 621-5
DOI 10.1136/jcp.40.6.621, PubMed 3301907

Kvale D, Schrumpf E, Brandtzaeg P, Solberg HE, Fausa O, Elgjo K (1987)
Circulating secretory immunoglobulins of the A and M isotypes in chronic liver disease
J Hepatol, 4 (2), 229-35
DOI 10.1016/s0168-8278(87)80085-5, PubMed 3584932

Sollid LM, Gaudernack G, Markussen G, Kvale D, Brandtzaeg P, Thorsby E (1987)
Induction of various HLA class II molecules in a human colonic adenocarcinoma cell line
Scand J Immunol, 25 (2), 175-80
DOI 10.1111/j.1365-3083.1987.tb01061.x, PubMed 2434988

Sollid LM, Kvale D, Brandtzaeg P, Markussen G, Thorsby E (1987)
Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins
J Immunol, 138 (12), 4303-6
PubMed 3108385

Sollid LM, Kvale D, Brandtzaeg P, Markussen G, Thorsby E (1987)
Synthesis of cytoplasmic and functional membrane SC induced by gamma-interferon
Adv Exp Med Biol, 216B, 1109-16
PubMed 3122531

Publications 1986

Kvale D, Brandtzaeg P (1986)
An enzyme-linked immunosorbent assay for differential quantitation of secretory immunoglobulins of the A and M isotypes in human serum
J Immunol Methods, 86 (1), 107-14
DOI 10.1016/0022-1759(86)90272-3, PubMed 3944464