Protein structure analysis

We can help with advanced protein structure analysis, for example

  • Analysis of protein secondary structure
  • Identification of probably disordered regions and post-translational modifications
  • Identification of potential model structures by advanced homology searches, threading, or fold recognition
  • Building 3D structural model, if possible
  • Analysis of conserved regions, potential active site residues, and protein-protein interactions
  • Prediction of effects of mutagenesis
  • Phylogenetic analysis
  • Classification of proteins in family, superfamily or fold type, which may suggest protein function

A conserved (dark red) patch on the surface of PCSK9 interacts with LDLR, leads to LDLR degradation, and elevated serum levels of LDL

 
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