Publications 2021

Otterhaug T, Janetzki S, Welters MJP, Håkerud M, Nedberg AG, Edwards VT, Boekestijn S, Loof NM, Selbo PK, Olivecrona H, van der Burg SH, Høgset A (2021)
Photochemical Internalization Enhanced Vaccination Is Safe, and Gives Promising Cellular Immune Responses to an HPV Peptide-Based Vaccine in a Phase I Clinical Study in Healthy Volunteers
Front Immunol, 11, 576756
DOI 10.3389/fimmu.2020.576756, PubMed 33488576

Publications 2018

Haug M, Brede G, Håkerud M, Nedberg AG, Gederaas OA, Flo TH, Edwards VT, Selbo PK, Høgset A, Halaas Ø (2018)
Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination
Front Immunol, 9, 650
DOI 10.3389/fimmu.2018.00650, PubMed 29670624

Publications 2017

Gaware VS, Håkerud M, Juzeniene A, Høgset A, Berg K, Másson M (2017)
Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
Biomacromolecules, 18 (4), 1108-1126
DOI 10.1021/acs.biomac.6b01670, PubMed 28245649

Publications 2016

Hjálmsdóttir Á, Bühler C, Vonwil V, Roveri M, Håkerud M, Wäckerle-Men Y, Gander B, Johansen P (2016)
Cytosolic Delivery of Liposomal Vaccines by Means of the Concomitant Photosensitization of Phagosomes
Mol Pharm, 13 (2), 320-9
DOI 10.1021/acs.molpharmaceut.5b00394, PubMed 26704885

Publications 2015

Bruno C, Waeckerle-Men Y, Håkerud M, Kündig TM, Gander B, Johansen P (2015)
Photosensitizer and Light Pave the Way for Cytosolic Targeting and Generation of Cytosolic CD8 T Cells Using PLGA Vaccine Particles
J Immunol, 195 (1), 166-73
DOI 10.4049/jimmunol.1500431, PubMed 26019274

Publications 2014

Håkerud M, Selbo PK, Waeckerle-Men Y, Contassot E, Dziunycz P, Kündig TM, Høgset A, Johansen P (2014)
Photosensitisation facilitates cross-priming of adjuvant-free protein vaccines and stimulation of tumour-suppressing CD8 T cells
J Control Release, 198, 10-7
DOI 10.1016/j.jconrel.2014.11.032, PubMed 25482339

Publications 2013

Gaware VS, Håkerud M, Leósson K, Jónsdóttir S, Høgset A, Berg K, Másson M (2013)
Tetraphenylporphyrin tethered chitosan based carriers for photochemical transfection
J Med Chem, 56 (3), 807-19
DOI 10.1021/jm301270r, PubMed 23281854

Håkerud M, Waeckerle-Men Y, Selbo PK, Kündig TM, Høgset A, Johansen P (2013)
Intradermal photosensitisation facilitates stimulation of MHC class-I restricted CD8 T-cell responses of co-administered antigen
J Control Release, 174, 143-50
DOI 10.1016/j.jconrel.2013.11.017, PubMed 24280261

Waeckerle-Men Y, Mauracher A, Håkerud M, Mohanan D, Kündig TM, Høgset A, Johansen P (2013)
Photochemical targeting of antigens to the cytosol for stimulation of MHC class-I-restricted T-cell responses
Eur J Pharm Biopharm, 85 (1), 34-41
DOI 10.1016/j.ejpb.2013.02.002, PubMed 23461859

Publications 2010

Li T, Bunnelle WH, Ryther KB, Anderson DJ, Malysz J, Helfrich R, Grønlien JH, Håkerud M, Peters D, Schrimpf MR, Gopalakrishnan M, Ji J (2010)
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands
Bioorg Med Chem Lett, 20 (12), 3636-9
DOI 10.1016/j.bmcl.2010.04.105, PubMed 20472430

Malysz J, Anderson DJ, Grønlien JH, Ji J, Bunnelle WH, Håkerud M, Thorin-Hagene K, Ween H, Helfrich R, Hu M, Gubbins E, Gopalakrishnan S, Puttfarcken PS, Briggs CA, Li J, Meyer MD, Dyhring T, Ahring PK, Nielsen EØ, Peters D, Timmermann DB, Gopalakrishnan M (2010)
In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107
J Pharmacol Exp Ther, 334 (3), 863-74
DOI 10.1124/jpet.110.167072, PubMed 20504915

Publications 2009

Anderson DJ, Malysz J, Grønlien JH, El Kouhen R, Håkerud M, Wetterstrand C, Briggs CA, Gopalakrishnan M (2009)
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
Biochem Pharmacol, 78 (7), 844-51
DOI 10.1016/j.bcp.2009.06.024, PubMed 19555668

Malysz J, Grønlien JH, Anderson DJ, Håkerud M, Thorin-Hagene K, Ween H, Wetterstrand C, Briggs CA, Faghih R, Bunnelle WH, Gopalakrishnan M (2009)
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile
J Pharmacol Exp Ther, 330 (1), 257-67
DOI 10.1124/jpet.109.151886, PubMed 19389923

Malysz J, Grønlien JH, Timmermann DB, Håkerud M, Thorin-Hagene K, Ween H, Trumbull JD, Xiong Y, Briggs CA, Ahring PK, Dyhring T, Gopalakrishnan M (2009)
Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station
Assay Drug Dev Technol, 7 (4), 374-90
DOI 10.1089/adt.2009.0194, PubMed 19689206

Publications 2008

Tietje KR, Anderson DJ, Bitner RS, Blomme EA, Brackemeyer PJ, Briggs CA, Browman KE, Bury D, Curzon P, Drescher KU, Frost JM, Fryer RM, Fox GB, Gronlien JH, Håkerud M, Gubbins EJ, Halm S, Harris R, Helfrich RJ, Kohlhaas KL, Law D, Malysz J, Marsh KC, Martin RL, Meyer MD et al. (2008)
Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
CNS Neurosci Ther, 14 (1), 65-82
DOI 10.1111/j.1527-3458.2008.00037.x, PubMed 18482100

Publications 2007

Briggs CA, Schrimpf MR, Anderson DJ, Gubbins EJ, Grønlien JH, Håkerud M, Ween H, Thorin-Hagene K, Malysz J, Li J, Bunnelle WH, Gopalakrishnan M, Meyer MD (2007)
alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues
Br J Pharmacol, 153 (5), 1054-61
DOI 10.1038/sj.bjp.0707649, PubMed 18157163

Grønlien JH, Håkerud M, Ween H, Thorin-Hagene K, Briggs CA, Gopalakrishnan M, Malysz J (2007)
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes
Mol Pharmacol, 72 (3), 715-24
DOI 10.1124/mol.107.035410, PubMed 17565004