Yvonne Andersson

  • Scientist PhD
  • +47 22 78 17 80


  • Different aspects examining the immunotoxin MOC31PE immunostimulatory effects, in vivo and ex vivo. New data and submitted data.
  • Establishing humanized colorectal cancer models in mice for studying the MOC31PE immunostimulatory effects in vivo.
  • Commersialization strategies for the immunotoxin MOC31PE in collaboration with Inven2
  • Preparing govermental documentations needed for clinical approval of the immunotoxin BM7PE for metastatic colorectal cancer patients. - Submitted and waiting for reply.
  • New anti-angiogenic treatment strategies for pseudomyxoma peritonei in vivo (manuscript)
  • Hyperthermia or not is the Q, in chemotherapeutic strategies for peritoneal metastasis from ovarian and colorectal cancer.
  • Manuscript on the preclinical data showing the effects of the melanoma spesific immunotoxin 9.2.27PE on chemoresistant melanoma cells.

Publications 2017

Andersson Y, Haavardtun SI, Davidson B, Dørum A, Fleten KG, Fodstad Ø, Flatmark K (2017)
MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer
Oncotarget, 8 (37), 61800-61809
PubMed 28977905

Flem-Karlsen K, Tekle C, Andersson Y, Flatmark K, Fodstad Ø, Nunes-Xavier CE (2017)
Immunoregulatory protein B7-H3 promotes growth and decreases sensitivity to therapy in metastatic melanoma cells
Pigment Cell Melanoma Res, 30 (5), 467-476
PubMed 28513992

Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Olsen KH, Giercksky KE, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2017)
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
PubMed 28224367

Saeednejad Zanjani L, Madjd Z, Abolhasani M, Andersson Y, Rasti A, Shariftabrizi A, Asgari M (2017)
Cytoplasmic expression of CD133 stemness marker is associated with tumor aggressiveness in clear cell renal cell carcinoma
Exp Mol Pathol, 103 (2), 218-228
PubMed 29050853

Zanjani LS, Madjd Z, Abolhasani M, Rasti A, Fodstad O, Andersson Y, Asgari M (2017)
Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma
Biomark Med, 12 (1), 45-61
PubMed 29243496

Publications 2015

Andersson Y, Engebraaten O, Juell S, Aamdal S, Brunsvig P, Fodstad Ø, Dueland S (2015)
Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
Br J Cancer, 113 (11), 1548-55
PubMed 26554649

Hektoen HH, Flatmark K, Andersson Y, Dueland S, Redalen KR, Ree AH (2015)
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
BMC Cancer, 15, 543
PubMed 26205955

Publications 2014

Wiiger MT, Bideli H, Fodstad O, Flatmark K, Andersson Y (2014)
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
J Ovarian Res, 7, 23
PubMed 24528603

Publications 2013

Flatmark K, Guldvik IJ, Svensson H, Fleten KG, Flørenes VA, Reed W, Giercksky KE, Fodstad Ø, Andersson Y (2013)
Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies
Int J Cancer, 133 (6), 1497-506
PubMed 23494569

Publications 2011

Risberg K, Fodstad Ø, Andersson Y (2011)
Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma
PLoS One, 6 (9), e24012
PubMed 21915275

Risberg K, Guldvik IJ, Palchaudhuri R, Xi Y, Ju J, Fodstad O, Hergenrother PJ, Andersson Y (2011)
Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins
J Immunother, 34 (5), 438-47
PubMed 21577141

Publications 2010

Risberg K, Fodstad O, Andersson Y (2010)
Immunotoxins: a promising treatment modality for metastatic melanoma?
Ochsner J, 10 (3), 193-9
PubMed 21603377

Risberg K, Fodstad O, Andersson Y (2010)
Anti-melanoma activity of the 9.2.27PE immunotoxin in dacarbazine resistant cells
J Immunother, 33 (3), 272-8
PubMed 20445347

Wiiger MT, Gehrken HB, Fodstad Ø, Maelandsmo GM, Andersson Y (2010)
A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
Cancer Immunol Immunother, 59 (11), 1665-74
PubMed 20635083

Publications 2009

Risberg K, Fodstad Ø, Andersson Y (2009)
The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro
Int J Cancer, 125 (1), 23-33
PubMed 19350633

Publications 2006

Andersson Y, Le H, Juell S, Fodstad Ø (2006)
AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death
Mol Cancer Ther, 5 (4), 1050-9
PubMed 16648577

Ree AH, Stokke T, Bratland A, Patzke S, Nome RV, Folkvord S, Meza-Zepeda LA, Flatmark K, Fodstad O, Andersson Y (2006)
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124

Publications 2005

Holthe MR, Andersson Y, Lyberg T (2005)
Lack of proinflammatory effects of free fatty acids on human umbilical cord vein endothelial cells and leukocytes
Acta Obstet Gynecol Scand, 84 (7), 672-8
PubMed 15954878

Nome RV, Bratland A, Harman G, Fodstad O, Andersson Y, Ree AH (2005)
Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death
Mol Cancer Ther, 4 (8), 1231-8
PubMed 16093439

Publications 2004

Ahmed MS, Øie E, Vinge LE, Yndestad A, Øystein Andersen G, Andersson Y, Attramadal T, Attramadal H (2004)
Connective tissue growth factor--a novel mediator of angiotensin II-stimulated cardiac fibroblast activation in heart failure in rats
J Mol Cell Cardiol, 36 (3), 393-404
PubMed 15010278

Andersson Y, Juell S, Fodstad Ø (2004)
Downregulation of the antiapoptotic MCL-1 protein and apoptosis in MA-11 breast cancer cells induced by an anti-epidermal growth factor receptor-Pseudomonas exotoxin a immunotoxin
Int J Cancer, 112 (3), 475-83
PubMed 15382075

Ree AH, Bratland A, Nome RV, Stokke T, Fodstad O, Andersson Y (2004)
Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?
Radiother Oncol, 72 (3), 305-10
PubMed 15450729

Publications 2003

Ahmed MS, Øie E, Vinge LE, Yndestad A, Andersen G GØ, Andersson Y, Attramadal T, Attramadal H (2003)
Induction of myocardial biglycan in heart failure in rats--an extracellular matrix component targeted by AT(1) receptor antagonism
Cardiovasc Res, 60 (3), 557-68
PubMed 14659801

Guren TK, Ødegård J, Abrahamsen H, Thoresen GH, Susa M, Andersson Y, Østby E, Christoffersen T (2003)
EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes
J Cell Physiol, 196 (1), 113-23
PubMed 12767047

Publications 1999

Andersson Y, Majd Z, Lefebvre AM, Martin G, Sechkin AV, Kosykh V, Fruchart JC, Najib J, Staels B (1999)
Developmental and pharmacological regulation of apolipoprotein C-II gene expression. Comparison with apo C-I and apo C-III gene regulation
Arterioscler Thromb Vasc Biol, 19 (1), 115-21
PubMed 9888873

Publications 1997

Andersson Y, Lookene A, Shen Y, Nilsson S, Thelander L, Olivecrona G (1997)
Guinea pig apolipoprotein C-II: expression in E. coli, functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins
J Lipid Res, 38 (10), 2111-24
PubMed 9374133

Publications 1991

Andersson Y, Thelander L, Bengtsson-Olivecrona G (1991)
Rat apolipoprotein C-II lacks the conserved site for proteolytic cleavage of the pro-form
J Lipid Res, 32 (11), 1805-9
PubMed 1770300

Andersson Y, Thelander L, Bengtsson-Olivecrona G (1991)
Demonstration of apolipoprotein CII in guinea pigs. Functional characteristics, cDNA sequence, and tissue expression
J Biol Chem, 266 (7), 4074-80
PubMed 1999402

Jan 16, 2004 Page visits: 13903