Publications
2026
Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Rydland A, Yran ES, Nyman TA, Strand EB, Trøseid AS, Øvstebø R, Heinicke F, Lie BA, Viken MK.
Biochem Biophys Rep. 2026 Jun 20;47:102679. doi: 10.1016/j.bbrep.2026.102679. eCollection 2026 Sep.PMID: 42375682
FLCN loss is characterized by SQSTM1/p62 accumulation despite functional autophagy flux in Birt-Hogg-Dubé syndrome-associated kidney cancer.
Ullern H, Johannessen JA, Kasikci F, Formica M, Karimi Melve N, Andresen S, Brech A, Axcrona K, Jørgensen K, Farkas L, Enserink JM, Knævelsrud H.
Autophagy Rep. 2026 Aug 5;5(1):2705631. doi: 10.1080/27694127.2026.2705631. eCollection 2026.PMID: 42569319
Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation.
Kostas M, Munthe E, Haugsten EM, Mateus D, Sørensen V, Laerdahl JK, Szybowska P, Wiedlocha A, Lecaudey LA, Nakken S, Schink KO, Stenmark H, Wesche
J.Cell Rep. 2026 Jun 23;45(6):117504. doi: 10.1016/j.celrep.2026.117504. Epub 2026 Jun 4.PMID: 42247296
Time-resolved functional genomics using deep learning reveals global hierarchical control of autophagy.
Chica N, Andersen AN, Orellana-Muñoz S, Garcia I, P AN, Nakken S, Ayuda-Durán P, Håkensbakken L, Schultz SW, Rødningen E, Putnam CD, Zucknick M, Rusten TE, Enserink JM.
Nat Cell Biol. 2026 Mar;28(3):465-479. doi: 10.1038/s41556-025-01837-0. Epub 2026 Mar 13.PMID: 41826700
2025
Newly-diagnosed rheumatoid arthritis patients have elevated levels of plasma extracellular vesicles with protein cargo altered towards inflammatory processes.
Rydland A, Heinicke F, Nyman TA, Trøseid AS, Flåm ST, Stensland M, Gehin J, Eikeland J, Øvstebø R, Mjaavatten MD, Lie BA.
Sci Rep. 2025 Apr 4;15(1):11632. doi: 10.1038/s41598-025-96325-8.PMID: 40185859
The Redox Enzyme Thioredoxin Is Increased in Plasma Extracellular Vesicles From Endurance-Trained Females in Response to Acute Exercise.
Sagini K, Selvarajah M, Romero S, Bassols-Citores E, Martin-Gracia B, Ramirez-Garrastacho M, Rise F, Endzeliņš E, Sadovska L, Skorinkina D, Boguševiča M, Cešeiko R, Čampa M, Klavina A, Linē A, Llorente A.
FASEB J. 2025 Aug 31;39(16):e70927. doi: 10.1096/fj.202500678R.PMID: 40810354
SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics.
Trachsel-Moncho L, Veroni C, Mathai BJ, Lapao A, Singh S, Asp NT, Schultz SW, Pankiv S, Simonsen A.
J Cell Biol. 2025 May 5;224(5):e202404009. doi: 10.1083/jcb.202404009. Epub 2025 Mar 7.PMID: 40052924
2024
BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways.
Pankiv S, Dahl AK, Aas A, Andersen RL, Brech A, Holland P, Singh S, Bindesbøll C, Simonsen A.
J Cell Biol. 2024 Dec 2;223(12):e202408173. doi: 10.1083/jcb.202408173.
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.
Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E.
Cell Mol Life Sci. 2024 Apr 10;81(1):171. doi: 10.1007/s00018-024-05165-8.PMID: 38597989
Bi-allelic variants in SNF8 cause a disease spectrum ranging from severe developmental and epileptic encephalopathy to syndromic optic atrophy.
Brugger M, Lauri A, Zhen Y, Gramegna LL, Zott B, Sekulić N, Fasano G, Kopajtich R, Cordeddu V, Radio FC, Mancini C, Pizzi S, Paradisi G, Zanni G, Vasco G, Carrozzo R, Palombo F, Tonon C, Lodi R, La Morgia C, Arelin M, Blechschmidt C, Finck T, Sørensen V, Kreiser K, Strobl-Wildemann G, Daum H, Michaelson-Cohen R, Ziccardi L, Zampino G, Prokisch H, Abou Jamra R, Fiorini C, Arzberger T, Winkelmann J, Caporali L, Carelli V, Stenmark H, Tartaglia M, Wagner M.Am
J Hum Genet. 2024 Mar 7;111(3):594-613. doi: 10.1016/j.ajhg.2024.02.005. Epub 2024 Feb 28.PMID: 38423010
Removal of hypersignaling endosomes by simaphagy.
Migliano SM, Schultz SW, Wenzel EM, Takáts S, Liu D, Mørk S, Tan KW, Rusten TE, Raiborg C, Stenmark H.
Autophagy. 2024 Apr;20(4):769-791. doi: 10.1080/15548627.2023.2267958. Epub 2023 Oct 25.PMID: 37840274
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding.
Wenzel EM, Pedersen NM, Elfmark LA, Wang L, Kjos I, Stang E, Malerød L, Brech A, Stenmark H, Raiborg C.
Nat Commun. 2024 Feb 10;15(1):1277. doi: 10.1038/s41467-024-45558-8.PMID: 38341434
2023
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy.
Rixon C, Andreassen K, Shen X, Erusappan PM, Almaas VM, Palmero S, Dahl CP, Ueland T, Sjaastad I, Louch WE, Stokke MK, Tønnessen T, Christensen G, Lunde IG.
ESC Heart Fail. 2023 Apr;10(2):858-871. doi: 10.1002/ehf2.14234. Epub 2022 Nov 29.PMID: 36444917
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes.
Sandoz PA, Kuhnigk K, Szabo EK, Thunberg S, Erikson E, Sandström N, Verron Q, Brech A, Watzl C, Wagner AK, Alici E, Malmberg KJ, Uhlin M, Önfelt B.
Nat Commun. 2023 Sep 27;14(1):6035. doi: 10.1038/s41467-023-41634-7.PMID: 37758698
Endocytic trafficking of connexins in cancer pathogenesis.
Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E.
Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166812. doi: 10.1016/j.bbadis.2023.166812. Epub 2023 Jul 16.PMID: 37454772
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk.
Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ.
J Immunol. 2023 Nov 1;211(9):1348-1358. doi: 10.4049/jimmunol.2300406.PMID: 37737664
siRNA screening reveals that SNAP29 contributes to exosome release.
Hessvik NP, Sagini K, Romero S, Ramirez-Garrastacho M, Rodriguez M, Tutturen AEV, Kvalvaag A, Stang E, Brech A, Sandvig K, Llorente A.
Cell Mol Life Sci. 2023 Jun 7;80(7):177. doi: 10.1007/s00018-023-04822-8.PMID: 37285022
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE.
Circ Res. 2023 May 26;132(11):e188-e205. doi: 10.1161/CIRCRESAHA.122.321732. Epub 2023 May 4.PMID: 37139790
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis.
Pust S, Brech A, Wegner CS, Stenmark H, Haglund K.
Cell Mol Life Sci. 2023 Jul 31;80(8):235. doi: 10.1007/s00018-023-04864-y.PMID: 37523003
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.
Garcia-Garcia J, Berge AKM, Overå KS, Larsen KB, Bhujabal Z, Brech A, Abudu YP, Lamark T, Johansen T, Sjøttem E.
FEBS J. 2023 Feb;290(4):1096-1116. doi: 10.1111/febs.16628. Epub 2022 Sep 24.PMID: 36111389
2022
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.
Radulovic M, Wenzel EM, Gilani S, Holland LK, Lystad AH, Phuyal S, Olkkonen VM, Brech A, Jäättelä M, Maeda K, Raiborg C, Stenmark H.
EMBO J. 2022 Dec 15;41(24):e112677. doi: 10.15252/embj.2022112677. Epub 2022 Nov 21.PMID: 36408828
Adaptation to hypoxia in Drosophila melanogaster requires autophagy.
Valko A, Perez-Pandolfo S, Sorianello E, Brech A, Wappner P, Melani M.
Autophagy. 2022 Apr;18(4):909-920. doi: 10.1080/15548627.2021.1991191. Epub 2021 Nov 18.PMID: 34793268
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.
Garcia-Garcia J, Berge AKM, Overå KS, Larsen KB, Bhujabal Z, Brech A, Abudu YP, Lamark T, Johansen T, Sjøttem E.
FEBS J. 2023 Feb;290(4):1096-1116. doi: 10.1111/febs.16628. Epub 2022 Sep 24.PMID: 36111389
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells.
Espeland K, Kleinauskas A, Juzenas P, Brech A, Darvekar S, Vasovic V, Warloe T, Christensen E, Jahnsen J, Peng Q.
Biomedicines. 2022 Jan 21;10(2):232. doi: 10.3390/biomedicines10020232.PMID: 35203441