Protein structure analysis
We can help with advanced protein structure analysis, for example
- Analysis of protein secondary structure
- Identification of probably disordered regions and post-translational modifications
- Identification of potential model structures by advanced homology searches, threading, or fold recognition
- Building 3D structural model, if possible
- Analysis of conserved regions, potential active site residues, and protein-protein interactions
- Prediction of effects of mutagenesis
- Phylogenetic analysis
- Classification of proteins in family, superfamily or fold type, which may suggest protein function
A conserved (dark red) patch on the surface of PCSK9 interacts with LDLR, leads to LDLR degradation, and elevated serum levels of LDL