Protein structure analysis

We can help with advanced protein structure analysis, for example

• Analysis of protein secondary structure
• Identification of probably disordered regions and post-translational modifications
• Identification of potential model structures by advanced homology searches, threading, or fold recognition
• Building 3D structural model, if possible
• Analysis of conserved regions, potential active site residues, and protein-protein interactions
• Prediction of effects of mutagenesis
• Phylogenetic analysis
• Classification of proteins in family, superfamily or fold type, which may suggest protein function

A conserved (dark red) patch on the surface of PCSK9 interacts with LDLR, leads to LDLR degradation, and elevated serum levels of LDL