Antoni Wiedlocha's group

Protein internalisation and signaling

 
A. Wiedlocha
A. Wiedlocha

Maintenance of tissue homeostasis depends on complex intercellular growth factor signaling networks that govern many basic cell functions.  Therefore, alterations in growth factor signalling networks are prerequisites for cancer development. The fibroblast growth factor family (FGF) and their high affinity cell-surface receptors (FGFR) represent one of the fundamental signaling networks governing cell communication. Imbalances in FGF signaling are known to induce/promote all hallmarks of cancer that malignant cells must acquire.
We want to understand in details the mechanisms how FGF/FGFR generate specific signaling outputs in diverse biological context and how such signaling is regulated in normal and cancer cells. It will result in better understanding of the biology of tumor induction and progression of malignancy as well as new opportunities to develop specific targeted therapies for cancer.

Antoni Wiedlocha's Group click to enlarge image

Antoni Wiedlocha's Group click to enlarge image

Contact information:
Email: Antoni.Wiedlocha@rr-research.no
Department of Molecular Cell Biology, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, 0379 Oslo, Norway
Phone +47 22 78 19 30 (Wiedlocha), Switchboard: +47 22 93 40 00

 
 

Selected publications

 

Wendel T, Zhen Y, Suo Z, Bruheim S, Wiedlocha A (2016)
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo
Exp Cell Res, 340 (2), 220-6
PubMed 26748184

Sletten T, Kostas M, Bober J, Sorensen V, Yadollahi M, Olsnes S, Tomala J, Otlewski J, Zakrzewska M, Wiedlocha A (2014)
Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1).
PLoS One. 2014 Mar 4;9(3)e90687.
Pubmed 24595027

Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A (2014)
RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.
Oncogene. 2014 Oct. 40, 4823-36
Pubmed 24141780

Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, Otlewski J, Wesche J, Wiedlocha A (2013)
ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser777 Inhibits Signaling.
Sci Signal. 6(262)
23405013  Free pdf

Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J (2012)
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
EMBO Rep, 2012 Jan. 14 (1), 57-64
PubMed 23154468

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A (2012)
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.
Traffic. 2012 Feb 9. [Epub ahead of print]
PubMed 22321063

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A (2011)
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein
Cell Signal. 11;1758-66
Pubmed 21745565.


 

 
 

Collaborations:

 

Project title: Highly cytotoxic FGF2-conjugates in targeted therapy for FGFR-expressing cancers.

This project is funded from Norway Grants in the Polish-Norwegian Research Programme operated by the National Centre for Research and Development.

 

 

Project Promoter


 

University of Wroclaw
Faculty of Biotechnology
Department of Protein Engineering