Project group leader Jørgen Wesche:
Cancer cell migration and metastasis
Cell migration is an important function for many cells. However, the ability of cells to migrate can transform a localized benign tumor to a metastatic and deadly cancer. In the process of metastasis, individual cells detach from the primary tumor and start to migrate to invade either nearby tissue or to enter lymphatic vessels or the bloodstream and then colonize in distant organs.
A deeper understanding of the process of cell migration may lead to new therapeutic strategies for the inhibition of tumor cell invasion. Importantly, the identification of new proteins involved in cancer cell migration could provide new targets for drug intervention in metastatic cancers.
Coworkers:
Ellen M. Haugsten
Kaja Askevold
Selected publications:
Haugsten EM, Wiedlocha A, Olsnes S, Wesche J
Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
Mol Cancer Res (in press)
Lobert VH, Brech A, Pedersen NM, Wesche J, Oppelt A, Malerød L, Stenmark H (2010)
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes
Dev Cell, 19 (1), 148-59
Haugsten, E.M., Malecki, J., Bjørklund, S.M.S., Olsnes, S., Wesche, J. (2008).
Ubiquitination of FGFR1 Is Required for Its Intracellular Sorting but Not for Its Endocytosis.
Mol Biol Cell. 2008 Aug;19(8):3390-403
Wesche, J. Malecki, J. Wiedlocha, A. Skjerpen, C. S. Claus, P. Olsnes, S. (2006)
FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus
J Biol Chem 281:11405-12
Haugsten, E. M. Sorensen, V. Brech, A. Olsnes, S. Wesche, J. (2005)
Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
J Cell Sci 118:3869-81
Total publication list
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Our research is supported by The Norwegian Cancer Society: |
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Contact information:
Email: Jorgen.Wesche@rr-research.no
Department of Biochemistry, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway
Phone +47 22 78 19 31 (Wesche), Switchboard: +47 22 93 40 00
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May 21, 2012
