Haugsten (left) and Zakrzewska

Ellen Margrethe Haugsten from Antoni Wiedlocha’s group at the Department of Biochemistry was awarded a prize for her talk - entitled "Clathrin – and dynamin-independent endocytosis of FGFR3 – implication for signaling", at the "Gordon Research Conference: Fibroblast Growth Factors in Development & Disease", held May 13-18, 2012 at Les Diablerets, Switzerland.
Malgorzata Zakrzewska received the price for a poster on "ERK-mediated phosphorylation of FGF receptor 1 on Ser777 confers negative feedback on FGF signaling", with Ellen M. Haugsten, Beata Nadratowska-Weselowska, Angela Oppelt, Yixin Jin, Jacek Otlewski, Jørgen Wesche and Antoni Wiedlocha,

The institute seminar on Wednesday May 23rd will be held by Giske Ursin, Director of the Cancer Registry of Norway.

Title of her talk: How can the Norwegian cancer registry improve our biological understanding of cancer and cancer care?

Time and place: 12.00, Auditorium, new research building, Montebello.

Langerød (left) and Børresen-Dale

In two back-to-back reports published online on 17 May in Cell (journal impact factor 32.4) , researchers have sequenced the genomes of 21 breast cancers and analysed the mutations that emerged during the tumours‟ development.
Led by researchers from the Wellcome Trust Sanger Institute, the team created a catalogue of all the mutations in the genomes of the 21 cancer genomes and identified the mutational processes that lead to breast cancer. They found that these mutations accumulate in breast cells over many years, initially rather slowly, but picking up more and more momentum as the genetic damage builds up.

Anita Langerød and Anne-Lise Børresen-Dale (photo) from the Department of Genetics at the Institute for Cancer Research have made strong contributions to this work.

In a study recently published in Nature (journal impact factor 36.1), researchers describe nine new genes that drive the development of breast cancer. This takes the tally of all genes associated with breast cancer development to 40.

The team - which includes Anita Langerød and Anne-Lise Børresen-Dale from the Department of Genetics at the Institute for Cancer Research - examined all the genes in the genomes of 100 cases of breast cancer. The mutated cancer-causing genes were different in different cancer samples, indicating that breast cancer is genetically very diverse. Understanding the consequences of this diversity will be important in progressing towards more rational treatment.