Our goal is to obtain new knowledge about the molecular mechanisms of DNA damage-induced signaling pathways, and to explore potential clinical applications of such knowledge.

In response to DNA damage, human cells activate signaling cascades that control cellular processes such as DNA damage repair, cell cycle checkpoint arrest, and induction of cell death. Over the past years intensive research in many laboratories have revealed several such signal cascades in some molecular detail. However, several major issues remain unresolved, both with respect to understanding the molecular mechanisms, and to understanding how this new knowledge about DNA damage signaling cascades can be applied to improve cancer therapy.