Laboratory for Molecular and Cellular Cancer Research
Professor Inger Helene Madshus' group was in 2012 merged with the group of Professor Henrik S. Huitfeldt (Laboratory for Toxicopathology), with Professor Inger Helene Madshus as the group leader. In 2013, Madshus retired and in 2014 PhD Espen Stang was appointed as new group leader.
The projects carried out in the group has centered around how EGFR family members can be down-regulated physiologically and experimentally. Such studies are motivated by the fact that over-expression of these RTKs is driving oncogenesis in a number of human cells. Potential ways of therapeutically down-regulating these proteins is therefore of utmost importance in treatment of diseases like breast cancer, colon cancer, prostate cancer, pancreatic cancer and glioblastomas. A prerequisite for designing mechanisms inducing therapeutic down-regulation is more detailed knowledge on mechanisms normally controlling endocytosis and degradation of the EGFR family members. Laboratory for Toxicopathology has been working with experimental liver carcinogenesis, or more specifically on how EGFR regulation of the cell cycle is altered during early rat liver carcinogenesis.
- Effects of therapeutic anti EGFR and anti ErbB2 antibodies on receptor dimerization, activation and downregulation
- Identification of adaptor proteins regulating clathrin mediated endocytosis of ErbB3 using a high throughput siRNA screen
- Molecular mechanisms regulating endosomal sorting and degradation of ErbB3.
- Immuno-electron microscopy studies of endocytosis and intracellular sorting of proteins belonging to the ErbB family of receptor tyrosine kinases.
- Plasma membrane anchoring of EGF receptor signaling by Gab1 and FAK
Group leader Dr. Espen Stang, Department of Pathology, Oslo University Hospital, PO Box 4950 Nydalen, NO-0424 Oslo, Norway
Phone: 47-23071483, email email@example.com
Early signs of mental illness in the developing brain
Feb 24, 2017
Core Facility for preclinical imaging (MRI and IVIS). What services can we offer?
Feb 21, 2017
Defining the role of tumor-secreted exosomes in pre-metastatic niche formation
Feb 21, 2017
Arne Klungland talks about embryo research
Feb 21, 2017
Are environmental pollutants in the Norwegian diet harmful to children?
Tidsskr Nor Laegeforen, 137 (4), 295-297
A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2
J Cell Mol Med, 20 (10), 1999-2011
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim Biophys Acta, 1863 (6 Pt A), 1179-88