Infections following surgery or trauma continue to be a major clinical problem. Due to the immunological consequences of surgery, infections frequently develop into severe septic complications and multiple organ injuries The problem in severe sepsis is a paradoxical and self-destructing inflammation leading to dysfunctional host defense and lethal injury to vital organ systems. More than one million patients are expected to die annually from severe sepsis world wide.

Aims
Our aim is to develop novel means to prevent or ameliorate the self-destructive inflammation in patients with infection.A major focus of our work is research into the cellular mechanisms involved.