Sandvig has been studying endocytosis and intracellular transport of protein toxins from bacteria and plants. These toxins include the bacterial toxins Shiga toxin and diphtheria toxin, as well as plant toxins such as ricin. The interactions of the toxins with cells are studied to learn more about endocytic mechanisms and intracellular transport in general, to investigate protein translocation across membranes, and to study toxins in particular with respect to their use in diagnosis and therapy of cancer. Increased knowledge about toxins and their interactions with cells is also of interest in connection with infectious diseases, and of interest to learn more about cell signalling and apoptosis.
There are two recently established project groups (subgroups), one headed by Iversen who studies nanoparticles and cell interations, and one headed by Llorente who investigates the formation and release mechanisms for exosomes and their composition.
Kirsten Sandvig Group click to enlarge image
The Sandvig research group is member of a Centre of Excellence,
Kirsten Sandvig, Department of Biochemistry, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, 0379 Oslo, Norway
Phone +47 22 78 18 28 (Sandvig), Switchboard: +47 22 93 40 00
May 6, 2013
May 2, 2013
Intracellul. transp. group
BiP Negatively Affects Ricin Transport
Toxins (Basel), 5 (5), 969-82
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
Biochim Biophys Acta (in press)