Torbjørn Rognes' group
CMBN Bioinformatics Group
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The bioinformatics group is one of the research groups in the Centre for Molecular Biology and Neuroscience (CMBN) at Rikshospitalet, Oslo University Hospital and the University of Oslo (UiO), Norway. The group also belongs to the Department of Microbiology at Rikshospitalet and UiO. The group is co-located in the Joint Centre for Bioinformatics with the Biomedical research group at the Department of Informatics, UiO. Publika - the scientific publication database for Oslo University Hospital has been developed in the group. We also work in structural bioinformatics, for instance by modelling the structure of proteins and predicting the effect of mutations. An example of this is the work by Jon K. Lærdahl et al. on the PCSK9 protein shown below (see publication for details).
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Latest publications
T. Rognes' group
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification
Hum Mol Genet (in press)
PubMed 22156580
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones
PLoS One, 6 (9), e25188
PubMed 21949882
Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors
J Lipid Res, 52 (10), 1787-94
PubMed 21771976







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