Borghild Roald's research group:
Fetal and Pregnancy related Pathology Research
Perinatal problems like fetal growth restriction and intrauterine fetal death are mainly related to placental insufficiency. Challenges are to understand the various placental pathology processes leading to insufficiency and their clinical implications to treatment and follow up.
Another perinatal problem is that premature born babies can experience hypoxia due to developmental immaturity in the fetal lungs, with serious complications in the fetal brain. Cochrane reviews have asked for research to explore the cellular and molecular mechanisms in corticosteroid treatment, clinically used to enhance lung maturation by threatening premature birth, - and to search for alternative treatment options. We aim to answer the questions raised by in ovo pharmacologic manipulation in a chicken experimental model.
Our placental pathology research is based on a clinical tissue material with controls. It has focus on placental pathology related to gestational diabetes and metabolic disease, spiral artery remodeling and immune regulation in the placental bed, including acute atherosis as a possible predictor of arteriosclerosis and later cardiovascular disease.
The fetal developmental biology and pathology research has focus on cellular and molecular events in the development and maturation of chick embryonal lungs by manipulation in ovo by clinical relevant pharmacological agents like corticosteroids and thryroid hormones in addition to inflammatory cytokines.
Professor Borghild Roald, MD PhD, Department of Pathology, Oslo University Hospital - Ullevål PO Box 4956 Nydalen NO-0424 Oslo, Norway, Tel: +47 22118924, Fax: +47 22118239 E-mail: email@example.com and firstname.lastname@example.org
Early phase drug development: From idea to concept
Feb 3, 2017
Feb 2, 2017
Oncolytic peptide LTX-315; the road from basic science to clinical trials
Jan 26, 2017
Indications for Cesarean Sections in Rural Nepal
J Obstet Gynaecol India, 66 (Suppl 1), 284-8