Translational Neurodegeneration Research & Neuropathology

 
Jens Pahnke<br>Group leader
Jens Pahnke
Group leader

Background

The lab mainly performs animal model based research on neurodegenerative diseases with special emphasis on Alzheimer’s disease. We develop mouse models that recapitulate impaired clearance mechanisms occurring in sporadic Alzheimer’s disease that will allow us to specifically define the impact of certain cell types at distinct point during disease progression. Furthermore, we develop/improve drugs and screen plant extracts for their ability to reduce amyloid pathology in our mouse models with aiming translation into clinical trials.

 
 

Projects / Funded

 
  • NeuroGem: Identification of genes that modulate the severity of neurodegenerative diseases – JPND / NFR
  • PROP-AD: Propagation behaviour of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier - JPND / NFR
  • Evaluation of phytopharmaca for the prevention and therapy of dementias and age-related cognitive dysfunctions (EFRE)
  • St. John’s wort as Alzheimer’s treatment – New ways of identification, exploitation and use of natural resources – SAW Leibniz Society Grant / EFRE
  • ABC transporter function in Neurodegeneration – Marie Currie Scientia Program
  • Benefits and detrimental effects of sequence variants of amyloid-β: towards the use of small peptides for aggregate dissolution therapy in dementia – NFR/VIAA grant
  • The role of the blood-brain barrier in Alzheimer s disease: Interaction of LRP1 and ABC transporter function - DFG
  • PETAD: PET imaging to assess blood-brain barrier function in Alzheimer’s disease – DFG/FWF
 
 
 

Contact information:
Group Leader Jens Pahnke, Department of Pathology, Tel: +47 23071466
E-mail: jens.pahnke@medisin.uio.no