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Tittel: "Studies of genomw-wide patterns of gene expression and methylation in osteosarcoma"
The biology of mesenchymal tumours (sarcomas)
Our group is using functional genomics to characterise mesenchymal oncogenesis, that is the processes leading to formation of malignant connective tissue tumours, or sarcomas. The Norwegian Radium Hospital is a national centre of competence on this kind of tumours, and our research is done in close collaboration with our clinical colleagues, both locally and within the Scandinavian Sarcoma Group.
- Genomic profiling (Aberrations in copy number along the chromosomes, deletions and amplifications)
- Expression profiling (genome-wide mRNA and microRNA levels)
- Epigenomic profiling (DNA methylation, chromatin modification, transcription factor binding patterns)
- Nuclear programming (FUGE project)
- Chemotherapy studies (Partner in the EURAMOS clinical trial)
- Experimental and clinical studies
- Model system development (adipocyte and osteocyte differentiation, immortalised mesenchymal cell systems)
Click on left menu item "Research interests" to see more
Find out more about cancer from the Inside Cancer web site of Cold Spring Harbor Laboratories and about Sarcomas from the educational pages of the Shriver Foundation. For norske sider om sarkom, se sarkom.no.
Paris, France – November 12, 2010 – The Liddy Shriver Sarcoma Initiative announced today that it is awarding a $250,000 grant to fund a global collaborative research study on liposarcoma. The unique project will be undertaken by a consortium of four investigators in three countries over the next two years. The announcement was made by Bruce Shriver, PhD, Co-Founder of the Liddy Shriver Sarcoma Initiative and Dr. David Thomas, one of the study’s principal investigators, at the annual meeting of the Connective Tissue Oncology Society in Paris.
Read the full press release
Read the report published in ESUN Feb 2013
The consortium will focus on the concept of a small population of stem-like cells being critical in tumour developement, and being able to regenerate the whole full-blown tumours on therapy faailure or metastasis. Isolation of such cells, and identification of their unique properties, may pawe the way for new diagnostics and therapies.
In a Commentary on "The future of gene therapy" in Nature (Cavazzana-Calvo et al. Nature 427, 779-781; 2004), a large map illustrated the number of gene therapy trials in different countries, indicating that no trials have been performed in Norway. Because Norway has the reputation of a prohibitive country when it comes to biotechnology, this incorrect impression can have serious consequences for the interest of pharmaceuticaal companies. Myklebost tries to set the record straight. Seven gene therapy trials have been performed in Norway, of which six at the Norwegian Radium Hospital.
Nature May 13th 2004
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