Ludvig A. Munthe heads a research team that studies how dysregulated interactions between Th cells and B cells predisposes for B cell cancer. They define how Th cells support and maintain B cell cancer in mice and humans.
Ludvig A. Munthe
About the group
The team investigate how Th cells can induce B cell lymphoma by chronically stimulating B cells in mice (J Exp Med, 2007). Work in animal models has been extended to humans by studying patients with chronic lymphocytic leukemia (CLL). We have demonstrated that CLL cells are patent antigen presenting cells and that they can collaborate with Th cells (Cell Rep 2013). Moreover, we discovered that patients had a high frequency of Th cells that were specific for CLL cells and stimulated CLL cell proliferation both in vitro and in vivo.
We also have interest in Idiotype networks (1)(2), Id specific Th cells and collaborations with Id+B cells (3)(4), see also the Bogen group presentation. This in mice as well as in humans, both in autoimmunity and in B cell cancer.
We are now extending the studies mentioned above to define the cytokines and inflammatory microenvironment in CLL. Moreover, we are studying the effect of EBV, identifying signaling aberrations for drug discovery (collaboration with NCMM), and are establishing ex vivo culture systems. We are now extending this work to acute lymphoctic leukemia (ALL) and myeloma.
- Audun Os A, Bürgler S, Ribes AP, Funderud A, Wang D, Thompson KM, Tjønnfjord GE, Bogen B, Munthe LA. Chronic Lymphocytic Leukemia Cells Are Activated and Proliferate in Response to Specific T Helper Cells. Cell Reports, Volume 4, Issue 3, p566–577, 15 August 2013.
- Zangani MM, Frøyland M, Qiu GY, Meza-Zepeda LA, Kutok JL, Thompson KM, Munthe LA, and Bogen B. Lymphomas can develop from B cells chronically helped by idiotype-specific T cells. J Exp Med. May 14, 2007; 204(5): 1181–1191..
- Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, PO Box 4950 Nydalen, Oslo 0424, Norway.
Early signs of mental illness in the developing brain
Feb 24, 2017
Core Facility for preclinical imaging (MRI and IVIS). What services can we offer?
Feb 21, 2017
Defining the role of tumor-secreted exosomes in pre-metastatic niche formation
Feb 21, 2017
Arne Klungland talks about embryo research
Feb 21, 2017
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity
J Allergy Clin Immunol, 138 (3), 839-851.e8