Microarrays

 
Project leader: Dr Leonardo Meza-Zepeda

Steering Committee: Now managed by the Steering Committee for Functional Genomics

 
 
 
Objectives
  • To establish resources and infrastructure that enables scientists at DNR to perform high throughput microarray analysis of gene expression, genomic copy numbers or other biomolecules at internationally competitive level, thus making them attractive for external collaborations.
  • This is done by establishing and running a core facility for array production and analysis, by maintaining a centre of competence in array-based laboratory techniques and bioinformatics, and by subsidising production costs for internal users.
Milestones
  • Dec 99, first routine production of arrays of 2700 human probes.
  • Aug 01 New robot installed, increased to 7000 probes/array,
  • Nov 01 increased to 12 000 probes/array,
  • Jan 02 adding arrays with 5000 mouse probes, test production of human genomic arrays.
  • Summer 02 increased to 15 k arrays (18 000 + probes). Started production of project-related genomic arrays. Summer 02 awarded FUGE grant as part of the Norwegian Microarray Consortium.
  • Fall 02 gradual start of FUGE-project.
  • Fall 02 implementation of the BASE microarray database and analysis environment in collaboration with SWEgene. January 03 purchase and test printing of global oligonucleotide sets for man, mouse and rat.
  • Fall 03 routine printing of 21 k human oligonucleotide arrays (Unigene-based)
  • Fall 03 test printing of global sequence path genomic arrays with approx 1 Mb coverage
  • Jan 04 test printing of 35 k human oligonucleotide arrays (Ensembl-based)