Edward Leithe's project group
Our research group studies the role of the ubiquitin system in cell communication and cancer. One important mechanism for intercellular communication involves the direct transfer of ions and signaling molecules between adjacent cells via intercellular channels. These channels assemble into arrays referred to as gap junctions. In vertebrates, gap junction channels are composed of members of a family of integral membrane proteins known as connexins. The connexins have important roles in controlling cell growth and differentiation and in maintaining tissue homeostasis. Several members of the connexin protein family have been shown to act as tumor suppressor proteins, and they are frequently downregulated during cancer development. We are studying the role of the ubiquitin system in the regulation of connexins and how the malfunction of these processes may contribute to the loss of intercellular communication via gap junctions during cancer pathogenesis. A major aim of our work is to identify and functionally characterize E3 ubiquitin ligases involved in intercellular communication and cancer.
The project group is a member of the Centre for Excellence in Cancer Biomedicine through Ragnhild Lothe's research group.
Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Phone: +47 2278 1737
E mail: firstname.lastname@example.org
Aug 25, 2016
Aug 11, 2016
Aug 3, 2016
Jun 29, 2016
Bilateral ovarian carcinomas differ in the expression of metastasis-related genes
Oncol Lett, 13 (1), 184-190