Edward Leithe

Our research group studies the role of ubiquitin and ubiquitin-like proteins in cell signaling and cancer. Modification of proteins with ubiquitin and ubiquitin-like proteins controls cellular processes relevant to cancer, such as gene transcription, DNA repair, cell-cycle progression, apoptosis and receptor downregulation. Our research is focused on understanding the role of ubiquitination in the control of intercellular communication via gap junctions, and whether deregulation of the ubiquitin system contributes to loss of this type of cell-cell communication during cancer development.

The group is member of "CoE - Centre for Cancer Biomedicine".

HECT E3 ubiquitin ligases in colorectal cancer development

Group contact information:
Department of Cancer Prevention, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1737
eleithe@rr-research.no