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Oslo University Hospital

 

The research group of Vessela N. Kristensen

Cancer Genome Variation

 

”If it were not for the great variability
among individuals medicine might as
well be science and not an art”

Sir William Osler, 1892


The tumor initiation, progression and clinical presentation are directly dependent on its genetic and biochemical environment – the entire body. Our group is working on different projects related to how genetic variation affects occurrence of somatic alterations, gene expression patterns and genome wide copy number alterations in human breast and ovarian tumors. Understanding inherited genetic variability and how it affects crucial biological pathways is likely to lead to new successful prevention and treatment strategies.

The research in the group is focusing on constitutive variation such as single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in relation to:
  • Susceptibility
  • Clinical presentation
  • Treatment response and adverse side effects of treatment
  • Gene regulation and proximal phenotypes (RNA expression and metabolic profiles)

List of our research projects
 
 

The group:

 
From left to right: Daniel Nebdal, Grethe I. Grenaker Alnæs, Jovana Jovanovic, Vessela N. Kristensen, Thomas Fleischer, Miriam Ragle Aure, Hege Edvardsen, Fatemeh Kaveh, Elen Møller, Helene Røtterud, Andliena Tahiri and Shakila Jabeen.
 
 

Group contact information:

 
Professor Vessela N. Kristensen, Email: Vessela.N.Kristensen@rr-research.no
Department of Genetics, Institute for Cancer Research,
Oslo University Hospital Radiumhospitalet, N-0310 Oslo, Norway
Phone: +47 22 78 13 75, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00

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