”If it were not for the great variability among individuals medicine might as well be science and not an art” Sir William Osler, 1892

The tumor initiation, progression and clinical presentation are directly dependent on its genetic and biochemical environment – the entire body. Our group is working on different projects related to how genetic variation affects occurrence of somatic alterations, gene expression patterns and genome wide copy number alterations in human breast and ovarian tumors. Understanding inherited genetic variability and how it affects crucial biological pathways is likely to lead to new successful prevention and treatment strategies.

The research in the group is focusing on constitutive variation such as single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in relation to:

• Susceptibility
• Clinical presentation
• Treatment response and adverse side effects of treatment
• Gene regulation and proximal phenotypes (RNA expression and metabolic profiles)

Link to list of our research projects

 

 

Professor Vessela N. Kristensen, Email: Vessela.N.Kristensen@rr-research.no
Department of Genetics, Institute for Cancer Research,
Oslo University Hospital Radiumhospitalet, N-0310 Oslo, Norway
Phone: +47 22 78 13 75, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00

More  

 

 

More publications