Immune Regulation and Allergy

Group Leader: Frode L Jahnsen M.D., Ph.D.

We aim to identify and characterise mechanisms of immune dysregulation that are common to several allergic diseases: primary candidates are aberrant presentation of allergen to T cells by antigen-presenting cells, faulty interaction between T and B cells and dysfunction of a specific type of T cells, suppressive regulatory T cells (Tregs).

These white blood cells (leukocytes) are the major players in acquired immunity. Thus, the primary goals of our research are

1. to characterise the mechanisms that underlie faulty interaction between T and B cells in allergy, with a special emphasis on T cells, and
2. to develop therapies.