Frode Jahnsen's Group
The Jahnsen group focuses on three areas of research.
- How the immune system in the airways functions and why we become allergic.
- How the immune system in the gut functions and studies on coeliac disease.
- Why transplanted organs are rejected.
The mucus membranes that line our internal body cavities (airways and gut) face the formidable task of protecting our body against incoming pathogens while allowing uptake of nutrients and exchange of gases. The mucosal immune system must react strongly and rapidly to pathogenic microbes such as bacteria and viruses, while being tolerant to harmless foods and antigens in inhaled air. We study how the local immune system in cooperation with stromal cells is able to maintain homeostasis at mucosal sites, and we try to understand why these regulatory mechanisms break down in allergy and coeliac disease. We also study how the immune system is involved in rejection of transplanted organs (kidney, liver, lung, pancreas, and intestine). We have developed novel techniques to distinguish the immune system from the patient and the donor (passenger cells) which allow us to study mechanisms of rejection with a completely new approach. The group collaborate closely with several clinical departments at the hospital which ensure very good supply We of clinically relevant human material.
- Studies on the immunopathology of upper airway allergy by the use of in vivo human disease models
- Define the role of monocytes/macrophages in the human intestine: origin, trafficking and function in the steady state and inflammation.
- Determine the role dendritic cell subsets in the human intestine: origin, trafficking and function during steady state and inflammation.
- Determine immunomechanisms responsible for rejection of transplanted organs.
Group leader Professor and senior consultant Frode Jahnsen - Department of Pathology and Centre for Immune Regulation Oslo University Hospital Rikshospitalet - Tel: +47 23071444 E-mail: email@example.com
Early phase drug development: From idea to concept
Feb 3, 2017
Feb 2, 2017
Oncolytic peptide LTX-315; the road from basic science to clinical trials
Jan 26, 2017
Frode L. Jahnsen
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
Obituary - In Memoriam Per Brandtzaeg
Scand J Immunol, 84 (6), 370-372
Long-term persistence of human donor alveolar macrophages in lung transplant recipients
Thorax, 71 (11), 1006-1011