The main research topics are the immunogenetics and the intrathecal T cell responses in MS.

In immunogenetics we are participating in the collaborative study "Genetic Analysis of Multiple Sclerosis in Europeans" (GAMES). Through a joint GAMES sub-study with an MS research group in Copenhagen we have identified four new genetic regions which displayed highly significant associations with MS, and have started fine-mapping in one of these chromosome regions (11q23).

From the cerebrospinal fluid (CSF) of several MS patients we have raised T cell lines which recognize Epstein Barr virus (EBV) transformed B cell lines (BCL), and we have also raised CSF T cell clones which could recognize an EBV DNA polymerase peptide. Some of these T cell clones cross-react with MBP. In two patients we have established EBV transformed BCL line which secrete monoclonal IgG1. To our knowledge these are the first monoclonal antibodies which have been raised from CSF.