Stephan A. Frye
Position: Research scientist, Dr. rer. nat.
Phone: +47 23079019
Email:

  

Stephan works with transformation in Neisseriaceae.
Academic interests:
- Transformation
- Neisseriaceae

 

Publications 2016

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
PubMed 27736945

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV (2016)
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
PubMed 27724857

Publications 2015

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
PubMed 26248334

Ricanek P, Lunde LK, Frye SA, Støen M, Nygård S, Morth JP, Rydning A, Vatn MH, Amiry-Moghaddam M, Tønjum T (2015)
Reduced expression of aquaporins in human intestinal mucosa in early stage inflammatory bowel disease
Clin Exp Gastroenterol, 8, 49-67
PubMed 25624769

Publications 2013

Frye SA, Nilsen M, Tønjum T, Ambur OH (2013)
Dialects of the DNA uptake sequence in Neisseriaceae
PLoS Genet, 9 (4), e1003458
PubMed 23637627

Publications 2012

Ambur OH, Frye SA, Nilsen M, Hovland E, Tønjum T (2012)
Restriction and sequence alterations affect DNA uptake sequence-dependent transformation in Neisseria meningitidis
PLoS One, 7 (7), e39742
PubMed 22768309

Ricanek P, Lothe SM, Frye SA, Rydning A, Vatn MH, Tønjum T (2012)
Gut bacterial profile in patients newly diagnosed with treatment-naïve Crohn's disease
Clin Exp Gastroenterol, 5, 173-86
PubMed 23049264

Publications 2011

Benam AV, Lång E, Alfsnes K, Fleckenstein B, Rowe AD, Hovland E, Ambur OH, Frye SA, Tønjum T (2011)
Structure-function relationships of the competence lipoprotein ComL and SSB in meningococcal transformation
Microbiology, 157 (Pt 5), 1329-42
PubMed 21330432

Lillenes MS, Espeseth T, Støen M, Lundervold AJ, Frye SA, Rootwelt H, Reinvang I, Tønjum T (2011)
DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span
Mech Ageing Dev, 132 (8-9), 449-58
PubMed 21884718

Publications 2009

Ambur OH, Davidsen T, Frye SA, Balasingham SV, Lagesen K, Rognes T, Tønjum T (2009)
Genome dynamics in major bacterial pathogens
FEMS Microbiol Rev, 33 (3), 453-70
PubMed 19396949

Balasingham SV, Davidsen T, Szpinda I, Frye SA, Tønjum T (2009)
Molecular diagnostics in tuberculosis: basis and implications for therapy
Mol Diagn Ther, 13 (3), 137-51
PubMed 19650669

Lång E, Haugen K, Fleckenstein B, Homberset H, Frye SA, Ambur OH, Tønjum T (2009)
Identification of neisserial DNA binding components
Microbiology, 155 (Pt 3), 852-62
PubMed 19246756

Tibballs KL, Ambur OH, Alfsnes K, Homberset H, Frye SA, Davidsen T, Tønjum T (2009)
Characterization of the meningococcal DNA glycosylase Fpg involved in base excision repair
BMC Microbiol, 9, 7
PubMed 19134198

Publications 2007

Assalkhou R, Balasingham S, Collins RF, Frye SA, Davidsen T, Benam AV, Bjørås M, Derrick JP, Tønjum T (2007)
The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
Microbiology, 153 (Pt 5), 1593-603
PubMed 17464074

Balasingham SV, Collins RF, Assalkhou R, Homberset H, Frye SA, Derrick JP, Tønjum T (2007)
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
PubMed 17526700

Publications 2006

Ambur OH, Frye SA, Tønjum T (2006)
New functional identity for the DNA uptake sequence in transformation and its presence in transcriptional terminators
J Bacteriol, 189 (5), 2077-85
PubMed 17194793

Frye SA, Assalkhou R, Collins RF, Ford RC, Petersson C, Derrick JP, Tønjum T (2006)
Topology of the outer-membrane secretin PilQ from Neisseria meningitidis
Microbiology, 152 (Pt 12), 3751-64
PubMed 17159226

Aas FE, Winther-Larsen HC, Wolfgang M, Frye S, Løvold C, Roos N, van Putten JP, Koomey M (2006)
Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions
Mol Microbiol, 63 (1), 69-85
PubMed 17140412

Publications 2005

Collins RF, Frye SA, Balasingham S, Ford RC, Tønjum T, Derrick JP (2005)
Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ
J Biol Chem, 280 (19), 18923-30
PubMed 15753075

Publications 2004

Collins RF, Frye SA, Kitmitto A, Ford RC, Tønjum T, Derrick JP (2004)
Structure of the Neisseria meningitidis outer membrane PilQ secretin complex at 12 A resolution
J Biol Chem, 279 (38), 39750-6
PubMed 15254043

Publications 2002

Aas FE, Wolfgang M, Frye S, Dunham S, Løvold C, Koomey M (2002)
Competence for natural transformation in Neisseria gonorrhoeae: components of DNA binding and uptake linked to type IV pilus expression
Mol Microbiol, 46 (3), 749-60
PubMed 12410832