
| Therese Sørlie | |
| Position: | Scientist, PhD |
| Phone: | +47 22 78 13 64 |
| Email: | |
Mini CV:
Education and positions:
- M.Sc., University of Trondheim, Norway 1993
- Special Training Award, IARC, Lyon, France, 1993-1994
- Ph.D., University of Oslo, Norway 2000
- Post doctoral fellowship, Stanford University with Prof. David Botstein 2001-2003
- Post doctoral fellowship, The Norwegian Radium Hospital, Dep. of Genetics with Prof. Anne-Lise Børresen-Dale, 2003-2005
- YFF fellowship, Norwegian research Council 2005-2009
- Researcher, Dep. of Genetics, Kreftforeningen 2006-2011
- Group leader, Dep of Genetics, Career fellowship funded by HSØ (South-Eastern Norway Regional Health Authority) 2012-2015
Author network for Therese Sørlie by COREMINE medical
Publications 2013
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
Mol Oncol, 7 (1), 130-42
PubMed 23142657
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
Mol Oncol, 7 (3), 704-18
PubMed 23562353
Different labour outcomes in primiparous women that have been subjected to childhood sexual abuse or rape in adulthood: a case-control study in a clinical cohort
BJOG, 120 (4), 487-95
PubMed 23157417
Publications 2012
Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement
Ann Oncol, 23 (12), 2997-3006
PubMed 23166150
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
Proc Natl Acad Sci U S A, 109 (16), 6124-9
PubMed 22454501
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
Proc Natl Acad Sci U S A, 109 (8), 2802-7
PubMed 21908711
Publications 2011
Glomeruloid microvascular proliferation is associated with lack of response to chemotherapy in breast cancer
Br J Cancer, 105 (1), 9-12
PubMed 21673677
Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
Mol Oncol, 5 (6), 564-76
PubMed 21917534
How to personalise treatment in early breast cancer
Eur J Cancer, 47 Suppl 3, S310-1
PubMed 21943994
Combining gene signatures improves prediction of breast cancer survival
PLoS One, 6 (3), e17845
PubMed 21423775
Publications 2010
Merging transcriptomics and metabolomics--advances in breast cancer profiling
BMC Cancer, 10, 628
PubMed 21080935
On the molecular biology of breast cancer
Mol Oncol, 4 (3), 171-3
PubMed 20483673
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
Mol Oncol, 4 (4), 357-68
PubMed 20663721
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
Breast Cancer Res, 12 (1), R3
PubMed 20056007
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
PLoS One, 5 (11), e14002
PubMed 21124964
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer (vol 1, pg 160, 2007)
Mol. Oncol., 4 (2), 169
Triple-negative breast cancer: present challenges and new perspectives
Mol Oncol, 4 (3), 209-29
PubMed 20537966
Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
Mol Oncol, 4 (2), 98-118
PubMed 20060370
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
PubMed 20592421
The importance of gene-centring microarray data
Lancet Oncol, 11 (8), 719-20; author reply 720-1
PubMed 20688275
Publications 2009
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
Clin Cancer Res, 15 (11), 3654-62
PubMed 19470724
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
Mol Oncol, 3 (5-6), 469-82
PubMed 19713161
Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line
BMC Med Genomics, 2, 26
PubMed 19432969
Introducing molecular subtyping of breast cancer into the clinic?
J Clin Oncol, 27 (8), 1153-4
PubMed 19204193
Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolution
Mol Oncol, 3 (3), 214-9
PubMed 19403344
Publications 2008
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
J Pathol, 214 (3), 357-67
PubMed 18044827
Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
Int J Cancer, 123 (3), 577-85
PubMed 18498133
Publications 2007
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer
Mol Oncol, 1 (2), 160-71
PubMed 19383292
Molecular classification of breast tumors: toward improved diagnostics and treatments
Methods Mol Biol, 360, 91-114
PubMed 17172726
Publications 2006
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
Genes Chromosomes Cancer, 45 (11), 1033-40
PubMed 16897746
Genetic variation in putative regulatory loci controlling gene expression in breast cancer
Proc Natl Acad Sci U S A, 103 (20), 7735-40
PubMed 16684880
Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
BMC Cancer, 6, 59
PubMed 16536878
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
Mol Cancer Ther, 5 (11), 2914-8
PubMed 17121939
Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
BMC Genomics, 7, 127
PubMed 16729877
Publications 2005
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Proc Natl Acad Sci U S A, 102 (10), 3738-43
PubMed 15701700
Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
Clin Cancer Res, 11 (2 Pt 2), 878s-83s
PubMed 15701881
Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
J Steroid Biochem Mol Biol, 95 (1-5), 105-11
PubMed 16023338
Genomics in breast cancer-therapeutic implications
Nat Clin Pract Oncol, 2 (1), 26-33
PubMed 16264853
Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
Methods Mol Biol, 291, 207-16
PubMed 15502225
NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer
Cell Oncol, 27 (3), 169-73
PubMed 16037637
Publications 2004
Molecular portraits of breast cancer: tumour subtypes as distinct disease entities
Eur J Cancer, 40 (18), 2667-75
PubMed 15571950
Cell-type-specific responses to chemotherapeutics in breast cancer
Cancer Res, 64 (12), 4218-26
PubMed 15205334
Publications 2003
Gene expression patterns in ovarian carcinomas
Mol Biol Cell, 14 (11), 4376-86
PubMed 12960427
Repeated observation of breast tumor subtypes in independent gene expression data sets
Proc Natl Acad Sci U S A, 100 (14), 8418-23
PubMed 12829800
Publications 2002
Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors
Proc Natl Acad Sci U S A, 99 (20), 12963-8
PubMed 12297621
Publications 2001
[Microarray technology--potential in cancer research]
Tidsskr Nor Laegeforen, 121 (21), 2498-503
PubMed 11875927
Microarrays in primary breast cancer--lessons from chemotherapy studies
Endocr Relat Cancer, 8 (3), 259-63
PubMed 11566617
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Proc Natl Acad Sci U S A, 98 (19), 10869-74
PubMed 11553815
Publications 2000
Molecular portraits of human breast tumours
Nature, 406 (6797), 747-52
PubMed 10963602
Publications 1999
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway
Genes Chromosomes Cancer, 26 (2), 151-60
PubMed 10469453
Publications 1998
Mutation screening of BRCA1 using PTT and LOH analysis at 17q21 in breast carcinomas from familial and non-familial cases
Breast Cancer Res Treat, 48 (3), 259-64
PubMed 9598872
Truncating somatic mutation in exon 15 of the APC gene is a rare event in human breast carcinomas. Mutations in brief no. 179. Online
Hum Mutat, 12 (3), 215
PubMed 10660330
Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines
Br J Cancer, 77 (10), 1573-9
PubMed 9635831
Publications 1995
Screening for p53 gene mutations in archived tumors of workers occupationally exposed to carcinogens: examples from analysis of bladder tumors
J Occup Environ Med, 37 (1), 59-68
PubMed 7620944
Publications 1994
Database of p53 gene somatic mutations in human tumors and cell lines
Nucleic Acids Res, 22 (17), 3551-5
PubMed 7937055




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