Research interests
- Qualitative transcript variation in cancer. We aim to identify and characterize cancer-specific transcript variants, such as those originating from alternative splicing, alternative promoter usage, and fusion genes. In particular we use methods such as exon level microarrays and high-throughput sequencing.
- Genomics of embryonal carcinomas and embryonic stem cells. To identify malignancy-specific expression of genes and transcript variants, we are comparing the transcriptomes of embryonal carcinomas to those of their non-malignant phenotypic counterparts, embryonic stem cells. More...
- Fusion genes. We have developed a novel oligonucleotide microarray-based system for fusion gene detection. This new tool enables screening of a sample for the presence of all oncogenic fusion transcripts known to date in a single experiment.
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