Publications

Publications from OUS - Genome Biology Group

49 publications found

Publications in press

1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA
   ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
   Gut (in press)
   PubMed 22213796
2. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, Lopez de Munain A, Briscoe J, Serrano M, Lovell-Badge R
   Oncogenicity of the developmental transcription factor Sox9
   Cancer Res (in press)
   PubMed 22246670
3. Sveen A, Bakken AC, Agesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI
   The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
   Int J Cancer (in press)
   PubMed 22173985

Publications 2012

1. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2012)
   FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
   Genes Chromosomes Cancer, 51 (3), 240-9
   PubMed 22081504

Publications 2011

1. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
   The testicular germ cell tumour transcriptome
   Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
   PubMed 21651573
2. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
   Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
   PLoS One, 6 (9), e24419
   PubMed 21909432
3. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
   Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
   Mol Cancer, 10, 85
   PubMed 21777459
4. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
   Fusion gene microarray reveals cancer type-specificity among fusion genes
   Genes Chromosomes Cancer, 50 (5), 348-57
   PubMed 21305644
5. Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
   Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
   PLoS One, 6 (7), e22317
   PubMed 21814574
6. Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011)
   A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
   PLoS One, 6 (3), e17086
   PubMed 21455500
7. Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
   Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
   Genome Med, 3 (5), 32
   PubMed 21619627
8. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
   CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
   Genes Immun, 12 (8), 653-62
   PubMed 21716316

Publications 2010

1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
   Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
   Mol Cancer, 9, 100
   PubMed 20459617
2. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
   Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
   J Clin Oncol, 28 (9), 1573-82
   PubMed 20159821
3. Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
   Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
   J Carcinog, 9, 1
   PubMed 20411023
4. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
   Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
   Clin Cancer Res, 16 (23), 5842-51
   PubMed 20975101
5. Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
   Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
   Genes Chromosomes Cancer, 49 (11), 1046-53
   PubMed 20725991
6. Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
   PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
   Nat Cell Biol, 12 (4), 362-71
   PubMed 20208530

Publications 2009

1. Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2009)
   TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
   Mol Cell Endocrinol, 306 (1-2), 75-80
   PubMed 19041365
2. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
   Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
   Neuro Oncol, 11 (5), 514-28
   PubMed 19182148
3. Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R (2009)
   The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma
   Mol Hum Reprod, 15 (8), 479-88
   PubMed 19505997
4. Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
   Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
   Genes Chromosomes Cancer, 48 (2), 184-93
   PubMed 18973136
5. Nilsen H, Olsen HG, Hayes B, Sehested E, Svendsen M, Nome T, Meuwissen T, Lien S (2009)
   Casein haplotypes and their association with milk production traits in Norwegian Red cattle
   Genet Sel Evol, 41, 24
   PubMed 19284706
6. Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
   A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
   Mol Cancer, 8, 5
   PubMed 19152679

Publications 2008

1. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
   Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
   Mol Cancer, 7, 94
   PubMed 19117505
2. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O (2008)
   Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
   Genome Biol, 9 (9), R139
   PubMed 18803840
3. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
   Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
   J Transl Med, 6, 13
   PubMed 18346269

Publications 2007

1. Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
   Improved gene expression signature of testicular carcinoma in situ
   Int J Androl, 30 (4), 292-302; discussion 303
   PubMed 17488342
2. Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
   Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
   Mol Cancer, 6, 2
   PubMed 17201907
3. Lind GE, Skotheim RI, Lothe RA (2007)
   The epigenome of testicular germ cell tumors
   APMIS, 115 (10), 1147-60
   PubMed 18042148
4. Skotheim RI, Nees M (2007)
   Alternative splicing in cancer: noise, functional, or systematic?
   Int J Biochem Cell Biol, 39 (7-8), 1432-49
   PubMed 17416541

Publications 2006

1. Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O (2006)
   TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
   Cancer Res, 66 (21), 10242-6
   PubMed 17079440
2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
   Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
   J Pathol, 210 (4), 441-9
   PubMed 17029216
3. Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA (2006)
   Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
   Cell Oncol, 28 (5-6), 315-26
   PubMed 17167184
4. von Eyben FE, Jacobsen GK, Skotheim RI, von der Maase H, Rorth M (2006)
   Precursor lesions in testis and dysgenetic gonads
   Hum Pathol, 37 (6), 773; author reply 774
   PubMed 16733221

Publications 2005

1. Hofer MD, Browne TJ, He L, Skotheim RI, Lothe RA, Rubin MA (2005)
   Identification of two molecular groups of seminomas by using expression and tissue microarrays
   Clin Cancer Res, 11 (16), 5722-9
   PubMed 16115909
2. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Henrique R, Saatcioglu F, Esteller M, Teixeira MR, Lothe RA (2005)
   The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
   Mol Cancer, 4 (1), 8
   PubMed 15691383
3. Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fosså SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW, Lothe RA (2005)
   Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
   Cancer Res, 65 (13), 5588-98
   PubMed 15994931
4. von Eyben FE, Jacobsen GK, Skotheim RI (2005)
   Microinvasive germ cell tumor of the testis
   Virchows Arch, 447 (3), 610-25
   PubMed 15968545

Publications 2003

1. Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA (2003)
   Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
   Cancer Genet Cytogenet, 147 (1), 1-8
   PubMed 14580764
2. Skotheim RI, Abeler VM, Nesland JM, Fosså SD, Holm R, Wagner U, Flørenes VA, Aass N, Kallioniemi OP, Lothe RA (2003)
   Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
   Neoplasia, 5 (5), 397-404
   PubMed 14670177
3. Skotheim RI, Kallioniemi A, Bjerkhagen B, Mertens F, Brekke HR, Monni O, Mousses S, Mandahl N, Soeter G, Nesland JM, Smeland S, Kallioniemi OP, Lothe RA (2003)
   Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
   J Clin Oncol, 21 (24), 4586-91
   PubMed 14673046
4. Skotheim RI, Korkmaz KS, Klokk TI, Abeler VM, Korkmaz CG, Nesland JM, Fosså SD, Lothe RA, Saatcioglu F (2003)
   NKX3.1 expression is lost in testicular germ cell tumors
   Am J Pathol, 163 (6), 2149-54
   PubMed 14633588
5. Skotheim RI, Lothe RA (2003)
   The testicular germ cell tumour genome
   APMIS, 111 (1), 136-50; discussion 50-1
   PubMed 12752254

Publications 2002

1. Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fosså SD, Stenwig AE, Peltomäki P, Lothe RA (2002)
   Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
   Genes Chromosomes Cancer, 34 (2), 168-74
   PubMed 11979550
2. Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A (2002)
   New insights into testicular germ cell tumorigenesis from gene expression profiling
   Cancer Res, 62 (8), 2359-64
   PubMed 11956097
3. Smith-Sørensen B, Lind GE, Skotheim RI, Fosså SD, Fodstad Ø, Stenwig AE, Jakobsen KS, Lothe RA (2002)
   Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
   Oncogene, 21 (57), 8878-84
   PubMed 12483540

Publications 2001

1. Skotheim RI, Diep CB, Kraggerud SM, Jakobsen KS, Lothe RA (2001)
   Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA
   Cancer Genet Cytogenet, 127 (1), 64-70
   PubMed 11408068
2. Skotheim RI, Kraggerud SM, Fosså SD, Stenwig AE, Gedde-Dahl T, Danielsen HE, Jakobsen KS, Lothe RA (2001)
   Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence
   Neoplasia, 3 (3), 196-203
   PubMed 11494113