Andreas M. Hoff
Position: Postdoc, PhD
Phone: +47 2278 1710
Email:

Research focus:

My research involves both wet lab work and the use of bioinformatics. I use these tools to study qualitative transcript variants and fusion genes that are involved in cancer biology and may ultimately have the potential as cancer biomarkers. More specifically:

 

1.Fusion transcripts involving the TCF7L2 gene in colorectal cancer and chimeric transcript overexpression in tumour versus normal.

2.Assessment of transcript structures and potential fusion genes in colorectal cancer by using a new custom targeted RNA sequencing approach.

3.Analysis of RNA sequencing data from embryonal carcinoma and embryonic stem cell lines in a testicular germ cell tumour setting.

 

Academic degrees:

2011: Msc in Molecular biology, University of Oslo, Norway. “Transcript variation and protein expression in testicular germ cell tumours”

 

Publications 2015

Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Cancer Res, 76 (1), 108-16
PubMed 26659575

Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
Novel RNA variants in colorectal cancers
Oncotarget, 6 (34), 36587-602
PubMed 26474385

Publications 2014

Nome T, Hoff AM, Bakken AC, Rognum TO, Nesbakken A, Skotheim RI (2014)
High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants
PLoS One, 9 (3), e91264
PubMed 24608966

Publications 2013

Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
Stem Cells Dev, 22 (7), 1136-46
PubMed 23137282

Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
Transl Oncol, 6 (5), 546-53
PubMed 24151535