Per O. Seglen

Publications published since 1965 or in press by Per O. Seglen

186 publications found

Publications 2011

1. Eskelinen EL, Reggiori F, Baba M, Kovács AL, Seglen PO (2011)
   Seeing is believing: the impact of electron microscopy on autophagy research
   Autophagy, 7 (9), 935-56
   PubMed 21566462
2. Øverbye A, Sætre F, Hagen LK, Johansen HT, Seglen PO (2011)
   Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain
   Autophagy, 7 (9), 1011-27
   PubMed 21610319

Publications 2010

1. Klionsky DJ, Seglen PO (2010)
   The Norse god of autophagy. Interviewed by Daniel J Klionsky
   Autophagy, 6 (8), 1017-31
   PubMed 20814236

Publications 2009

1. Seglen PO, Øverbye A, Saetre F (2009)
   Sequestration assays for mammalian autophagy
   Methods Enzymol, 452, 63-83
   PubMed 19200876
2. Øverbye A, Seglen PO (2009)
   Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues
   Biochem J, 417 (2), 535-45
   PubMed 18831714

Publications 2008

1. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y et al. (2008)
   Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
   Autophagy, 4 (2), 151-75
   PubMed 18188003
2. Klionsky DJ, Elazar Z, Seglen PO, Rubinsztein DC (2008)
   Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
   Autophagy, 4 (7), 849-950
   PubMed 18758232

Publications 2007

1. Klionsky DJ, Cuervo AM, Dunn WA, Levine B, van der Klei I, Seglen PO (2007)
   How shall I eat thee?
   Autophagy, 3 (5), 413-6
   PubMed 17568180
2. Klionsky DJ, Cuervo AM, Seglen PO (2007)
   Methods for monitoring autophagy from yeast to human
   Autophagy, 3 (3), 181-206
   PubMed 17224625
3. Øverbye A, Fengsrud M, Seglen PO (2007)
   Proteomic analysis of membrane-associated proteins from rat liver autophagosomes
   Autophagy, 3 (4), 300-22
   PubMed 17377489

Publications 2005

1. Lindstad RI, Sylte I, Mikalsen SO, Seglen PO, Berg E, Winberg JO (2005)
   Pancreatic trypsin activates human promatrix metalloproteinase-2
   J Mol Biol, 350 (4), 682-98
   PubMed 15950241
2. Samari HR, Møller MT, Holden L, Asmyhr T, Seglen PO (2005)
   Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins
   Biochem J, 386 (Pt 2), 237-44
   PubMed 15461583
3. Sneve ML, Øverbye A, Fengsrud M, Seglen PO (2005)
   Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels
   Autophagy, 1 (3), 157-62
   PubMed 16874067

Publications 2004

1. Møller MT, Samari HR, Seglen PO (2004)
   Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation
   Toxicol Sci, 82 (2), 628-37
   PubMed 15342961
2. Rusten TE, Lindmo K, Juhász G, Sass M, Seglen PO, Brech A, Stenmark H (2004)
   Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
   Dev Cell, 7 (2), 179-92
   PubMed 15296715

Publications 2003

1. Møller MT, Samari HR, Fengsrud M, Strømhaug PE, øStvold AC, Seglen PO (2003)
   Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes
   Biochem J, 373 (Pt 2), 505-13
   PubMed 12697024

Publications 2002

1. Larsen AK, Møller MT, Blankson H, Samari HR, Holden L, Seglen PO (2002)
   Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes
   J Biol Chem, 277 (38), 34826-35
   PubMed 12095991

Publications 2001

1. Berven G, Saetre F, Halvorsen K, Seglen PO (2001)
   Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells
   Toxicon, 39 (2-3), 349-62
   PubMed 10978754
2. Mousavi SA, Kjeken R, Berg TO, Seglen PO, Berg T, Brech A (2001)
   Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy
   Biochim Biophys Acta, 1510 (1-2), 243-57
   PubMed 11342162

Publications 2000

1. Blankson H, Grotterød EM, Seglen PO (2000)
   Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin
   Cell Death Differ, 7 (8), 739-46
   PubMed 10918448
2. Fengsrud M, Erichsen ES, Berg TO, Raiborg C, Seglen PO (2000)
   Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy
   Eur J Cell Biol, 79 (12), 871-82
   PubMed 11152279
3. Fengsrud M, Raiborg C, Berg TO, Strømhaug PE, Ueno T, Erichsen ES, Seglen PO (2000)
   Autophagosome-associated variant isoforms of cytosolic enzymes
   Biochem J, 352 Pt 3, 773-81
   PubMed 11104685

Publications 1998

1. Berg TO, Fengsrud M, Strømhaug PE, Berg T, Seglen PO (1998)
   Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes
   J Biol Chem, 273 (34), 21883-92
   PubMed 9705327
2. Kovács AL, Gordon PB, Grotterød EM, Seglen PO (1998)
   Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP
   Biol Chem, 379 (11), 1341-7
   PubMed 9865607
3. Rundén E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, Laake JH (1998)
   Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism
   J Neurosci, 18 (18), 7296-305
   PubMed 9736650
4. Samari HR, Seglen PO (1998)
   Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase
   J Biol Chem, 273 (37), 23758-63
   PubMed 9726984
5. Seglen PO (1998)
   Citation rates and journal impact factors are not suitable for evaluation of research
   Acta Orthop Scand, 69 (3), 224-9
   PubMed 9703393
6. Strømhaug PE, Berg TO, Fengsrud M, Seglen PO (1998)
   Purification and characterization of autophagosomes from rat hepatocytes
   Biochem J, 335 ( Pt 2), 217-24
   PubMed 9761717

Publications 1997

1. Seglen PO (1997)
   DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival
   Cell Biol Toxicol, 13 (4-5), 301-15
   PubMed 9298250
2. Seglen PO (1997)
   Why the impact factor of journals should not be used for evaluating research
   BMJ, 314 (7079), 498-502
   PubMed 9056804
3. Seglen PO (1997)
   Citations and journal impact factors: questionable indicators of research quality
   Allergy, 52 (11), 1050-6
   PubMed 9404555
4. Strømhaug PE, Berg TO, Berg K, Seglen PO (1997)
   A novel method for the study of autophagy: destruction of hepatocytic lysosomes, but not autophagosomes, by the photosensitizing porphyrin tetra(4-sulphonatophenyl)porphine
   Biochem J, 321 ( Pt 1), 217-25
   PubMed 9003422
5. Strømhaug PE, Berg TO, Gjøen T, Seglen PO (1997)
   Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes
   Eur J Cell Biol, 73 (1), 28-39
   PubMed 9174669

Publications 1996

1. Holen I, Gordon PB, Strømhaug PE, Seglen PO (1996)
   Role of cAMP in the regulation of hepatocytic autophagy
   Eur J Biochem, 236 (1), 163-70
   PubMed 8617261
2. Seglen PO, Berg TO, Blankson H, Fengsrud M, Holen I, Strømhaug PE (1996)
   Structural aspects of autophagy
   Adv Exp Med Biol, 389, 103-11
   PubMed 8860999

Publications 1995

1. Blankson H, Holen I, Seglen PO (1995)
   Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid
   Exp Cell Res, 218 (2), 522-30
   PubMed 7540986
2. Fengsrud M, Roos N, Berg T, Liou W, Slot JW, Seglen PO (1995)
   Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions
   Exp Cell Res, 221 (2), 504-19
   PubMed 7493651
3. Fosse M, Berg TO, O'Reilly DS, Seglen PO (1995)
   Vanadate inhibition of hepatocytic autophagy. Calcium-modulated and osmolality-modulated antagonism by asparagine
   Eur J Biochem, 230 (1), 17-24
   PubMed 7601097
4. Gordon PB, Holen I, Seglen PO (1995)
   Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid
   J Biol Chem, 270 (11), 5830-8
   PubMed 7890712
5. Holen I, Gordon PB, Strømhaug PE, Berg TO, Fengsrud M, Brech A, Roos N, Berg T, Seglen PO (1995)
   Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors
   Biochem J, 311 ( Pt 1), 317-26
   PubMed 7575471
6. Holen I, Strømhaug PE, Gordon PB, Fengsrud M, Berg TO, Seglen PO (1995)
   Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins)
   J Biol Chem, 270 (21), 12823-31
   PubMed 7759538

Publications 1994

1. Berg TO, Strømhaug PE, Berg T, Seglen PO (1994)
   Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate
   Eur J Biochem, 221 (1), 595-602
   PubMed 8168547
2. Drettner B, Seglen PO, Sivertsen G (1994)
   [The impact factor as an instrument of allocation. Not accepted by the journals in Scandinavia]
   Lakartidningen, 91 (8), 744-5
   PubMed 8189977
3. Gerlyng P, Grotmol T, Seglen PO (1994)
   Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation
   Carcinogenesis, 15 (2), 371-9
   PubMed 7508825
4. Gerlyng P, Grotmol T, Stokke T, Erikstein B, Seglen PO (1994)
   Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver
   Carcinogenesis, 15 (1), 53-9
   PubMed 8293549
5. Jonassen TS, Seglen PO, Stokke T (1994)
   The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle
   Cell Prolif, 27 (2), 95-104
   PubMed 10465029
6. Mossin L, Blankson H, Huitfeldt H, Seglen PO (1994)
   Ploidy-dependent growth and binucleation in cultured rat hepatocytes
   Exp Cell Res, 214 (2), 551-60
   PubMed 7925649
7. Seglen P, Saeter G, Schwarze P (1994)
   Proliferation of diploid hepatocytes and nonparenchymal (oval) cells during rat-liver regeneration in the presence of 2-acetylaminofluorene
   Int J Oncol, 5 (4), 805-10
   PubMed 21559645
8. Seglen PO (1994)
   [How should the research be directed?]
   Tidsskr Nor Laegeforen, 114 (25), 2970-2
   PubMed 7974410

Publications 1993

1. Gerlyng P, Abyholm A, Grotmol T, Erikstein B, Huitfeldt HS, Stokke T, Seglen PO (1993)
   Binucleation and polyploidization patterns in developmental and regenerative rat liver growth
   Cell Prolif, 26 (6), 557-65
   PubMed 9116122
2. Gordon PB, Holen I, Fosse M, Røtnes JS, Seglen PO (1993)
   Dependence of hepatocytic autophagy on intracellularly sequestered calcium
   J Biol Chem, 268 (35), 26107-12
   PubMed 8253727
3. Holen I, Gordon PB, Seglen PO (1993)
   Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
   Eur J Biochem, 215 (1), 113-22
   PubMed 8393787
4. Kisen GO, Tessitore L, Costelli P, Gordon PB, Schwarze PE, Baccino FM, Seglen PO (1993)
   Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells
   Carcinogenesis, 14 (12), 2501-5
   PubMed 8269618
5. Strømhaug PE, Seglen PO (1993)
   Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes)
   Biochem J, 291 ( Pt 1), 115-21
   PubMed 8471030

Publications 1992

1. Bohley P, Seglen PO (1992)
   Proteases and proteolysis in the lysosome
   Experientia, 48 (2), 151-7
   PubMed 1740187
2. Gerlyng P, Grotmol T, Erikstein B, Stokke T, Seglen PO (1992)
   Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma
   Carcinogenesis, 13 (10), 1795-801
   PubMed 1330342
3. Gerlyng P, Stokke T, Huitfeldt HS, Stenersen T, Danielsen HE, Grotmol T, Seglen PO (1992)
   Analytical methods for the study of liver cell proliferation
   Cytometry, 13 (4), 404-15
   PubMed 1382009
4. Gordon PB, Høyvik H, Seglen PO (1992)
   Prelysosomal and lysosomal connections between autophagy and endocytosis
   Biochem J, 283 ( Pt 2), 361-9
   PubMed 1575680
5. Holen I, Gordon PB, Seglen PO (1992)
   Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity
   Biochem J, 284 ( Pt 3), 633-6
   PubMed 1320371
6. Seglen PO, Bohley P (1992)
   Autophagy and other vacuolar protein degradation mechanisms
   Experientia, 48 (2), 158-72
   PubMed 1740188

Publications 1991

1. Gordon PB, Holen I, Seglen PO (1991)
   Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells
   Biomed Biochim Acta, 50 (4-6), 383-7
   PubMed 1801702
2. Holen I, Gordon PB, Seglen PO (1991)
   Role of cyclic nucleotides in the control of hepatic autophagy
   Biomed Biochim Acta, 50 (4-6), 389-92
   PubMed 1666282
3. Høyvik H, Gordon PB, Berg TO, Strømhaug PE, Seglen PO (1991)
   Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine
   J Cell Biol, 113 (6), 1305-12
   PubMed 1904444
4. Schwarze PE, Saeter G, Armstrong D, Cameron RG, Laconi E, Sarma DS, Préat V, Seglen PO (1991)
   Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments
   Carcinogenesis, 12 (2), 325-7
   PubMed 1847321
5. Seglen PO (1991)
   Citation frequency and journal impact: valid indicators of scientific quality?
   J Intern Med, 229 (2), 109-11
   PubMed 1997634
6. Seglen PO, Gordon PB, Holen I, Høyvik H (1991)
   Hepatocytic autophagy
   Biomed Biochim Acta, 50 (4-6), 373-81
   PubMed 1666281

Publications 1990

1. Gerlyng P, Seglen PO (1990)
   Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth
   Bull Cancer, 77 (5), 461-6
   PubMed 2400817
2. Hendil KB, Lauridsen AM, Seglen PO (1990)
   Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine
   Biochem J, 272 (3), 577-81
   PubMed 1702625
3. Kopitz J, Kisen GO, Gordon PB, Bohley P, Seglen PO (1990)
   Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes
   J Cell Biol, 111 (3), 941-53
   PubMed 2391370
4. Pichiri-Coni G, Coni P, Laconi E, Schwarze PE, Seglen PO, Rao PM, Rajalakshmi S, Sarma DS (1990)
   Studies on the mitoinhibitory effect of orotic acid on hepatocytes in primary culture
   Carcinogenesis, 11 (6), 981-4
   PubMed 2347072
5. Saeter G, Seglen PO (1990)
   Cell biology of hepatocarcinogenesis
   Crit Rev Oncog, 1 (4), 437-66
   PubMed 1964598
6. Seglen PO, Gerlyng P (1990)
   Growth-related alterations during liver carcinogenesis: effect of promoters
   Environ Health Perspect, 88, 197-205
   PubMed 2272315
7. Seglen PO, Gordon PB, Holen I (1990)
   Non-selective autophagy
   Semin Cell Biol, 1 (6), 441-8
   PubMed 2103895
8. Seglen PO, Saeter G, Schwarze PE (1990)
   Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas
   Hepatology, 12 (2), 295-300
   PubMed 2167869

Publications 1989

1. Gordon PB, Kisen GO, Kovács AL, Seglen PO (1989)
   Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes
   Biochem Soc Symp, 55, 129-43
   PubMed 2619764
2. Plomp PJ, Gordon PB, Meijer AJ, Høyvik H, Seglen PO (1989)
   Energy dependence of different steps in the autophagic-lysosomal pathway
   J Biol Chem, 264 (12), 6699-704
   PubMed 2708336
3. Saeter G, Schwarze PE, Nesland JM, Seglen PO (1989)
   Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells
   Br J Cancer, 59 (2), 198-205
   PubMed 2930686
4. Seglen PO (1989)
   [Evaluation of scientific quality using citation analysis and other bibliometric methods]
   Nord Med, 104 (12), 331-5, 341
   PubMed 2594499
5. Seglen PO (1989)
   From bad to worse: evaluation by Journal Impact
   Trends Biochem Sci, 14 (8), 326-7
   PubMed 2799903
6. Seglen PO (1989)
   [Use of citation analysis and other bibliometric methods in evaluation of the quality of research]
   Tidsskr Nor Laegeforen, 109 (31), 3229-4
   PubMed 2595690
7. Seglen PO, Skomedal H, Saeter G, Schwarze PE, Nesland JM (1989)
   Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours
   Carcinogenesis, 10 (1), 21-5
   PubMed 2910524

Publications 1988

1. Gordon PB, Seglen PO (1988)
   Prelysosomal convergence of autophagic and endocytic pathways
   Biochem Biophys Res Commun, 151 (1), 40-7
   PubMed 3126737
2. Saeter G, Lee CZ, Schwarze PE, Ous S, Chen DS, Sung JL, Seglen PO (1988)
   Changes in ploidy distributions in human liver carcinogenesis
   J Natl Cancer Inst, 80 (18), 1480-5
   PubMed 2846856
3. Saeter G, Schwarze PE, Nesland JM, Juul N, Pettersen EO, Seglen PO (1988)
   The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas
   Carcinogenesis, 9 (6), 939-45
   PubMed 3370757
4. Saeter G, Schwarze PE, Nesland JM, Seglen PO (1988)
   2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism
   Carcinogenesis, 9 (4), 581-7
   PubMed 2895691

Publications 1987

1. Gordon PB, Høyvik H, Seglen PO (1987)
   Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes
   Biochem J, 243 (3), 655-60
   PubMed 3663095
2. Gordon PB, Kovacs AL, Seglen PO (1987)
   Temperature dependence of protein degradation, autophagic sequestration and mitochondrial sugar uptake in rat hepatocytes
   Biochim Biophys Acta, 929 (2), 128-33
   PubMed 3593777
3. Plomp PJ, Wolvetang EJ, Groen AK, Meijer AJ, Gordon PB, Seglen PO (1987)
   Energy dependence of autophagic protein degradation in isolated rat hepatocytes
   Eur J Biochem, 164 (1), 197-203
   PubMed 3830181
4. Saeter G, Schwarze PE, Nesland JM, Seglen PO (1987)
   Transplantation of preneoplastic rat hepatocytes by intraportal injection
   Toxicol Pathol, 15 (1), 78-81
   PubMed 3554470
5. Schwarze PE, Tolleshaug H, Seglen PO (1987)
   Endocytosis of asialo-glycoproteins and attachment to asialo-glycoproteins of hepatocytes from carcinogen-treated rats
   Toxicol Pathol, 15 (1), 88-92
   PubMed 3576077

Publications 1986

1. Gordon PB, Seglen PO (1986)
   Use of electrical methods in the study of hepatocytic autophagy
   Biomed Biochim Acta, 45 (11-12), 1635-45
   PubMed 3579882
2. Høyvik H, Gordon PB, Seglen PO (1986)
   Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway
   Exp Cell Res, 166 (1), 1-14
   PubMed 3743649
3. Melvik JE, Pettersen EO, Gordon PB, Seglen PO (1986)
   Increase in cis-dichlorodiammineplatinum (II) cytotoxicity upon reversible electropermeabilization of the plasma membrane in cultured human NHIK 3025 cells
   Eur J Cancer Clin Oncol, 22 (12), 1523-30
   PubMed 3595677
4. Schwarze PE, Pettersen EO, Seglen PO (1986)
   Characterization of hepatocytes from carcinogen-treated rats by two-parametric flow cytometry
   Carcinogenesis, 7 (1), 171-3
   PubMed 3943139
5. Schwarze PE, Pettersen EO, Tolleshaug H, Seglen PO (1986)
   Isolation of carcinogen-induced diploid rat hepatocytes by centrifugal elutriation
   Cancer Res, 46 (9), 4732-7
   PubMed 2873888
6. Seglen PO, Gordon PB, Høyvik H (1986)
   Radiolabelled sugars as probes of hepatocytic autophagy
   Biomed Biochim Acta, 45 (11-12), 1647-56
   PubMed 3579883
7. Seglen PO, Gordon PB, Tolleshaug H, Høyvik H (1986)
   Use of [3H]raffinose as a specific probe of autophagic sequestration
   Exp Cell Res, 162 (1), 273-7
   PubMed 3940229
8. Seglen PO, Schwarze PE, Saeter G (1986)
   Changes in cellular ploidy and autophagic responsiveness during rat liver carcinogenesis
   Toxicol Pathol, 14 (3), 342-8
   PubMed 3787117

Publications 1985

1. Gordon PB, Høyvik H, Seglen PO (1985)
   Sequestration and hydrolysis of electroinjected [14C]lactose as a means of investigating autophagosome-lysosome fusion in isolated rat hepatocytes
   Prog Clin Biol Res, 180, 475-7
   PubMed 4034554
2. Gordon PB, Tolleshaug H, Seglen PO (1985)
   Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes
   Biochem J, 232 (3), 773-80
   PubMed 4091820
3. Gordon PB, Tolleshaug H, Seglen PO (1985)
   Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods
   Exp Cell Res, 160 (2), 449-58
   PubMed 4043252
4. Rogne S, Rønning OW, Myklebost O, Seglen PO, Pettersen EO (1985)
   Cell cycle traverse and protein metabolism in human NHIK 3025 cells: the role of anchorage
   J Cell Physiol, 125 (3), 528-32
   PubMed 4066771
5. Schwarze PE, Seglen PO (1985)
   Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats
   Exp Cell Res, 157 (1), 15-28
   PubMed 2857648
6. Seglen PO, Gordon PB, Tolleshaug H, Høyvik H (1985)
   Pathways of intracellular sequestration and protein degradation in isolated rat hepatocytes
   Prog Clin Biol Res, 180, 437-46
   PubMed 4034550
7. Seglen PO, Gordon PB, Tolleshaug H, Høyvik H (1985)
   Autophagy and protein degradation in isolated rat hepatocytes
   Biochem Soc Trans, 13 (6), 1007-10
   PubMed 4092819
8. Seglen PO, Solheim AE (1985)
   Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy
   Exp Cell Res, 157 (2), 550-5
   PubMed 3979450
9. Tolleshaug H, Seglen PO (1985)
   Autophagic-lysosomal and mitochondrial sequestration of [14C]sucrose. Density gradient distribution of sequestered radioactivity
   Eur J Biochem, 153 (2), 223-9
   PubMed 4076173

Publications 1984

1. Schwarze PE, Pettersen EO, Shoaib MC, Seglen PO (1984)
   Emergence of a population of small, diploid hepatocytes during hepatocarcinogenesis
   Carcinogenesis, 5 (10), 1267-75
   PubMed 6149024
2. Seglen PO, Gordon PB (1984)
   Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes
   J Cell Biol, 99 (2), 435-44
   PubMed 6746735
3. Seglen PO, Munthe-Kaas AC, Dybedal MA (1984)
   Amino acid control of protein degradation in normal and leukemic human lymphocytes
   Exp Cell Res, 155 (1), 121-8
   PubMed 6489454
4. Tolleshaug H, Gordon PB, Solheim AE, Seglen PO (1984)
   Trapping of electro-injected [14C]sucrose by hepatocyte mitochondria: a mechanism for cellular autofiltration?
   Biochem Biophys Res Commun, 119 (3), 955-61
   PubMed 6712679

Publications 1983

1. Schwarze PE, Seglen PO (1983)
   Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes
   Biochem Biophys Res Commun, 117 (2), 509-16
   PubMed 6661239
2. Seglen PO (1983)
   Inhibitors of lysosomal function
   Methods Enzymol, 96, 737-64
   PubMed 6361463
3. Solheim AE, Seglen PO (1983)
   Structural and physical changes in lysosomes from isolated rat hepatocytes treated with methylamine
   Biochim Biophys Acta, 763 (3), 284-91
   PubMed 6626583
4. Solheim AE, Seglen PO (1983)
   Cellular and lysosomal uptake of methylamine in isolated rat hepatocytes
   Biochem J, 210 (3), 929-36
   PubMed 6870811

Publications 1982

1. Gordon PB, Seglen PO (1982)
   Autophagic sequestration of [14C]sucrose, introduced into rat hepatocytes by reversible electro-permeabilization
   Exp Cell Res, 142 (1), 1-14
   PubMed 7140848
2. Gordon PB, Seglen PO (1982)
   6-substituted purines: a novel class of inhibitors of endogenous protein degradation in isolated rat hepatocytes
   Arch Biochem Biophys, 217 (1), 282-94
   PubMed 6889839
3. Kovács AL, Reith A, Seglen PO (1982)
   Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine
   Exp Cell Res, 137 (1), 191-201
   PubMed 7056284
4. Kovács AL, Seglen PO (1982)
   Inhibition of hepatocytic protein degradation by inducers of autophagosome accumulation
   Acta Biol Med Ger, 41 (1), 125-30
   PubMed 7113543
5. Rønning OW, Seglen PO (1982)
   The relation between protein accumulation and cell cycle traverse of human NHIK 3025 cells in unbalanced growth
   J Cell Physiol, 112 (1), 19-26
   PubMed 7107714
6. Schwarze PE, Solheim AE, Seglen PO (1982)
   Amino acid and energy requirements for rat hepatocytes in primary culture
   In Vitro, 18 (1), 43-54
   PubMed 6763597
7. Seglen PO, Gordon PB (1982)
   3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
   Proc Natl Acad Sci U S A, 79 (6), 1889-92
   PubMed 6952238

Publications 1981

1. Grinde B, Seglen PO (1981)
   Role of microtubuli in the lysosomal degradation of endogenous and exogenous protein in isolated rat hepatocytes
   Hoppe Seylers Z Physiol Chem, 362 (5), 549-56
   PubMed 6166527
2. Grinde B, Seglen PO (1981)
   Effects of amino acids and amino acid analogues on lysosomal protein degradation in isolated rat hepatocytes
   Acta Biol Med Ger, 40 (10-11), 1603-12
   PubMed 6177140
3. Grinde B, Seglen PO (1981)
   Leucine inhibition of autophagic vacuole formation in isolated rat hepatocytes
   Exp Cell Res, 134 (1), 33-9
   PubMed 7250217
4. Grinde B, Seglen PO (1981)
   Effects of amino acid analogues on protein degradation in isolated rat hepatocytes
   Biochim Biophys Acta, 676 (1), 43-50
   PubMed 7260111
5. Kovács AL, Grinde B, Seglen PO (1981)
   Inhibition of autophagic vacuole formation and protein degradation by amino acids in isolated hepatocytes
   Exp Cell Res, 133 (2), 431-6
   PubMed 7238609
6. Kovács AL, Molnár K, Seglen PO (1981)
   Inhibition of autophagic sequestration and endogenous protein degradation in isolated rat hepatocytes by methylated adenosine derivatives
   FEBS Lett, 134 (2), 194-6
   PubMed 7308488
7. Kovács AL, Seglen PO (1981)
   Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis
   Biochim Biophys Acta, 676 (2), 213-20
   PubMed 7260116
8. Poli A, Gordon PB, Schwarze PE, Grinde B, Seglen PO (1981)
   Effects of insulin and anchorage on hepatocytic protein metabolism and amino acid transport
   J Cell Sci, 48, 1-18
   PubMed 7024288
9. Rønning OW, Lindmo T, Pettersen EO, Seglen PO (1981)
   The role of protein accumulation in the cell cycle control of human NHIK 3025 cells
   J Cell Physiol, 109 (3), 411-8
   PubMed 7320058
10. Rønning OW, Lindmo T, Pettersen EO, Seglen PO (1981)
    Effect of serum step-down on protein metabolism and proliferation kinetics of NHIK 3025 cells
    J Cell Physiol, 107 (1), 47-57
    PubMed 7194351
11. Schwarze PE, Seglen PO (1981)
    Effects of antibiotics on protein synthesis and degradation in primary cultures of rat hepatocytes
    In Vitro, 17 (1), 71-6
    PubMed 7216241
12. Seglen PO, Gordon PB (1981)
    Vanadate inhibits protein degradation in isolated rat hepatocytes
    J Biol Chem, 256 (15), 7699-701
    PubMed 6167567
13. Seglen PO, Gordon PB, Grinde B, Solheim A, Kovács AL, Poli A (1981)
    Inhibitors and pathways of hepatocytic protein degradation
    Acta Biol Med Ger, 40 (10-11), 1587-98
    PubMed 7342604

Publications 1980

1. Gjessing R, Seglen PO (1980)
   Adsorption, simple binding and complex binding of rat hepatocytes to various in vitro substrata
   Exp Cell Res, 129 (1), 239-49
   PubMed 6159218
2. Grinde B, Seglen PO (1980)
   Differential effects of proteinase inhibitors and amines on the lysosomal and non-lysosomal pathways of protein degradation in isolated rat hepatocytes
   Biochim Biophys Acta, 632 (1), 73-86
   PubMed 7417519
3. Schwarze PE, Seglen PO (1980)
   Protein metabolism and survival of rat hepatocytes in early culture
   Exp Cell Res, 130 (1), 185-90
   PubMed 6161016
4. Seglen PO, Gordon PB (1980)
   Effects of lysosomotropic monoamines, diamines, amino alcohols, and other amino compounds on protein degradation and protein synthesis in isolated rat hepatocytes
   Mol Pharmacol, 18 (3), 468-75
   PubMed 7464813
5. Seglen PO, Gordon PB, Poli A (1980)
   Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes
   Biochim Biophys Acta, 630 (1), 103-18
   PubMed 7388042
6. Seglen PO, Solheim AE, Grinde B, Gordon PB, Schwarze PE, Gjessing R, Poli A (1980)
   Amino acid control of protein synthesis and degradation in isolated rat hepatocytes
   Ann N Y Acad Sci, 349, 1-17
   PubMed 6939359
7. Solheim AE, Seglen PO (1980)
   Subcellular distribution of proteolytically generated valine in isolated rat hepatocytes
   Eur J Biochem, 107 (2), 587-96
   PubMed 7398655

Publications 1979

1. Rønning OW, Pettersen EO, Seglen PO (1979)
   Protein synthesis and protein degradation through the cell cycle of human NHIK 3025 cells in vitro
   Exp Cell Res, 123 (1), 63-72
   PubMed 488184
2. Seglen PO (1979)
   Hepatocyte suspensions and cultures as tools in experimental carcinogenesis
   J Toxicol Environ Health, 5 (2-3), 551-60
   PubMed 224209
3. Seglen PO, Gordon PB (1979)
   Inhibition of cell spreading by lysosomotropic amines
   FEBS Lett, 105 (2), 345-8
   PubMed 488362
4. Seglen PO, Grinde B, Solheim AE (1979)
   Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin
   Eur J Biochem, 95 (2), 215-25
   PubMed 456353

Publications 1978

1. Seglen PO (1978)
   Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes
   Biochem J, 174 (2), 469-74
   PubMed 708399
2. Seglen PO, Fossa J (1978)
   Attachment of rat hepatocytes in vitro to substrata of serum protein, collagen, or concanavalin A
   Exp Cell Res, 116 (1), 199-206
   PubMed 29767
3. Seglen PO, Gjessing R (1978)
   Effect of temperature and divalent cations on the substratum attachment of rat hepatocytes in vitro
   J Cell Sci, 34, 117-31
   PubMed 748333
4. Seglen PO, Solheim AE (1978)
   Effects of aminooxyacetate, alanine and other amino acids on protein synthesis in isolated rat hepatocytes
   Biochim Biophys Acta, 520 (3), 630-41
   PubMed 718918
5. Seglen PO, Solheim AE (1978)
   Valine uptake and incorporation into protein in isolated rat hepatocytes. Nature of the precursor pool for protein synthesis
   Eur J Biochem, 85 (1), 15-25
   PubMed 639812

Publications 1977

1. Seglen PO (1977)
   Inhibitor of protein degradation formed during incubation of isolated rat hepatocytes in a cell culture medium. Its identification as ammonia
   Exp Cell Res, 107 (1), 207-17
   PubMed 16760
2. Seglen PO (1977)
   Protein-catabolic stage of isolated rat hepatocytes
   Biochim Biophys Acta, 496 (1), 182-91
   PubMed 836893
3. Seglen PO, Reith A (1977)
   Ammonia inhibits protein secretion in isolated rat hepatocytes
   Biochim Biophys Acta, 496 (1), 29-35
   PubMed 836896
4. Seglen PO, Solheim AE (1977)
   Protein degradation in isolated rat hepatocytes
   Acta Biol Med Ger, 36 (11-12), 1789-804
   PubMed 616724

Publications 1976

1. Reith A, Seglen PO (1976)
   [Ammonia inhibition of protein degradation in isolated rat hepatocytes: quantitative alterations in the lysosomal system (author's transl)]
   Verh Dtsch Ges Pathol, 223-6
   PubMed 1035828
2. Seglen PO (1976)
   Preparation of isolated rat liver cells
   Methods Cell Biol, 13, 29-83
   PubMed 177845
3. Seglen PO (1976)
   Incorporation of radioactive amino acids into protein in isolated rat hepatocytes
   Biochim Biophys Acta, 442 (3), 391-404
   PubMed 963056
4. Seglen PO, Reith A (1976)
   Ammonia inhibition of protein degradation in isolated rat hepatocytes. Quantitative ultrastructural alterations in the lysosomal system
   Exp Cell Res, 100 (2), 276-80
   PubMed 939253

Publications 1975

1. Munthe-Kaas AC, Berg T, Seglen PO, Seljelid R (1975)
   Mass isolation and culture of rat kupffer cells
   J Exp Med, 141 (1), 1-10
   PubMed 1090696
2. Seglen PO (1975)
   [The university's odontological collection]
   Nor Tannlaegeforen Tid, 85 (6), 236-40
   PubMed 1094410
3. Seglen PO (1975)
   Protein degradation in isolated rat hepatocytes is inhibited by ammonia
   Biochem Biophys Res Commun, 66 (1), 44-52
   PubMed 1164434

Publications 1974

1. Munthe-Kaas AC, Seglen PO (1974)
   The use of Metrizamide as a gradient medium for isopycnic separation of rat liver cells
   FEBS Lett, 43 (3), 252-6
   PubMed 4416578
2. Seglen PO (1974)
   Control of glycogen metabolism in isolated rat liver cells by glucose, insulin and glucagon
   Acta Endocrinol Suppl (Copenh), 191, 153-8
   PubMed 4548796
3. Seglen PO (1974)
   Proceedings: Carbohydrate metabolism of isolated parenchymal rat liver cells
   Hoppe Seylers Z Physiol Chem, 355 (10), 1255
   PubMed 4461596
4. Seglen PO (1974)
   [The pelican]
   Tid Tann, 35 (2), 92-7
   PubMed 4527569

Publications 1973

1. Seglen PO (1973)
   Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion
   Exp Cell Res, 82 (2), 391-8
   PubMed 4358115
2. Seglen PO (1973)
   Preparation of rat liver cells. II. Effects of ions and chelators on tissue dispersion
   Exp Cell Res, 76 (1), 25-30
   PubMed 4630105
3. Seglen PO (1973)
   Glycogen synthesis in isolated parenchymal rat liver cells
   FEBS Lett, 30 (1), 25-28
   PubMed 11947054
4. Seglen PO (1973)
   Effects of anaerobiosis, glucose, insulin and glucagon on glycogen metabolism in isolated parenchymal rat liver cells
   FEBS Lett, 36 (3), 309-12
   PubMed 4763310

Publications 1972

1. Berg T, Boman D, Seglen PO (1972)
   Induction of tryptophan oxygenase in primary rat liver cell suspensions by glucocorticoid hormone
   Exp Cell Res, 72 (2), 571-4
   PubMed 5037935
2. Christoffersen T, Morland J, Osnes JB, Berg T, Boman D, Seglen PO (1972)
   Enrichment of glucagon sensitive adenyl cyclase upon preparation of parenchymal cells from rat liver
   Arch Biochem Biophys, 150 (2), 807-9
   PubMed 5044053
3. Morland J, Christoffersen T, Osnes JB, Seglen PO, Jervell KF (1972)
   An effect of ethanol administration on tryptophan oxygenase in the perfused rat liver. Decreased enzyme synthesis dependent on low perfusate pH
   Biochem Pharmacol, 21 (13), 1849-59
   PubMed 4405195
4. Seglen PO (1972)
   The effect of perfusate pH on respiration and glycolysis in the isolated rat liver perfused with an erythrocyte- and protein-free medium
   Biochim Biophys Acta, 264 (3), 398-410
   PubMed 5027624
5. Seglen PO (1972)
   Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver
   Exp Cell Res, 74 (2), 450-4
   PubMed 4343020

Publications 1971

1. Ekren T, Jervell KF, Seglen PO (1971)
   Insulin and amino-acid regulation of polysomes in perfused, diabetic rat liver
   Nat New Biol, 229 (8), 244-5
   PubMed 5279798
2. Seglen PO (1971)
   [Dental extraction forceps]
   Tid Tann, 32, 273-9
   PubMed 11633374
3. Seglen PO (1971)
   [Extraction devices]
   Tid Tann, 32 (5), 273-9
   PubMed 5292780
4. Seglen PO (1971)
   Regulation of tyrosine transaminase degradation in the isolated perfused rat liver by cycloheximide and insulin
   Biochim Biophys Acta, 230 (2), 319-26
   PubMed 4396768

Publications 1970

1. Berg T, Morland J, Seglen PO (1970)
   An effect of glucocorticoid hormone on the nuclear ribonucleoprotein of rat liver
   Hoppe Seylers Z Physiol Chem, 351 (7), 898-900
   PubMed 5432756
2. Seglen P (1970)
   [Drug effects on enzyme synthesis]
   Tidsskr Nor Laegeforen, 90 (2), 208-10
   PubMed 4914233

Publications 1969

1. Jevell KF, Seglen PO (1969)
   Tyrosine transaminase degradation in perfused liver after inhibition of protein synthesis by cycloheximide
   Biochim Biophys Acta, 174 (1), 398-400
   PubMed 4387935
2. Seglen PO, Jervell KF (1969)
   A simple perfusion technique applied to glucocorticoid regulation of tryptophan oxygenase turnover and bile production in the isolated rat liver
   Hoppe Seylers Z Physiol Chem, 350 (3), 308-16
   PubMed 5769958
3. Seglen PO, Jervell KF (1969)
   Tryptophan oxygenase activation and ascorbate oxidation in whole homogenates from rat liver
   Biochim Biophys Acta, 171 (1), 47-57
   PubMed 5763409

Publications 1968

1. Seglen PO (1968)
   Insulin inhibition of tyrosine transaminase degradation in the isolated, perfused rat liver
   Hoppe Seylers Z Physiol Chem, 349 (9), 1229-30
   PubMed 4387600
2. Seglen PO (1968)
   [The history of instruments for cleaning the teeth]
   Nor Tannlaegeforen Tid, 78 (5), 301-8
   PubMed 4876473