
| Øyvind S. Bruland | |
| Position: | Professor, oncologist |
| Phone: | +47 22 93 47 67 |
| Email: | |
Author network for Øyvind Sverre Bruland by COREMINE medical
Publications 2011
Experimental ?-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
EJNMMI Res, 1 (1), 18
PubMed 22214432
Age-period-cohort analysis of primary bone cancer incidence rates in the United States (1976-2005)
Cancer Epidemiol Biomarkers Prev, 20 (8), 1770-7
PubMed 21724855
Breed-specific incidence rates of canine primary bone tumors--a population based survey of dogs in Norway
Can J Vet Res, 75 (3), 209-15
PubMed 22210997
Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
Curr Radiopharm, 4 (4), 321-8
PubMed 22202154
Five-year results from a Scandinavian sarcoma group study (SSG XIII) of adjuvant chemotherapy combined with accelerated radiotherapy in high-risk soft tissue sarcoma of extremities and trunk wall
Int J Radiat Oncol Biol Phys, 81 (5), 1359-66
PubMed 20933339
Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections
Anticancer Res, 31 (12), 4053-60
PubMed 22199261
DW MRI for evaluation of treatment response to imatinib in a rectal gastrointestinal stromal tumour
Acta Oncol, 50 (1), 148-50
PubMed 21110775
Monitoring the effect of targeted therapies in a gastrointestinal stromal tumor xenograft using a clinical PET/CT
Mol Imaging Biol, 13 (6), 1234-40
PubMed 21161686
Stromal targeted therapies in prostate and renal cancer: new concepts and knowledge
Clin Genitourin Cancer, 9 (1), 1-2
PubMed 21925102
Stromal targeted therapy in bone metastatic prostate cancer: promise delivered
Asian J Androl, 13 (6), 783-4
PubMed 21857688
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years
Acta Orthop, 82 (2), 211-6
PubMed 21434784
Radiotherapy or surgery for spine metastases?
Acta Orthop, 82 (3), 365-71
PubMed 21434789
Publications 2010
Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
J Photochem Photobiol B, 101 (2), 174-8
PubMed 20430639
CT density in lung cancer patients after radiotherapy sensitized by metoclopramide. A subgroup analysis of a randomized trial
Strahlenther Onkol, 186 (3), 163-8
PubMed 20165821
Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association?
Mol Nutr Food Res, 54 (8), 1127-33
PubMed 20512788
Seasonal variations of cancer incidence and prognosis
Dermatoendocrinol, 2 (2), 55-7
PubMed 21547098
Publications 2009
Definitive radiotherapy with adjuvant long-term antiandrogen treatment for locally advanced prostate cancer: health-related quality of life and hormonal changes
Prostate Cancer Prostatic Dis, 12 (3), 269-76
PubMed 19290019
Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience
Acta Oncol, 48 (8), 1165-72
PubMed 19863225
Treatment of osteosarcoma. The Scandinavian Sarcoma Group experience
Cancer Treat Res, 152, 309-18
PubMed 20213398
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients
Cancer Treat Res, 152, 509-15
PubMed 20213412
Treatment of soft tissue sarcoma of the extremity and trunk wall The Scandinavian Sarcoma Group perspective
Acta Orthop., 80, 52-59
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
Int J Radiat Oncol Biol Phys, 75 (3), 878-85
PubMed 19665318
Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice
Anticancer Res, 29 (11), 4331-6
PubMed 20032375
Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: results from a randomised multicentre trial
Radiother Oncol, 91 (2), 261-6
PubMed 19307034
The role of radiotherapy in oseosarcoma
Cancer Treat Res, 152, 147-64
PubMed 20213389
Scandinavian experience in classical osteosarcoma Results of the SSG XIV protocol
Acta Orthop., 80, 60-66
DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis
Radiother Oncol, 93 (3), 618-24
PubMed 19747746
Publications 2008
Disseminated tumor cells in bone marrow following definitive radiotherapy for intermediate or high-risk prostate cancer
Prostate, 68 (15), 1607-14
PubMed 18655095
Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
Int J Radiat Oncol Biol Phys, 72 (1), 186-92
PubMed 18722269
The impact of enzymatic degradation on the uptake of differently sized therapeutic molecules
Anticancer Res, 28 (6A), 3557-66
PubMed 19189635
Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study
Int J Radiat Oncol Biol Phys, 71 (4), 1196-203
PubMed 18207661
Sun beds and cod liver oil as vitamin D sources
J Photochem Photobiol B, 91 (2-3), 125-31
PubMed 18417354
DCEMRI monitoring of canine tumors during fractionated radiotherapy
Acta Oncol, 47 (7), 1249-56
PubMed 18618342
Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation
Acta Oncol, 47 (2), 248-54
PubMed 18210300
Publications 2007
Some musculo-skeletal sequelae in cancer survivors
Acta Oncol, 46 (4), 490-6
PubMed 17497316
Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy
Int J Cancer, 120 (8), 1603-9
PubMed 17230512
10-year survival and quality of life in patients with high-risk pN0 prostate cancer following definitive radiotherapy
Int J Radiat Oncol Biol Phys, 69 (4), 1074-83
PubMed 17703896
Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
Blood, 110 (6), 2049-56
PubMed 17536011
Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability
Cancer Biother Radiopharm, 22 (3), 431-7
PubMed 17651051
Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
Lancet Oncol, 8 (7), 587-94
PubMed 17544845
Proton therapy - a systematic review of clinical effectiveness
Radiother Oncol, 83 (2), 123-32
PubMed 17499374
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
Lung Cancer, 55 (3), 263-70
PubMed 17207891
Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study
Phys Med Biol, 52 (2), 499-513
PubMed 17202629
Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
Int J Radiat Oncol Biol Phys, 68 (5), 1496-504
PubMed 17674980
Publications 2006
Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience
Acta Oncol, 45 (1), 38-46
PubMed 16464794
[Jumping after the Swedes]
Tidsskr Nor Laegeforen, 126 (5), 637
PubMed 16505887
High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
Clin Cancer Res, 12 (20 Pt 2), 6250s-6257s
PubMed 17062709
Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
Nucl Med Biol, 33 (2), 271-9
PubMed 16546683
First in vivo evaluation of liposome-encapsulated 223Ra as a potential alpha-particle-emitting cancer therapeutic agent
Anticancer Res, 26 (4B), 2841-8
PubMed 16886603
Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases
Radiother Oncol, 79 (3), 278-84
PubMed 16793154
Radiotoxicity of the alpha-emitting bone-seeker 223Ra injected intravenously into mice: histology, clinical chemistry and hematology
In Vivo, 20 (3), 325-31
PubMed 16724665
Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
Clin Cancer Res, 12 (20 Pt 2), 6209s-6212s
PubMed 17062702
Adapting radiotherapy to hypoxic tumours
Phys Med Biol, 51 (19), 4903-21
PubMed 16985278
Publications 2005
Hematogenous micrometastases in osteosarcoma patients
Clin Cancer Res, 11 (13), 4666-73
PubMed 16000559
Primary osteosarcoma of the breast
Acta Oncol, 44 (7), 767-70
PubMed 16227171
Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers
Br J Radiol, 78 (930), 528-32
PubMed 15900058
Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts
Br J Cancer, 93 (1), 81-8
PubMed 15942637
Preparation and preclinical assessment of folate-conjugated, radiolabelled antibodies
Anticancer Res, 25 (1A), 9-15
PubMed 15816513
First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
Clin Cancer Res, 11 (12), 4451-9
PubMed 15958630
Telemedicine in radiotherapy: a study exploring remote treatment planning, supervision and economics
J Telemed Telecare, 11 (5), 245-50
PubMed 16035967
TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma
Clin Orthop Relat Res (430), 142-8
PubMed 15662316
Publications 2004
Human osteosarcoma xenografts and their sensitivity to chemotherapy
Pathol Oncol Res, 10 (3), 133-41
PubMed 15448748
Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
Cancer Res, 64 (14), 4768-73
PubMed 15256445
Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents
Anticancer Res, 24 (1), 101-5
PubMed 15015582
Sterically stabilized liposomes as a carrier for alpha-emitting radium and actinium radionuclides
Nucl Med Biol, 31 (4), 441-9
PubMed 15093814
Publications 2003
Comparative analyses of the dynamic properties of the rectum studied by cryo-sections of human cadavers and pelvic CT scans of patients
Br J Radiol, 76 (902), 104-8
PubMed 12642278
Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice
J Nucl Med, 44 (2), 252-9
PubMed 12571218
Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
Anticancer Res, 23 (3B), 2201-16
PubMed 12894494
Publications 2002
High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases
J Clin Oncol, 20 (1), 189-96
PubMed 11773169
Radiation doses to non-Hodgkin's lymphoma cells and normal bone marrow exposed in vitro. Comparison of an alpha-emitting radioimmunoconjugate and external gamma-irradiation
Int J Radiat Biol, 78 (2), 133-42
PubMed 11779363
Significant antitumor effect from bone-seeking, alpha-particle-emitting (223)Ra demonstrated in an experimental skeletal metastases model
Cancer Res, 62 (11), 3120-5
PubMed 12036923
A method for measurement of the uptake patterns of two beta-emitting radionuclides in the same tissue section with a digital silicon detector: application to a study of 89SrCl2 and 153Sm-EDTMP in a dog with spontaneous osteosarcoma
Eur J Nucl Med Mol Imaging, 29 (2), 191-7
PubMed 11926381
Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
Anticancer Res, 22 (4), 1949-57
PubMed 12174869
[Bone and soft tissue sarcomas treated at the Norwegian Radium Hospital 1980-99]
Tidsskr Nor Laegeforen, 122 (21), 2089-94
PubMed 12555642
Publications 2001
Radionuclide therapy with bone-seeking compounds: Monte Carlo calculations of dose-volume histograms for bone marrow in trabecular bone
Phys Med Biol, 46 (4), 1149-61
PubMed 11324957
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A
J Immunother, 24 (2), 144-50
PubMed 11265772
Publications 2000
Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry
Int J Radiat Biol, 76 (8), 1129-41
PubMed 10947126
Demonstration of highly specific toxicity of the alpha-emitting radioimmunoconjugate(211)At-rituximab against non-Hodgkin's lymphoma cells
Br J Cancer, 83 (10), 1375-9
PubMed 11044364
[Radiotherapy of skeletal metastases]
Tidsskr Nor Laegeforen, 120 (16), 1870-4
PubMed 10925615
Interstitial fluid pressure in human osteosarcoma xenografts: significance of implantation site and the response to intratumoral injection of hyaluronidase
Anticancer Res, 20 (5B), 3503-12
PubMed 11131654
Hyaluronidase-induced periodic modulation of the interstitial fluid pressure increases selective antibody uptake in human osteosarcoma xenografts
Anticancer Res, 20 (5B), 3513-9
PubMed 11131655
Oral presentations in science and medicine. An art in decline?
Anticancer Res, 20 (5A), 2795-9
PubMed 11062686
Publications 1999
Two human osteoblast-like osteosarcoma cell lines show distinct expression and differential regulation of parathyroid hormone-related protein
J Bone Miner Res, 14 (6), 904-14
PubMed 10352098
211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation
J Nucl Med, 40 (7), 1197-203
PubMed 10405142
Influence of pretreatment with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APB) on organ uptake of 211At and 125I-labeled amidobisphosphonates in mice
Nucl Med Biol, 26 (7), 791-4
PubMed 10628558
Complement-mediated lysis of cultured osteosarcoma cell lines using chimeric mouse/human TP-1 IgG1 and IgG3 antibodies
Cancer Immunol Immunother, 48 (7), 411-8
PubMed 10501855
Expression of a novel factor in human breast cancer cells with metastatic potential
Cancer Res, 59 (18), 4675-80
PubMed 10493524
[Patient treatment in radiation accidents]
Tidsskr Nor Laegeforen, 119 (10), 1446-50
PubMed 10354753
Internal radionuclide therapy of primary osteosarcoma in dogs, using 153Sm-ethylene-diamino-tetramethylene-phosphonate (EDTMP)
Clin Cancer Res, 5 (10 Suppl), 3148s-3152s
PubMed 10541356
Publications 1998
Predicting detectability in radioguided surgery: a study based on physical characterization of the probe and on tissue uptake ratios of 125I-, 153Sm- and 165Er-labelled radiopharmaceuticals
Nucl Med Commun, 19 (3), 207-17
PubMed 9625495
Intratumour injection of immunoglobulins labelled with the alpha-particle emitter 211At: analyses of tumour retention, microdistribution and growth delay
Br J Cancer, 77 (7), 1115-22
PubMed 9569048
Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers
Anal Cell Pathol, 16 (1), 45-62
PubMed 9584899
IgM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells
Immunotechnology, 4 (2), 141-53
PubMed 9853955
Radiotherapy in Scandinavia
Acta Oncol, 37 (6), 553-60
PubMed 9860313
Publications 1997
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy
Eur J Cancer, 33 (11), 1725-31
PubMed 9470825
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis
Life Sci, 61 (19), PL275-80
PubMed 9364204
212Bi-DOTMP: an alpha particle emitting bone-seeking agent for targeted radiotherapy
Nucl Med Biol, 24 (3), 231-7
PubMed 9228657
Synovial sarcoma: immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance
Pathol Res Pract, 193 (1), 21-36
PubMed 9112270
Publications 1996
Targeted radiotherapy of osteosarcoma using 153 Sm-EDTMP. A new promising approach
Acta Oncol, 35 (3), 381-4
PubMed 8679270
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation
J Cell Biochem, 60 (1), 95-106
PubMed 8825419
Maxillectomy and targeted radionuclide therapy with 153Sm-EDTMP in a recurrent canine osteosarcoma
J Small Anim Pract, 37 (5), 241-6
PubMed 8736231
Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling
Acta Oncol, 35 (3), 297-301
PubMed 8679259
Extremity and non-extremity high-grade osteosarcoma -- the Norwegian Radium Hospital experience during the modern chemotherapy era
Acta Oncol, 35 Suppl 8, 129-34
PubMed 9073059
Publications 1995
Cancer therapy with radiolabeled antibodies. An overview
Acta Oncol, 34 (8), 1085-94
PubMed 8608033
Alpha-particle radiotherapy with 211At-labeled monodisperse polymer particles, 211At-labeled IgG proteins, and free 211At in a murine intraperitoneal tumor model
Gynecol Oncol, 57 (1), 9-15
PubMed 7705707
Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling
Nucl Med Biol, 22 (6), 765-71
PubMed 8535337
Publications 1994
Immunoscintigraphy of bone sarcomas--results in 5 patients
Eur J Cancer, 30A (10), 1484-9
PubMed 7833107
Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays
Radiat Res, 139 (2), 178-84
PubMed 8052693
Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody
Br J Cancer, 69 (6), 1000-5
PubMed 8198960
PET imaging of osteosarcoma in dogs using a fluorine-18-labeled monoclonal antibody Fab fragment
J Nucl Med, 35 (9), 1506-13
PubMed 8071702
Publications 1993
p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179
Publications 1992
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624
Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab')2 fragments of osteosarcoma-associated monoclonal antibody TP-1
Anticancer Res, 12 (6B), 2151-7
PubMed 1295462
Publications 1990
Radioimmunotargeting of human tumour cells in immunocompetent animals
Br J Cancer, 62 (4), 573-8
PubMed 2223574
Publications 1989
Immunohistochemical detection of osteosarcoma-associated antigen in canine osteosarcoma
Anticancer Res, 9 (4), 903-7
PubMed 2684000
Publications 1988
Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen
Cancer Res, 48 (18), 5302-9
PubMed 2457439




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