Ola Myklebost
Position: Senior Researcher, Professor, dr. philos
Phone: +47 2278 1779
Email:

Ola Myklebost is Senior Scientist and Group Leader at the Department of Tumor Biology, Institute for Cancer Research, and Professor at the Department for Molecular Biosciences at the University of Oslo. He is also Assistant Director of CAST, the Centre for research-based Innovation (SFI) on Cancer Stem Cells, and previous head of the Norwegian Genomics Consortium. Currently he is heading the Norwegian Cancer Genomics Consortium, with the aim to introduce and investigate the use of tumour genome profiles for therapeutic decisions.


Fax +47 2278 1795

Publications in OUS Publika Database

Background

He took his MSc under Per Seglen at what is now Dept. of Cell Biology in 1982, then went to St Mary's Hospital in London and got experience with recombinant DNA technology under the leadership of Bob Williamson. Returning to Oslo, he worked at the Institute for Internal Medicine at the National Hospital under Hans Prydz until 1987, when he had a research stay in the group of Keith Stanley at EMBL. From 1988 he has again been employed at the Institute of Cancer Research, now at the Dept. of Tumour Biology.

Education

  • Examen Artium (Naturfaglinjen) Eikeli Gymnasium1974
  • Cand mag (4 years of basic science) Universityof Oslo spring 1979
  • Cand real (3 years research project) University of Oslo Jan 1982
  • Doctor philosophia from the Medical Faculty, University of Oslo Oct 1990


Present positions:

Senior scientist/Group leader, Institute for Cancer Research,  Radiumhospitalet-OUS

Professor II in Bioinformatics, Institute for Molecular Biosciences, University of Oslo

Vice-Director, CAST Cancer Stem Cell Innovation Centre, OUS (cancerstemcell.no)

Head Norwegian Genomics Consortium Oslo (FUGE Platform, genomics.no), University of Oslo

Head Norwegian Cancer Genomics Consortium (cancergenomics.no)

Previous academic positions:

1983-85 Doctoral grant from Norwegian Research Council, at Institute for internal medicine, National Hospital, Oslo

1986-87 Doctoral grant from the Cancer Society, at Institute for internal medicine, National Hospital, Oslo

1995-99 Senior advisor to the National Health Board and secretary of their advisory board on the use of biotechnology in medicine, part time

International research experience:

1982-83 Royal Society Exchange grant, at Biochemistry Dept, St Mary's Hospital Medical School, London

1985 Visiting scientist at Leiden University

1987 Visiting scientist at the EMBL, Heidelberg

Academic Qualifications: Doctor Philosophiae (PhD), The Medical Faculty, University of Oslo 1990

Selected professional merits last 10 years 2001-2011:

International

Member of medical advisory board of the Liddy Shriver Sarcoma Initiative and editorial board of their newsletter, 2012-.

Work package leader in the EU Network on Excellence on bone tumours, EuroBoNet.eu, 2006-11

Head organiser of the international conference “Frontiers in cancer stem cell research, - from basic science towards a cure” with 30 top international speakers and 270 participants, Oslo, 2009

Partner of the International Liposarcoma Consortium, 2010-

Norwegian Radium Hospital representative, the Scandinavian Sarcoma Group Working Group, 1997-

Member of the EURAMOS trial Translational studies group, 2008-

National

Member of the Advisory Board on Medical Application of Biotechno­logy, Norwegian Board of Health, 2000-2

Project leader, National Norwegian Microarray Platform, Functional Genomics programme, 2002-3,-6, -9

Project leader, Norwegian Cancer Genomics Consortium, 2011 -

Regional/Institutional

Board member, FUGE-programme, “EMBIO”, UiO, 2001-6

Board member, Institute of Biochemistry, 2001-3, and the Inst. of Molecular Biosciences 2003-5, UiO

Board member (for UiO), the East Regional FUGE programme 2003-8

Board member (for UiO), the FUGE Platform for Genetic Variation (SNP or CIGENE Platform), 2003-8

Board member, the Institute for Cancer Research, The Norwegian Radium Hospital, 2004-7

Board member, the National Hospital Biobank 2007-9

Head of the National Hospital HE/UiO Microarray Core Facility, Aug 2006-7

Committee member, the South East Health Authority for core facilities 2008-9

Member, Research Council, the Clinic for Cancer, Surgery and transplantation (~3000 employees), OUS.

Innovation: Vice-Director of Centre for research-based innovation on Cancer Stem Cells funded by Norwegian Research Council, 2006-

Scientific evaluations for foreign institutions: the UK Cancer Research Campaign (CRC), Biotechnology and Biological Sciences Research Council (UK), Dutch Cancer Society (KWF), Danish Strategic Research Council, Danish Board of Health, The Dutch Cancer Society, Wallenberg Consortium North, and Italian Association for Cancer Research (AIRC)

Supervision of PhD students

Presently under supervision: 4 as main supervisor

Completed 5 as main supervisor

Publications past five years 2007-12

Publications in peer-reviewed journals: 28

Total career publications (Original): 108

Total citations 4836, average 41,7, H index 35

Impact > 5: - EMBO J (1), PNAS (1), Nature Biotechnology (1), Blood (1), J Natl Cancer Inst (1),
J Biol Chem (1), Cancer Res (6), Clin Cancer Res (1), Cancer (1), Oncogene (5), Leukemia (2), Bioinformatics (2), Biochem J (1), Nucl Acids Res (2)

 

 

Author network for Ola Myklebost by COREMINE medical


Publications in press

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Høgset A, Myklebost O, Selbo PK
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta (in press)
PubMed 23643966

Publications 2013

Bianchini L, Birtwisle L, Saâda E, Bazin A, Long E, Roussel JF, Michiels JF, Forest F, Dani C, Myklebost O, Birtwisle-Peyrottes I, Pedeutour F (2013)
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
Genes Chromosomes Cancer, 52 (6), 580-90
PubMed 23508853

Doorn J, Fernandes HA, Le BQ, van de Peppel J, van Leeuwen JP, De Vries MR, Aref Z, Quax PH, Myklebost O, Saris DB, van Blitterswijk CA, de Boer J (2013)
A small molecule approach to engineering vascularized tissue
Biomaterials, 34 (12), 3053-63
PubMed 23369216

Ohnstad HO, Castro R, Sun J, Heintz KM, Vassilev LT, Bjerkehagen B, Kresse SH, Meza-Zepeda LA, Myklebost O (2013)
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
Cancer, 119 (5), 1013-22
PubMed 23165797

Publications 2012

Kresse SH, Meza-Zepeda LA, Machado I, Llombart-Bosch A, Myklebost O (2012)
Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
Cancer, 118 (2), 558-70
PubMed 21713766

Kresse SH, Rydbeck H, Skårn M, Namløs HM, Barragan-Polania AH, Cleton-Jansen AM, Serra M, Liestøl K, Hogendoorn PC, Hovig E, Myklebost O, Meza-Zepeda LA (2012)
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
PLoS One, 7 (11), e48262
PubMed 23144859

Kuijjer ML, Rydbeck H, Kresse SH, Buddingh EP, Lid AB, Roelofs H, Bürger H, Myklebost O, Hogendoorn PC, Meza-Zepeda LA, Cleton-Jansen AM (2012)
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data
Genes Chromosomes Cancer, 51 (7), 696-706
PubMed 22454324

Namløs HM, Kresse SH, Müller CR, Henriksen J, Holdhus R, Sæter G, Bruland OS, Bjerkehagen B, Steen VM, Myklebost O (2012)
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
Sarcoma, 2012, 639038
PubMed 22518090

Namløs HM, Meza-Zepeda LA, Barøy T, Østensen IH, Kresse SH, Kuijjer ML, Serra M, Bürger H, Cleton-Jansen AM, Myklebost O (2012)
Modulation of the osteosarcoma expression phenotype by microRNAs
PLoS One, 7 (10), e48086
PubMed 23133552

Skotheim RI, Meza-Zepeda LA, Hovig E, Lønning PE, Lothe RA, Myklebost O (2012)
[Genome sequencing for personalized cancer treatment]
Tidsskr Nor Laegeforen, 132 (21), 2406-8
PubMed 23160594

Skårn M, Namløs HM, Noordhuis P, Wang MY, Meza-Zepeda LA, Myklebost O (2012)
Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
Stem Cells Dev, 21 (6), 873-83
PubMed 21756067

Stratford EW, Castro R, Daffinrud J, Skårn M, Lauvrak S, Munthe E, Myklebost O (2012)
Characterization of liposarcoma cell lines for preclinical and biological studies
Sarcoma, 2012, 148614
PubMed 22911243

Publications 2011

Buddingh EP, Kuijjer ML, Duim RA, Bürger H, Agelopoulos K, Myklebost O, Serra M, Mertens F, Hogendoorn PC, Lankester AC, Cleton-Jansen AM (2011)
Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agents
Clin Cancer Res, 17 (8), 2110-9
PubMed 21372215

Hjortland GO, Meza-Zepeda LA, Beiske K, Ree AH, Tveito S, Hoifodt H, Bohler PJ, Hole KH, Myklebost O, Fodstad O, Smeland S, Hovig E (2011)
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
BMC Cancer, 11, 455
PubMed 22014070

Kuijjer ML, Namløs HM, Hauben EI, Machado I, Kresse SH, Serra M, Llombart-Bosch A, Hogendoorn PC, Meza-Zepeda LA, Myklebost O, Cleton-Jansen AM (2011)
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
BMC Med Genomics, 4, 66
PubMed 21933437

Ohnstad HO, Paulsen EB, Noordhuis P, Berg M, Lothe RA, Vassilev LT, Myklebost O (2011)
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
BMC Cancer, 11, 211:1-11
PubMed 21624110

Stratford EW, Castro R, Wennerstrom A, Holm R, Munthe E, Lauvrak S, Bjerkehagen B, Myklebost O (2011)
Liposarcoma Cells with Aldefluor and CD133 Activity have a Cancer Stem Cell Potential
Clin Sarcoma Res, 1 (1), 8
PubMed 22612877

Publications 2010

Eide MB, Liestøl K, Lingjaerde OC, Hystad ME, Kresse SH, Meza-Zepeda L, Myklebost O, Trøen G, Aamot HV, Holte H, Smeland EB, Delabie J (2010)
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
PubMed 20505157

Henriksen J, Stabell M, Meza-Zepeda LA, Lauvrak SA, Kassem M, Myklebost O (2010)
Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
BMC Cancer, 10, 329
PubMed 20576167

Kresse SH, Ohnstad HO, Bjerkehagen B, Myklebost O, Meza-Zepeda LA (2010)
DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
PLoS One, 5 (11), e15378
PubMed 21085701

Kresse SH, Szuhai K, Barragan-Polania AH, Rydbeck H, Cleton-Jansen AM, Myklebost O, Meza-Zepeda LA (2010)
Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
BMC Res Notes, 3, 223
PubMed 20691109

Mayordomo E, Machado I, Giner F, Kresse SH, Myklebost O, Carda C, Navarro S, Llombart-Bosch A (2010)
A tissue microarray study of osteosarcoma: histopathologic and immunohistochemical validation of xenotransplanted tumors as preclinical models
Appl Immunohistochem Mol Morphol, 18 (5), 453-61
PubMed 20436344

Ottaviano L, Schaefer KL, Gajewski M, Huckenbeck W, Baldus S, Rogel U, Mackintosh C, de Alava E, Myklebost O, Kresse SH, Meza-Zepeda LA, Serra M, Cleton-Jansen AM, Hogendoorn PC, Buerger H, Aigner T, Gabbert HE, Poremba C (2010)
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort
Genes Chromosomes Cancer, 49 (1), 40-51
PubMed 19787792

Tenstad E, Tourovskaia A, Folch A, Myklebost O, Rian E (2010)
Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device
Lab Chip, 10 (11), 1401-1409
PubMed 20386793

Publications 2009

Kresse SH, Ohnstad HO, Paulsen EB, Bjerkehagen B, Szuhai K, Serra M, Schaefer KL, Myklebost O, Meza-Zepeda LA (2009)
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
Genes Chromosomes Cancer, 48 (8), 679-93
PubMed 19441093

Lehne G, Grasmo-Wendler UH, Berner JM, Meza-Zepeda LA, Adamsen BL, Flack A, Reiner A, Clausen OP, Hovig E, Myklebost O (2009)
Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
Leuk Res, 33 (10), 1379-85
PubMed 19394083

Myklebost O, Noordhuis P (2009)
Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGF beta/BMP-6 and TIEG1 in chemotherapy escape. (vol 123, pg 2759, 2008)
Int. J. Cancer, 124 (9), 2250

Publications 2008

Kresse SH, Skårn M, Ohnstad HO, Namløs HM, Bjerkehagen B, Myklebost O, Meza-Zepeda LA (2008)
DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
Mol Cancer, 7, 48
PubMed 18522746

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008)
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
PubMed 18500990

Meza-Zepeda LA, Noer A, Dahl JA, Micci F, Myklebost O, Collas P (2008)
High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
J Cell Mol Med, 12 (2), 553-63
PubMed 18419597

Roman E, Meza-Zepeda LA, Kresse SH, Myklebost O, Vasstrand EN, Ibrahim SO (2008)
Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization
Oncol Rep, 20 (4), 825-43
PubMed 18813824

Publications 2007

Francis P, Namløs HM, Müller C, Edén P, Fernebro J, Berner JM, Bjerkehagen B, Akerman M, Bendahl PO, Isinger A, Rydholm A, Myklebost O, Nilbert M (2007)
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential
BMC Genomics, 8, 73
PubMed 17359542

Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Mol Cancer, 6, 2
PubMed 17201907

Müller CR, Paulsen EB, Noordhuis P, Pedeutour F, Saeter G, Myklebost O (2007)
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
Int J Cancer, 121 (1), 199-205
PubMed 17354236

Publications 2006

Berner JM, Muller CR, Holden M, Wang J, Hovig E, Myklebost O (2006)
Sampling effects on gene expression data from a human tumour xenograft
Scand. J. Lab. Anim. Sci., 33 (1), 17-30

MAQC Consortium, Shi L, Reid LH, Jones WD, Shippy R, Warrington JA, Baker SC, Collins PJ, de Longueville F, Kawasaki ES, Lee KY, Luo Y, Sun YA, Willey JC, Setterquist RA, Fischer GM, Tong W, Dragan YP, Dix DJ, Frueh FW, Goodsaid FM, Herman D, Jensen RV, Johnson CD, Lobenhofer EK et al. (2006)
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
Nat Biotechnol, 24 (9), 1151-61
PubMed 16964229

Meza-Zepeda LA, Kresse SH, Barragan-Polania AH, Bjerkehagen B, Ohnstad HO, Namløs HM, Wang J, Kristiansen BE, Myklebost O (2006)
Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
Cancer Res, 66 (18), 8984-93
PubMed 16982739

Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, Patzke S, Smeland EB, Stokke T (2006)
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
PubMed 16437153

Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT (2006)
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
Proc Natl Acad Sci U S A, 103 (6), 1888-93
PubMed 16443686

Publications 2005

Agesen TH, Flørenes VA, Molenaar WM, Lind GE, Berner JM, Plaat BE, Komdeur R, Myklebost O, van den Berg E, Lothe RA (2005)
Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 64 (1), 74-81
PubMed 15715087

Bjerkehagen B, Myklebost O (2005)
[Molecular genetics in the diagnosis of bone and soft tissue tumours]
Tidsskr Nor Laegeforen, 125 (23), 3286-9
PubMed 16327856

Galteland E, Sivertsen EA, Svendsrud DH, Smedshammer L, Kresse SH, Meza-Zepeda LA, Myklebost O, Suo Z, Mu D, Deangelis PM, Stokke T (2005)
Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas
Leukemia, 19 (12), 2313-23
PubMed 16193090

Kresse SH, Berner JM, Meza-Zepeda LA, Gregory SG, Kuo WL, Gray JW, Forus A, Myklebost O (2005)
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
Mol Cancer, 4, 39
PubMed 16274472

Lyng H, Landsverk KS, Kristiansen E, DeAngelis PM, Ree AH, Myklebost O, Hovig E, Stokke T (2005)
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
PubMed 15723354

Nygaard V, Holden M, Løland A, Langaas M, Myklebost O, Hovig E (2005)
Limitations of mRNA amplification from small-size cell samples
BMC Genomics, 6, 147
PubMed 16253144

Publications 2004

Cekaite L, Haug O, Myklebost O, Aldrin M, Østenstad B, Holden M, Frigessi A, Hovig E, Sioud M (2004)
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-82
PubMed 15352232

Lyng H, Badiee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T (2004)
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
PubMed 15018648

Myklebost O (2004)
Putting Norway on the gene-therapy map
Nature, 429 (6988), 129
PubMed 15141186

Nilbert M, Meza-Zepeda LA, Francis P, Berner JM, Namløs HM, Fernebro J, Myklebost O (2004)
Lessons from genetic profiling in soft tissue sarcomas
Acta Orthop Scand Suppl, 75 (311), 35-50
PubMed 15188664

Nilsson M, Meza-Zepeda LA, Mertens F, Forus A, Myklebost O, Mandahl N (2004)
Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas
Int J Cancer, 109 (3), 363-9
PubMed 14961574

Trøen G, Nygaard V, Jenssen TK, Ikonomou IM, Tierens A, Matutes E, Gruszka-Westwood A, Catovsky D, Myklebost O, Lauritzsen G, Hovig E, Delabie J (2004)
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
J Mol Diagn, 6 (4), 297-307
PubMed 15507668

Wang J, Meza-Zepeda LA, Kresse SH, Myklebost O (2004)
M-CGH: analysing microarray-based CGH experiments
BMC Bioinformatics, 5, 74
PubMed 15189572

Publications 2003

Andersen K, Smith-Sørensen B, Pedersen KB, Hovig E, Myklebost O, Fodstad Ø, Maelandsmo GM (2003)
Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest
Br J Cancer, 88 (12), 1995-2001
PubMed 12799648

Henriksen J, Aagesen TH, Maelandsmo GM, Lothe RA, Myklebost O, Forus A (2003)
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
Oncogene, 22 (34), 5358-61
PubMed 12917637

Maire G, Forus A, Foa C, Bjerkehagen B, Mainguené C, Kresse SH, Myklebost O, Pedeutour F (2003)
11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5
Genes Chromosomes Cancer, 37 (4), 389-95
PubMed 12800150

Nygaard V, Løland A, Holden M, Langaas M, Rue H, Liu F, Myklebost O, Fodstad Ø, Hovig E, Smith-Sørensen B (2003)
Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance
BMC Genomics, 4 (1), 11
PubMed 12659661

Wang J, Bø TH, Jonassen I, Myklebost O, Hovig E (2003)
Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data
BMC Bioinformatics, 4, 60
PubMed 14651757

Wang J, Myklebost O, Hovig E (2003)
MGraph: graphical models for microarray data analysis
Bioinformatics, 19 (17), 2210-1
PubMed 14630649

Publications 2002

Jenssen TK, Langaas M, Kuo WP, Smith-Sørensen B, Myklebost O, Hovig E (2002)
Analysis of repeatability in spotted cDNA microarrays
Nucleic Acids Res, 30 (14), 3235-44
PubMed 12136105

Meza-Zepeda LA, Forus A, Lygren B, Dahlberg AB, Godager LH, South AP, Marenholz I, Lioumi M, Flørenes VA, Maelandsmo GM, Serra M, Mischke D, Nizetic D, Ragoussis J, Tarkkanen M, Nesland JM, Knuutila S, Myklebost O (2002)
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
Oncogene, 21 (14), 2261-9
PubMed 11948409

Wang J, Delabie J, Aasheim H, Smeland E, Myklebost O (2002)
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
BMC Bioinformatics, 3, 36
PubMed 12445336

Wang J, Nygaard V, Smith-Sørensen B, Hovig E, Myklebost O (2002)
MArray: analysing single, replicated or reversed microarray experiments
Bioinformatics, 18 (8), 1139-40
PubMed 12176840

Xie Y, Skytting B, Nilsson G, Grimer RJ, Mangham CD, Fisher C, Shipley J, Bjerkehagen B, Myklebost O, Larsson O (2002)
The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery
Oncogene, 21 (37), 5791-6
PubMed 12173050

Publications 2001

Forus A, Bjerkehagen B, Sirvent N, Meza-Zepeda LA, Coindre JM, Berner JM, Myklebost O, Pedeutour F (2001)
A well-differentiated liposarcoma with a new type of chromosome 12-derived markers
Cancer Genet Cytogenet, 131 (1), 13-8
PubMed 11734312

Forus A, D'Angelo A, Henriksen J, Merla G, Maelandsmo GM, Flørenes VA, Olivieri S, Bjerkehagen B, Meza-Zepeda LA, del Vecchio Blanco F, Müller C, Sanvito F, Kononen J, Nesland JM, Fodstad Ø, Reymond A, Kallioniemi OP, Arrigoni G, Ballabio A, Myklebost O, Zollo M (2001)
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity
Oncogene, 20 (47), 6881-90
PubMed 11687967

Forus A, Larramendy ML, Meza-Zepeda LA, Bjerkehagen B, Godager LH, Dahlberg AB, Saeter G, Knuutila S, Myklebost O (2001)
Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases
Cancer Genet Cytogenet, 125 (2), 100-11
PubMed 11369052

Forus A, Sørlie T, Børresen-Dale AL, Myklebost O (2001)
[Microarray technology--potential in cancer research]
Tidsskr Nor Laegeforen, 121 (21), 2498-503
PubMed 11875927

Hovig E, Myklebost O, Aamdal S, Smeland EB (2001)
[Gene therapy in cancer]
Tidsskr Nor Laegeforen, 121 (4), 482-8
PubMed 11255868

Meza-Zepeda LA, Berner JM, Henriksen J, South AP, Pedeutour F, Dahlberg AB, Godager LH, Nizetic D, Forus A, Myklebost O (2001)
Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions
Genes Chromosomes Cancer, 31 (3), 264-73
PubMed 11391797

Sandvik AK, Støren O, Nørsett K, Laegreid A, Børresen-Dale AL, Myklebost O (2001)
[Measurement of gene activity by DNA microarrays]
Tidsskr Nor Laegeforen, 121 (10), 1225-8
PubMed 11402749

Publications 2000

Simons A, Schepens M, Jeuken J, Sprenger S, van de Zande G, Bjerkehagen B, Forus A, Weibolt V, Molenaar I, van den Berg E, Myklebost O, Bridge J, van Kessel AG, Suijkerbuijk R (2000)
Frequent loss of 9p21 (p16(INK4A)) and other genomic imbalances in human malignant fibrous histiocytoma
Cancer Genet Cytogenet, 118 (2), 89-98
PubMed 10748288

Sirvent N, Forus A, Lescaut W, Burel F, Benzaken S, Chazal M, Bourgeon A, Vermeesch JR, Myklebost O, Turc-Carel C, Ayraud N, Coindre JM, Pedeutour F (2000)
Characterization of centromere alterations in liposarcomas
Genes Chromosomes Cancer, 29 (2), 117-29
PubMed 10959091

Publications 1999

Berner JM, Sørlie T, Mertens F, Henriksen J, Saeter G, Mandahl N, Brøgger A, Myklebost O, Lothe RA (1999)
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway
Genes Chromosomes Cancer, 26 (2), 151-60
PubMed 10469453

Forus A, Høifødt HK, Overli GE, Myklebost O, Fodstad O (1999)
Sensitive fluorescent in situ hybridisation method for the characterisation of breast cancer cells in bone marrow aspirates
Mol Pathol, 52 (2), 68-74
PubMed 10474684

Pedeutour F, Forus A, Coindre JM, Berner JM, Nicolo G, Michiels JF, Terrier P, Ranchere-Vince D, Collin F, Myklebost O, Turc-Carel C (1999)
Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors
Genes Chromosomes Cancer, 24 (1), 30-41
PubMed 9892106

Simons A, Schepens M, Forus A, Godager L, van Asseldonk M, Myklebost O, van Kessel AG (1999)
A novel chromosomal region of allelic loss, 4q32-q34, in human osteosarcomas revealed by representational difference analysis
Genes Chromosomes Cancer, 26 (2), 115-24
PubMed 10469449

Wolf M, Tarkkanen M, Hulsebos T, Larramendy ML, Forus A, Myklebost O, Aaltonen LA, Elomaa I, Knuutila S (1999)
Characterization of the 17p amplicon in human sarcomas: microsatellite marker analysis
Int J Cancer, 82 (3), 329-33
PubMed 10399948

Publications 1998

Forus A, Berner JM, Meza-Zepeda LA, Saeter G, Mischke D, Fodstad O, Myklebost O (1998)
Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas
Br J Cancer, 78 (4), 495-503
PubMed 9716033

Myklebost O (1998)
[Molecular biology diagnosis of sarcoma]
Tidsskr Nor Laegeforen, 118 (14), 2188-93
PubMed 9656816

Myklebost O (1998)
GLI gene and rhabdomyosarcoma
Nat Med, 4 (8), 869
PubMed 9701218

Publications 1997

Armengol G, Tarkkanen M, Virolainen M, Forus A, Valle J, Böhling T, Asko-Seljavaara S, Blomqvist C, Elomaa I, Karaharju E, Kivioja AH, Siimes MA, Tukiainen E, Caballín MR, Myklebost O, Knuutila S (1997)
Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization
Br J Cancer, 75 (10), 1403-9
PubMed 9166930

Berner JM, Meza-Zepeda LA, Kools PF, Forus A, Schoenmakers EF, Van de Ven WJ, Fodstad O, Myklebost O (1997)
HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas
Oncogene, 14 (24), 2935-41
PubMed 9205100

Geurts van Kessel A, dos Santos NR, Simons A, de Bruijn D, Forus A, Fodstad O, Myklebost O, Balemans M, Baats E, Olde Weghuis D, Suijkerbuijk RF, van den Berg E, Molenaar WM, de Leeuw B (1997)
Molecular cytogenetics of bone and soft tissue tumors
Cancer Genet Cytogenet, 95 (1), 67-73
PubMed 9140455

vanKessel AG, dosSantos NR, Simons A, deBruijn D, Forus A, Fodstad O, Myklebost O, Balemans M, Baats E, Weghuis DO, Suijkerbuijk RF, vandenBerg E, Molenaar WM, deLeeuw B (1997)
Molecular cytogenetics of bone and soft tissue tumors
Cancer Genet. Cytogenet., 95 (1), 67-73

Wolf M, Aaltonen LA, Szymanska J, Tarkkanen M, Blomqvist C, Berner JM, Myklebost O, Knuutila S (1997)
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis
Genes Chromosomes Cancer, 18 (1), 66-70
PubMed 8993982

Publications 1996

Berner JM, Forus A, Elkahloun A, Meltzer PS, Fodstad O, Myklebost O (1996)
Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas
Genes Chromosomes Cancer, 17 (4), 254-9
PubMed 8946207

Maelandsmo GM, Hovig E, Skrede M, Engebraaten O, Flørenes VA, Myklebost O, Grigorian M, Lukanidin E, Scanlon KJ, Fodstad O (1996)
Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme
Cancer Res, 56 (23), 5490-8
PubMed 8968106

Myklebost O (1996)
First for biotech
Nature, 384 (6606), 208
PubMed 8918866

Publications 1995

Forus A, Weghuis DO, Smeets D, Fodstad O, Myklebost O, Geurts van Kessel A (1995)
Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas
Genes Chromosomes Cancer, 14 (1), 15-21
PubMed 8527379

Forus A, Weghuis DO, Smeets D, Fodstad O, Myklebost O, van Kessel AG (1995)
Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas
Genes Chromosomes Cancer, 14 (1), 8-14
PubMed 8527390

Kulseth MA, Krajci P, Myklebost O, Rogne S (1995)
Cloning and characterization of two forms of bovine polymeric immunoglobulin receptor cDNA
DNA Cell Biol, 14 (3), 251-6
PubMed 7880445

Maelandsmo GM, Berner JM, Flørenes VA, Forus A, Hovig E, Fodstad O, Myklebost O (1995)
Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1
Br J Cancer, 72 (2), 393-8
PubMed 7640224

Van Roy N, Forus A, Myklebost O, Cheng NC, Versteeg R, Speleman F (1995)
Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP
Cancer Genet Cytogenet, 82 (2), 151-4
PubMed 7664245

Publications 1994

Flørenes VA, Holm R, Myklebost O, Lendahl U, Fodstad O (1994)
Expression of the neuroectodermal intermediate filament nestin in human melanomas
Cancer Res, 54 (2), 354-6
PubMed 8275467

Flørenes VA, Maelandsmo GM, Forus A, Andreassen A, Myklebost O, Fodstad O (1994)
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status
J Natl Cancer Inst, 86 (17), 1297-302
PubMed 8064888

Forus A, Flørenes VA, Maelandsmo GM, Fodstad O, Myklebost O (1994)
The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas
Cancer Genet Cytogenet, 78 (2), 165-71
PubMed 7828148

Forus A, Kools PF, Schoenmakers EF, Van de Ven WJ, Myklebost O (1994)
A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12
Hum Genet, 94 (3), 259-64
PubMed 8076941

Suijkerbuijk RF, Olde Weghuis DE, Van den Berg M, Pedeutour F, Forus A, Myklebost O, Glier C, Turc-Carel C, Geurts van Kessel A (1994)
Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas
Genes Chromosomes Cancer, 9 (4), 292-5
PubMed 7519052

Publications 1993

ANDREASSEN A, BORRESEN AL, OYJORD T, SOLHEIM OP, FLORENES VA, BRULAND O, MYKLEBOST O, HOIE J, FODSTAD O (1993)
CHROMOSOME-17P ABERRATIONS AND P53 EXPRESSION IN HUMAN SARCOMAS
FRONTIERS OF OSTEOSARCOMA RESEARCH: INTERDISCIPLINARY SURVEY OF CLINICAL AND RESEARCH ADVANCES, 419-422

Andreassen A, Oyjord T, Hovig E, Holm R, Flørenes VA, Nesland JM, Myklebost O, Høie J, Bruland OS, Børresen AL (1993)
p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179

Brzozowska A, Fries R, Womack JE, Grimholt U, Myklebost O, Rogne S (1993)
Isolation, sequencing, and expression analysis of a bovine apolipoprotein E (APOE) cDNA and chromosomal localization of the APOE locus
Mamm Genome, 4 (1), 53-7
PubMed 8422503

Forus A, Flørenes VA, Maelandsmo GM, Meltzer PS, Fodstad O, Myklebost O (1993)
Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2
Cell Growth Differ, 4 (12), 1065-70
PubMed 8117620

Publications 1992

Flørenes VA, Aamdal S, Myklebost O, Maelandsmo GM, Bruland OS, Fodstad O (1992)
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624

Forus A, Myklebost O (1992)
A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci
Genomics, 14 (1), 117-20
PubMed 1427818

Skrede B, Blomhoff R, Maelandsmo GM, Ose L, Myklebost O, Norum KR (1992)
Uptake of chylomicron remnant retinyl esters in human leukocytes in vivo
Eur J Clin Invest, 22 (4), 229-34
PubMed 1499639

Publications 1991

Rogne S, Myklebost O, Olving JH, Kyrkjebø HT, Jonassen R, Olaisen B, Gedde-Dahl T (1991)
The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5
J Med Genet, 28 (9), 587-90
PubMed 1683409

Publications 1990

Myklebost O, Rogne S, Hjermann I, Olaisen B, Prydz H (1990)
Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms
Hum Genet, 86 (2), 209-14
PubMed 1979958

Rogne S, Mevåg B, Gedde-Dahl T, Myklebost O (1990)
Multiple RFLPs of human complement component nine (C9) detected by TaqI
Nucleic Acids Res, 18 (10), 3112
PubMed 1971940

Publications 1989

Myklebost O, Arheden K, Rogne S, Geurts van Kessel A, Mandahl N, Herz J, Stanley K, Heim S, Mitelman F (1989)
The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14
Genomics, 5 (1), 65-9
PubMed 2548950

Nenseter MS, Myklebost O, Blomhoff R, Drevon CA, Nilsson A, Norum KR, Berg T (1989)
Low-density-lipoprotein receptors in different rabbit liver cells
Biochem J, 261 (2), 587-93
PubMed 2549976

Rogne S, Myklebost O, Høyheim B, Olaisen B, Gedde-Dahl T (1989)
The genes for apolipoprotein all (APOA2) and the Duffy blood group (FY) are linked on chromosome 1 in man
Genomics, 4 (2), 169-73
PubMed 2500391

Rogne S, Myklebost O, Stanley K, Geurts van Kessel A (1989)
The gene for human complement C9 is on chromosome 5
Genomics, 5 (1), 149-52
PubMed 2767685

Publications 1988

Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK (1988)
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
EMBO J, 7 (13), 4119-27
PubMed 3266596

Myklebost O, Rogne S (1988)
A physical map of the apolipoprotein gene cluster on human chromosome 19
Hum Genet, 78 (3), 244-7
PubMed 2894348

Publications 1987

Rogne S, Skretting G, Larsen F, Myklebost O, Mevåg B, Carlson LA, Holmquist L, Gjone E, Prydz H (1987)
The isolation and characterisation of a cDNA clone for human lecithin:cholesterol acyl transferase and its use to analyse the genes in patients with LCAT deficiency and fish eye disease
Biochem Biophys Res Commun, 148 (1), 161-9
PubMed 2823801

Publications 1986

Myklebost O, Rogne S (1986)
The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19
Hum Genet, 73 (4), 286-9
PubMed 3017837

Rogne S, Myklebost O, Olaisen B, Gedde-Dahl T, Prydz H (1986)
Confirmation of the close linkage between the loci for human apolipoproteins AI and AIV by the use of a cloned cDNA probe and two restriction site polymorphisms
Hum Genet, 72 (1), 68-71
PubMed 3002953

Publications 1985

Rogne S, Rønning OW, Myklebost O, Seglen PO, Pettersen EO (1985)
Cell cycle traverse and protein metabolism in human NHIK 3025 cells: the role of anchorage
J Cell Physiol, 125 (3), 528-32
PubMed 4066771

Shaw DJ, Meredith AL, Sarfarazi M, Huson SM, Brook JD, Myklebost O, Harper PS (1985)
The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus
Hum Genet, 70 (3), 271-3
PubMed 2991117

Publications 1984

Humphries SE, Williams L, Myklebost O, Stalenhoef AF, Demacker PN, Baggio G, Crepaldi G, Galton DJ, Williamson R (1984)
Familial apolipoprotein CII deficiency: a preliminary analysis of the gene defect in two independent families
Hum Genet, 67 (2), 151-5
PubMed 6547689

Myklebost O, Rogne S, Olaisen B, Gedde-Dahl T, Prydz H (1984)
The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man
Hum Genet, 67 (3), 309-12
PubMed 6088388

Myklebost O, Williamson B, Markham AF, Myklebost SR, Rogers J, Woods DE, Humphries SE (1984)
The isolation and characterization of cDNA clones for human apolipoprotein CII
J Biol Chem, 259 (7), 4401-4
PubMed 6546757

Publications 1983

Humphries SE, Jowett NI, Williams L, Rees A, Vella M, Kessling A, Myklebost O, Lydon A, Seed M, Galton DJ (1983)
A DNA polymorphism adjacent to the human apolipoprotein CII gene
Mol Biol Med, 1 (5), 463-71
PubMed 6094958