Current research activity

 

1. Mechanisms of endocytosis. Cells internalize molecules from the exterior by at least two distinct pathways of endocytosis. While the clathrin dependent pathway of endocytosis is best characterized so far, this group also studies the alternative mechanism of clathrin independent endocytosis.

2. Retrograde transport of protein toxins. After being endocytosed, certain protein toxins, such as Shiga toxin, are transported in a retrograde manner through the Golgi stack before they translocate their enzymatic moiety to the cytosol. The mechanisms of retrograde transport are being studied.