
| Kirsten Sandvig | |
| Position: | Professor / Group Leader |
| Phone: | +47 22 78 18 28 |
| Email: | |
Curriculum Vitae
The Technical University of Norway, Trondheim, Norway, 1973.
Ph.D.:
The University of Oslo, 1979. Dissertation: Interaction of the toxic lectins abrin, ricin and modeccin with mammalian cells.
Postgraduate positions:
1979- cont. Senior biochemist at The Institute for Cancer Research at the Norwegian Radium Hospital, Oslo, Norway.
1996- Professor of Biochemistry at the University of Oslo (in addition to the position at the Norwegian Radium Hospital).
Visiting scientist:
The University of Michigan, Ann Arbor, USA, 3 months, 1979.
The Biological Laboratories, Harvard, Cambridge, USA, 2 months, 1980.
Awards and Honours:
1989: Anders Jahres Medical Prize for Younger Scientists.
1990: Award of The Norwegian Research Council for Science and the Humanities.
1993: Member of The Norwegian Academy of Science.
1995: Stiansen's Biomedical Prize.
1998: King Olav V´s Cancer Research Prize.
1998: Elected member of EMBO.
1999: Award from the Res.Comp. of the the Norwegian Radium Hospital.
2002: Elected member of Academia Europaea.
2007: Member of the centre of excellence: Centre for Cancer Biomedicine.
2007: Honorary Doctor at the University of Copenhagen, Denmark.
2010: Member of the American Academy of Microbiology.
Societies:
The Norwegian Biochemical Society (NBS).
American Society for Cell Biology (ASCB).
American Association for Cancer Research (AACR).
European Life Scientist Organization (ELSO).
Administration and Boards:
Chairman of the Oslo division of the Norwegian Biochemical Society, 1981.
Member of the board at the Norwegian Radium Hospital from 1987-1990.
Member of the Scientific Counsil of the Norwegian Cancer Society from 1992-1997.
Member of the Editorial Board of Eur.J.Cell Biol. from January 1995.
Member of the Editorial Board of Physiological Reviews from 1996-2002.
Member of the Scientific Evaluation Committee of the Norwegian Cancer Society from 1997.
Member of the EMBO course committee from January 2000-2003.
Member of the ETOX steering committee from 2007.
Member of the board for the Centre of Excellence: Centre for Molecular Biology and Neuroscience (CMBN) from August 2008.
Publications and Research Interests:
Number of articles:~270. The publications include studies in the following fields: Mechanism of action of toxins, virology, anion transport and regulation of intracellular pH, endocytosis and intracellular transport. 2 patents on related subjects.
Author network for Kirsten Sandvig by COREMINE medical
Publications in press
Highly potent inhibitors of the proprotein convertase furin as potential drugs for the treatment of infectious diseases
J Biol Chem (in press)
PubMed 22539349
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3
Mol Cell Proteomics (in press)
PubMed 22457534
Publications 2012
Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner
Traffic, 13 (3), 443-54
PubMed 22132807
Publications 2011
Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity
Biochem Biophys Res Commun, 408 (3), 405-10
PubMed 21513701
Derlin-dependent retrograde transport from endosomes to the Golgi apparatus
Traffic, 12 (10), 1417-31
PubMed 21722281
Shiga toxin and its use in targeted cancer therapy and imaging
Microb Biotechnol, 4 (1), 32-46
PubMed 21255370
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling
PLoS One, 6 (7), e21708
PubMed 21779335
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
Nano Today, 6 (2), 176-185
Role of phospholipase a(2) in retrograde transport of ricin
Toxins (Basel), 3 (9), 1203-19
PubMed 22069763
Clathrin-independent endocytosis: mechanisms and function
Curr Opin Cell Biol, 23 (4), 413-20
PubMed 21466956
Comment on >short ligands affect modes of QD uptake and elimination in human cells>
ACS Nano, 5 (10), 7690; author reply 7691-2
PubMed 22023400
A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
Biochem J, 436 (2), 371-85
PubMed 21388347
Protein C mutation (A267T) results in ER retention and unfolded protein response activation
PLoS One, 6 (8), e24009
PubMed 21901152
Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells
FEMS Immunol Med Microbiol, 61 (1), 63-75
PubMed 21054580
Publications 2010
Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms
Cell Microbiol, 12 (12), 1809-20
PubMed 20690924
Interplay between toxin transport and flotillin localization
PLoS One, 5 (1), e8844
PubMed 20107503
Endocytosis and retrograde transport of Shiga toxin
Toxicon, 56 (7), 1181-5
PubMed 19951719
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine
FEBS Lett, 584 (12), 2626-34
PubMed 20385131
New metal-based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging
Nanomedicine, 6 (6), 730-7
PubMed 20570639
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport
BMC Cell Biol, 11, 67
PubMed 20815936
The Intracellular Journey of Shiga Toxins
The Open Toxinology Journal, 3, 3-12
PublikaID 24
Shiga toxin increases formation of clathrin-coated pits through Syk kinase
PLoS One, 5 (7), e10944
PubMed 20668539
Publications 2009
Sorting nexin 8 regulates endosome-to-Golgi transport
Biochem Biophys Res Commun, 390 (1), 109-14
PubMed 19782049
Ligand-specific induction of endocytosis in taste receptor cells
J Exp Biol, 212 (Pt 1), 42-9
PubMed 19088209
Quantum dot bioconjugates: uptake into cells and induction of changes in normal cellular transport
San Jose, CA, USA, SPIE, 1, 7189[1], 71890T-9
PublikaID 29
Quantum dot bioconjugates: Uptake into cells and induction of changes in normal cellular transport
P SOC PHOTO-OPT INS, 7189, 71890T
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin
Traffic, 10 (7), 868-82
PubMed 19453975
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
PubMed 19529763
?-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
PubMed 19159388
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
PubMed 19289168
Publications 2008
Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity
Histochem Cell Biol, 129 (3), 267-76
PubMed 18193449
Cell biology: Viruses in camouflage
Nature, 453 (7194), 466-7
PubMed 18497813
Cellular trafficking of quantum dot-ligand bioconjugates and their induction of changes in normal routing of unconjugated ligands
Nano Lett, 8 (7), 1858-65
PubMed 18570482
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
PubMed 17959827
Publications 2007
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
PubMed 17382318
Structural requirements for furin-induced cleavage and activation of Shiga toxin
Biochem Biophys Res Commun, 357 (1), 144-9
PubMed 17407762
Cholesterol regulates prostasome release from secretory lysosomes in PC-3 human prostate cancer cells
Eur J Cell Biol, 86 (7), 405-15
PubMed 17601634
Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol
Virology, 369 (1), 105-18
PubMed 17714753
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
PubMed 17319803
Polyunsaturated fatty acids regulate Shiga toxin transport
Biochem Biophys Res Commun, 364 (2), 283-8
PubMed 17942073
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
PubMed 17403690
SNX1 and SNX2 mediate retrograde transport of Shiga toxin
Biochem Biophys Res Commun, 358 (2), 566-70
PubMed 17498660
Publications 2006
Depletion of sphingolipids facilitates endosome to Golgi transport of ricin
Traffic, 7 (9), 1243-53
PubMed 16919154
Shiga toxin regulates its entry in a Syk-dependent manner
Mol Biol Cell, 17 (3), 1096-109
PubMed 16371508
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Mol Biol Cell, 17 (4), 1664-75
PubMed 16452630
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'
Traffic, 7 (6), 663-72
PubMed 16683916
Publications 2005
Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism
Traffic, 6 (2), 144-56
PubMed 15634214
Cellular internalization of cytolethal distending toxin: a new end to a known pathway
Cell Microbiol, 7 (7), 921-34
PubMed 15953025
Caveolae: stable membrane domains with a potential for internalization
Traffic, 6 (9), 720-4
PubMed 16101676
Delivery into cells: lessons learned from plant and bacterial toxins
Gene Ther, 12 (11), 865-72
PubMed 15815697
Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids
Biochem Biophys Res Commun, 329 (2), 465-73
PubMed 15737610
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria
Toxicon, 46 (8), 900-6
PubMed 16260019
The A-subunit of surface-bound Shiga toxin stimulates clathrin-dependent uptake of the toxin
FEBS J, 272 (16), 4103-13
PubMed 16098193
Publications 2004
Efficient endosome-to-Golgi transport of Shiga toxin is dependent on dynamin and clathrin
J Cell Sci, 117 (Pt 11), 2321-31
PubMed 15126632
Pathways followed by protein toxins into cells
Int J Med Microbiol, 293 (7-8), 483-90
PubMed 15149022
Publications 2003
Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
J Biol Chem, 278 (3), 1991-7
PubMed 12419802
Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA
Proc Natl Acad Sci U S A, 100 (9), 5175-80
PubMed 12682302
Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP)
J Biol Chem, 278 (37), 35850-5
PubMed 12847103
Cholera toxin internalization and intoxication - Reply
J. Cell Sci., 116 (3), 432-433
Role of lipids in the retrograde pathway of ricin intoxication
Traffic, 4 (8), 544-552
Role of lipids in the retrograde pathway of ricin intoxication
Traffic, 4 (8), 544-52
PubMed 12839497
Differential role of actin, clathrin, and dynamin in Fc gamma receptor-mediated endocytosis and phagocytosis
J Biol Chem, 278 (5), 3331-8
PubMed 12424246
Caveolae: anchored, multifunctional platforms in the lipid ocean
Trends Cell Biol, 13 (2), 92-100
PubMed 12559760
Cholesterol loading induces a block in the exit of VSVG from the TGN
Traffic, 4 (11), 772-84
PubMed 14617359
Publications 2002
Membrane ruffling and macropinocytosis in A431 cells require cholesterol
J Cell Sci, 115 (Pt 14), 2953-62
PubMed 12082155
Selective regulation of the Rab9-independent transport of ricin to the Golgi apparatus by calcium
J Cell Sci, 115 (Pt 17), 3449-56
PubMed 12154075
Sequestration of epidermal growth factor receptors in non-caveolar lipid rafts inhibits ligand binding
J Biol Chem, 277 (21), 18954-60
PubMed 11886870
Pathways followed by ricin and Shiga toxin into cells
Histochem Cell Biol, 117 (2), 131-41
PubMed 11935289
Membrane traffic exploited by protein toxins
Annu Rev Cell Dev Biol, 18, 1-24
PubMed 12142266
Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin
FEBS Lett, 529 (1), 49-53
PubMed 12354612
Publications 2001
Reconstitution of clathrin-independent endocytosis at the apical domain of permeabilized MDCK II cells: requirement for a Rho-family GTPase
Traffic, 2 (1), 26-36
PubMed 11208166
Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases
Mol Biol Cell, 12 (7), 2099-107
PubMed 11452006
Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosis
J Cell Sci, 114 (Pt 2), 335-43
PubMed 11148135
Shiga toxins
Toxicon, 39 (11), 1629-35
PubMed 11595626
In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
Int J Cancer, 92 (5), 761-6
PubMed 11340584
Internalization of cholera toxin by different endocytic mechanisms
J Cell Sci, 114 (Pt 20), 3737-47
PubMed 11707525
Publications 2000
Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphtheria toxin
J Biol Chem, 275 (6), 4363-8
PubMed 10660606
Penetration of protein toxins into cells
Curr Opin Cell Biol, 12 (4), 407-13
PubMed 10873820
Endosome to Golgi transport of ricin is regulated by cholesterol
Mol Biol Cell, 11 (12), 4205-16
PubMed 11102518
Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway
J Cell Sci, 113 ( Pt 7), 1213-21
PubMed 10704372
Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor
Mol Biol Cell, 11 (2), 481-95
PubMed 10679008
Ricin transport into cells: studies of endocytosis and intracellular transport
Int J Med Microbiol, 290 (4-5), 415-20
PubMed 11111920
Apical macropinocytosis in polarized MDCK cells: regulation by N-ethylmaleimide-sensitive proteins
Eur J Cell Biol, 79 (7), 447-57
PubMed 10961444
Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives
EMBO J, 19 (22), 5943-50
PubMed 11080141
Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
Biochim Biophys Acta, 1475 (3), 307-13
PubMed 10913830
Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
Int J Cancer, 87 (6), 853-9
PubMed 10956397
Caveolae: uniform structures with multiple functions in signaling, cell growth, and cancer
Exp Cell Res, 261 (1), 111-8
PubMed 11082281
Publications 1999
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
Cancer Res, 59 (6), 1180-3
PubMed 10096543
Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
Mol Biol Cell, 10 (4), 961-74
PubMed 10198050
Endocytosis and intracellular transport of ricin: recent discoveries
FEBS Lett, 452 (1-2), 67-70
PubMed 10376680
Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor
J Cell Sci, 112 ( Pt 22), 3899-909
PubMed 10547351
Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells
Mol Biol Cell, 10 (1), 179-95
PubMed 9880335
Publications 1998
Phacoemulsification in eyes with pseudoexfoliation
J Cataract Refract Surg, 24 (6), 787-92
PubMed 9642589
Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus
J Cell Biol, 140 (3), 553-63
PubMed 9456316
Transport of apically but not basolaterally internalized ricin to the Golgi apparatus is stimulated by 8-Br-cAMP in MDCK cells
FEBS Lett, 431 (2), 200-4
PubMed 9708902
Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells
J Cell Sci, 111 ( Pt 6), 825-32
PubMed 9472010
Publications 1997
Role of the disulfide bond in Shiga toxin A-chain for toxin entry into cells
J Biol Chem, 272 (17), 11414-9
PubMed 9111051
Intracellular transport and processing of protein toxins produced by enteric bacteria
Adv Exp Med Biol, 412, 225-32
PubMed 9192018
Publications 1996
Comparison of a diffractive bifocal and a monofocal intraocular lens
J Cataract Refract Surg, 22 (4), 446-51
PubMed 8733848
Effect of calmodulin antagonists on endocytosis and intracellular transport of ricin in polarized MDCK cells
Exp Cell Res, 227 (2), 298-308
PubMed 8831568
Thapsigargin-induced transport of cholera toxin to the endoplasmic reticulum
Proc Natl Acad Sci U S A, 93 (22), 12339-43
PubMed 8901582
Importance of glycolipid synthesis for butyric acid-induced sensitization to shiga toxin and intracellular sorting of toxin in A431 cells
Mol Biol Cell, 7 (9), 1391-404
PubMed 8885234
Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin
Physiol Rev, 76 (4), 949-66
PubMed 8874490
Inhibition of the vacuolar H(+)-ATPase with bafilomycin reduces delivery of internalized molecules from mature multivesicular endosomes to lysosomes in HEp-2 cells
Eur J Cell Biol, 69 (4), 343-50
PubMed 8741216
Destabilization of plasma membrane structure by prevention of actin polymerization. Microtubule-dependent tubulation of the plasma membrane
J Cell Sci, 109 ( Pt 7), 1655-65
PubMed 8832388
Publications 1995
CELL PENETRATION OF BACTERIAL PROTEIN TOXINS - RESPONSE
Trends Microbiol., 3 (5), 167-168
Role of processing and intracellular transport for optimal toxicity of Shiga toxin and toxin mutants
Exp Cell Res, 218 (1), 39-49
PubMed 7737376
Furin-induced cleavage and activation of Shiga toxin
J Biol Chem, 270 (18), 10817-21
PubMed 7738018
Phorbol myristate acetate selectively stimulates apical endocytosis via protein kinase C in polarized MDCK cells
Exp Cell Res, 217 (1), 157-68
PubMed 7867714
Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells
Biochem J, 310 ( Pt 1), 285-9
PubMed 7646457
Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes
Eur J Cell Biol, 66 (4), 309-23
PubMed 7544728
Publications 1994
Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP
J Biol Chem, 269 (28), 18607-15
PubMed 8034609
Diphtheria toxin at low pH depolarizes the membrane, increases the membrane conductance and induces a new type of ion channel in Vero cells
EMBO J, 13 (19), 4433-9
PubMed 7523112
Intermediates in translocation of diphtheria toxin across the plasma membrane
J Biol Chem, 269 (6), 4648-52
PubMed 7508447
ENTRY OF SHIGA TOXIN INTO CELLS
INT CONGR SER, 1072, 139-146
Retrograde transport from the Golgi complex to the ER of both Shiga toxin and the nontoxic Shiga B-fragment is regulated by butyric acid and cAMP
J Cell Biol, 126 (1), 53-64
PubMed 8027186
Endocytosis without clathrin
Trends Cell Biol, 4 (8), 275-7
PubMed 14731589
Endocytosis and intracellular sorting of ricin and Shiga toxin
FEBS Lett, 346 (1), 99-102
PubMed 8206167
ENTRY OF SHIGA TOXIN INTO CELLS
ZBL BAKT S, 24, 365-374
Dual mode of signal transduction by externally added acidic fibroblast growth factor
Cell, 76 (6), 1039-51
PubMed 7511061
Publications 1993
Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification
J Cell Biol, 121 (1), 61-72
PubMed 8458873
Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors
J Cell Biol, 123 (1), 89-97
PubMed 8408209
Endocytosis of desmosomal plaques depends on intact actin filaments and leads to a nondegradative compartment
Eur J Cell Biol, 62 (2), 362-71
PubMed 7925492
Rapid increase in pH set-point of the Na(+)-in-dependent chloride/bicarbonate antiporter in Vero cells exposed to heat shock
J Membr Biol, 134 (2), 143-53
PubMed 8411117
Entry of protein toxins in polarized epithelial cells
Cancer Res, 53 (8), 1755-60
PubMed 8467493
Protein toxins acting on intracellular targets: cellular uptake and translocation to the cytosol
Med Microbiol Immunol, 182 (2), 51-61
PubMed 8392658
Entry of Shiga toxin into cells
Zentralbl Bakteriol, 278 (2-3), 296-305
PubMed 8347933
Endocytosis and intracellular transport of protein toxins
Biochem Soc Trans, 21 ( Pt 3) (3), 707-11
PubMed 8224494
Multivesicular bodies in HEp-2 cells are maturing endosomes
Eur J Cell Biol, 61 (2), 208-24
PubMed 8223712
Are caveolae involved in clathrin-independent endocytosis?
Trends Cell Biol, 3 (8), 249-51
PubMed 14731741
Publications 1992
Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels
J Biol Chem, 267 (17), 12284-90
PubMed 1376320
Internalization efficiency of the transferrin receptor
Exp Cell Res, 199 (1), 19-28
PubMed 1735458
Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis
Curr Top Microbiol Immunol, 180, 65-94
PubMed 1324134
Effects of brefeldin A on endocytosis, transcytosis and transport to the Golgi complex in polarized MDCK cells
J Cell Biol, 119 (2), 259-72
PubMed 1400572
Protein toxins: mode of action and cell entry
Biochem Soc Trans, 20 (4), 724-7
PubMed 1487049
Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
Nature, 358 (6386), 510-2
PubMed 1641040
Toxin-induced cell lysis: protection by 3-methyladenine and cycloheximide
Exp Cell Res, 200 (2), 253-62
PubMed 1572394
Publications 1991
The preendosomal compartment comprises distinct coated and noncoated endocytic vesicle populations
J Cell Biol, 113 (4), 731-41
PubMed 1673969
Evidence for involvement of protein kinase C in regulation of intracellular pH by Cl-/HCO-3 antiport
J Membr Biol, 119 (2), 179-86
PubMed 2046087
Entry of diphtheria toxin-protein A chimeras into cells
J Biol Chem, 266 (26), 17446-53
PubMed 1894632
Effect of monensin on ricin and fluid phase transport in polarized MDCK cells
J Cell Biochem, 47 (3), 251-60
PubMed 1791187
Bacterial protein toxins acting on intracellular targets
Semin Cell Biol, 2 (1), 7-14
PubMed 1954345
Ricin transport in brefeldin A-treated cells: correlation between Golgi structure and toxic effect
J Cell Biol, 115 (4), 971-81
PubMed 1955466
Endocytosis and intracellular transport of the glycolipid-binding ligand Shiga toxin in polarized MDCK cells
J Cell Biol, 113 (3), 553-62
PubMed 1901867
Endocytosis without clathrin (a minireview)
Cell Biol Int Rep, 15 (1), 3-8
PubMed 1900741
Peptides fused to the amino-terminal end of diphtheria toxin are translocated to the cytosol
J Cell Biol, 113 (5), 1025-32
PubMed 2040642
Internalization and action of an immunotoxin containing mistletoe lectin A-chain
Cancer Res, 51 (3), 916-20
PubMed 1988131
Publications 1990
Translocation of diphtheria toxin to the cytosol and formation of cation selective channels
J Physiol (Paris), 84 (3), 191-6
PubMed 1705980
Protein toxins with intracellular targets
Microb Pathog, 8 (3), 163-8
PubMed 1696341
Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis
J Biol Chem, 265 (11), 6382-8
PubMed 1969411
Role of Na(+)-H+ and Cl(-)-HCO3- antiports in the regulation of cytosolic pH near neutrality
Am J Physiol, 258 (6 Pt 1), C1117-26
PubMed 2163200
Endocytosis, intracellular transport and transcytosis of the toxic protein ricin by a polarized epithelium
Eur J Cell Biol, 51 (1), 96-109
PubMed 2328741
Publications 1989
Internalized ricin and the plasma membrane glycoprotein MAM-6 colocalize in the trans-Golgi network of T47D human breast carcinoma cells
Exp Cell Res, 185 (2), 373-86
PubMed 2689197
Membrane interactions of diphtheria toxin analyzed using in vitro synthesized mutants
EMBO J, 8 (10), 2843-8
PubMed 2684631
Role of anions in low pH-induced translocation of diphtheria toxin
J Biol Chem, 264 (19), 11367-72
PubMed 2500440
Translocation of diphtheria toxin A-fragment to the cytosol. Role of the site of interfragment cleavage
J Biol Chem, 264 (26), 15709-13
PubMed 2768283
Immunotoxins--entry into cells and mechanisms of action
Immunol Today, 10 (9), 291-5
PubMed 2686677
FORMATION OF ACTIVE DIPHTHERIA-TOXIN INVITRO BASED ON LIGATED FRAGMENTS OF CLONED MUTANT-GENES
J. Biol. Chem., 264 (22), 12749-12751
Formation of active diphtheria toxin in vitro based on ligated fragments of cloned mutant genes
J Biol Chem, 264 (22), 12747-51
PubMed 2753882
Endocytosis from coated pits of Shiga toxin: a glycolipid-binding protein from Shigella dysenteriae 1
J Cell Biol, 108 (4), 1331-43
PubMed 2564398
Control of coated-pit function by cytoplasmic pH
Methods Cell Biol, 32, 365-82
PubMed 2575206
Permeabilization of the plasma membrane by deletion mutants of diphtheria toxin
EMBO J, 8 (10), 2849-53
PubMed 2479538
Inhibition of chloride/bicarbonate antiports in monkey kidney cells (Vero) by non-steroidal anti-inflammatory drugs
Biochem Pharmacol, 38 (20), 3583-91
PubMed 2818647
Effect of anti-inflammatory analgesic drugs on the regulation of cytosolic pH by anion antiport
J Pharmacol Exp Ther, 248 (3), 1197-206
PubMed 2703970
The ways of endocytosis
Int Rev Cytol, 117, 131-77
PubMed 2573583
[Endocytosis, intracellular transport and sorting of proteins]
Nord Med, 104 (1), 9-11
PubMed 2911460
Publications 1988
Characterization of a toxic lectin in Iscador, a mistletoe preparation with alleged cancerostatic properties
Oncology, 45 (3), 172-9
PubMed 3368193
Low pH-induced release of diphtheria toxin A-fragment in Vero cells. Biochemical evidence for transfer to the cytosol
J Biol Chem, 263 (5), 2518-25
PubMed 3339019
Diphtheria toxin entry: protein translocation in the reverse direction
Trends Biochem Sci, 13 (9), 348-51
PubMed 3072713
How protein toxins enter and kill cells
Cancer Treat Res, 37, 39-73
PubMed 2908634
Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport
J Biol Chem, 263 (23), 11117-25
PubMed 3403517
Diphtheria toxin-induced channels in Vero cells selective for monovalent cations
J Biol Chem, 263 (25), 12352-9
PubMed 2457582
Inhibition of endocytosis from coated pits by acidification of the cytosol
J Cell Biochem, 36 (1), 73-81
PubMed 2893802
Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane
J Biol Chem, 263 (26), 13449-55
PubMed 3417666
Estimation of the amount of internalized ricin that reaches the trans-Golgi network
J Cell Biol, 106 (2), 253-67
PubMed 2892843
Publications 1987
Effect of reduced endocytosis induced by hypotonic shock and potassium depletion on the infection of Hep 2 cells by picornaviruses
J Cell Physiol, 131 (1), 14-22
PubMed 3032992
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
PubMed 3571337
Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin. A new system to study toxin entry at low pH
J Biol Chem, 262 (21), 10339-45
PubMed 3112141
Bicarbonate/chloride antiport in Vero cells: II. Mechanisms for bicarbonate-dependent regulation of intracellular pH
J Cell Physiol, 132 (2), 192-202
PubMed 3624315
Effect of intracellular pH on the rate of chloride uptake and efflux in different mammalian cell lines
Biochemistry, 26 (10), 2778-85
PubMed 3606992
Ionic requirements for entry of Shiga toxin from Shigella dysenteriae 1 into cells
Infect Immun, 55 (2), 298-303
PubMed 3542829
Pseudomonas toxin binds triton X-114 at low pH
Biochem J, 245 (3), 899-901
PubMed 3117052
Acidification of the cytosol inhibits endocytosis from coated pits
J Cell Biol, 105 (2), 679-89
PubMed 2887575
Bicarbonate/chloride antiport in Vero cells: I. Evidence for both sodium-linked and sodium-independent exchange
J Cell Physiol, 132 (2), 183-91
PubMed 3624314
Delivery of internalized ricin from endosomes to cisternal Golgi elements is a discontinuous, temperature-sensitive process
Exp Cell Res, 171 (1), 137-52
PubMed 3622628
Formation and activity of covalent conjugates of poliovirus and ligands binding to cell surface structures
Exp Cell Res, 170 (2), 483-90
PubMed 3036553
Publications 1986
Interactions between diphtheria toxin entry and anion transport in vero cells. III. Effect on toxin binding and anion transport of tumor-promoting phorbol esters, vanadate, fluoride, and salicylate
J Biol Chem, 261 (4), 1562-9
PubMed 3632976
Interactions between diphtheria toxin entry and anion transport in Vero cells. I. Anion antiport in Vero cells
J Biol Chem, 261 (4), 1542-52
PubMed 3944100
Interactions between diphtheria toxin entry and anion transport in Vero cells. II. Inhibition of anion antiport by diphtheria toxin
J Biol Chem, 261 (4), 1553-61
PubMed 3944101
pH-regulated anion antiport in nucleated mammalian cells
J Cell Biol, 102 (3), 967-71
PubMed 3949885
Interactions between diphtheria toxin entry and anion transport in Vero cells. IV. Evidence that entry of diphtheria toxin is dependent on efficient anion transport
J Biol Chem, 261 (4), 1570-5
PubMed 2418015
REQUIREMENT OF A TRANSMEMBRANE PH GRADIENT FOR THE ENTRY OF DIPHTHERIA-TOXIN INTO CELLS AT LOW PH
J. Biol. Chem., 261 (25), 1639-1644
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin
Cancer Res, 46 (12 Pt 1), 6418-22
PubMed 3096563
Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH
J Biol Chem, 261 (25), 11639-44
PubMed 3745160
Routing of internalized ricin and ricin conjugates to the Golgi complex
J Cell Biol, 102 (1), 37-47
PubMed 3001103
Publications 1985
Entry of diphtheria toxin linked to concanavalin A into primate and murine cells
J Cell Physiol, 122 (2), 193-9
PubMed 3844014
Tumor-promoting phorbol esters and vanadate alter the sensitivity of HeLa S3 cells to poliovirus type 1
Exp Cell Res, 160 (1), 240-4
PubMed 2995095
Evidence that membrane phospholipids and protein are required for binding of diphtheria toxin in Vero cells
Biochim Biophys Acta, 846 (3), 334-41
PubMed 4041483
ENTRY MECHANISMS OF PROTEIN TOXINS AND PICORNAVIRUSES
Biochem. Soc. Symp. (50), 171-191
Entry mechanisms of protein toxins and picornaviruses
Biochem Soc Symp, 50, 171-91
PubMed 3915869
Effect of the chaotropic anions thiocyanate and perchlorate on the entry of ricin into Vero cells
Biochem J, 228 (2), 521-3
PubMed 2990449
Effect of potassium depletion of cells on their sensitivity to diphtheria toxin and pseudomonas toxin
J Cell Physiol, 124 (1), 54-60
PubMed 3930519
Properties of volkensin, a toxic lectin from Adenia volkensii
J Biol Chem, 260 (27), 14589-95
PubMed 3932357
PROPERTIES OF VOLKENSIN, A TOXIC LECTIN FROM ADENIA-VOLKENSII
J. Biol. Chem., 260 (27), 4589-4595
Receptor-mediated endocytosis of a ricin-colloidal gold conjugate in vero cells. Intracellular routing to vacuolar and tubulo-vesicular portions of the endosomal system
Exp Cell Res, 159 (2), 287-304
PubMed 2863159
Publications 1984
Mechanism of entry into the cytosol of poliovirus type 1: requirement for low pH
J Cell Biol, 98 (4), 1194-200
PubMed 6325467
Requirements for entry of poliovirus RNA into cells at low pH
EMBO J, 3 (9), 1945-50
PubMed 6092049
Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus
Virology, 139 (2), 346-57
PubMed 6097029
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus
Biochem J, 219 (3), 935-40
PubMed 6331401
Anion requirement and effect of anion transport inhibitors on the response of vero cells to diphtheria toxin and modeccin
J Cell Physiol, 119 (1), 7-14
PubMed 6707104
Receptor-mediated entry of protein toxins into cells
Acta Histochem Suppl, 29, 79-94
PubMed 6144140
Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments
J Cell Biol, 98 (3), 963-70
PubMed 6699094
Calmodulin antagonists sensitize cells to pseudomonas toxin
J Cell Physiol, 119 (1), 15-22
PubMed 6707099
Effect of malignant transformation, retinoic acid, trifluoperazine, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W7) on the sensitivity of rodent cells to Pseudomonas toxin
Cancer Res, 44 (11), 4919-23
PubMed 6435858
Publications 1983
DANCYLCADAVERINE ELIMINATES CALMODULIN STIMULATION OF PHOSPHODIESTERASE
Biochem. Biophys. Res. Commun., 117 (2), 562-567
Dansylcadaverine eliminates calmodulin stimulation of phosphodiesterase
Biochem Biophys Res Commun, 117 (2), 562-7
PubMed 6318763
Preparation and properties of a hybrid toxin of modeccin A-chain and ricin B-chain
Biochim Biophys Acta, 761 (3), 296-302
PubMed 6652111
Publications 1982
The toxic lectin modeccin
Methods Enzymol, 83, 357-62
PubMed 6178935
ISOLATION AND CHARACTERIZATION OF VISCUMIN, A TOXIC LECTIN FROM VISCUM-ALBUM L (MISTLETOE)
J. Biol. Chem., 257 (22), 3263-3270
Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe)
J Biol Chem, 257 (22), 13263-70
PubMed 7142144
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors, and ionophores and evidence for toxin penetration from endocytotic vesicles
J Biol Chem, 257 (13), 7504-13
PubMed 7085634
Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium
J Biol Chem, 257 (13), 7495-503
PubMed 6806276
ACTION OF VISCUMIN, A TOXIC LECTIN FROM MISTLETOE, ON CELLS IN CULTURE
J. Biol. Chem., 257 (22), 3271-3277
Action of viscumin, a toxic lectin from mistletoe, on cells in culture
J Biol Chem, 257 (22), 13271-7
PubMed 7142145
Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway
J Biol Chem, 257 (16), 9733-9
PubMed 7107588
Publications 1981
Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule
J Biol Chem, 256 (17), 9068-76
PubMed 7263699
Effects of retinoids and phorbol esters on the sensitivity of different cell lines to the polypeptide toxins modeccin, abrin, ricin and diphtheria toxin
Biochem J, 194 (3), 821-7
PubMed 7306026
Publications 1980
[Receptors for polypeptide hormones]
Tidsskr Nor Laegeforen, 100 (14), 964-6, 970
PubMed 6250247
[Intracellular mediators for polypeptide hormones]
Tidsskr Nor Laegeforen, 100 (15), 1021-23
PubMed 6250248
Corneal Changes During Chloroquine Treatment: An investigation of 70 patients with chronic rheumatoid arthritis receiving chloroquine treatment
Scand J Rheumatol, 9 (1), 150-6
PubMed 19919350
Diphtheria toxin entry into cells is facilitated by low pH
J Cell Biol, 87 (3 Pt 1), 828-32
PubMed 7462324
Publications 1979
Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells
Exp Cell Res, 121 (1), 15-25
PubMed 446525
Inhibitory effect of ammonium chloride and chloroquine on the entry of the toxic lectin modeccin into HeLa cells
Biochem Biophys Res Commun, 90 (2), 648-55
PubMed 508328
Publications 1978
Properties and action mechanism of the toxic lectin modeccin: interaction with cell lines resistant to modeccin, abrin, and ricin
J Supramol Struct, 9 (1), 15-25
PubMed 732310
Cell density affects the binding of the toxic lectin abrin to HeLa cells in monolayer cultures
FEBS Lett, 89 (2), 233-6
PubMed 658411
Interactions between abrus lectins and Sephadex particles possessing immobilized desialylated fetuin. Model studies of the interaction of lectins with cell surface receptors
Eur J Biochem, 88 (1), 307-13
PubMed 78847
Binding, uptake and degradation of the toxic proteins abrin and ricin by toxin-resistant cell variants
Eur J Biochem, 82 (1), 13-23
PubMed 620666
Chemical modifications of the toxic lectins abrin and ricin
Eur J Biochem, 84 (2), 323-31
PubMed 639792
Publications 1977
MODECCIN - PLANT TOXIN INHIBITING PROTEIN-SYNTHESIS
Biochem. Biophys. Res. Commun., 79 (4), 1176-1183
Modeccin--a plant toxin inhibiting protein synthesis
Biochem Biophys Res Commun, 79 (4), 1176-83
PubMed 603653
Publications 1976
Rates of different steps involved in the inhibition of protein synthesis by the toxic lectins abrin and ricin
J Biol Chem, 251 (13), 3985-92
PubMed 932017
Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells
J Biol Chem, 251 (13), 3977-84
PubMed 6468




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