Einar K. Rofstad
Position: Professor and group leader
Phone: +47 22 78 12 06
Email:
Education: Ph.D.
Research interests/projects: Non-invasive detection of tumor hypoxia by DCE-MRI; Combined radiation and antiangiogenic therapy; Microenvironment- and radiation-induced metastasis
 

Author network for Einar K. Rofstad by COREMINE medical


Publications 2017

Andersen LMK, Wegner CS, Simonsen TG, Huang R, Gaustad JV, Hauge A, Galappathi K, Rofstad EK (2017)
Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
Oncotarget (in press)
PubMed 28624797

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2017)
The Effect of Sunitinib Treatment in Human Melanoma Xenografts: Associations with Angiogenic Profiles
Transl Oncol, 10 (2), 158-167
PubMed 28167241

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts
BMC Cancer, 17 (1), 411
PubMed 28606060

Huang R, Rofstad EK (2017)
Cancer stem cells (CSCs), cervical CSCs and targeted therapies
Oncotarget, 8 (21), 35351-35367
PubMed 27343550

Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2017)
Pretreatment late-phase DCE-MRI predicts outcome in locally advanced cervix cancer
Acta Oncol, 56 (5), 675-681
PubMed 28447564

Wegner CS, Hauge A, Gaustad JV, Andersen LMK, Simonsen TG, Galappathi K, Rofstad EK (2017)
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
Acta Oncol, 1-9 (in press)
PubMed 28661213

Publications 2016

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2016)
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression
Oncotarget, 7 (47), 76806-76815
PubMed 27756886

Rofstad EK, Huang R, Galappathi K, Andersen LM, Wegner CS, Hauge A, Gaustad JV, Simonsen TG (2016)
Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis
Oncotarget, 7 (35), 56986-56997
PubMed 27486768

Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
Cancer Lett, 373 (2), 147-55
PubMed 26828134

Simonsen TG, Gaustad JV, Rofstad EK (2016)
Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma
Transl Oncol, 9 (3), 211-8
PubMed 27267839

Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
J Transl Med, 14 (1), 161
PubMed 27268062

Publications 2015

Ellingsen C, Andersen LM, Galappathi K, Rofstad EK (2015)
Hypoxia biomarkers in squamous cell carcinoma of the uterine cervix
BMC Cancer, 15, 805
PubMed 26502718

Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
BMC Cancer, 15, 900
PubMed 26573613

Gorad SS, Ellingsen C, Bathen TF, Mathiesen BS, Moestue SA, Rofstad EK (2015)
Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS
Neoplasia, 17 (10), 767-75
PubMed 26585232

Lund KV, Simonsen TG, Hompland T, Kristensen GB, Rofstad EK (2015)
Short-term pretreatment DCE-MRI in prediction of outcome in locally advanced cervical cancer
Radiother Oncol, 115 (3), 379-85
PubMed 25998804

Simonsen TG, Gaustad JV, Rofstad EK (2015)
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
J Exp Clin Cancer Res, 34, 150
PubMed 26667022

Publications 2014

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2014)
Thrombospondin-1 domain-containing peptide properdistatin improves vascular function in human melanoma xenografts
Microvasc Res, 98, 159-65
PubMed 24555949

Hompland T, Ellingsen C, Galappathi K, Rofstad EK (2014)
DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts
BMC Cancer, 14, 92
PubMed 24528854

Hompland T, Lund KV, Ellingsen C, Kristensen GB, Rofstad EK (2014)
Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma
Radiother Oncol, 113 (1), 132-8
PubMed 25443501

Rofstad EK, Galappathi K, Mathiesen BS (2014)
Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis
Neoplasia, 16 (7), 586-94
PubMed 25117980

Publications 2013

Ellingsen C, Hompland T, Galappathi K, Mathiesen B, Rofstad EK (2013)
DCE-MRI of the hypoxic fraction, radioresponsiveness, and metastatic propensity of cervical carcinoma xenografts
Radiother Oncol, 110 (2), 335-41
PubMed 24231244

Ellingsen C, Walenta S, Hompland T, Mueller-Klieser W, Rofstad EK (2013)
The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI
Transl Oncol, 6 (5), 607-17
PubMed 24151541

Gaustad JV, Pozdniakova V, Hompland T, Simonsen TG, Rofstad EK (2013)
Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts
J Exp Clin Cancer Res, 32, 93
PubMed 24245934

Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG (2013)
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
Mol Cancer Ther, 12 (5), 705-16
PubMed 23635654

Hompland T, Ellingsen C, Galappathi K, Rofstad EK (2013)
Connective tissue of cervical carcinoma xenografts: associations with tumor hypoxia and interstitial fluid pressure and its assessment by DCE-MRI and DW-MRI
Acta Oncol, 53 (1), 6-15
PubMed 23445339

Publications 2012

Ellingsen C, Hompland T, Mathiesen B, Rofstad EK (2012)
Microenvironment-associated lymph node metastasis of human cervical carcinoma xenografts
Acta Oncol, 51 (4), 465-72
PubMed 22292610

Ellingsen C, Ovrebø KM, Galappathi K, Mathiesen B, Rofstad EK (2012)
pO₂ fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts
Int J Radiat Oncol Biol Phys, 83 (4), 1317-23
PubMed 22270159

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
A novel application of dorsal window chambers: repetitive imaging of tumor-associated lymphatics
Microvasc Res, 83 (3), 360-5
PubMed 22342351

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts
BMC Cancer, 12, 388
PubMed 22947392

Gaustad JV, Simonsen TG, Roa AM, Rofstad EK (2012)
Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply
Microvasc Res, 85, 10-5
PubMed 23154277

Hompland T, Ellingsen C, Rofstad EK (2012)
Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure
BMC Cancer, 12, 544
PubMed 23173554

Hompland T, Ellingsen C, Øvrebø KM, Rofstad EK (2012)
Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI
Cancer Res, 72 (19), 4899-908
PubMed 23027087

Hompland T, Gulliksrud K, Ellingsen C, Rofstad EK (2012)
Assessment of the interstitial fluid pressure of tumors by dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights
Acta Oncol, 52 (3), 627-35
PubMed 23126523

Ovrebø KM, Ellingsen C, Galappathi K, Rofstad EK (2012)
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts
Int J Radiat Oncol Biol Phys, 83 (1), e121-7
PubMed 22381901

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts
PLoS One, 7 (6), e40006
PubMed 22768196

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Tumor-line specific causes of intertumor heterogeneity in blood supply in human melanoma xenografts
Microvasc Res, 85, 16-23
PubMed 23149341

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Vascular abnormalities associated with acute hypoxia in human melanoma xenografts
Radiother Oncol, 105 (1), 72-8
PubMed 23022175

Øvrebø KM, Ellingsen C, Hompland T, Rofstad EK (2012)
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of tumors: a preclinical study of cervical carcinoma and melanoma xenografts
Acta Oncol, 52 (3), 604-11
PubMed 22671573

Publications 2011

Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2011)
Dynamic contrast-enhanced-MRI of tumor hypoxia
Magn Reson Med, 67 (2), 519-30
PubMed 21661044

Gulliksrud K, Galappathi K, Rofstad EK (2011)
Interstitial fluid pressure and vascularity of intradermal and intramuscular human tumor xenografts
Int J Radiat Oncol Biol Phys, 80 (1), 258-64
PubMed 21255944

Gulliksrud K, Hompland T, Galappathi K, Rofstad EK (2011)
Assessment of tumor hypoxia and interstitial fluid pressure by gadomelitol-based dynamic contrast-enhanced magnetic resonance imaging
Radiother Oncol, 101 (1), 217-22
PubMed 21840612

Gulliksrud K, Øvrebø KM, Mathiesen B, Rofstad EK (2011)
Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging
Radiother Oncol, 98 (3), 360-4
PubMed 21262548

Øvrebø KM, Gulliksrud K, Mathiesen B, Rofstad EK (2011)
Assessment of tumor radioresponsiveness and metastatic potential by dynamic contrast-enhanced magnetic resonance imaging
Int J Radiat Oncol Biol Phys, 81 (1), 255-61
PubMed 21816291

Øvrebø KM, Hompland T, Mathiesen B, Rofstad EK (2011)
Assessment of hypoxia and radiation response in intramuscular experimental tumors by dynamic contrast-enhanced magnetic resonance imaging
Radiother Oncol, 102 (3), 429-35
PubMed 22197352

Publications 2010

Egeland TA, Gaustad JV, Galappathi K, Rofstad EK (2010)
Magnetic resonance imaging of tumor necrosis
Acta Oncol, 50 (3), 427-34
PubMed 20950229

Ellingsen C, Egeland TA, Galappathi K, Rofstad EK (2010)
Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology
Radiother Oncol, 97 (2), 217-24
PubMed 20656365

Gulliksrud K, Egeland TAM, Gaustad JV, Rofstad EK (2010)
Interstitial fluid pressure of tumors as a function of parameters derived by dynamic contrast-enhanced magnetic resonance imaging: Response to letter by Farace and Boschi
Radiother. Oncol., 94 (3), 385-386

Gulliksrud K, Mathiesen B, Galappathi K, Rofstad EK (2010)
Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors
Radiother Oncol, 97 (2), 233-8
PubMed 20934767

Rofstad EK, Gaustad JV, Egeland TA, Mathiesen B, Galappathi K (2010)
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
Int J Cancer, 127 (7), 1535-46
PubMed 20091868

Rofstad EK, Mathiesen B (2010)
Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia
Neoplasia, 12 (11), 889-98
PubMed 21076614

Rofstad EK, Ruud EB, Mathiesen B, Galappathi K (2010)
Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue
Clin Cancer Res, 16 (3), 936-45
PubMed 20103667

Simonsen TG, Gaustad JV, Rofstad EK (2010)
Development of hypoxia in a preclinical model of tumor micrometastases
Int J Radiat Oncol Biol Phys, 76 (3), 879-88
PubMed 20159362

Publications 2009

Egeland TA, Simonsen TG, Gaustad JV, Gulliksrud K, Ellingsen C, Rofstad EK (2009)
Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images
Radiat Res, 172 (3), 339-47
PubMed 19708783

Ellingsen C, Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2009)
Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging
Int J Radiat Oncol Biol Phys, 73 (3), 838-45
PubMed 19215820

Ellingsen C, Natvig I, Gaustad JV, Gulliksrud K, Egeland TA, Rofstad EK (2009)
Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors
J Cancer Res Clin Oncol, 135 (9), 1177-84
PubMed 19214568

Gaustad JV, Simonsen TG, Brurberg KG, Huuse EM, Rofstad EK (2009)
Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries
Neoplasia, 11 (3), 277-85
PubMed 19242609

Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, Simonsen TG (2009)
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts
Neoplasia, 11 (11), 1243-51
PubMed 19881960

Publications 2008

Benjaminsen IC, Melås EA, Mathiesen BS, Rofstad EK (2008)
Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts
J Magn Reson Imaging, 28 (5), 1209-18
PubMed 18972344

Brurberg KG, Gaustad JV, Mollatt CS, Rofstad EK (2008)
Temporal heterogeneity in blood supply in human tumor xenografts
Neoplasia, 10 (7), 727-35
PubMed 18592011

Egeland TA, Gaustad JV, Benjaminsen IC, Hedalen K, Mathiesen B, Rofstad EK (2008)
Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI
Radiat Res, 169 (6), 689-99
PubMed 18494552

Gaustad JV, Brurberg KG, Simonsen TG, Mollatt CS, Rofstad EK (2008)
Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging
Neoplasia, 10 (4), 354-62
PubMed 18392132

Gulliksrud K, Brurberg KG, Rofstad EK (2008)
Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure
Radiother Oncol, 91 (1), 107-13
PubMed 18973959

Gulliksrud K, Vestvik IK, Galappathi K, Mathiesen B, Rofstad EK (2008)
Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry
Radiat Res, 170 (5), 638-50
PubMed 18959463

Norum OJ, Gaustad JV, Angell-Petersen E, Rofstad EK, Peng Q, Giercksky KE, Berg K (2008)
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
Photochem Photobiol, 85 (3), 740-9
PubMed 19076314

Publications 2007

Benjaminsen IC, Brurberg KG, Ruud EB, Rofstad EK (2007)
Assessment of extravascular extracellular space fraction in human melanoma xenografts by DCE-MRI and kinetic modeling
Magn Reson Imaging, 26 (2), 160-70
PubMed 17692490

Brurberg KG, Benjaminsen IC, Dørum LM, Rofstad EK (2007)
Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI
Magn Reson Med, 58 (3), 473-81
PubMed 17763357

Gaustad JV, Benjaminsen IC, Ruud EB, Rofstad EK (2007)
Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions
J Magn Reson Imaging, 26 (1), 133-43
PubMed 17659570

Rofstad EK, Galappathi K, Mathiesen B, Ruud EB (2007)
Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis
Clin Cancer Res, 13 (7), 1971-8
PubMed 17360973

Vestvik IK, Egeland TA, Gaustad JV, Mathiesen B, Rofstad EK (2007)
Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI
J Magn Reson Imaging, 26 (4), 1033-42
PubMed 17896373

Øye KS, Gulati G, Graff BA, Gaustad JV, Brurberg KG, Rofstad EK (2007)
A novel method for mapping the heterogeneity in blood supply to normal and malignant tissues in the mouse dorsal window chamber
Microvasc Res, 75 (2), 179-87
PubMed 17688890

Publications 2006

Brurberg KG, Thuen M, Ruud EB, Rofstad EK (2006)
Fluctuations in pO2 in irradiated human melanoma xenografts
Radiat Res, 165 (1), 16-25
PubMed 16392958

Egeland TA, Gaustad JV, Vestvik IK, Benjaminsen IC, Mathiesen B, Rofstad EK (2006)
Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI
Magn Reson Med, 55 (4), 874-82
PubMed 16506163

Rofstad EK, Mathiesen B, Kindem K, Galappathi K (2006)
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
Cancer Res, 66 (13), 6699-707
PubMed 16818644

Publications 2005

Brurberg KG, Skogmo HK, Graff BA, Olsen DR, Rofstad EK (2005)
Fluctuations in pO2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy
Radiother Oncol, 77 (2), 220-6
PubMed 16257074

Gaustad JV, Benjaminsen IC, Graff BA, Brurberg KG, Ruud EB, Rofstad EK (2005)
Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging
J Magn Reson Imaging, 21 (6), 792-800
PubMed 15906326

Graff BA, Benjaminsen IC, Brurberg KG, Ruud EB, Rofstad EK (2005)
Comparison of tumor blood perfusion assessed by dynamic contrast-enhanced MRI with tumor blood supply assessed by invasive imaging
J Magn Reson Imaging, 21 (3), 272-81
PubMed 15723369

Graff BA, Benjaminsen IC, Melås EA, Brurberg KG, Rofstad EK (2005)
Changes in intratumor heterogeneity in blood perfusion in intradermal human melanoma xenografts during tumor growth assessed by DCE-MRI
Magn Reson Imaging, 23 (9), 961-6
PubMed 16310112

Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T (2005)
Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms
Cancer Res, 65 (5), 1877-86
PubMed 15753386

Rofstad EK, Mathiesen B, Henriksen K, Kindem K, Galappathi K (2005)
The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
Cancer Res, 65 (6), 2387-96
PubMed 15781654

Publications 2004

Barth RF, Grecula JC, Yang W, Rotaru JH, Nawrocky M, Gupta N, Albertson BJ, Ferketich AK, Moeschberger ML, Coderre JA, Rofstad EK (2004)
Combination of boron neutron capture therapy and external beam radiotherapy for brain tumors
Int J Radiat Oncol Biol Phys, 58 (1), 267-77
PubMed 14697448

Benjaminsen IC, Graff BA, Brurberg KG, Rofstad EK (2004)
Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts
Magn Reson Med, 52 (2), 269-76
PubMed 15282808

Brurberg KG, Graff BA, Olsen DR, Rofstad EK (2004)
Tumor-line specific pO(2) fluctuations in human melanoma xenografts
Int J Radiat Oncol Biol Phys, 58 (2), 403-9
PubMed 14751509

Graff BA, Vangberg L, Rofstad EK (2004)
Quantitative assessment of uptake and distribution of iron oxide particles (NC100150) in human melanoma xenografts by contrast-enhanced MRI
Magn Reson Med, 51 (4), 727-35
PubMed 15065245

Rofstad EK, Galappathi K, Mathiesen B (2004)
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts
Int J Radiat Oncol Biol Phys, 58 (2), 493-9
PubMed 14751520

Rofstad EK, Mathiesen B, Galappathi K (2004)
Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor
Cancer Res, 64 (1), 13-8
PubMed 14729600

Publications 2003

Brurberg KG, Graff BA, Rofstad EK (2003)
Temporal heterogeneity in oxygen tension in human melanoma xenografts
Br J Cancer, 89 (2), 350-6
PubMed 12865929

Graff BA, Kvinnsland Y, Skretting A, Rofstad EK (2003)
Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts
Br J Cancer, 88 (2), 291-7
PubMed 12610516

Rofstad EK, Henriksen K, Galappathi K, Mathiesen B (2003)
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
Cancer Res, 63 (14), 4055-61
PubMed 12874006

Publications 2002

Barth RF, Yang W, Bartus RT, Rotaru JH, Ferketich AK, Moeschberger ML, Nawrocky MM, Coderre JA, Rofstad EK (2002)
Neutron capture therapy of intracerebral melanoma: enhanced survival and cure after blood-brain barrier opening to improve delivery of boronophenylalanine
Int J Radiat Oncol Biol Phys, 52 (3), 858-68
PubMed 11849812

Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn H, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara K, Ziche M, Rofstad EK, Schweigerer L, Fotsis T (2002)
N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth
Oncogene, 21 (22), 3552-61
PubMed 12032857

Rofstad EK, Halsør EF (2002)
Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8
Br J Cancer, 86 (2), 301-8
PubMed 11870523

Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA (2002)
Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
Cancer Res, 62 (6), 1847-53
PubMed 11912164

Rofstad EK, Tunheim SH, Mathiesen B, Graff BA, Halsør EF, Nilsen K, Galappathi K (2002)
Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
Cancer Res, 62 (3), 661-4
PubMed 11830516

Publications 2001

Bjørnaes I, Rofstad EK (2001)
Microvascular permeability to macromolecules in human melanoma xenografts assessed by contrast-enhanced MRI--intertumor and intratumor heterogeneity
Magn Reson Imaging, 19 (5), 723-30
PubMed 11672631

Bjørnaes I, Rofstad EK (2001)
Transvascular and interstitial transport of a 19 kDa linear molecule in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
J Magn Reson Imaging, 14 (5), 608-16
PubMed 11747014

Graff BA, Bjørnaes I, Rofstad EK (2001)
Microvascular permeability of human melanoma xenografts to macromolecules: relationships to tumor volumetric growth rate, tumor angiogenesis, and VEGF expression
Microvasc Res, 61 (2), 187-98
PubMed 11254398

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy
Int J Cancer, 96 (3), 182-90
PubMed 11410887

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging
J Magn Reson Imaging, 14 (6), 750-6
PubMed 11747032

Måseide K, Lyng H, Rofstad EK (2001)
Microvessel oxyhemoglobin saturation does not reflect tissue oxygen tension in human melanoma xenografts
Microvasc Res, 61 (2), 199-202
PubMed 11254399

Måseide K, Rofstad EK (2001)
Intratumour heterogeneity in microvessel oxyhaemoglobin saturations
Cancer Lett, 162 (2), 245-51
PubMed 11146232

Rofstad EK, Graff BA (2001)
Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts
J Invest Dermatol, 117 (5), 1042-9
PubMed 11710911

Publications 2000

Bjørnaes I, Halsør EF, Skretting A, Rofstad EK (2000)
Measurement of the extracellular volume of human melanoma xenografts by contrast enhanced magnetic resonance imaging
Magn Reson Imaging, 18 (1), 41-8
PubMed 10642101

Bjørnaes I, Lyng H, Dahle GA, Kaalhus O, Rofstad EK (2000)
Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
Magn Reson Imaging, 18 (8), 997-1002
PubMed 11121704

Danielsen T, Rofstad EK (2000)
The constitutive level of vascular endothelial growth factor (VEGF) is more important than hypoxia-induced VEGF up-regulation in the angiogenesis of human melanoma xenografts
Br J Cancer, 82 (9), 1528-34
PubMed 10789719

Graff BA, Bjornaes I, Rofstad EK (2000)
Macromolecule uptake in human melanoma xenografts. relationships to blood supply, vascular density, microvessel permeability and extracellular volume fraction
Eur J Cancer, 36 (11), 1433-40
PubMed 10899658

Lyng H, Haraldseth O, Rofstad EK (2000)
Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging
Magn Reson Med, 43 (6), 828-36
PubMed 10861877

Lyng H, Sundfør K, Rofstad EK (2000)
Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis
Int J Radiat Oncol Biol Phys, 46 (4), 935-46
PubMed 10705016

Lyng H, Sundfør K, Tropé C, Rofstad EK (2000)
Disease control of uterine cervical cancer: relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
Clin Cancer Res, 6 (3), 1104-12
PubMed 10741740

Måseide K, Rofstad EK (2000)
Mathematical modeling of chronical hypoxia in tumors considering potential doubling time and hypoxic cell lifetime
Radiother Oncol, 54 (2), 171-7
PubMed 10699481

Rofstad EK (2000)
Microenvironment-induced cancer metastasis
Int J Radiat Biol, 76 (5), 589-605
PubMed 10866281

Rofstad EK, Halsør EF (2000)
Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
Cancer Res, 60 (17), 4932-8
PubMed 10987309

Rofstad EK, Sundfør K, Lyng H, Tropé CG (2000)
Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
Br J Cancer, 83 (3), 354-9
PubMed 10917551

Sundfør K, Lyng H, Tropé CG, Rofstad EK (2000)
Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization
Radiother Oncol, 54 (2), 101-7
PubMed 10699471

Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, Mueller-Klieser W (2000)
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
Cancer Res, 60 (4), 916-21
PubMed 10706105

Publications 1999

Danielsen T, Smith-Sørensen B, Grønlund HA, Hvidsten M, Børresen-Dale AL, Rofstad EK (1999)
No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
Int J Radiat Biol, 75 (9), 1149-60
PubMed 10528923

Lyng H, Tanum G, Evensen JF, Rofstad EK (1999)
Changes in oxygen tension during radiotherapy of head and neck tumours
Acta Oncol, 38 (8), 1037-42
PubMed 10665759

Olsen DR, Rofstad EK (1999)
Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts
Radiother Oncol, 52 (3), 261-7
PubMed 10580874

Olsen DR, Singstad TE, Rofstad EK (1999)
Effects of hyperthermia on bioenergetic status and phosphorus T1S in human melanoma xenografts monitored by 31P-MRS
Magn Reson Imaging, 17 (7), 1049-56
PubMed 10463656

Olsen G, Lyng H, Tufto I, Solberg K, Bjørnaes I, Rofstad EK (1999)
Measurement of proliferation activity in human melanoma xenografts by magnetic resonance imaging
Magn Reson Imaging, 17 (3), 393-402
PubMed 10195582

Rofstad EK, Danielsen T (1999)
Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis
Br J Cancer, 80 (11), 1697-707
PubMed 10468285

Rofstad EK, Måseide K (1999)
Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours
Int J Radiat Biol, 75 (11), 1377-93
PubMed 10597912

Tufto I, Rofstad EK (1999)
Interstitial fluid pressure and capillary diameter distribution in human melanoma xenografts
Microvasc Res, 58 (3), 205-14
PubMed 10527764

Publications 1998

Danielsen T, Hvidsten M, Stokke T, Solberg K, Rofstad EK (1998)
Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells
Br J Cancer, 78 (12), 1547-58
PubMed 9862563

Danielsen T, Rofstad EK (1998)
VEGF, bFGF and EGF in the angiogenesis of human melanoma xenografts
Int J Cancer, 76 (6), 836-41
PubMed 9626350

Lyng H, Dahle GA, Kaalhus O, Skretting A, Rofstad EK (1998)
Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging
Magn Reson Med, 40 (1), 89-98
PubMed 9660558

Lyng H, Sundfør K, Rofstad EK (1998)
Oxygen tension in human squamous cell carcinoma and adenocarcinoma of the uterine cervix
Adv Exp Med Biol, 454, 635-41
PubMed 9889944

Rofstad EK, Danielsen T (1998)
Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma
Br J Cancer, 77 (6), 897-902
PubMed 9528831

Rofstad EK, Måseide K (1998)
Fraction of radiobiologically hypoxic cells in human melanoma xenografts measured by using single-cell survival, tumour growth delay and local tumour control as end points
Br J Cancer, 78 (7), 893-8
PubMed 9764580

Sundfør K, Lyng H, Rofstad EK (1998)
Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
Br J Cancer, 78 (6), 822-7
PubMed 9743308

Sundfør K, Lyng H, Rofstad EK (1998)
Oxygen tension and vascular density in adenocarcinoma and squamous cell carcinoma of the uterine cervix
Acta Oncol, 37 (7-8), 665-70
PubMed 10050984

Tufto I, Lyng H, Rofstad EK (1998)
Vascular density in human melanoma xenografts: relationship to angiogenesis, perfusion and necrosis
Cancer Lett, 123 (2), 159-65
PubMed 9489483

Tufto I, Rofstad EK (1998)
Interstitial fluid pressure, fraction of necrotic tumor tissue, and tumor cell density in human melanoma xenografts
Acta Oncol, 37 (3), 291-7
PubMed 9677102

Publications 1997

Blomlie V, Rofstad EK, Tropé C, Lien HH (1997)
Critical soft tissues of the female pelvis: serial MR imaging before, during, and after radiation therapy
Radiology, 203 (2), 391-7
PubMed 9114093

Danielsen T, Skøyum R, Rofstad EK (1997)
Hypoxia-induced changes in radiation sensitivity in human melanoma cells: importance of oxygen-regulated proteins, adenylate energy charge and cell cycle distribution
Radiother Oncol, 44 (2), 177-82
PubMed 9288847

Lyng H, Sundfør K, Rofstad EK (1997)
Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
Radiother Oncol, 44 (2), 163-9
PubMed 9288845

Lyng H, Sundfør K, Tanum G, Rofstad EK (1997)
Oxygen tension in primary tumours of the uterine cervix and lymph node metastases of the head and neck
Adv Exp Med Biol, 428, 55-60
PubMed 9500029

Lyng H, Tufto I, Skretting A, Rofstad EK (1997)
Proton relaxation times and interstitial fluid pressure in human melanoma xenografts
Br J Cancer, 75 (2), 180-3
PubMed 9010023

Måseide K, Rofstad EK (1997)
CCD imaging in cryospectrophotometric determination of microvascular oxyhemoglobin saturations
Am J Physiol, 273 (6 Pt 2), H2910-8
PubMed 9435631

Olsen DR, Petersen SB, Rofstad EK (1997)
Radiation-induced changes in phosphorus T1 values in human melanoma xenografts studied by 31P-MRS
Magn Reson Imaging, 15 (10), 1187-92
PubMed 9408139

Skøyum R, Eide K, Berg K, Rofstad EK (1997)
Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro
Br J Cancer, 76 (4), 421-8
PubMed 9275017

Sundfør K, Lyng H, Kongsgård UL, Tropé C, Rofstad EK (1997)
Polarographic measurement of pO2 in cervix carcinoma
Gynecol Oncol, 64 (2), 230-6
PubMed 9038268

Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, Mueller-Klieser W (1997)
Correlation of high lactate levels in head and neck tumors with incidence of metastasis
Am J Pathol, 150 (2), 409-15
PubMed 9033256

Publications 1996

Blomlie V, Rofstad EK, Talle K, Sundfør K, Winderen M, Lien HH (1996)
Incidence of radiation-induced insufficiency fractures of the female pelvis: evaluation with MR imaging
AJR Am J Roentgenol, 167 (5), 1205-10
PubMed 8911181

Blomlie V, Rofstad EK, Tverå K, Lien HH (1996)
Noncritical soft tissues of the female pelvis: serial MR imaging before, during, and after radiation therapy
Radiology, 199 (2), 461-8
PubMed 8668795

Lyng H, Sundfør K, Tropé C, Rofstad EK (1996)
Oxygen tension and vascular density in human cervix carcinoma
Br J Cancer, 74 (10), 1559-63
PubMed 8932335

Rofstad EK, Eide K, Skøyum R, Hystad ME, Lyng H (1996)
Apoptosis, energy metabolism, and fraction of radiobiologically hypoxic cells: a study of human melanoma multicellular spheroids
Int J Radiat Biol, 70 (3), 241-9
PubMed 8800195

Rofstad EK, Johnsen NM, Lyng H (1996)
Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro
Br J Cancer Suppl, 27, S136-9
PubMed 8763866

Rofstad EK, Lyng H (1996)
Xenograft model systems for human melanoma
Mol Med Today, 2 (9), 394-403
PubMed 8885259

Tufto I, Lyng H, Rofstad EK (1996)
Interstitial fluid pressure, perfusion rate and oxygen tension in human melanoma xenografts
Br J Cancer Suppl, 27, S252-5
PubMed 8763891

Publications 1995

Blomlie V, Rofstad EK, Skjønsberg A, Tverå K, Lien HH (1995)
Female pelvic bone marrow: serial MR imaging before, during, and after radiation therapy
Radiology, 194 (2), 537-43
PubMed 7824737

Jakobsen I, Kaalhus O, Lyng H, Rofstad EK (1995)
Detection of necrosis in human tumour xenografts by proton magnetic resonance imaging
Br J Cancer, 71 (3), 456-61
PubMed 7880724

Jakobsen I, Lyng H, Kaalhus O, Rofstad EK (1995)
MRI of human tumor xenografts in vivo: proton relaxation times and extracellular tumor volume
Magn Reson Imaging, 13 (5), 693-700
PubMed 8569443

Kroeger M, Walenta S, Rofstad EK, Mueller-Klieser W (1995)
Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network
Br J Cancer, 72 (4), 912-6
PubMed 7547239

Lyng H, Olsen DR, Petersen SB, Rofstad EK (1995)
31P NMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation
NMR Biomed, 8 (2), 65-71
PubMed 7547188

Lyng H, Rofstad EK (1995)
Treatment failure following sequential thermoradiotherapy of locally advanced breast carcinoma occurs primarily in poorly vascularized tumors
Oncology, 52 (6), 443-7
PubMed 7478428

Olsen DR, Lyng H, Petersen S, Rofstad EK (1995)
Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension
Acta Oncol, 34 (3), 339-43
PubMed 7779420

Olsen DR, Lyng H, Petersen SB, Rofstad EK (1995)
Effect of melanin on phosphorus T1S in human melanoma xenografts studied by 31P MRS
Magn Reson Imaging, 13 (6), 847-52
PubMed 8544656

Rofstad EK (1995)
Metastatic behavior of human tumors in congenitally athymic nude mice: intrinsic properties of the tumor cells and host immune reactivity
Int J Cancer, 63 (5), 744-9
PubMed 7591295

Schwickert G, Walenta S, Sundfør K, Rofstad EK, Mueller-Klieser W (1995)
Correlation of high lactate levels in human cervical cancer with incidence of metastasis
Cancer Res, 55 (21), 4757-9
PubMed 7585499

Tufto I, Rofstad EK (1995)
Transient perfusion in human melanoma xenografts
Br J Cancer, 71 (4), 789-93
PubMed 7536022

Tufto I, Rofstad EK (1995)
Interstitial fluid pressure in human melanoma xenografts. Relationship to fractional tumor water content, tumor size, and tumor volume-doubling time
Acta Oncol, 34 (3), 361-5
PubMed 7779424

Publications 1994

Barth RF, Matalka KZ, Bailey MQ, Staubus AE, Soloway AH, Moeschberger ML, Coderre JA, Rofstad EK (1994)
A nude rat model for neutron capture therapy of human intracerebral melanoma
Int J Radiat Oncol Biol Phys, 28 (5), 1079-88
PubMed 8175392

Hystad ME, Rofstad EK (1994)
Oxygen consumption rate and mitochondrial density in human melanoma monolayer cultures and multicellular spheroids
Int J Cancer, 57 (4), 532-7
PubMed 8181856

Larsen RH, Bruland OS, Hoff P, Alstad J, Lindmo T, Rofstad EK (1994)
Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays
Radiat Res, 139 (2), 178-84
PubMed 8052693

Larsen RH, Bruland OS, Hoff P, Alstad J, Rofstad EK (1994)
Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody
Br J Cancer, 69 (6), 1000-5
PubMed 8198960

Olsen DR, Lyng H, Southon TE, Rofstad EK (1994)
31P-nuclear magnetic resonance spectroscopy in vivo of four human melanoma xenograft lines: spin-lattice relaxation times
Radiother Oncol, 32 (1), 54-62
PubMed 7938679

Rofstad EK (1994)
Fractionation sensitivity (alpha/beta ratio) of human melanoma xenografts
Radiother Oncol, 33 (2), 133-8
PubMed 7708956

Rofstad EK (1994)
Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern
Br J Cancer, 70 (5), 804-12
PubMed 7947084

Rofstad EK (1994)
Step-down heating of human melanoma xenografts: effects of the tumour microenvironment
Br J Cancer, 70 (3), 453-8
PubMed 8080730

Rofstad EK, Lyng H, Olsen DR, Steinsland E (1994)
Non-invasive assessment of tumor oxygenation status by integrated 31P NMR spectroscopy and 1H NMR imaging
Adv Exp Med Biol, 345, 531-8
PubMed 8079755

Rofstad EK, Steinsland E, Kaalhus O, Chang YB, Høvik B, Lyng H (1994)
Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue
Int J Radiat Biol, 65 (3), 387-401
PubMed 7908318

Sanna K, Rofstad EK (1994)
Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
Int J Cancer, 58 (2), 258-62
PubMed 8026888

Zaffaroni N, Orlandi L, Villa R, Bearzatto A, Rofstad EK, Silvestrini R (1994)
DNA double-strand break repair and radiation response in human tumour primary cultures
Int J Radiat Biol, 66 (3), 279-85
PubMed 7930830

Publications 1993

Lyng H, Monge OR, Sager EM, Rofstad EK (1993)
Prediction of treatment temperatures in clinical hyperthermia of locally advanced breast carcinoma: the use of contrast enhanced computed tomography
Int J Radiat Oncol Biol Phys, 26 (3), 451-7
PubMed 8390419

Lyng H, Olsen DR, Southon TE, Rofstad EK (1993)
31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply
Br J Cancer, 68 (6), 1061-70
PubMed 8260356

Lyng H, Rofstad EK (1993)
Thermal dose and secondary tumour cell death
Int J Hyperthermia, 9 (5), 755-61
PubMed 8245585

Matalka KZ, Bailey MQ, Barth RF, Staubus AE, Soloway AH, Moeschberger ML, Coderre JA, Rofstad EK (1993)
Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent
Cancer Res, 53 (14), 3308-13
PubMed 8324742

Nagelhus TA, Rofstad EK (1993)
Expression of the chondroitin sulphate proteoglycan molecular complex in six human melanoma xenograft lines studied by flow cytometry and immunohistochemistry
Melanoma Res, 3 (3), 187-94
PubMed 7691291

Pettersen EO, Larsen RO, Dornish JM, Børretzen B, Juul ME, Aastveit TE, Nesland JM, Rofstad EK, Oftebro R (1993)
Tumour necrotisation in nude mice xenografts by the reversible protein synthesis inhibitor zilascorb(2H)
Br J Cancer, 67 (4), 650-6
PubMed 8471421

Publications 1992

Lyng H, Skretting A, Rofstad EK (1992)
Blood flow in six human melanoma xenograft lines with different growth characteristics
Cancer Res, 52 (3), 584-92
PubMed 1732046

Rofstad EK (1992)
Repopulation between radiation fractions in human melanoma xenografts
Int J Radiat Oncol Biol Phys, 23 (1), 63-8
PubMed 1572831

Rofstad EK (1992)
Radiation sensitivity in vitro of primary tumors and metastatic lesions of malignant melanoma
Cancer Res, 52 (16), 4453-7
PubMed 1643637

Rofstad EK (1992)
Comparative sensitivity of cells from human tumors and derivative tumor xenografts to radiation and heat treatments
J Natl Cancer Inst, 84 (19), 1517-24
PubMed 1433336

Rofstad EK (1992)
Retention of cellular radiation sensitivity in cell and xenograft lines established from human melanoma surgical specimens
Cancer Res, 52 (7), 1764-9
PubMed 1551106

Publications 1991

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Temperature distribution in locally advanced breast carcinoma during hyperthermic treatment: relationship to perfusion, vascular density, and histology
Int J Radiat Oncol Biol Phys, 21 (2), 423-30
PubMed 1648045

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
The relevance of tumour and surrounding normal tissue vascular density in clinical hyperthermia of locally advanced breast carcinoma
Int J Radiat Biol, 60 (1-2), 189-93
PubMed 1677970

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Relationships between thermal dose and heat-induced tissue and vascular damage after thermoradiotherapy of locally advanced breast carcinoma
Int J Hyperthermia, 7 (3), 403-15
PubMed 1919137

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Changes in temperatures and thermal doses with fraction number during hyperthermic treatment of locally advanced breast carcinoma
Int J Hyperthermia, 7 (6), 815-25
PubMed 1666900

Monge OR, Rofstad EK (1991)
Fractionated thermochemotherapy in vivo of a C3H mouse mammary carcinoma
Radiother Oncol, 21 (3), 171-8
PubMed 1924852

Mueller-Klieser W, Kroeger M, Walenta S, Rofstad EK (1991)
Comparative imaging of structure and metabolites in tumours
Int J Radiat Biol, 60 (1-2), 147-59
PubMed 1677963

Rofstad EK (1991)
Heterogeneity in vascular architecture and heat-induced vascular damage of human melanoma xenograft lines established from different lesions in the same patient
Int J Radiat Biol, 60 (1-2), 183-7
PubMed 1677969

Rofstad EK (1991)
Influence of cellular radiation sensitivity on local tumor control of human melanoma xenografts given fractionated radiation treatment
Cancer Res, 51 (17), 4609-12
PubMed 1873806

Rofstad EK, Wahl A, Hystad ME, Nesland JM, Stokke T (1991)
Establishment in monolayer culture and characterization of four human melanoma cell lines
Virchows Arch B Cell Pathol Incl Mol Pathol, 60 (3), 189-97
PubMed 1679270

Publications 1990

Mueller-Klieser W, Schaefer C, Walenta S, Rofstad EK, Fenton BM, Sutherland RM (1990)
Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry
Cancer Res, 50 (6), 1681-5
PubMed 2306721

Rofstad EK (1990)
NMR spectroscopy in prediction and monitoring of radiation response of tumours in vivo
Int J Radiat Biol, 57 (1), 1-5
PubMed 1967281

Rofstad EK (1990)
PLD-repair in human melanoma xenografts following single dose and fractionated irradiation
Br J Cancer, 61 (6), 856-60
PubMed 2372487

Rofstad EK (1990)
Heat sensitivity and thermotolerance in vitro of human breast carcinoma, malignant melanoma and squamous cell carcinoma of the head and neck
Br J Cancer, 61 (1), 22-8
PubMed 2297488

Rofstad EK, Wahl A, Stokke T, Nesland JM (1990)
Establishment and characterization of six human melanoma xenograft lines
APMIS, 98 (10), 945-53
PubMed 2245014

Rofstad EK, Zaffaroni N, Hystad ME (1990)
Heterogeneous radiation and heat sensitivity in vitro of human melanoma xenograft lines established from different lesions in the same patient. Comparisons with the radiation and heat sensitivity of cells isolated from the donor patient's surgical specimens
Int J Radiat Biol, 57 (6), 1113-22
PubMed 1971838

Publications 1989

Lee FY, Vessey A, Rofstad E, Siemann DW, Sutherland RM (1989)
Heterogeneity of glutathione content in human ovarian cancer
Cancer Res, 49 (19), 5244-8
PubMed 2766292

Monge OR, Rofstad EK (1989)
Thermochemotherapy in vivo of a C3H mouse mammary carcinoma: thermotolerant tumours
Int J Hyperthermia, 5 (5), 579-87
PubMed 2504842

Rofstad EK (1989)
Influence of cellular, microenvironmental, and growth parameters on thermotolerance kinetics in vivo in human melanoma xenografts
Cancer Res, 49 (18), 5027-32
PubMed 2766273

Rofstad EK (1989)
Local tumor control following single dose irradiation of human melanoma xenografts: relationship to cellular radiosensitivity and influence of an immune response by the athymic mouse
Cancer Res, 49 (12), 3163-7
PubMed 2655893

Rofstad EK (1989)
Hypoxia and reoxygenation in human melanoma xenografts
Int J Radiat Oncol Biol Phys, 17 (1), 81-9
PubMed 2745212

Rofstad EK (1989)
Radiation biology of human tumour xenografts
Int J Radiat Biol, 56 (5), 573-81
PubMed 2573649

Rofstad EK, DeMuth P, Fenton BM, Ceckler TL, Sutherland RM (1989)
31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia
Int J Radiat Oncol Biol Phys, 16 (4), 919-23
PubMed 2703397

Rofstad EK, Sutherland RM (1989)
Growth and radiation sensitivity of the MLS human ovarian carcinoma cell line grown as multicellular spheroids and xenografted tumours
Br J Cancer, 59 (1), 28-35
PubMed 2757922

Publications 1988

Brustad T, Rofstad EK (1988)
Effects of heat treatment in vitro and in vivo on human melanoma xenografts
Recent Results Cancer Res, 109, 183-97
PubMed 3175290

Davies CL, Ranheim T, Malik Z, Rofstad EK, Moan J, Lindmo T (1988)
Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
Br J Cancer, 58 (3), 306-13
PubMed 3179182

Fenton BM, Rofstad EK, Degner FL, Sutherland RM (1988)
Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth
J Natl Cancer Inst, 80 (20), 1612-9
PubMed 3193479

Monge OR, Rofstad EK, Kaalhus O (1988)
Thermochemotherapy in vivo of a C3H mouse mammary carcinoma: single fraction heat and drug treatment
Eur J Cancer Clin Oncol, 24 (10), 1661-9
PubMed 3145205

Rofstad EK, DeMuth P, Fenton BM, Sutherland RM (1988)
31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia
Cancer Res, 48 (19), 5440-6
PubMed 3416301

Rofstad EK, DeMuth P, Sutherland RM (1988)
31P NMR spectroscopy measurements of human ovarian carcinoma xenografts: relationship to tumour volume, growth rate, necrotic fraction and differentiation status
Radiother Oncol, 12 (4), 315-26
PubMed 3187070

Rofstad EK, Fenton BM, Sutherland RM (1988)
Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells
Br J Cancer, 57 (5), 494-502
PubMed 3395554

Rofstad EK, Howell RL, DeMuth P, Ceckler TL, Sutherland RM (1988)
31P NMR spectroscopy in vivo of two murine tumor lines with widely different fractions of radiobiologically hypoxic cells
Int J Radiat Biol, 54 (4), 635-49
PubMed 2902161

Rofstad EK, Sutherland RM (1988)
Radiation sensitivity of human ovarian carcinoma cell lines in vitro: effects of growth factors and hormones, basement membrane, and intercellular contact
Int J Radiat Oncol Biol Phys, 15 (4), 921-9
PubMed 3182331

Publications 1987

Rofstad EK, Brustad T (1987)
Radioresponsiveness of human melanoma xenografts given fractionated irradiation in vivo--relationship to the initial slope of the cell survival curves in vitro
Radiother Oncol, 9 (1), 45-56
PubMed 3602429

Rofstad EK, Wahl A, Brustad T (1987)
Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens
Cancer Res, 47 (1), 106-10
PubMed 3791195

Publications 1986

Rofstad EK (1986)
Growth and radiosensitivity of malignant melanoma multicellular spheroids initiated directly from surgical specimens of tumours in man
Br J Cancer, 54 (4), 569-78
PubMed 3778801

Rofstad EK (1986)
Radiation biology of malignant melanoma
Acta Radiol Oncol, 25 (1), 1-10
PubMed 3010642

Rofstad EK, Brustad T (1986)
Heterogeneity in radiosensitization by heat of cloned cell lines derived from a single human melanoma xenograft
Int J Radiat Biol Relat Stud Phys Chem Med, 50 (1), 93-102
PubMed 3487528

Rofstad EK, Brustad T (1986)
Arrhenius analysis of the heat response in vivo and in vitro of human melanoma xenografts
Int J Hyperthermia, 2 (4), 359-68
PubMed 3805805

Rofstad EK, Brustad T (1986)
Differences in thermosensitization among cloned cell lines isolated from a single human melanoma xenograft
Radiat Res, 106 (2), 147-55
PubMed 3704108

Rofstad EK, Brustad T (1986)
Primary and secondary cell death in human melanoma xenografts following hyperthermic treatment
Cancer Res, 46 (1), 355-61
PubMed 3940201

Rofstad EK, Wahl A, Brustad T (1986)
Radiation response of human melanoma multicellular spheroids measured as single cell survival, growth delay, and spheroid cure: comparisons with the parent tumor xenograft
Int J Radiat Oncol Biol Phys, 12 (6), 975-82
PubMed 3721939

Rofstad EK, Wahl A, Brustad T (1986)
Radiation response of multicellular spheroids initiated from five human melanoma xenograft lines. Relationship to the radioresponsiveness in vivo
Br J Radiol, 59 (706), 1023-9
PubMed 3768626

Rofstad EK, Wahl A, Davies Cde L, Brustad T (1986)
Growth characteristics of human melanoma multicellular spheroids in liquid-overlay culture: comparisons with the parent tumour xenografts
Cell Tissue Kinet, 19 (2), 205-16
PubMed 3698078

Publications 1985

Davies Cde L, Rofstad EK, Lindmo T (1985)
Hyperthermia-induced changes in antigen expression on human FME melanoma cells
Cancer Res, 45 (9), 4109-14
PubMed 3896477

Rofstad EK (1985)
Human tumour xenografts in radiotherapeutic research
Radiother Oncol, 3 (1), 35-46
PubMed 3975440

Rofstad EK, Brustad T (1985)
Tumour growth delay following single dose irradiation of human melanoma xenografts. Correlations with tumour growth parameters, vascular structure and cellular radiosensitivity
Br J Cancer, 51 (2), 201-10
PubMed 3966977

Rofstad EK, Brustad T (1985)
Heterogeneity in heat sensitivity and development of thermotolerance of cloned cell lines derived from a single human melanoma xenograft
Int J Hyperthermia, 1 (1), 85-96
PubMed 3837083

Rofstad EK, Wahl A, Brustad T (1985)
Heat response of human melanoma multicellular spheroids: comparisons with single cells and xenografted tumors
Radiat Res, 102 (3), 324-35
PubMed 4070547

Rofstad EK, Wahl A, Tveit KM, Monge OR, Brustad T (1985)
Survival curves after X-ray and heat treatments for melanoma cells derived directly from surgical specimens of tumours in man
Radiother Oncol, 4 (1), 33-44
PubMed 4035001

Solesvik OV, Rofstad EK, Brustad T (1985)
Vascular structure of the C3H mammary carcinoma, the B16 melanoma and the Lewis lung carcinoma in syngeneic, conventional mice and congenitally athymic mice
Eur J Cancer Clin Oncol, 21 (4), 499-505
PubMed 4007018

Publications 1984

Falkvoll KH, Rofstad EK, Brustad T, Marton P (1984)
A transparent chamber for the dorsal skin fold of athymic mice
Exp Cell Biol, 52 (4), 260-8
PubMed 6734890

Lindmo T, Davies C, Rofstad EK, Fodstad O, Sundan A (1984)
Antigen expression in human melanoma cells in relation to growth conditions and cell-cycle distribution
Int J Cancer, 33 (2), 167-71
PubMed 6693198

Rofstad EK (1984)
Growth and vascular structure of human melanoma xenografts
Cell Tissue Kinet, 17 (1), 91-101
PubMed 6692466

Rofstad EK, Brustad T (1984)
Response to heat treatment (42.5 degrees C) in vivo and in vitro of five human melanoma xenografts
Br J Radiol, 57 (683), 1023-32
PubMed 6535617

Rofstad EK, Brustad T (1984)
Differential responses to radiation and hyperthermia of cloned cell lines derived from a single human melanoma xenograft
Int J Radiat Oncol Biol Phys, 10 (6), 857-64
PubMed 6735769

Rofstad EK, Brustad T (1984)
Development of thermotolerance in a human melanoma xenograft
Cancer Res, 44 (2), 525-30
PubMed 6692358

Rofstad EK, Brustad T (1984)
Hyperthermic radiosensitization of cells from a human melanoma xenograft
Radiat Res, 99 (1), 59-72
PubMed 6739727

Rofstad EK, Falkvoll KH, Oftedal P (1984)
Micronucleus formation in human melanoma xenografts following exposure to hyperthermia
Radiat Environ Biophys, 23 (1), 51-60
PubMed 6709827

Rofstad EK, Midthjell H, Brustad T (1984)
Heat sensitivity and thermotolerance in cells from five human melanoma xenografts
Cancer Res, 44 (10), 4347-54
PubMed 6467196

Rofstad EK, Solesvik OV, Brustad T (1984)
Tumour growth delay, cell inactivation and vascular damage following hyperthermic treatment of a human melanoma xenograft
Eur J Cancer Clin Oncol, 20 (10), 1295-1305
PubMed 6541585

Rofstad EK, Wahl A, Brustad T (1984)
Radiation and heat sensitivity of cells from two slowly growing human melanoma xenografts
Br J Cancer, 49 (6), 745-52
PubMed 6733021

Solesvik OV, Rofstad EK, Brustad T (1984)
Vascular changes in a human malignant melanoma xenograft following single-dose irradiation
Radiat Res, 98 (1), 115-28
PubMed 6718687

Publications 1983

Fodstad O, Rofstad EK, Tveit KM, Pihl A (1983)
Spontaneous alteration in growth rates of two human melanoma xenografts. Concurrent changes in chemosensitivity
Eur J Cancer Clin Oncol, 19 (8), 1175-8
PubMed 6684563

Rofstad EK, Brustad T (1983)
Radiation and heat sensitivity of cells from human melanoma xenografts. Lack of correlations with tumour growth parameters
Eur J Cancer Clin Oncol, 19 (3), 427-32
PubMed 6683180

Rofstad EK, Brustad T (1983)
Intercellular contact and the radiation response of cells of human melanoma xenografts
Int J Radiat Oncol Biol Phys, 9 (2), 191-5
PubMed 6833022

Rofstad EK, Brustad T (1983)
Tumour control following single-dose irradiation of a human melanoma xenograft
Eur J Cancer Clin Oncol, 19 (8), 1127-31
PubMed 6684558

Rofstad EK, Brustad T (1983)
Radiosensitivity of the cells of an established human melanoma cell line and the parent melanoma xenograft
Int J Radiat Biol Relat Stud Phys Chem Med, 44 (5), 447-54
PubMed 6605949

Publications 1982

Rofstad EK, Brustad T (1982)
Effect of hyperthermia on human melanoma cells heated either as solid tumors in athymic nude mice or in vitro
Cancer, 50 (7), 1304-8
PubMed 7104974

Rofstad EK, Fodstad O, Lindmo T (1982)
Growth characteristics of human melanoma xenografts
Cell Tissue Kinet, 15 (5), 545-54
PubMed 7127402

Solesvik OV, Rofstad EK, Brustad T (1982)
Vascular structure of five human malignant melanomas grown in athymic nude mice
Br J Cancer, 46 (4), 557-67
PubMed 7138764

Publications 1981

Flaten TP, Rofstad EK, Brustad T (1981)
Radiation response of two human malignant melanomas grown in athymic nude mice
Eur J Cancer, 17 (5), 527-32
PubMed 7297592

Pettersen EO, Rofstad EK, Brustad T (1981)
Sensitising effect of misonidazole on NHIK 1922 cells irradiated in vitro or as solid tumour in athymic nude mice
Acta Radiol Oncol, 20 (2), 101-8
PubMed 6270961

Rofstad EK (1981)
Radiation response of the cells of a human malignant melanoma xenograft. Effect of hypoxic cell radiosensitizers
Radiat Res, 87 (3), 670-83
PubMed 7280191

Rofstad EK, Brustad T (1981)
Response of human malignant melanoma xenografts to hyperthermia: effect of vascular occlusion
Int J Radiat Oncol Biol Phys, 7 (12), 1685-7
PubMed 7333910

Rofstad EK, Brustad T (1981)
Radiation response in vitro of cells from five human malignant melanoma xenografts
Int J Radiat Biol Relat Stud Phys Chem Med, 40 (6), 677-80
PubMed 6978304

Rofstad EK, Brustad T (1981)
Broad-shouldered survival curves of a human melanoma xenograft. Implications for radiation therapy in the absence and presence of misonidazole
Acta Radiol Oncol, 20 (4), 261-5
PubMed 6277155

Publications 1980

Rofstad EK, Brustad T (1980)
Radiosensitizing effect of misonidazole in acute and fractionated irradiation of a human osteosarcoma xenograft
Int J Radiat Oncol Biol Phys, 6 (9), 1163-7
PubMed 6936394

Rofstad EK, Brustad T (1980)
Radiosensitization by misonidazole of a human malignant melanoma grown in athymic nude mice
Br J Radiol, 53 (631), 678-86
PubMed 7426890

Rofstad EK, Lindmo T, Brustad T (1980)
Effect of single dose irradiation on the proliferation kinetics in a human malignant melanoma in athymic nude mice
Acta Radiol Oncol, 19 (4), 261-9
PubMed 6257048

Rofstad EK, Pettersen EO, Lindmo T, Oftebro R (1980)
The proliferation kinetics of NHIK 1922 cells in vitro and in solid tumours in athymic mice
Cell Tissue Kinet, 13 (2), 163-71
PubMed 7363302

Publications 1979

Rofstad EK, Brustad T (1979)
Radiosensitizing effect of misonidazole in fractionated gamma-ray treatment of a human malignant melanoma grown in athymic nude mice
Br J Radiol, 52 (617), 393-7
PubMed 444837

Publications 1978

Rofstad EK, Brustad T (1978)
The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse
Br J Radiol, 51 (605), 381-6
PubMed 638410

Publications 1977

Rofstad EK, Brustad T, Johannessen JV (1977)
Effect of clinically relevant irradiation regimes on human malignant melanomas grown in athymic nude mice
Acta Radiol Ther Phys Biol, 16 (3), 273-80
PubMed 906896

Rofstad EK, Brustad T, Johannessen JV, Mossige J (1977)
Effect of cobalt-60 gamma rays and DTIC (5-(3,3 dimethyl-1-triazeno)-imidazole-r-carboxamide) on human malignant melanomas grown in athymic nude mice
Br J Radiol, 50 (593), 314-20
PubMed 861450

Rofstad EK, Brustad T, Kaalhus O (1977)
Cell proliferation kinetics in two human tumors grown in athymic nude mice
Virchows Arch B Cell Pathol, 24 (3), 219-25
PubMed 410153

Publications 1976

Brustad T, Rofstad EK, Davy M, Mossige J (1976)
A pilot experiment to compare regression of transplants of two different human tumors in athymic nude mice following single exposures to 60co radiation
Strahlentherapie, 152 (5), 477-81
PubMed 996892