Jens Pahnke
Position: Group leader
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Publications 2017

Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstål H (2017)
Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity
Biochimie, 140, 176-192
PubMed 28751216

Sike Á, Wengenroth J, Upīte J, Brüning T, Eiriz I, Sántha P, Biverstål H, Jansone B, Haugen HJ, Krohn M, Pahnke J (2017)
Improved method for cannula fixation for long-term intracerebral brain infusion
J Neurosci Methods, 290, 145-150
PubMed 28754434

Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J (2017)
Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
Acta Neuropathol Commun, 5 (1), 49
PubMed 28637503

Publications 2016

Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J (2016)
Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula
Schizophr Res, 177 (1-3), 52-58
PubMed 26948503

Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J (2016)
Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice
J Alzheimers Dis, 53 (3), 967-80
PubMed 27258424

Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, Palha JA (2016)
The choroid plexus in health and in disease: dialogues into and out of the brain
Neurobiol Dis, 107, 32-40
PubMed 27546055

Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR (2016)
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes
Acta Neuropathol Commun, 4, 25
PubMed 26984535

Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J (2016)
Revisiting rodent models: Octodon degus as Alzheimer's disease model?
Acta Neuropathol Commun, 4 (1), 91
PubMed 27566602

Publications 2015

Apostolova I, Niedzielska D, Derlin T, Koziolek EJ, Amthauer H, Salmen B, Pahnke J, Brenner W, Mautner VF, Buchert R (2015)
Perfusion single photon emission computed tomography in a mouse model of neurofibromatosis type 1: towards a biomarker of neurologic deficits
J Cereb Blood Flow Metab, 35 (8), 1304-12
PubMed 25785829

Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT (2015)
Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease
PLoS Genet, 11 (8), e1005267
PubMed 26247199

Fröhlich C, Zschiebsch K, Gröger V, Paarmann K, Steffen J, Thurm C, Schropp EM, Brüning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J (2015)
Activation of Mitochondrial Complex II-Dependent Respiration Is Beneficial for α-Synucleinopathies
Mol Neurobiol, 53 (7), 4728-44
PubMed 26319560

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen Und Halbach O, Pahnke J (2015)
Accumulation of murine amyloid-β mimics early Alzheimer's disease
Brain, 138 (Pt 8), 2370-82
PubMed 25991605

Lill CM, Rengmark A, Pihlstrøm L, Fogh I, Shatunov A, Sleiman PM, Wang LS, Liu T, Lassen CF, Meissner E, Alexopoulos P, Calvo A, Chio A, Dizdar N, Faltraco F, Forsgren L, Kirchheiner J, Kurz A, Larsen JP, Liebsch M, Linder J, Morrison KE, Nissbrandt H, Otto M, Pahnke J et al. (2015)
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
Alzheimers Dement, 11 (12), 1407-1416
PubMed 25936935

Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O (2015)
Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography
Mol Pharm, 12 (9), 3214-25
PubMed 26202880

Publications 2014

Bernstein HG, Hölzl G, Dobrowolny H, Hildebrandt J, Trübner K, Krohn M, Bogerts B, Pahnke J (2014)
Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary
Mech Ageing Dev, 141-142, 12-21
PubMed 25218792

Lemcke S, Müller S, Möller S, Schillert A, Ziegler A, Cepok-Kauffeld S, Comabella M, Montalban X, Rülicke T, Nandakumar KS, Hemmer B, Holmdahl R, Pahnke J, Ibrahim SM (2014)
Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene
Am J Pathol, 184 (9), 2420-9
PubMed 25129256

Pahnke J, Fröhlich C, Paarmann K, Krohn M, Bogdanovic N, Årsland D, Winblad B (2014)
Cerebral ABC transporter-common mechanisms may modulate neurodegenerative diseases and depression in elderly subjects
Arch Med Res, 45 (8), 738-43
PubMed 25446622

Pahnke J, Langer O, Krohn M (2014)
Alzheimer's and ABC transporters--new opportunities for diagnostics and treatment
Neurobiol Dis, 72 Pt A, 54-60
PubMed 24746857

Publications 2013

Fröhlich C, Paarmann K, Steffen J, Stenzel J, Krohn M, Heinze HJ, Pahnke J (2013)
Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease
Eur J Microbiol Immunol (Bp), 3 (1), 21-27
PubMed 23814667

Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Heinze HJ, Crockett S, Sharbel TF, Pahnke J (2013)
Reduced Alzheimer's disease pathology by St. John's Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice
Curr Alzheimer Res, 10 (10), 1057-69
PubMed 24156265

Pahnke J, Fröhlich C, Krohn M, Schumacher T, Paarmann K (2013)
Impaired mitochondrial energy production and ABC transporter function-A crucial interconnection in dementing proteopathies of the brain
Mech Ageing Dev, 134 (10), 506-15
PubMed 24012632

Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Fürst K, Kowtharapu BS, Engelmann D, Petigk J, Egberts F, Schäd-Trcka SG, Gross G, Nettelbeck DM, Niemetz A, Pützer BM (2013)
DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling
Cancer Cell, 24 (4), 512-27
PubMed 24135282

Publications 2012

Ehler J, Patejdl R, Junghanss C, Lehmitz R, Pahnke J, Großmann A, Vogelgesang S, Brüggemann M, Benecke R, Zettl UK (2012)
Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma
Clin Neurol Neurosurg, 114 (7), 1102-3
PubMed 22421252

Scheffler K, Krohn M, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen Und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J (2012)
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis
Acta Neuropathol, 124 (2), 199-208
PubMed 22526016

Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E (2012)
A novel sialyl Le(X) expression score as a potential prognostic tool in colorectal cancer
World J Surg Oncol, 10, 95
PubMed 22621806

Schmidt A, Pahnke J (2012)
Efficient near-infrared in vivo imaging of amyoid-β deposits in Alzheimer's disease mouse models
J Alzheimers Dis, 30 (3), 651-64
PubMed 22460331

Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, Dunkelmann T, Paarmann K, Fröhlich C, Uecker A, Plath AS, Sommer A, Brüning T, Heinze HJ, Pahnke J (2012)
ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice
PLoS One, 7 (4), e35613
PubMed 22545122

Publications 2011

Kamm C, Uflacker N, Asmus F, Schrader C, Wolters A, Wittstock M, Pahnke J, Gasser T, Volkmann J, Münchau A, Hagenah J, Benecke R, Klein C, Lohmann K (2011)
No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia
Mov Disord, 26 (11), 2136-7
PubMed 21638323

Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J (2011)
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice
J Clin Invest, 121 (10), 3924-31
PubMed 21881209

Scheffler K, Stenzel J, Krohn M, Lange C, Hofrichter J, Schumacher T, Brüning T, Plath AS, Walker L, Pahnke J (2011)
Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease
Curr Alzheimer Res, 8 (7), 781-8
PubMed 21244350

Teipel SJ, Buchert R, Thome J, Hampel H, Pahnke J (2011)
Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
Prog Neurobiol, 95 (4), 547-56
PubMed 21601614

Teipel SJ, Kaza E, Hadlich S, Bauer A, Brüning T, Plath AS, Krohn M, Scheffler K, Walker LC, Lotze M, Pahnke J (2011)
Automated detection of amyloid-β-related cortical and subcortical signal changes in a transgenic model of Alzheimer's disease using high-field MRI
J Alzheimers Dis, 23 (2), 221-37
PubMed 20966552

Publications 2010

Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O (2010)
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease
Neurogenetics, 11 (2), 203-15
PubMed 19730898

Publications 2009

Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM (2009)
E2F1 in melanoma progression and metastasis
J Natl Cancer Inst, 102 (2), 127-33
PubMed 20026813

Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A (2009)
Functionally relevant domains of the prion protein identified in vivo
PLoS One, 4 (9), e6707
PubMed 19738901

Pahnke J, Walker LC, Scheffler K, Krohn M (2009)
Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
Neurosci Biobehav Rev, 33 (7), 1099-108
PubMed 19481107

Westman E, Spenger C, Oberg J, Reyer H, Pahnke J, Wahlund LO (2009)
In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
BMC Neurosci, 10, 33
PubMed 19351388

Publications 2008

Miksch RM, Armbrust S, Pahnke J, Fusch C (2008)
Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP
Eur J Pediatr, 167 (8), 909-16
PubMed 18172681

Pahnke J, Wolkenhauer O, Krohn M, Walker LC (2008)
Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
Curr Alzheimer Res, 5 (4), 396-405
PubMed 18690837

Publications 2007

Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwalder M, Rülicke T, Bürkle A, Aguzzi A (2007)
Lethal recessive myelin toxicity of prion protein lacking its central domain
EMBO J, 26 (2), 538-47
PubMed 17245436

Bramkamp M, Dedes KJ, Strobel K, Pahnke J, Breitenstein S, Clavien PA (2007)
Cholestasis from malignant melanoma
J Clin Oncol, 25 (6), 725-6
PubMed 17308277

Henning J, Koczan D, Glass A, Karopka T, Pahnke J, Rolfs A, Benecke R, Gimsa U (2007)
Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression
Eur J Neurosci, 25 (1), 239-50
PubMed 17241285

Hoffrogge R, Beyer S, Hübner R, Mikkat S, Mix E, Scharf C, Schmitz U, Pauleweit S, Berth M, Zubrzycki IZ, Christoph H, Pahnke J, Wolkenhauer O, Uhrmacher A, Völker U, Rolfs A (2007)
2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells
Proteomics, 7 (1), 33-46
PubMed 17146836

Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, Krüger R (2007)
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
FASEB J, 21 (8), 1759-67
PubMed 17327361

Wyss MT, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, Weber B, Neri D, Buck A (2007)
Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis
J Nucl Med, 48 (4), 608-14
PubMed 17401099

Publications 2006

Hoffrogge R, Mikkat S, Scharf C, Beyer S, Christoph H, Pahnke J, Mix E, Berth M, Uhrmacher A, Zubrzycki IZ, Miljan E, Völker U, Rolfs A (2006)
2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)
Proteomics, 6 (6), 1833-47
PubMed 16475233

Mix E, Ibrahim SM, Pahnke J, Glass A, Mazón-Peláez I, Lemcke S, Koczan D, Gimsa U, Bansemer S, Scheel T, Karopka T, Böttcher T, Müller J, Dazert E, Antipova V, Hoffrogge R, Wree A, Zschiesche M, Strauss U, Kundt G, Warzok R, Gierl L, Rolfs A (2006)
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
J Autoimmun, 27 (4), 251-65
PubMed 17085013

Spaeth N, Wyss MT, Pahnke J, Biollaz G, Lutz A, Goepfert K, Westera G, Treyer V, Weber B, Buck A (2006)
Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat
Eur J Nucl Med Mol Imaging, 33 (6), 673-82
PubMed 16538503

Spaeth N, Wyss MT, Pahnke J, Biollaz G, Trachsel E, Drandarov K, Treyer V, Weber B, Neri D, Buck A (2006)
Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19)
Nucl Med Biol, 33 (5), 661-6
PubMed 16843841

Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, Ibrahim SM (2006)
Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
Am J Pathol, 168 (5), 1570-5
PubMed 16651623

Publications 2005

Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM (2005)
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease
Hum Mol Genet, 14 (14), 1977-89
PubMed 15917267

Möller S, Mix E, Blüggel M, Serrano-Fernández P, Koczan D, Kotsikoris V, Kunz M, Watson M, Pahnke J, Illges H, Kreutzer M, Mikkat S, Thiesen HJ, Glocker MO, Zettl UK, Ibrahim SM (2005)
Collection of soluble variants of membrane proteins for transcriptomics and proteomics
In Silico Biol, 5 (3), 295-311
PubMed 15984938

Rolfs A, Böttcher T, Zschiesche M, Morris P, Winchester B, Bauer P, Walter U, Mix E, Löhr M, Harzer K, Strauss U, Pahnke J, Grossmann A, Benecke R (2005)
Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
Lancet, 366 (9499), 1794-6
PubMed 16298216

Publications 2004

Mix E, Ibrahim S, Pahnke J, Koczan D, Sina C, Böttcher T, Thiesen HJ, Rolfs A (2004)
Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
J Neuroimmunol, 151 (1-2), 158-70
PubMed 15145614

Pahnke J, Mix E, Knoblich R, Müller J, Zschiesche M, Schubert B, Koczan D, Bauer P, Böttcher T, Thiesen HJ, Lazarov L, Wree A, Rolfs A (2004)
Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
Exp Cell Res, 297 (2), 484-94
PubMed 15212950

Peters S, Mix E, Bauer P, Weinelt S, Schubert B, Knoblich R, Böttcher T, Strauss U, Pahnke J, Cattaneo E, Wree A, Rolfs A (2004)
Wnt-5a expression in the rat neuronal progenitor cell line ST14A
Exp Brain Res, 158 (2), 189-95
PubMed 15309358

Spaeth N, Wyss MT, Weber B, Scheidegger S, Lutz A, Verwey J, Radovanovic I, Pahnke J, Wild D, Westera G, Weishaupt D, Hermann DM, Kaser-Hotz B, Aguzzi A, Buck A (2004)
Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence
J Nucl Med, 45 (11), 1931-8
PubMed 15534065

Strauss U, Kole MH, Bräuer AU, Pahnke J, Bajorat R, Rolfs A, Nitsch R, Deisz RA (2004)
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
Eur J Neurosci, 19 (11), 3048-58
PubMed 15182313

Vogelgesang S, Warzok RW, Cascorbi I, Kunert-Keil C, Schroeder E, Kroemer HK, Siegmund W, Walker LC, Pahnke J (2004)
The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
Curr Alzheimer Res, 1 (2), 121-5
PubMed 15975076

Publications 2003

Böttcher T, Mix E, Koczan D, Bauer P, Pahnke J, Peters S, Weinelt S, Knoblich R, Strauss U, Cattaneo E, Thiesen HJ, Rolfs A (2003)
Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
J Neurosci Res, 73 (1), 42-53
PubMed 12815707

Fischer G, Ibrahim SM, Brockmann GA, Pahnke J, Bartocci E, Thiesen HJ, Serrano-Fernández P, Möller S (2003)
Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl
Genome Biol, 4 (11), R77
PubMed 14611663

Jung HH, Hergersberg M, Vogt M, Pahnke J, Treyer V, Röthlisberger B, Kollias SS, Russo D, Frey BM (2003)
McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement
Transfusion, 43 (7), 928-38
PubMed 12823753

Publications 2002

Mix E, Pahnke J, Ibrahim SM (2002)
Gene-expression profiling of experimental autoimmune encephalomyelitis
Neurochem Res, 27 (10), 1157-63
PubMed 12462414

Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, Warzok RW (2002)
Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
Pharmacogenetics, 12 (7), 535-41
PubMed 12360104

Vogelgesang S, Junge MH, Pahnke J, Gaab MR, Warzok RW (2002)
August 2001: Sellar/suprasellar mass in a 59-year-old woman
Brain Pathol, 12 (1), 135-6, 139
PubMed 11770897