Reidun Øvstebø
Position: Group leader, PhD
Phone: +47 22 11 94 91
Email:
 

Author network for Reidun Øvstebø by COREMINE medical


Publications 2017

Aqrawi LA, Galtung HK, Vestad B, Øvstebø R, Thiede B, Rusthen S, Young A, Guerreiro EM, Utheim TP, Chen X, Utheim ØA, Palm Ø, Jensen JL (2017)
Identification of potential saliva and tear biomarkers in primary Sjögren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis
Arthritis Res Ther, 19 (1), 14
PubMed 28122643

Publications 2016

Hellum M, Trøseid AS, Berg JP, Brandtzaeg P, Øvstebø R, Henriksson CE (2016)
The Neisseria meningitidis lpxL1 mutant induces less tissue factor expression and activity in primary human monocytes and monocyte-derived microvesicles than the wild type meningococcus
Innate Immun, 23 (2), 196-205
PubMed 28024455

Skogstad M, Lunde LK, Skare Ø, Mamen A, Alfonso JH, Øvstebø R, Ulvestad B (2016)
Physical activity initiated by employer and its health effects; an eight week follow-up study
BMC Public Health, 16, 377
PubMed 27146485

Stylianou E, Ueland T, Borchsenius F, Michelsen AE, Øvstebø R, Mollnes TE, Skjønsberg OH, Aukrust P (2016)
Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis
Scand J Clin Lab Invest, 76 (2), 118-27
PubMed 26878875

Publications 2014

Gopinathan U, Brusletto BS, Olstad OK, Kierulf P, Berg JP, Brandtzaeg P, Øvstebø R (2014)
IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes
Innate Immun, 21 (4), 429-49
PubMed 25233959

Publications 2013

Hellum M, Øvstebø R, Brusletto BS, Berg JP, Brandtzaeg P, Henriksson CE (2013)
Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock
Thromb Res, 133 (3), 507-14
PubMed 24423888

Øvstebø R, Hellum M, Aass HC, Trøseid AM, Brandtzaeg P, Mollnes TE, Henriksson CE (2013)
Microparticle-associated tissue factor activity is reduced by inhibition of the complement protein 5 in Neisseria meningitidis-exposed whole blood
Innate Immun, 20 (5), 552-60
PubMed 24051102

Publications 2012

Dahm AE, Eilertsen AL, Goeman J, Olstad OK, Ovstebø R, Kierulf P, Mowinckel MC, Skretting G, Sandset PM (2012)
A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women
Thromb Res, 130 (1), 45-51
PubMed 22217510

Gopinathan U, Ovstebø R, Olstad OK, Brusletto B, Dalsbotten Aass HC, Kierulf P, Brandtzaeg P, Berg JP (2012)
Global effect of interleukin-10 on the transcriptional profile induced by Neisseria meningitidis in human monocytes
Infect Immun, 80 (11), 4046-54
PubMed 22966040

Hellum M, Øvstebø R, Trøseid AM, Berg JP, Brandtzaeg P, Henriksson CE (2012)
Microparticle-associated tissue factor activity measured with the Zymuphen MP-TF kit and the calibrated automated thrombogram assay
Blood Coagul Fibrinolysis, 23 (6), 520-6
PubMed 22732249

Publications 2011

Fell AK, Notø H, Skogstad M, Nordby KC, Eduard W, Svendsen MV, Ovstebø R, Trøseid AM, Kongerud J (2011)
A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers
Occup Environ Med, 68 (11), 799-805
PubMed 21297153

Henriksson CE, Hellum M, Haug KB, Aass HC, Joø GB, Øvstebø R, Trøseid AM, Klingenberg O, Kierulf P (2011)
Anticoagulant effects of an antidiabetic drug on monocytes in vitro
Thromb Res, 128 (5), e100-6
PubMed 21862110

Opstad TB, Pettersen AA, Weiss TW, Akra S, Øvstebø R, Arnesen H, Seljeflot I (2011)
Genetic variation, gene-expression and circulating levels of matrix metalloproteinase-9 in patients with stable coronary artery disease
Clin Chim Acta, 413 (1-2), 113-20
PubMed 21963461

Skogstad M, Sikkeland LI, Øvstebø R, Haug KB, Heldal KK, Skare Ø, Kongerud J, Kierulf P, Eduard W (2011)
Long-term occupational outcomes of endotoxin exposure and the effect of exposure cessation
Occup Environ Med, 69 (2), 107-12
PubMed 21810928

Øvstebø R, Aass HC, Haug KB, Trøseid AM, Gopinathan U, Kierulf P, Berg JP, Brandtzaeg P, Henriksson CE (2011)
LPS from Neisseria meningitidis is crucial for inducing monocyte- and microparticle-associated tissue factor activity but not for tissue factor expression
Innate Immun, 18 (4), 580-91
PubMed 22180561

Aass HC, Øvstebø R, Trøseid AM, Kierulf P, Berg JP, Henriksson CE (2011)
Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis
Cytometry A, 79 (12), 990-9
PubMed 21990118

Publications 2010

Piehler AP, Grimholt RM, Ovstebø R, Berg JP (2010)
Gene expression results in lipopolysaccharide-stimulated monocytes depend significantly on the choice of reference genes
BMC Immunol, 11, 21
PubMed 20441576

Publications 2009

Lund PK, Øvstebø R, Møller AS, Olstad OK, Landsverk KS, Hellum M, Kierulf P (2009)
Using global gene expression patterns to characterize Annexin V positive and negative human monocytes in culture
Scand J Clin Lab Invest, 69 (2), 251-64
PubMed 18951241

Publications 2008

Ovstebø R, Olstad OK, Brusletto B, Møller AS, Aase A, Haug KB, Brandtzaeg P, Kierulf P (2008)
Identification of genes particularly sensitive to lipopolysaccharide (LPS) in human monocytes induced by wild-type versus LPS-deficient Neisseria meningitidis strains
Infect Immun, 76 (6), 2685-95
PubMed 18362127

Rojahn A, Brusletto B, Øvstebø R, Haug KB, Kierulf P, Brandtzaeg P (2008)
Does granulocyte colony-stimulating factor ameliorate the proinflammatory response in human meningococcal septic shock?
Crit Care Med, 36 (9), 2583-9
PubMed 18679115

Rødland EK, Mattingsdal M, Olstad OK, Ovstebø R, Kierulf P, Muller F, Frøland SS (2008)
Expression of genes in normal human monocytes in response to Aspergillus fumigatus
Med Mycol, 46 (4), 327-36
PubMed 18415839

Publications 2007

Sikkeland LI, Skogstad M, Ovstebø R, Brusletto B, Haug KB, Kongerud J, Eduard W, Kierulf P (2007)
Circulating lipopolysaccharides in the blood from "bioprotein" production workers
Occup Environ Med, 65 (3), 211-4
PubMed 17855504

Øvstebø R, Lande K, Kierulf P, Haug KB (2007)
Quantification of relative changes in specific mRNAs from frozen whole blood - methodological considerations and clinical implications
Clin Chem Lab Med, 45 (2), 171-6
PubMed 17311503

Publications 2005

Henriksson CE, Klingenberg O, Ovstebø R, Joø GB, Westvik AB, Kierulf P (2005)
Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis
Thromb Haemost, 94 (6), 1236-44
PubMed 16411400

Møller AS, Ovstebø R, Haug KB, Joø GB, Westvik AB, Kierulf P (2005)
Chemokine production and pattern recognition receptor (PRR) expression in whole blood stimulated with pathogen-associated molecular patterns (PAMPs)
Cytokine, 32 (6), 304-15
PubMed 16406558

Ovstebo R, Brandtzaeg P, Brusletto B, Haug KBF, Lande K, Hoiby EA, Kierulf P (2005)
Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease (vol 42, pg 2980, 2004)
J. Clin. Microbiol., 43 (1), 532

Publications 2004

Øvstebø R, Brandtzaeg P, Brusletto B, Haug KB, Lande K, Høiby EA, Kierulf P (2004)
Use of robotized DNA isolation and real-time PCR to quantify and identify close correlation between levels of Neisseria meningitidis DNA and lipopolysaccharides in plasma and cerebrospinal fluid from patients with systemic meningococcal disease
J Clin Microbiol, 42 (7), 2980-7
PubMed 15243048

Publications 2003

Bjerre A, Brusletto B, Øvstebø R, Joø GB, Kierulf P, Brandtzaeg P (2003)
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex
J Endotoxin Res, 9 (3), 155-63
PubMed 12831456

Distante S, Elmberg M, Foss Haug KB, Ovstebø R, Berg JP, Kierulf P, Hultcrantz R, Bell H (2003)
Tumour necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemochromatosis
Scand J Gastroenterol, 38 (8), 871-7
PubMed 12940442

Møller AS, Øvstebø R, Westvik AB, Joø GB, Haug KB, Kierulf P (2003)
Effects of bacterial cell wall components (PAMPs) on the expression of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and the chemokine receptor CCR2 by purified human blood monocytes
J Endotoxin Res, 9 (6), 349-60
PubMed 14733721

Øvstebø R, Haug KB, Lande K, Kierulf P (2003)
PCR-based calibration curves for studies of quantitative gene expression in human monocytes: development and evaluation
Clin Chem, 49 (3), 425-32
PubMed 12600954

Publications 2002

Lund PK, Namork E, Brorson SH, Westvik AB, Joo GB, Ovstebo R, Kierulf P (2002)
The fate of monocytes during 24 h of culture as revealed by flow cytometry and electron microscopy
J. Immunol. Methods, 270 (1), PII S0022-1759(02)00272-7-76

Lund PK, Namork E, Brorson SH, Westvik AB, Joø GB, Øvstebø R, Kierulf P (2002)
The fate of monocytes during 24 h of culture as revealed by flow cytometry and electron microscopy
J Immunol Methods, 270 (1), 63-76
PubMed 12379339

Publications 2001

Brandtzaeg P, Bjerre A, Øvstebø R, Brusletto B, Joø GB, Kierulf P (2001)
Neisseria meningitidis lipopolysaccharides in human pathology
J Endotoxin Res, 7 (6), 401-20
PubMed 11753210

Brandtzaeg P, Ovstebø R, Kierulf P (2001)
Quantitative detection of bacterial lipopolysaccharides in clinical specimens
Methods Mol Med, 67, 427-39
PubMed 21337159

Lund PK, Westvik AB, Joø GB, Øvstebø R, Haug KB, Kierulf P (2001)
Flow cytometric evaluation of apoptosis, necrosis and recovery when culturing monocytes
J Immunol Methods, 252 (1-2), 45-55
PubMed 11334964

Møller AW, Haug KB, Øvstebø R, Joø GB, Westvik AB, Kierulf P (2001)
Non-mannose-capped lipoarabinomannan stimulates human peripheral monocytes to expression of the "early immediate genes" tissue factor and tumor necrosis factor-alpha
Thromb Res, 102 (3), 273-83
PubMed 11369421

Publications 2000

Bjerre A, Brusletto B, Rosenqvist E, Namork E, Kierulf P, Øvstebø R, Joø GB, Brandtzaeg P (2000)
Cellular activating properties and morphology of membrane-bound and purified meningococcal lipopolysaccharide
J Endotoxin Res, 6 (6), 437-45
PubMed 11521068

Bjerre A, Ovstebø R, Kierulf P, Halvorsen S, Brandtzaeg P (2000)
Fulminant meningococcal septicemia: dissociation between plasma thrombopoietin levels and platelet counts
Clin Infect Dis, 30 (4), 643-7
PubMed 10770723

Lund PK, Joø GB, Westvik AB, Ovstebø R, Kierulf P (2000)
Isolation of monocytes from whole blood by density gradient centrifugation and counter-current elutriation followed by cryopreservation: six years' experience
Scand J Clin Lab Invest, 60 (5), 357-65
PubMed 11003255

Osnes LT, Haug KB, Joø GB, Westvik AB, Ovstebø R, Kierulf P (2000)
Aspirin potentiates LPS-induced fibrin formation (FPA) and TNF-alpha-synthesis in whole blood
Thromb Haemost, 83 (6), 868-73
PubMed 10896240

Publications 1996

Brandtzaeg P, Osnes L, Ovstebø R, Joø GB, Westvik AB, Kierulf P (1996)
Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes
J Exp Med, 184 (1), 51-60
PubMed 8691149

Osnes LT, Foss KB, Joø GB, Okkenhaug C, Westvik AB, Ovstebø R, Kierulf P (1996)
Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-kappa B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-alpha) in human monocytes
Thromb Haemost, 76 (6), 970-6
PubMed 8972019

Publications 1995

Brandtzaeg P, Ovstebø R, Kierulf P (1995)
Bacteremia and compartmentalization of LPS in meningococcal disease
Prog Clin Biol Res, 392, 219-33
PubMed 8524927

Eggesbø JB, Hjermann I, Joø GB, Ovstebø R, Kierulf P (1995)
LPS-induced release of EGF, GM-CSF, GRO alpha, LIF, MIP-1 alpha and PDGF-AB in PBMC from persons with high or low levels of HDL lipoprotein
Cytokine, 7 (6), 562-7
PubMed 8580373

Eggesbø JB, Hjermann I, Ovstebø R, Joø GB, Kierulf P (1995)
LPS induced procoagulant activity and plasminogen activator activity in mononuclear cells from persons with high or low levels of HDL lipoprotein
Thromb Res, 77 (5), 441-52
PubMed 7778059

Publications 1994

Eggesbø JB, Hjermann I, Lund PK, Joø GB, Ovstebø R, Kierulf P (1994)
LPS-induced release of IL-1 beta, IL-6, IL-8, TNF-alpha and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein
Cytokine, 6 (5), 521-9
PubMed 7530060

Nordsletten L, Kaastad TS, Madsen JE, Reikerås O, Ovstebø R, Strømme JH, Falch J (1994)
The development of femoral osteopenia in ovariectomized rats is not reduced by high intensity treadmill training: a mechanical and densitometric study
Calcif Tissue Int, 55 (6), 436-42
PubMed 7895182

Publications 1992

Brandtzaeg P, Bryn K, Kierulf P, Ovstebø R, Namork E, Aase B, Jantzen E (1992)
Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy
J Clin Invest, 89 (3), 816-23
PubMed 1541674

Høgevold HE, Kierulf P, Ovstebø R, Reikerås O (1992)
Acute phase reactants and interleukin 6 after total hip replacement. Effects of high dose corticosteroids
Eur J Surg, 158 (6-7), 339-45
PubMed 1382623

Osnes T, Kierulf P, Skar V, Skar AG, Ovstebø R, Osnes M (1992)
Quantification of lipopolysaccharides in human bile with or without gram-negative bacteria
Scand J Gastroenterol, 27 (6), 453-8
PubMed 1631492

Publications 1989

Brandtzaeg P, Sandset PM, Joø GB, Ovstebø R, Abildgaard U, Kierulf P (1989)
The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease
Thromb Res, 55 (4), 459-70
PubMed 2510354