Sigbjørn Smeland
Position: Physician in chief, oncologist, PhD
Phone: +47 22 93 48 00
Email:
 

Author network for Sigbjørn Smeland by COREMINE medical


Publications 2017

Henriksen HB, Ræder H, Bøhn SK, Paur I, Kværner AS, Billington SÅ, Eriksen MT, Wiedsvang G, Erlund I, Færden A, Veierød MB, Zucknick M, Smeland S, Blomhoff R (2017)
The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: a food-based multicentre randomized controlled trial
BMC Cancer, 17 (1), 83
PubMed 28137255

Ræder H, Kværner AS, Henriksen C, Florholmen G, Henriksen HB, Bøhn SK, Paur I, Smeland S, Blomhoff R (2017)
Validity of bioelectrical impedance analysis in estimation of fat-free mass in colorectal cancer patients
Clin Nutr (in press)
PubMed 28122662

Publications 2016

Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KLB, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS et al. (2016)
Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial
Lancet Oncol, 17 (10), 1396-1408
PubMed 27569442

Russnes KM, Möller E, Wilson KM, Carlsen M, Blomhoff R, Smeland S, Adami HO, Grönberg H, Mucci LA, Bälter K (2016)
Total antioxidant intake and prostate cancer in the Cancer of the Prostate in Sweden (CAPS) study. A case control study
BMC Cancer, 16, 438
PubMed 27400803

Thorsen L, Dahl AA, Nystad R, Kiserud CE, Geirdal AØ, Smeland S (2016)
Baseline characteristics in female cancer patients with unimproved work status after an outpatient rehabilitation program and health changes during the intervention
Springerplus, 5 (1), 1009
PubMed 27398282

Publications 2015

Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, Nadel H, Randall RL, Deffenbaugh C, Nagarajan R, Brennan B, Letson GD, Teot LA, Goorin A, Baumhoer D, Kager L, Werner M, Lau CC, Sundby Hall K, Gelderblom H, Meyers P et al. (2015)
Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial
J Clin Oncol, 33 (20), 2279-87
PubMed 26033801

Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
Mol Oncol, 9 (6), 1129-39
PubMed 25769404

Publications 2014

Bruheim M, Woods KV, Smeland S, Nortvedt MW (2014)
An educational program to transition oncology nurses at the Norwegian Radium Hospital to an evidence-based practice model: development, implementation, and preliminary outcomes
J Cancer Educ, 29 (2), 224-32
PubMed 24197689

Danielsen SA, Lind GE, Kolberg M, Høland M, Bjerkehagen B, Sundby Hall K, van den Berg E, Mertens F, Smeland S, Picci P, Lothe RA (2014)
Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
Neuro Oncol, 17 (1), 63-9
PubMed 25038505

Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G et al. (2014)
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment
Ann Oncol, 26 (2), 407-14
PubMed 25421877

Publications 2013

Bjerkehagen B, Småstuen MC, Hall KS, Skjeldal S, Bruland ØS, Smeland S, Johannesen TB, Fosså SD (2013)
Incidence and mortality of second sarcomas - a population-based study
Eur J Cancer, 49 (15), 3292-302
PubMed 23787025

Collins M, Wilhelm M, Conyers R, Herschtal A, Whelan J, Bielack S, Kager L, Kühne T, Sydes M, Gelderblom H, Ferrari S, Picci P, Smeland S, Eriksson M, Petrilli AS, Bleyer A, Thomas DM (2013)
Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis
J Clin Oncol, 31 (18), 2303-12
PubMed 23669227

Russnes KM, Wilson KM, Epstein MM, Kasperzyk JL, Stampfer MJ, Kenfield SA, Smeland S, Blomhoff R, Giovannucci EL, Willett WC, Mucci LA (2013)
Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study
Int J Cancer, 134 (5), 1156-65
PubMed 23959920

Publications 2012

Bøhn SK, Russnes KM, Sakhi AK, Thoresen M, Holden M, Moskaug JØ, Myhrstad MC, Olstad OK, Smeland S, Blomhoff R (2012)
Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients
BMC Cancer, 12, 426
PubMed 23009663

Kolberg M, Høland M, Agesen TH, Brekke HR, Liestøl K, Hall KS, Mertens F, Picci P, Smeland S, Lothe RA (2012)
Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
Neuro Oncol, 15 (2), 135-47
PubMed 23161774

Luksch R, Tienghi A, Hall KS, Fagioli F, Picci P, Barbieri E, Gandola L, Eriksson M, Ruggieri P, Daolio P, Lindholm P, Prete A, Bisogno G, Tamburini A, Grignani G, Abate ME, Podda M, Smeland S, Ferrari S (2012)
Primary metastatic Ewing's family tumors: results of the Italian Sarcoma Group and Scandinavian Sarcoma Group ISG/SSG IV Study including myeloablative chemotherapy and total-lung irradiation
Ann Oncol, 23 (11), 2970-6
PubMed 22771824

Stensvold A, Dahl AA, Brennhovd B, Småstuen MC, Fosså SD, Lilleby W, Steinsvik A, Axcrona K, Smeland S (2012)
Bother problems in prostate cancer patients after curative treatment
Urol Oncol, 31 (7), 1067-78
PubMed 22341412

Wien TN, Pike E, Wisløff T, Staff A, Smeland S, Klemp M (2012)
Cancer risk with folic acid supplements: a systematic review and meta-analysis
BMJ Open, 2 (1), e000653
PubMed 22240654

Publications 2011

Bjerkehagen B, Småstuen MC, Hall KS, Skjeldal S, Smeland S, Fosså SD (2011)
Why do patients with radiation-induced sarcomas have a poor sarcoma-related survival?
Br J Cancer, 106 (2), 297-306
PubMed 22173669

Hjortland GO, Meza-Zepeda LA, Beiske K, Ree AH, Tveito S, Hoifodt H, Bohler PJ, Hole KH, Myklebost O, Fodstad O, Smeland S, Hovig E (2011)
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
BMC Cancer, 11, 455
PubMed 22014070

Smeland S, Bruland OS, Hjorth L, Brosjö O, Bjerkehagen B, Osterlundh G, Jakobson A, Hall KS, Monge OR, Björk O, Alvegaard TA (2011)
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years
Acta Orthop, 82 (2), 211-6
PubMed 21434784

Stensvold A, Dahl AA, Brennhovd B, Cvancarova M, Fosså SD, Lilleby W, Axcrona K, Smeland S (2011)
Methods for prospective studies of adverse effects as applied to prostate cancer patients treated with surgery or radiotherapy without hormones
Prostate, 72 (6), 668-76
PubMed 21809351

Publications 2010

Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
J Clin Oncol, 28 (9), 1573-82
PubMed 20159821

Ferrari S, Sundby Hall K, Luksch R, Tienghi A, Wiebe T, Fagioli F, Alvegard TA, Brach Del Prever A, Tamburini A, Alberghini M, Gandola L, Mercuri M, Capanna R, Mapelli S, Prete A, Carli M, Picci P, Barbieri E, Bacci G, Smeland S (2010)
Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol
Ann Oncol, 22 (5), 1221-7
PubMed 21059639

Sakhi AK, Bøhn SK, Smeland S, Thoresen M, Smedshaug GB, Tausjø J, Svilaas A, Karlsen A, Russnes KM, Svilaas T, Blomhoff R (2010)
Postradiotherapy plasma lutein, alpha-carotene, and beta-carotene are positively associated with survival in patients with head and neck squamous cell carcinoma
Nutr Cancer, 62 (3), 322-8
PubMed 20358469

Stensvold A, Dahl AA, Fosså SD, Axcrona K, Lilleby W, Brennhovd B, Smeland S (2010)
Clinicians' use of guidelines as illustrated by curative treatment of prostate cancer at a comprehensive cancer center
Acta Oncol, 50 (3), 408-14
PubMed 20586661

Whelan J, Patterson D, Perisoglou M, Bielack S, Marina N, Smeland S, Bernstein M (2010)
The role of interferons in the treatment of osteosarcoma
Pediatr Blood Cancer, 54 (3), 350-4
PubMed 19902521

Publications 2009

Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
Neuro Oncol, 11 (5), 514-28
PubMed 19182148

Bruland ØS, Bauer H, Alvegaard T, Smeland S (2009)
Treatment of osteosarcoma. The Scandinavian Sarcoma Group experience
Cancer Treat Res, 152, 309-18
PubMed 20213398

Bruland ØS, Høifødt H, Hall KS, Smeland S, Fodstad Ø (2009)
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients
Cancer Treat Res, 152, 509-15
PubMed 20213412

Jetne V, Kvaløy S, Smeland S, Johannesen TB, Tveit KM (2009)
[Use of radiotherapy in South-Eastern Norway Regional Health Authority]
Tidsskr Nor Laegeforen, 129 (24), 2602-5
PubMed 20029555

Marina N, Bielack S, Whelan J, Smeland S, Krailo M, Sydes MR, Butterfass-Bahloul T, Calaminus G, Bernstein M (2009)
International collaboration is feasible in trials for rare conditions: the EURAMOS experience
Cancer Treat Res, 152, 339-53
PubMed 20213400

Sakhi AK, Russnes KM, Thoresen M, Bastani NE, Karlsen A, Smeland S, Blomhoff R (2009)
Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study
BMC Cancer, 9, 458
PubMed 20025747

Smeland S, Bruland OS, Hjorth L, Brosjo O, Bjerkehagen B, Osterlundh G, Jakobson A, Hall KS, Monge OR, Bjork O, Alvegaard TA (2009)
Scandinavian experience in classical osteosarcoma Results of the SSG XIV protocol
Acta Orthop., 80, 60-66

Smeland S, Wiebe T, Monge OR, Brosjo O, Bohling T, Hjorth L, Hall KS, Jakobson A, Alvegaard TA (2009)
Treatment of localized Ewing sarcoma family of tumors The Scandinavian Sarcoma Group experience
Acta Orthop., 80, 75-78

Publications 2008

Bielack SS, Marina N, Ferrari S, Helman LJ, Smeland S, Whelan JS, Reaman GH (2008)
Osteosarcoma: the same old drugs or more?
J Clin Oncol, 26 (18), 3102-3; author reply 3104-5
PubMed 18565904

Bjerkehagen B, Smeland S, Walberg L, Skjeldal S, Hall KS, Nesland JM, Småstuen MC, Fosså SD, Saeter G (2008)
Radiation-induced sarcoma: 25-year experience from the Norwegian Radium Hospital
Acta Oncol, 47 (8), 1475-82
PubMed 18607853

Fosså SD, Dahl AA, Smeland S, Thorsen L, Loge JH (2008)
[Rehabilitation after cancer]
Tidsskr Nor Laegeforen, 128 (22), 2615-6
PubMed 19023358

Publications 2006

Sakhi AK, Russnes KM, Smeland S, Blomhoff R, Gundersen TE (2006)
Simultaneous quantification of reduced and oxidized glutathione in plasma using a two-dimensional chromatographic system with parallel porous graphitized carbon columns coupled with fluorescence and coulometric electrochemical detection
J Chromatogr A, 1104 (1-2), 179-89
PubMed 16376913

Serra M, Pasello M, Manara MC, Scotlandi K, Ferrari S, Bertoni F, Mercuri M, Alvegard TA, Picci P, Bacci G, Smeland S (2006)
May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol
Int J Oncol, 29 (6), 1459-68
PubMed 17088985

Storlazzi CT, Brekke HR, Mandahl N, Brosjö O, Smeland S, Lothe RA, Mertens F (2006)
Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
J Pathol, 209 (4), 492-500
PubMed 16721726

Publications 2005

Bruland OS, Høifødt H, Saeter G, Smeland S, Fodstad O (2005)
Hematogenous micrometastases in osteosarcoma patients
Clin Cancer Res, 11 (13), 4666-73
PubMed 16000559

Bøhn SK, Smeland S, Sakhi AK, Thoresen M, Russnes KM, Tausjø J, Svilaas A, Svilaas T, Blomhoff R (2005)
Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma
Cancer Lett, 238 (2), 240-7
PubMed 16157445

Ferrari S, Smeland S, Mercuri M, Bertoni F, Longhi A, Ruggieri P, Alvegard TA, Picci P, Capanna R, Bernini G, Müller C, Tienghi A, Wiebe T, Comandone A, Böhling T, Del Prever AB, Brosjö O, Bacci G, Saeter G, Italian and Scandinavian Sarcoma Groups (2005)
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups
J Clin Oncol, 23 (34), 8845-52
PubMed 16246977

Müller CR, Smeland S, Bauer HC, Saeter G, Strander H (2005)
Interferon-alpha as the only adjuvant treatment in high-grade osteosarcoma: long term results of the Karolinska Hospital series
Acta Oncol, 44 (5), 475-80
PubMed 16118081

Staff AC, Holven K, Løken EB, Sygnestveit K, Vollset SE, Smeland S (2005)
[Does folic acid have effects on other health problems than neural tube defects?]
Tidsskr Nor Laegeforen, 125 (4), 438-41
PubMed 15742017

Staff AC, Løken EB, Holven K, Sygnestveit K, Vollset SE, Smeland S (2005)
[Effects of public initiatives aimed at reducing neural tube defects with folic acid supplementation]
Tidsskr Nor Laegeforen, 125 (4), 435-7
PubMed 15742016

Publications 2004

Alvegård TA, Bauer H, Blomqvist C, Rydholm A, Smeland S (2004)
The Scandinavian Sarcoma Group--background, organization and the SSG Register--the first 25 years
Acta Orthop Scand Suppl, 75 (311), 1-7
PubMed 15188658

Bauer HC, Alvegård TA, Berlin O, Erlanson M, Kalén A, Lindholm P, Gustafson P, Smeland S, Trovik CS (2004)
The Scandinavian Sarcoma Group Register 1986-2001
Acta Orthop Scand Suppl, 75 (311), 8-10
PubMed 15188659

Smeland S, Blystad AK, Kvaløy SO, Ikonomou IM, Delabie J, Kvalheim G, Hammerstrøm J, Lauritzsen GF, Holte H (2004)
Treatment of Burkitt's/Burkitt-like lymphoma in adolescents and adults: a 20-year experience from the Norwegian Radium Hospital with the use of three successive regimens
Ann Oncol, 15 (7), 1072-8
PubMed 15205201

Smeland S, Wiebe T, Brosjö O, Böhling T, Alvegård TA (2004)
Chemotherapy in Ewing's sarcoma. The Scandinavian Sarcoma Group experience
Acta Orthop Scand Suppl, 75 (311), 87-91
PubMed 15188670

Smeland S, Wiebe T, Böhling T, Brosjö O, Jonsson K, Alvegård TA (2004)
Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience
Acta Orthop Scand Suppl, 75 (311), 92-8
PubMed 15188671

Publications 2003

Skotheim RI, Kallioniemi A, Bjerkhagen B, Mertens F, Brekke HR, Monni O, Mousses S, Mandahl N, Soeter G, Nesland JM, Smeland S, Kallioniemi OP, Lothe RA (2003)
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
J Clin Oncol, 21 (24), 4586-91
PubMed 14673046

Smeland S, Erikstein B, Aas M, Skovlund E, Hess SL, Fosså SD (2003)
Role of strontium-89 as adjuvant to palliative external beam radiotherapy is questionable: results of a double-blind randomized study
Int J Radiat Oncol Biol Phys, 56 (5), 1397-404
PubMed 12873686

Smeland S, Muller C, Alvegard TA, Wiklund T, Wiebe T, Bjork O, Stenwig AE, Willen H, Holmstrom T, Folleras G, Brosjo O, Kivioja A, Jonsson K, Monge O, Saeter G (2003)
Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders
Eur. J. Cancer, 39 (4), PII S0959-8049(02)00747-5-494

Smeland S, Muller C, Saeter G (2003)
Reply to comment on "Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders"
Eur. J. Cancer, 39 (17), 2567-2568

Smeland S, Müller C, Alvegard TA, Wiklund T, Wiebe T, Björk O, Stenwig AE, Willén H, Holmström T, Follerås G, Brosjö O, Kivioja A, Jonsson K, Monge O, Saeter G (2003)
Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders
Eur J Cancer, 39 (4), 488-94
PubMed 12751380

Publications 2002

Holte H, Smeland S, Blystad AK, Kvaløy S, Hammerstrøm J, Tjønnfjord GE (2002)
[Intensive chemotherapy in Burkitt's lymphoma and aggressive non-Hodgkin's lymphoma]
Tidsskr Nor Laegeforen, 122 (4), 364-9
PubMed 11915663

Publications 2000

Thune I, Smeland S (2000)
[Is physical activity important in treatment and rehabilitation of cancer patients?]
Tidsskr Nor Laegeforen, 120 (27), 3302-4
PubMed 11187175

Thune I, Smeland S (2000)
[Can physical activity prevent cancer?]
Tidsskr Nor Laegeforen, 120 (27), 3296-301
PubMed 11187174

Publications 1999

Hagen E, Myhre AM, Smeland S, Halvorsen B, Norum KR, Blomhoff R (1999)
Uptake of vitamin A in macrophages from physiologic transport proteins: role of retinol-binding protein and chylomicron remnants
J Nutr Biochem, 10 (6), 345-52
PubMed 15539309

Publications 1998

Reppe S, Smeland S, Moskaug JO, Blomhoff R (1998)
Retinol-induced secretion of human retinol-binding protein in yeast
FEBS Lett, 427 (2), 213-9
PubMed 9607314

Publications 1997

Natarajan V, Smeland S, Moskaug JO, Kamiyama S, Masushige S, Kato S, Blomhoff R (1997)
Role of the C-termini of human and chicken plasma retinol-binding proteins
Eur J Cell Biol, 73 (4), 316-20
PubMed 9270874

Smeland S, Kolset SO, Lyon M, Norum KR, Blomhoff R (1997)
Binding of perlecan to transthyretin in vitro
Biochem J, 326 ( Pt 3), 829-36
PubMed 9307034

Publications 1995

Malaba L, Smeland S, Senoo H, Norum KR, Berg T, Blomhoff R, Kindberg GM (1995)
Retinol-binding protein and asialo-orosomucoid are taken up by different pathways in liver cells
J Biol Chem, 270 (26), 15686-92
PubMed 7797569

Smeland S, Bjerknes T, Malaba L, Eskild W, Norum KR, Blomhoff R (1995)
Tissue distribution of the receptor for plasma retinol-binding protein
Biochem J, 305 ( Pt 2), 419-24
PubMed 7832754

Publications 1993

Senoo H, Smeland S, Malaba L, Bjerknes T, Stang E, Roos N, Berg T, Norum KR, Blomhoff R (1993)
Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells
Proc Natl Acad Sci U S A, 90 (8), 3616-20
PubMed 8386378

Publications 1992

Blomhoff R, Senoo H, Smeland S, Bjerknes T, Norum KR (1992)
Cellular uptake of vitamin A
J Nutr Sci Vitaminol (Tokyo), Spec No, 327-30
PubMed 1338447

Publications 1986

Maeland JA, Smeland S (1986)
Exemplification of serological cross-reactivity of Neisseria lipopolysaccharides
Acta Pathol Microbiol Immunol Scand B, 94 (4), 223-9
PubMed 2428203