Developement and progression of mesenchymal tumours
Project leader and key members:
Ola Myklebost
Leonardo Meza-Zepeda
Sigbjørn Smeland
Kirsten Sundby Hall
Gunnar Sæter
Home address Internet:
radium.no/myklebost
Department Institute:
Tumour Biology, Inst. for Cancer Research, Norw. Radium Hospital
Main aim project:
Our group is using functional genomics to characterise mesenchymal oncogenesis, that is the processes leading to formation of malignant connective tissue tumours, or sarcomas. Our aim is to contribute to basic understanding of mesenchymal biology, to better diagnostics for sarcomas, and to improved biologically designed treatments.
Important results:
please see web site
Methods:
Cell and molecular biology
Fluorescent in situ hybridisation
Microarray technologies (expression and genomic)
Proteomics
Experiments on human tumours transplanted to immunodeficient mice
Collaborators Helse Sor:
http://radium.no/myklebost/index.php?mid=5&k=myklebost/collaborators&aid=1955
Key search words:
sarcoma
functional genomics
microarray
mesenchymal tumours
gene amplification
mesenchymal stem cells
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