Karl-Johan Malmberg
Position: Professor
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Author network for Karl-Johan Malmberg by COREMINE medical


Publications 2012

Béziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, Hervier B, Theodorou I, Martinot M, Debré P, Björkström NK, Malmberg KJ, Marcellin P, Vieillard V (2012)
CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients
Eur J Immunol, 42 (2), 447-57
PubMed 22105371

Publications 2011

Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaëlsson J, Malmberg KJ, Klingström J, Ahlm C, Ljunggren HG (2011)
Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
J Exp Med, 208 (1), 13-21
PubMed 21173105

Björkström NK, Svensson A, Malmberg KJ, Eriksson K, Ljunggren HG (2011)
Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection
PLoS One, 6 (11), e27664
PubMed 22110712

Enqvist M, Nilsonne G, Hammarfjord O, Wallin RP, Björkström NK, Björnstedt M, Hjerpe A, Ljunggren HG, Dobra K, Malmberg KJ, Carlsten M (2011)
Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells
J Immunol, 187 (7), 3546-54
PubMed 21890659

Kuylenstierna C, Björkström NK, Andersson SK, Sahlström P, Bosnjak L, Paquin-Proulx D, Malmberg KJ, Ljunggren HG, Moll M, Sandberg JK (2011)
NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Eur J Immunol, 41 (7), 1913-23
PubMed 21590763

Malmberg KJ, Michaëlsson J, Parham P, Ljunggren HG (2011)
Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation
Immunity, 35 (5), 653-7
PubMed 22118518

Remberger M, Ackefors M, Berglund S, Blennow O, Dahllöf G, Dlugosz A, Garming-Legert K, Gertow J, Gustafsson B, Hassan M, Hassan Z, Hauzenberger D, Hägglund H, Karlsson H, Klingspor L, Kumlien G, Le Blanc K, Ljungman P, Machaczka M, Malmberg KJ, Marschall HU, Mattsson J, Olsson R, Omazic B, Sairafi D et al. (2011)
Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study
Biol Blood Marrow Transplant, 17 (11), 1688-97
PubMed 21620989

Taner SB, Pando MJ, Roberts A, Schellekens J, Marsh SG, Malmberg KJ, Parham P, Brodsky FM (2011)
Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention
J Immunol, 186 (1), 62-72
PubMed 21115737

Publications 2010

Andersson S, Malmberg JA, Malmberg KJ (2010)
Tolerant and diverse natural killer cell repertoires in the absence of selection
Exp Cell Res, 316 (8), 1309-15
PubMed 20206161

Björklund AT, Schaffer M, Fauriat C, Ringdén O, Remberger M, Hammarstedt C, Barrett AJ, Ljungman P, Ljunggren HG, Malmberg KJ (2010)
NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Blood, 115 (13), 2686-94
PubMed 20097883

Björkström NK, Fauriat C, Bryceson YT, Sandberg JK, Ljunggren HG, Malmberg KJ (2010)
Analysis of the KIR repertoire in human NK cells by flow cytometry
Methods Mol Biol, 612, 353-64
PubMed 20033653

Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Björklund AT, Flodström-Tullberg M, Michaëlsson J, Rottenberg ME, Guzmán CA, Ljunggren HG, Malmberg KJ (2010)
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
Blood, 116 (19), 3853-64
PubMed 20696944

Carlsten M, Baumann BC, Simonsson M, Jädersten M, Forsblom AM, Hammarstedt C, Bryceson YT, Ljunggren HG, Hellström-Lindberg E, Malmberg KJ (2010)
Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome
Leukemia, 24 (9), 1607-16
PubMed 20613786

Fasth AE, Björkström NK, Anthoni M, Malmberg KJ, Malmström V (2010)
Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis
Eur J Immunol, 40 (2), 378-87
PubMed 19904767

Fauriat C, Ivarsson MA, Ljunggren HG, Malmberg KJ, Michaëlsson J (2010)
Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Blood, 115 (6), 1166-74
PubMed 19903900

Rotzius P, Thams S, Soehnlein O, Kenne E, Tseng CN, Björkström NK, Malmberg KJ, Lindbom L, Eriksson EE (2010)
Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice
Am J Pathol, 177 (1), 493-500
PubMed 20472897

Schellekens J, Schaffer M, Malmberg KJ, Madrigal JA, Marsh SG (2010)
Identification of a novel KIR3DL1*072 allele by sequence-based typing
Tissue Antigens, 76 (1), 74-5
PubMed 20210921

Publications 2009

Andersson S, Fauriat C, Malmberg JA, Ljunggren HG, Malmberg KJ (2009)
KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Blood, 114 (1), 95-104
PubMed 19304956

Carlsten M, Malmberg KJ, Ljunggren HG (2009)
Natural killer cell-mediated lysis of freshly isolated human tumor cells
Int J Cancer, 124 (4), 757-62
PubMed 19035446

Carlsten M, Norell H, Bryceson YT, Poschke I, Schedvins K, Ljunggren HG, Kiessling R, Malmberg KJ (2009)
Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells
J Immunol, 183 (8), 4921-30
PubMed 19801517

Curbo S, Gaudin R, Carlsten M, Malmberg KJ, Troye-Blomberg M, Ahlborg N, Karlsson A, Johansson M, Lundberg M (2009)
Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Biochem Biophys Res Commun, 390 (4), 1272-7
PubMed 19878651

Fasth AE, Dastmalchi M, Rahbar A, Salomonsson S, Pandya JM, Lindroos E, Nennesmo I, Malmberg KJ, Söderberg-Nauclér C, Trollmo C, Lundberg IE, Malmström V (2009)
T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells
J Immunol, 183 (7), 4792-9
PubMed 19752224

Malmberg KJ, Ljunggren HG (2009)
Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Nat Immunol, 10 (1), 11-2
PubMed 19088733

Publications 2008

Björkström NK, Gonzalez VD, Malmberg KJ, Falconer K, Alaeus A, Nowak G, Jorns C, Ericzon BG, Weiland O, Sandberg JK, Ljunggren HG (2008)
Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
J Immunol, 181 (6), 4219-28
PubMed 18768879

Fauriat C, Andersson S, Björklund AT, Carlsten M, Schaffer M, Björkström NK, Baumann BC, Michaëlsson J, Ljunggren HG, Malmberg KJ (2008)
Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype
J Immunol, 181 (9), 6010-9
PubMed 18941190

Gonzalez VD, Björkström NK, Malmberg KJ, Moll M, Kuylenstierna C, Michaëlsson J, Ljunggren HG, Sandberg JK (2008)
Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
J Immunol Methods, 330 (1-2), 64-74
PubMed 18083186

Hühn MH, Hultcrantz M, Lind K, Ljunggren HG, Malmberg KJ, Flodström-Tullberg M (2008)
IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
Cell Microbiol, 10 (2), 426-36
PubMed 17961184

Malmberg KJ, Bryceson YT, Carlsten M, Andersson S, Björklund A, Björkström NK, Baumann BC, Fauriat C, Alici E, Dilber MS, Ljunggren HG (2008)
NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Cancer Immunol Immunother, 57 (10), 1541-52
PubMed 18317755

Publications 2007

Carlsten M, Björkström NK, Norell H, Bryceson Y, van Hall T, Baumann BC, Hanson M, Schedvins K, Kiessling R, Ljunggren HG, Malmberg KJ (2007)
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Cancer Res, 67 (3), 1317-25
PubMed 17283169

Hanson MG, Ozenci V, Carlsten MC, Glimelius BL, Frödin JE, Masucci G, Malmberg KJ, Kiessling RV (2007)
A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients
Cancer Immunol Immunother, 56 (7), 973-84
PubMed 17143612

Harlin H, Hanson M, Johansson CC, Sakurai D, Poschke I, Norell H, Malmberg KJ, Kiessling R (2007)
The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subset
J Immunol, 179 (7), 4513-9
PubMed 17878347

Ljunggren HG, Malmberg KJ (2007)
Prospects for the use of NK cells in immunotherapy of human cancer
Nat Rev Immunol, 7 (5), 329-39
PubMed 17438573

Publications 2006

Malmberg KJ, Ljunggren HG (2006)
Escape from immune- and nonimmune-mediated tumor surveillance
Semin Cancer Biol, 16 (1), 16-31
PubMed 16140546

Norell H, Carlsten M, Ohlum T, Malmberg KJ, Masucci G, Schedvins K, Altermann W, Handke D, Atkins D, Seliger B, Kiessling R (2006)
Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity
Cancer Res, 66 (12), 6387-94
PubMed 16778217

Publications 2005

Malmberg KJ, Schaffer M, Ringdén O, Remberger M, Ljunggren HG (2005)
KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Mol Immunol, 42 (4), 531-4
PubMed 15607809

Takahashi A, Hanson MG, Norell HR, Havelka AM, Kono K, Malmberg KJ, Kiessling RV (2005)
Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress
J Immunol, 174 (10), 6080-7
PubMed 15879102

Publications 2004

Malmberg KJ (2004)
Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?
Cancer Immunol Immunother, 53 (10), 879-92
PubMed 15338206

Schaffer M, Malmberg KJ, Ringdén O, Ljunggren HG, Remberger M (2004)
Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Transplantation, 78 (7), 1081-5
PubMed 15480179

Publications 2002

Malmberg KJ, Lenkei R, Petersson M, Ohlum T, Ichihara F, Glimelius B, Frödin JE, Masucci G, Kiessling R (2002)
A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer
Clin Cancer Res, 8 (6), 1772-8
PubMed 12060616

Malmberg KJ, Levitsky V, Norell H, de Matos CT, Carlsten M, Schedvins K, Rabbani H, Moretta A, Söderström K, Levitskaya J, Kiessling R (2002)
IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism
J Clin Invest, 110 (10), 1515-23
PubMed 12438449

Publications 2001

Charo J, Geluk A, Sundbäck M, Mirzai B, Diehl AD, Malmberg KJ, Achour A, Huriguchi S, van Meijgaarden KE, Drijfhout JW, Beekman N, van Veelen P, Ossendorp F, Ottenhoff TH, Kiessling R (2001)
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Eur J Immunol, 31 (12), 3602-11
PubMed 11745380

Malmberg KJ, Arulampalam V, Ichihara F, Petersson M, Seki K, Andersson T, Lenkei R, Masucci G, Pettersson S, Kiessling R (2001)
Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-kappaB activation
J Immunol, 167 (5), 2595-601
PubMed 11509600

Publications 1999

Rongcun Y, Salazar-Onfray F, Charo J, Malmberg KJ, Evrin K, Maes H, Kono K, Hising C, Petersson M, Larsson O, Lan L, Appella E, Sette A, Celis E, Kiessling R (1999)
Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas
J Immunol, 163 (2), 1037-44
PubMed 10395702