
| Gunhild Mari Mælandsmo | |
| Position: | Senior scientist |
| Phone: | +47 22 78 18 79 |
| Email: | |
CURRICULUM VITAE
- Master of Science, Department of Biochemistry, University of Oslo, 1989
- Dr. philos, University of Oslo, 1996
- Postdoctoral fellow in Prof Frank Grahams laboratory, McMaster University, Hamilton, Canada, 1997-1998
- Postdoctoral fellow, Department of Tumor Biology, Norwegian Radium Hospital, 1998 - 2001
- Group leader, Department of Tumor Biology, Norwegian Radium Hospital, 2000 – present
- Acting Head, Department of Tumor Biology, Norwegian Radium Hospital, 2003 – 2008
Author network for Gunhild Mari Mælandsmo by COREMINE medical
Publications in press
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts
Mol Oncol (in press)
PubMed 22521242
Publications 2012
In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts
J Magn Reson Imaging, 35 (5), 1098-107
PubMed 22170753
Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival
BMC Cancer, 12, 73
PubMed 22356677
B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes
Int J Cancer, 130 (10), 2282-90
PubMed 21671471
Publications 2011
The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis
Dev Biol, 352 (2), 181-90
PubMed 21195708
Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma
Amino Acids, 41 (4), 875-84
PubMed 20191297
Evaluation of potential interactions between the metastasis-associated protein S100A4 and the tumor suppressor protein p53
Amino Acids, 41 (4), 863-73
PubMed 20177948
Osteopontin--an important downstream effector of S100A4-mediated invasion and metastasis
Int J Cancer, 129 (4), 780-90
PubMed 20957651
Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells
Cancer Biol Ther, 12 (1), 47-58
PubMed 21508672
B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation
Mol Cancer Ther, 10 (6), 960-71
PubMed 21518725
TD-11 workshop report: characterization of monoclonal antibodies to S100 proteins
Tumour Biol, 32 (1), 1-12
PubMed 20652782
Publications 2010
Comment on the Importance of S100A4 in regulation of MMP-13
J Biol Chem, 285 (53), le23; author reply le24
PubMed 21186294
S100A4 and metastasis: a small actor playing many roles
Am J Pathol, 176 (2), 528-35
PubMed 20019188
Nuclear S100A4 is a novel prognostic marker in colorectal cancer
Eur J Cancer, 46 (16), 2919-25
PubMed 20719498
Cystatin E/M suppresses legumain activity and invasion of human melanoma
BMC Cancer, 10, 17
PubMed 20074384
Signal transduction mechanisms involved in S100A4-induced activation of the transcription factor NF-kappaB
BMC Cancer, 10, 241
PubMed 20507646
PI3K-AKT-mTOR pathway is dominant over androgen receptor signaling in prostate cancer cells
Cell Oncol, 32 (1-2), 11-27
PubMed 20203370
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
BMC Cancer, 10, 433
PubMed 20716336
Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma
Int J Cancer, 126 (2), 350-61
PubMed 19588500
Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma
PLoS One, 5 (5), e10731
PubMed 20505780
Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells
Pigment Cell Melanoma Res, 23 (3), 449-51
PubMed 20236249
Longitudinal magnetic resonance imaging-based assessment of vascular changes and radiation response in androgen-sensitive prostate carcinoma xenografts under androgen-exposed and androgen-deprived conditions
Neoplasia, 12 (10), 818-25
PubMed 20927320
STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer
Cancer Res, 70 (14), 5818-28
PubMed 20587517
A novel human recombinant single-chain antibody targeting CD166/ALCAM inhibits cancer cell invasion in vitro and in vivo tumour growth
Cancer Immunol Immunother, 59 (11), 1665-74
PubMed 20635083
Publications 2009
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
Mol Oncol, 3 (5-6), 469-82
PubMed 19713161
Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts
Cancer Res, 69 (9), 3746-54
PubMed 19383913
Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4
FEBS J, 276 (18), 5275-86
PubMed 19682073
Didanosine ester prodrugs: synthesis, albumin binding properties and pharmacokinetic studies in rats
Eur J Med Chem, 44 (10), 3874-9
PubMed 19433342
Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites
Tumour Biol, 30 (1), 15-25
PubMed 19194111
Publications 2008
The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer
Cancer Res, 68 (22), 9255-64
PubMed 19010898
Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes
Int J Cancer, 123 (6), 1301-10
PubMed 18548584
S100B in bone marrow aspirates in healthy individuals and malignant melanoma patients
Melanoma Res, 18 (2), 134-40
PubMed 18337650
The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications
BMC Cancer, 8, 172
PubMed 18554396
Publications 2007
Photochemical internalization: a new tool for drug delivery
Curr Pharm Biotechnol, 8 (6), 362-72
PubMed 18289045
Interferon-gamma-induced suppression of S100A4 transcription is mediated by the class II transactivator
Tumour Biol, 28 (1), 27-35
PubMed 17143014
Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer
Int J Cancer, 121 (7), 1433-44
PubMed 17565747
Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
J Gene Med, 9 (6), 440-51
PubMed 17410615
Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes
Anticancer Res, 27 (3A), 1301-7
PubMed 17593623
Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic value
Clin Exp Metastasis, 24 (5), 317-27
PubMed 17530423
Publications 2006
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
J Gene Med, 8 (3), 286-97
PubMed 16342300
Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
Cancer Biol Ther, 5 (11), 1511-20
PubMed 17012835
Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
J Gene Med, 8 (6), 707-18
PubMed 16518880
Publications 2005
Matrix metalloproteinases participate in osteosarcoma invasion
J Surg Res, 127 (2), 151-6
PubMed 16083752
PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles
Cancer Gene Ther, 12 (5), 439-48
PubMed 15678152
Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers
Cancer Gene Ther, 12 (11), 864-72
PubMed 15891771
Use of a murine secreted alkaline phosphatase as a non-immunogenic reporter gene in mice
J Gene Med, 7 (3), 307-15
PubMed 15515146
Microarray analysis of phosphatase gene expression in human melanoma
Br J Dermatol, 152 (5), 925-30
PubMed 15888148
Publications 2004
Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant melanoma
Mod Pathol, 17 (8), 990-7
PubMed 15133476
Transgene expression is increased by photochemically mediated transduction of polycation-complexed adenoviruses
Gene Ther, 11 (2), 152-60
PubMed 14712299
Human osteosarcoma xenografts and their sensitivity to chemotherapy
Pathol Oncol Res, 10 (3), 133-41
PubMed 15448748
Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice
Eur J Cancer, 40 (10), 1593-8
PubMed 15196545
Immunofluorometric assay for the metastasis-related protein S100A4: release of S100A4 from normal blood cells prohibits the use of S100A4 as a tumor marker in plasma and serum
Tumour Biol, 25 (1-2), 31-40
PubMed 15192310
Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome
Am J Clin Pathol, 122 (3), 412-20
PubMed 15362372
Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo
J Virol, 78 (11), 5966-72
PubMed 15140994
Sensitization of interferon-gamma induced apoptosis in human osteosarcoma cells by extracellular S100A4
BMC Cancer, 4, 52
PubMed 15318945
Publications 2003
Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest
Br J Cancer, 88 (12), 1995-2001
PubMed 12799648
The metalloproteinase inhibitor TIMP-2 is down-regulated by androgens in LNCaP prostate carcinoma cells
Clin Exp Metastasis, 20 (6), 541-7
PubMed 14598888
Nuclear localization of the metastasis-related protein S100A4 correlates with tumour stage in colorectal cancer
J Pathol, 200 (5), 589-95
PubMed 12898594
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
Oncogene, 22 (34), 5358-61
PubMed 12917637
Light directed gene transfer by photochemical internalisation
Curr Gene Ther, 3 (2), 89-112
PubMed 12653404
Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcome
Clin Cancer Res, 9 (14), 5325-31
PubMed 14614017
Colchicine induces membrane-associated activation of matrix metalloproteinase-2 in osteosarcoma cells in an S100A4-independent manner
Biochem Pharmacol, 66 (12), 2341-53
PubMed 14637192
Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma
Clin Cancer Res, 9 (9), 3383-8
PubMed 12960126
S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
Clin Exp Metastasis, 20 (8), 701-11
PubMed 14713104
Publications 2002
Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy
Cancer Gene Ther, 9 (4), 365-71
PubMed 11960287
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
Oncogene, 21 (14), 2261-9
PubMed 11948409
Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies
Br J Cancer, 87 (11), 1281-6
PubMed 12439718
Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
Anticancer Res, 22 (4), 1949-57
PubMed 12174869
Publications 2001
Expression of matrix metalloproteinases and the metastasis-associated gene S100A4 in human neuroblastoma and primitive neuroectodermal tumor cells
J Pediatr Surg, 36 (7), 1040-4
PubMed 11431772
Cyclin A expression in superficial spreading malignant melanomas correlates with clinical outcome
J Pathol, 195 (5), 530-6
PubMed 11745687
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity
Oncogene, 20 (47), 6881-90
PubMed 11687967
Optimization of hammerhead ribozymes for the cleavage of S100A4 (CAPL) mRNA
Antisense Nucleic Acid Drug Dev, 11 (2), 67-75
PubMed 11334142
Protein tyrosine phosphatase genes downregulated in melanoma
J Invest Dermatol, 117 (5), 1255-60
PubMed 11710941
Publications 2000
Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells
Cancer Res, 60 (19), 5578-83
PubMed 11034106
Levels of cyclin D1 and D3 in malignant melanoma: deregulated cyclin D3 expression is associated with poor clinical outcome in superficial melanoma
Clin Cancer Res, 6 (9), 3614-20
PubMed 10999753
Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer
Br J Cancer, 83 (6), 743-9
PubMed 10952778
Publications 1999
S100A4 involvement in metastasis: deregulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in osteosarcoma cells transfected with an anti-S100A4 ribozyme
Cancer Res, 59 (18), 4702-8
PubMed 10493528
Publications 1998
Interleukin-1 alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis associated protein CAPL
Anticancer Res, 18 (5A), 3299-303
PubMed 9858899
Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival
Am J Pathol, 153 (1), 305-12
PubMed 9665492
Hybridization of a 99Tcm-labelled oligodeoxynucleotide to CAPL RNA
Nucl Med Commun, 19 (8), 803-12
PubMed 9751936
Intracellular metabolism of a 2'-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or asfree ribozyme. A study by capillary electrophoresis
Nucleic Acids Res, 26 (18), 4241-8
PubMed 9722645
Publications 1997
Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastasis detection: studies on the epithelial glycoprotein gene EGP-2
Int J Cancer, 72 (1), 191-6
PubMed 9212242
Differential expression patterns of S100A2, S100A4 and S100A6 during progression of human malignant melanoma
Int J Cancer, 74 (4), 464-9
PubMed 9291441
High levels of messenger RNAs for tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in primary breast carcinomas are associated with development of distant metastases
Clin Cancer Res, 3 (9), 1623-8
PubMed 9815852
Publications 1996
Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas
Br J Cancer, 73 (8), 909-16
PubMed 8611425
Cyclin kinase inhibitor p21WAF1/CIP1 in malignant melanoma: reduced expression in metastatic lesions
Am J Pathol, 149 (6), 1813-22
PubMed 8952518
Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme
Cancer Res, 56 (23), 5490-8
PubMed 8968106
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression
Clin Exp Metastasis, 14 (4), 381-8
PubMed 8878412
Publications 1995
Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1
Br J Cancer, 72 (2), 393-8
PubMed 7640224
Publications 1994
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status
J Natl Cancer Inst, 86 (17), 1297-302
PubMed 8064888
The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas
Cancer Genet Cytogenet, 78 (2), 165-71
PubMed 7828148
Publications 1993
Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2
Cell Growth Differ, 4 (12), 1065-70
PubMed 8117620
Publications 1992
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624
Role of liver endothelial and Kupffer cells in clearing low density lipoprotein from blood in hypercholesterolemic rabbits
J Lipid Res, 33 (6), 867-77
PubMed 1324967
Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans
Arterioscler Thromb, 12 (3), 369-79
PubMed 1532127
Uptake of chylomicron remnant retinyl esters in human leukocytes in vivo
Eur J Clin Invest, 22 (4), 229-34
PubMed 1499639
Publications 1989
Phosphorylation of the high-mobility-group-like protein P1 by casein kinase-2
Eur J Biochem, 184 (3), 529-34
PubMed 2806236




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